D:Osteoporosis

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Disease Term
Synonyms Age Related Bone Loss, AGE RELATED BONE LOSSES, AGE RELATED OSTEOPOROSES, Age Related Osteoporosis, BONE LOSS AGE RELATED, Bone Losses Age Related, OSTEOBLAST, OSTEOBLASTGENESIS, Osteoblastic, Osteoclastgenesis, OSTEOCLASTIC
Documents 4369
Hot Single Events 200
Hot Interactions 200

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Osteoporosis. They are ordered first by their relevance to Osteoporosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT209881 Binding of TNFRSF11B and TNFSF11 8 0.36 8.92 0.86 100.00
2 INT148531 Binding of TNFRSF11A and Tnfsf11 2 0.08 1.77 0.17 100.00
3 INT295121 Proc Regulation of Grxcr1 1 0.00 1.26 0.03 100.00
4 INT88937 Mmv7 Regulation of Gene_expression of SPP1 1 0.00 1.24 0.12 100.00
5 INT328384 Ghrl Positive_regulation of ALPL 1 0.01 0.93 0.13 100.00
6 INT171976 Il18 Positive_regulation of Gene_expression of IFNA1 1 0.01 1.37 0.64 100.00
7 INT302311 PTH Negative_regulation of Gene_expression of SOST 1 0.29 0.59 0 100.00
8 INT332159 Gh Positive_regulation of Gene_expression of Igfbp3 1 0.07 1.11 0 100.00
9 INT89475 TGFB1 Positive_regulation of Gene_expression of PTHLH 3 0.61 3.64 0.21 100.00
10 INT295129 Proc Regulation of Bmp2 1 0.00 0.48 0 100.00
11 INT295127 Proc Regulation of Igf1 1 0.00 0.48 0 100.00
12 INT223963 Binding of Bglap and Runx2 1 0.14 1.74 0.13 100.00
13 INT188801 Il6 Positive_regulation of Positive_regulation of Tnfsf11 1 0.06 0.46 0.21 99.84
14 INT295120 Bmp2 Regulation of Transcription of Pou1f1 1 0.24 0.66 0.06 99.74
15 INT295128 Igf1 Regulation of Transcription of Pou1f1 1 0.16 0.64 0.06 99.74
16 INT295126 Proc Regulation of Transcription of Pou1f1 1 0.00 0.3 0.03 99.74
17 INT264326 IL-17 Positive_regulation of Gene_expression of Il6 1 0.13 0.83 0.43 99.72
18 INT81991 Bmpr2 Positive_regulation of Gene_expression of ODF1 1 0.03 1.59 0.41 99.60
19 INT68256 Binding of GH1 and SCT 1 0.04 0.54 0 99.56
20 INT339779 IGF1 Regulation of GHRH 1 0.08 0.38 0.05 99.56
21 INT262172 Nr1i2 Regulation of Msx2 1 0.12 0.53 0 99.50
22 INT164034 Npb Positive_regulation of Localization of Ceacam1 1 0.29 0.32 0.31 99.48
23 INT164035 Npw Positive_regulation of Localization of Ceacam1 1 0.26 0.32 0.28 99.48
24 INT197649 NR1I2 Positive_regulation of VDR 1 0.15 0.54 0.07 99.48
25 INT197648 ESRRB Positive_regulation of VDR 1 0.03 0.54 0.07 99.48
26 INT119413 SEMA6A Positive_regulation of TNFRSF11A 1 0.10 2.48 1.7 99.44
27 INT270775 PTH Regulation of DMD 1 0.09 0.64 0.03 99.40
28 INT270776 PTH Regulation of Negative_regulation of DMD 1 0.09 0.3 0.03 99.40
29 INT68257 Binding of CALCA and GH1 1 0.00 0.54 0 99.36
30 INT146893 TNF Negative_regulation of Dkk1 1 0.01 1.27 0.3 99.36
31 INT293412 GOPC Regulation of Localization of VEGFA 1 0.04 0.61 0 99.36
32 INT295005 Binding of TNFRSF11A and Tnfsf11 3 0.20 2.02 0.09 99.32
33 INT295006 Binding of TNFRSF11A and Tnfrsf11b 2 0.10 1.6 0.04 99.32
34 INT264300 CTSK Positive_regulation of CYP27A1 1 0.03 0.69 0.07 99.24
35 INT321594 Bmp2 Regulation of Gene_expression of Lxn 1 0.42 1.71 0 99.20
36 INT182636 Binding of TNFSF11 and TNFRSF11A 16 0.29 17.5 0.84 99.16
37 INT254278 Binding of Il13 and Il4 1 0.02 0.74 0.38 99.16
38 INT295003 Binding of Tnfrsf11b and Tnfsf11 3 0.22 1.85 0.08 99.12
39 INT133307 Binding of CD44 and SPP1 5 0.26 2.6 0.35 99.00
40 INT133306 Positive_regulation of Binding of CD44 and SPP1 1 0.16 0.83 0.07 99.00
41 INT293413 GOPC Regulation of Localization of IL11 1 0.03 0.6 0 99.00
42 INT197651 TNF Regulation of PTH 1 0.05 1.67 0 98.96
43 INT197643 TNF Regulation of VDR 1 0.04 1.67 0 98.96
44 INT295122 Bmp2 Regulation of Grxcr1 1 0.02 0.66 0.06 98.86
45 INT295130 Igf1 Regulation of Grxcr1 1 0.02 0.64 0.06 98.86
46 INT256579 Negative_regulation of Bglap Negative_regulation of Localization of Ins1 1 0.33 0.38 0 98.84
47 INT182817 EEF1A2 Positive_regulation of BMP2 1 0.26 1.62 0.28 98.80
48 INT238034 Binding of DMD and SNRNP70 1 0.00 1.18 0.04 98.80
49 INT225801 Binding of Enpp1 and Npp 1 0.17 0.46 0.04 98.80
50 INT218934 Cyp3a23/3a1 Negative_regulation of Ephb1 1 0.01 0.95 0.28 98.76
51 INT321890 Slc3a2 Regulation of Dkk1 1 0.01 0.93 0.04 98.64
52 INT321891 Dkk1 Negative_regulation of Wnt2 1 0.12 0.94 0.05 98.56
53 INT341666 ALPI Positive_regulation of ENPEP 1 0.01 1.05 0 98.56
54 INT272951 Binding of TNF and Igf1 1 0.14 1.48 0.36 98.16
55 INT272953 Negative_regulation of Binding of TNF and Igf1 1 0.16 1.48 0.36 98.16
56 INT181997 TNFRSF11B Negative_regulation of CTSK 1 0.05 0.58 0.14 98.08
57 INT111892 Ptger2 Regulation of Ptger1 1 0.08 2.09 1.55 97.92
58 INT277622 Esr1 Positive_regulation of Gene_expression of Cyp19a1 1 0.03 1.37 0 97.92
59 INT254242 TNF Positive_regulation of Gene_expression of DKK1 1 0.14 1.24 0.91 97.92
60 INT52702 Capza2 Positive_regulation of Ptgs2 1 0.00 0.27 0.11 97.64
61 INT238038 Binding of BMP2 and OPLL 1 0.20 2.45 0.09 97.52
62 INT210595 Binding of TNF and TNFSF11 1 0.10 5.13 0.09 97.44
63 INT187233 Positive_regulation of Mapk8 Positive_regulation of Jun 1 0.12 0.92 0.37 97.44
64 INT180566 Binding of COMP and DMD 1 0.02 0.72 0.15 97.32
65 INT73167 Regulation of Lhb Positive_regulation of Gh 1 0.00 0.48 0.1 97.20
66 INT168143 Tnf Positive_regulation of PLF 1 0.02 0.63 0.06 97.12
67 INT52701 Slc3a1 Positive_regulation of Ptgs2 1 0.06 0.27 0.11 97.08
68 INT171974 Binding of Tnfrsf11a and Tnfsf11 14 0.35 13.11 3.11 96.68
69 INT73168 Lhb Positive_regulation of Gh 2 0.00 0.95 0.2 96.64
70 INT73165 Gh Positive_regulation of Prl 2 0.00 0.95 0.2 96.64
71 INT291556 Binding of ESR1 and Sec22b 2 0.00 0.86 0.5 96.60
72 INT293415 HRAS Positive_regulation of Localization of IL8 1 0.01 0.73 0.09 96.60
73 INT210597 Negative_regulation of Binding of TNFSF11 and TNFRSF11A 3 0.26 5.66 0.33 96.56
74 INT224423 Binding of TNFRSF11B and TNFRSF11A 3 0.19 2.36 0.37 96.56
75 INT52562 Lhb Positive_regulation of Prl 3 0.00 1.09 1.02 96.48
76 INT181996 TNFRSF11B Positive_regulation of Gene_expression of TIMP1 1 0.00 0.67 0.18 96.48
77 INT269759 PTH Positive_regulation of DMD 2 0.06 0.37 0.03 96.16
78 INT254281 Il4 Negative_regulation of Gene_expression of Acp5 1 0.02 0.41 0.22 96.00
79 INT272952 Igf1 Positive_regulation of Localization of TNF 1 0.19 1.53 0.35 95.92
80 INT178437 Mapk8 Positive_regulation of Jun 3 0.40 2.69 0.58 95.88
81 INT278021 BMP2 Positive_regulation of Gene_expression of RUNX1T1 1 0.02 0.5 0 95.76
82 INT186783 Binding of ESR1 and NRIP1 1 0.31 0.79 0.25 95.72
83 INT174532 PTH Positive_regulation of Transcription of IGF1 1 0.06 0.51 0 95.68
84 INT289242 Il6 Positive_regulation of Gene_expression of Prtn3 1 0.00 0.5 0.09 95.36
85 INT289243 Il6 Positive_regulation of Prtn3 1 0.00 0.5 0.09 95.36
86 INT338999 Binding of BTF3P11 and Tnfsf11 1 0.01 0.35 0.08 95.20
87 INT165763 Tnfsf11 Positive_regulation of Phosphorylation of Mapk3 1 0.40 1.08 0.33 94.72
88 INT186685 Edn1 Regulation of Gene_expression of Il6 1 0.11 1.1 0 94.60
89 INT148532 Binding of CCL3 and Tnfsf11 1 0.03 0.71 0.14 94.44
90 INT173949 Binding of IGF1 and Atp6v1e1 1 0.01 0.89 0.28 94.28
91 INT210598 PTHLH Positive_regulation of Gene_expression of TNFSF11 1 0.23 0.98 0.04 94.16
92 INT345190 Lpar1 Regulation of Localization of Il6 1 0.05 1.19 0.04 94.08
93 INT165764 Tnfsf11 Positive_regulation of Mapk3 1 0.17 1.08 0.33 94.00
94 INT334044 Cdt1 Regulation of Gene_expression of ALPP 1 0.04 0.72 0.12 93.88
95 INT171991 Binding of DMD and ERAL1 1 0.01 0.54 0 93.72
96 INT301292 Negative_regulation of Clec5a Negative_regulation of TNF 1 0.05 1.04 0.27 93.68
97 INT165766 Tnfsf11 Negative_regulation of Tnfsf11 Positive_regulation of Nfkb1 1 0.00 1.08 0.33 93.64
98 INT165765 Tnfsf11 Positive_regulation of Nfkb1 1 0.01 1.07 0.33 93.64
99 INT121191 KCNMA1 Positive_regulation of Phosphorylation of MAPK1 1 0.06 0.61 1.18 93.60
100 INT262214 Binding of Msx2 and Nr1i2 1 0.19 0.55 0.06 93.44
101 INT262173 Binding of Msx2 and Ep300 1 0.07 0.55 0.06 93.44
102 INT264324 Olr614 Regulation of IL-17 1 0.02 2.3 1.03 93.40
103 INT262207 Binding of Nr1i2 and Ep300 1 0.14 1.08 0.11 93.36
104 INT224420 Regulation of Binding of NFKB2 and TNFRSF11B 1 0.13 1.39 0.6 93.36
105 INT224422 Regulation of Binding of NFKB2 and TNFSF11 1 0.13 0.69 0.3 93.36
106 INT316598 Pth Regulation of Fgf23 1 0.10 0.28 0.03 93.32
107 INT33647 Calca Positive_regulation of Localization of POMC 1 0.01 0.27 0.17 92.96
108 INT339778 Binding of EDNRA and PTH 1 0.12 0.35 0.05 92.48
109 INT131185 PTH Positive_regulation of Gene_expression of IGF1 3 0.44 3.31 1.31 92.40
110 INT224419 Binding of NFKB2 and TNFRSF11B 1 0.11 1.37 0.6 92.00
111 INT210581 Binding of AMELX and Tnfsf11 1 0.01 0.15 0 91.96
112 INT270116 DMD Regulation of St13 1 0.01 0.09 0 91.92
113 INT185733 Hpse Positive_regulation of Gene_expression of Tnfrsf11b 1 0.20 0.24 0 91.76
114 INT254433 Binding of Lrp5 and Sost 2 0.39 1.51 0.03 91.60
115 INT180956 PLG Regulation of Positive_regulation of MMP13 1 0.32 0.38 0.04 91.60
116 INT180957 Binding of PLG and Regulation of Positive_regulation of MMP13 1 0.14 0.38 0.04 91.60
117 INT171990 Binding of DMD and VDR 5 0.05 2.58 0.39 91.36
118 INT342265 Binding of VDR and HHIP 1 0.00 0.93 0 91.36
119 INT144500 CCL3 Positive_regulation of Gene_expression of Tnfsf11 1 0.77 1.62 0.31 91.32
120 INT180955 PLG Regulation of Positive_regulation of TIMP1 1 0.21 0.38 0.04 90.96
121 INT188805 TNF Positive_regulation of Gene_expression of Crp 1 0.15 2.96 0.95 90.92
122 INT102130 Il6 Positive_regulation of Gene_expression of Crp 4 0.05 7.39 1.91 90.92
123 INT188803 Il1 Positive_regulation of Gene_expression of Crp 1 0.03 2.95 0.94 90.92
124 INT315984 Rhd Positive_regulation of Localization of Igf1 1 0.07 0.25 0 90.84
125 INT315985 Rhd Positive_regulation of Igf1 1 0.07 0.25 0 90.84
126 INT173659 Map2k3 Positive_regulation of MAPK8 1 0.15 0.28 0.07 90.44
127 INT173660 Map2k6 Positive_regulation of MAPK8 1 0.15 0.27 0.07 90.24
128 INT224418 Binding of NFKB2 and TNFSF11 1 0.11 0.68 0.3 90.20
129 INT28947 GH1 Positive_regulation of Gene_expression of IGF1 4 0.22 3.78 0.69 90.16
130 INT217473 Nup62 Regulation of Tnfrsf11a 1 0.38 0.66 0 90.08
131 INT197646 DPH1 Negative_regulation of Localization of BGLAP 1 0.01 0.26 0.04 90.04
132 INT314373 Binding of Cd34 and Eng 1 0.08 0.9 0 90.00
133 INT314371 Binding of Cd34 and Thy1 1 0.08 0.9 0 90.00
134 INT220148 Binding of IGF1 and IGFBP3 12 0.36 5.56 0.66 89.76
135 INT301402 Enpp2 Positive_regulation of Lpar1 2 0.33 0.55 0.07 89.40
136 INT314374 Binding of Ptprc and Thy1 1 0.04 0.85 0 89.28
137 INT314372 Binding of Eng and Ptprc 1 0.04 0.84 0 89.28
138 INT269758 Negative_regulation of IGF1 Negative_regulation of Positive_regulation of IGFBP2 1 0.10 2.15 0.16 89.20
139 INT225799 Il1 Regulation of Ppi-rs 1 0.01 0.44 0.05 88.60
140 INT225779 Il1 Regulation of Npp 1 0.03 0.43 0.05 88.60
141 INT225790 Il1 Regulation of Gene_expression of Enpp1 1 0.07 0.43 0.05 88.60
142 INT225780 Il1 Regulation of Gene_expression of Npp 1 0.03 0.43 0.05 88.60
143 INT225806 Il1 Regulation of ALPI 1 0.00 0.44 0.05 88.60
144 INT254432 Binding of Best1 and Sost 1 0.12 0.69 0 88.56
145 INT254434 Binding of Lrp5 and Best1 3 0.29 2.53 0 88.52
146 INT205411 SORT1 Negative_regulation of TNFRSF9 1 0.10 0.23 0.03 88.16
147 INT210580 Negative_regulation of Binding of TNFRSF11A and Tnfsf11 1 0.07 0.19 0 87.96
148 INT197644 NR1I2 Negative_regulation of Positive_regulation of CYP3A 1 0.02 0.47 0.08 87.92
149 INT197650 NR1I2 Negative_regulation of Positive_regulation of CYP2A 1 0.02 0.47 0.08 87.92
150 INT197652 NR1I2 Positive_regulation of Positive_regulation of CYP2A 1 0.02 0.47 0.08 87.92
151 INT210601 IL8 Positive_regulation of TNFSF11 1 0.06 1.46 0.08 87.76
152 INT156667 Gh Positive_regulation of Gene_expression of Igf1 6 0.28 0.88 0.56 87.76
153 INT297352 KLF2 Regulation of PPARA 1 0.12 1.31 0.35 87.48
154 INT302841 Mdk Positive_regulation of Positive_regulation of TNF 1 0.01 0.35 0.33 87.36
155 INT218932 Cyp3a23/3a1 Regulation of Gene_expression of Alpi 1 0.00 0.53 0.46 87.04
156 INT218935 Cyp3a23/3a1 Regulation of Bcl2 1 0.00 1.08 0.74 87.04
157 INT218933 Cyp3a23/3a1 Regulation of Alpi 1 0.00 1.07 0.73 87.04
158 INT137418 MAPK7 Negative_regulation of Gene_expression of TNF 1 0.01 0.63 0.28 86.92
159 INT335743 Binding of PDB1 and Salpa1 1 0.01 1.66 0.09 86.76
160 INT335742 Binding of PDB1 and Dpyd 1 0.02 1.75 0.09 86.76
161 INT210600 IL1B Regulation of TNFSF11 1 0.04 1.45 0.08 86.32
162 INT355364 Regulation of PTHLH Positive_regulation of Tnfsf11 1 0.04 1.51 0.19 86.28
163 INT355363 PTHLH Positive_regulation of Tnfsf11 1 0.04 1.47 0.19 86.28
164 INT188802 Il1 Negative_regulation of Gene_expression of Col7a1 1 0.00 0.71 0.26 86.24
165 INT350169 Binding of DMD and MRI1 1 0.11 3.08 0.54 86.16
166 INT81983 IL1A Positive_regulation of Positive_regulation of PTGS2 1 0.01 0.27 0.13 86.08
167 INT342386 Binding of CALCR and Best1 1 0.01 0.96 0 86.04
168 INT166724 Binding of Vdr and Rxra 1 0.28 0.32 0.09 86.04
169 INT210599 IL8 Regulation of TNFSF11 1 0.05 1.44 0.08 85.92
170 INT334043 Cdt1 Positive_regulation of Gene_expression of ALPP 1 0.08 0.39 0.05 85.72
171 INT342378 Binding of Vdr and Best1 1 0.05 0.4 0 85.72
172 INT355365 CSF1 Positive_regulation of Tnfsf11 1 0.03 1.49 0.19 85.60
173 INT355366 Regulation of CSF1 Positive_regulation of Tnfsf11 1 0.02 1.5 0.19 85.60
174 INT27759 Calca Regulation of Sct 1 0.00 0.9 0.08 85.48
175 INT269061 Binding of Il6 and Il6ra 3 0.04 2.59 0.45 85.36
176 INT293411 IL8 Regulation of IL11 1 0.03 1.17 0.1 85.28
177 INT293416 IL8 Regulation of PTHLH 1 0.04 1.18 0.1 85.28
178 INT293409 IL8 Regulation of VEGFA 1 0.04 1.18 0.1 85.28
179 INT81992 IL1A Positive_regulation of Positive_regulation of Tnfsf11 1 0.05 0.27 0.13 85.24
180 INT166723 Binding of Vdr and Rxrb 1 0.11 0.31 0.09 84.96
181 INT245111 MMP9 Positive_regulation of Localization of Gtf3a 1 0.00 0.99 0 84.88
182 INT293417 HRAS Regulation of IL11 1 0.00 1.17 0.1 84.80
183 INT293414 HRAS Regulation of PTHLH 1 0.00 1.18 0.1 84.80
184 INT293408 HRAS Regulation of VEGFA 1 0.00 1.18 0.1 84.80
185 INT256577 Bglap Regulation of Localization of Ins1 1 0.47 0.44 0.04 84.12
186 INT256572 Bglap Regulation of Gene_expression of Ins1 1 0.47 0.44 0 84.12
187 INT210596 TNFRSF11B Negative_regulation of Binding of TNFSF11 2 0.11 1.62 0.04 83.72
188 INT210593 TNFRSF11B Negative_regulation of Binding of TNFSF11 and TNFRSF11A 2 0.10 1.62 0.04 83.72
189 INT245734 Binding of COL9A1 and COL9A2 1 0.26 0.52 0 83.36
190 INT245729 Binding of COL9A1 and COL9A3 1 0.29 0.52 0 83.36
191 INT123180 Bmp6 Positive_regulation of Lamtor1 1 0.01 0.61 0.14 82.88
192 INT123192 Bmp6 Positive_regulation of CDKN1A 1 0.18 0.61 0.14 82.88
193 INT123194 Bmp6 Positive_regulation of TAF9 1 0.18 0.61 0.14 82.88
194 INT123193 Bmp6 Positive_regulation of Negative_regulation of TAF9 1 0.18 0.61 0.14 82.88
195 INT239572 DPF1 Positive_regulation of AIS 1 0.02 0.71 0.24 82.76
196 INT270778 Binding of TNFSF11 and CALCRL 1 0.00 0.44 0 82.48
197 INT335886 Binding of Sost and Lrp4 1 0.28 0.65 0.07 82.24
198 INT289250 Il6 Positive_regulation of Gene_expression of Timp1 1 0.11 0.64 0.03 82.20
199 INT257577 CALCA Positive_regulation of DMD 1 0.01 0.57 0.26 82.16
200 INT254277 Binding of Hand1 and Tnfsf11 1 0.02 0.08 0.08 82.16

Single Events

The table below shows the top 200 pain related interactions that have been reported for Osteoporosis. They are ordered first by their pain relevance and then by number of times they were reported in Osteoporosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 100.00
2 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 100.00
3 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 100.00
4 INT6515 Gene_expression of BGLAP 110 0.75 45.13 10.81 100.00
5 INT119700 Gene_expression of VDR 88 0.75 65.33 11.5 100.00
6 INT122901 Positive_regulation of Spp1 67 0.67 58.03 7.49 100.00
7 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15 100.00
8 INT2649 Regulation of Calca 433 0.62 146.05 330.95 100.00
9 INT110427 Gene_expression of Spp1 199 0.78 176.11 23.31 100.00
10 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 100.00
11 INT37541 Gene_expression of SPP1 113 0.77 68.54 11.35 100.00
12 INT145305 Positive_regulation of Bmp2 12 0.69 8.65 0.24 100.00
13 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44 100.00
14 INT211971 Binding of Best1 16 0.22 7.73 0.33 100.00
15 INT229632 Binding of PADI4 21 0.48 37.45 0.34 100.00
16 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 100.00
17 INT158123 Negative_regulation of Gene_expression of COL5A2 19 0.46 15.27 2.23 100.00
18 INT139475 Negative_regulation of DKK1 14 0.52 9.2 1.76 100.00
19 INT4535 Localization of PROC 106 0.73 76.24 21.1 100.00
20 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54 100.00
21 INT19963 Gene_expression of COL1A1 118 0.59 42.11 15.15 100.00
22 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38 100.00
23 INT1760 Gene_expression of PTGER2 524 0.57 226.94 96.4 100.00
24 INT2867 Gene_expression of CALCA 247 0.78 78.78 138.47 100.00
25 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 100.00
26 INT28094 Binding of PTH 29 0.37 13.57 3.09 100.00
27 INT12339 Localization of IL8 437 0.81 251.87 117.39 100.00
28 INT90938 Gene_expression of Eng 48 0.72 15.76 1.24 100.00
29 INT158978 Localization of TNFRSF11B 19 0.78 11.8 3.32 100.00
30 INT126368 Gene_expression of MSX2 12 0.65 7.2 2.71 100.00
31 INT142120 Gene_expression of Runx2 45 0.77 15.76 2.55 100.00
32 INT91341 Negative_regulation of Gene_expression of BGLAP 17 0.55 4.91 3.02 100.00
33 INT171614 Positive_regulation of Runx2 13 0.63 3.04 0.19 100.00
34 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 100.00
35 INT64797 Regulation of ALPP 18 0.24 9.71 2.24 100.00
36 INT110599 Gene_expression of Bglap 49 0.74 41.23 6.97 100.00
37 INT3823 Positive_regulation of ALPI 27 0.69 19.49 2.15 100.00
38 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 100.00
39 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 100.00
40 INT19131 Localization of CYP27A1 14 0.80 8.19 2.15 100.00
41 INT45576 Positive_regulation of Ibsp 4 0.41 3.41 1.21 100.00
42 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 100.00
43 INT179788 Gene_expression of Sparc 42 0.77 19.96 2.57 100.00
44 INT184303 Positive_regulation of Bglap 16 0.66 8.66 1.25 100.00
45 INT118124 Binding of USE1 24 0.16 16.64 5.44 100.00
46 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 100.00
47 INT176513 Transcription of Spp1 5 0.63 4.32 0.67 100.00
48 INT108306 Positive_regulation of TNFRSF11B 28 0.60 12.74 4.46 100.00
49 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 100.00
50 INT166131 Positive_regulation of Positive_regulation of Col7a1 8 0.46 6.4 1.65 100.00
51 INT185407 Binding of PER1 13 0.42 9.32 2.6 100.00
52 INT209893 Positive_regulation of Gene_expression of TNFRSF11B 31 0.68 11.77 4.8 100.00
53 INT97318 Gene_expression of SPARC 11 0.67 5.07 1.59 100.00
54 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 100.00
55 INT57274 Positive_regulation of Gene_expression of COL7A1 50 0.69 24.19 4.72 100.00
56 INT169665 Gene_expression of Sp7 2 0.29 1.2 0 100.00
57 INT158025 Regulation of Bglap 6 0.60 7.03 1.11 100.00
58 INT54054 Binding of App 4 0.48 10.89 2.78 100.00
59 INT19929 Negative_regulation of Positive_regulation of TNF 52 0.59 38.16 16.51 100.00
60 INT192156 Negative_regulation of Col1a1 6 0.39 3.92 0.8 100.00
61 INT1764 Negative_regulation of Gene_expression of PTGER2 81 0.34 34.74 19.45 100.00
62 INT97905 Positive_regulation of FGF2 33 0.70 26.74 5.17 100.00
63 INT88810 Positive_regulation of Gene_expression of FGF2 17 0.50 12.62 2.98 100.00
64 INT157941 Gene_expression of IL-17 65 0.65 20.39 9.89 100.00
65 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2 100.00
66 INT36032 Gene_expression of Col3a1 23 0.72 10.55 3.18 100.00
67 INT24819 Positive_regulation of VTN 8 0.49 3.52 1.23 100.00
68 INT69215 Gene_expression of Col1a1 38 0.68 17.39 4.77 100.00
69 INT59355 Gene_expression of Fosl1 6 0.68 2.09 0.41 100.00
70 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 100.00
71 INT283496 Localization of CASR 2 0.76 2.04 0.41 100.00
72 INT22715 Positive_regulation of Gene_expression of Pth 29 0.64 22.53 2.31 100.00
73 INT215660 Gene_expression of Alpl 5 0.57 2.95 0.07 100.00
74 INT176518 Positive_regulation of Positive_regulation of Spp1 5 0.47 3.36 0.28 100.00
75 INT233436 Localization of BPs 2 0.06 1.48 0.5 100.00
76 INT73100 Negative_regulation of PADI4 3 0.57 3.42 0.37 100.00
77 INT123458 Positive_regulation of Tnfrsf11b 9 0.43 14.3 2.01 100.00
78 INT182010 Regulation of Tnfrsf11b 2 0.18 1.13 0.67 100.00
79 INT64186 Positive_regulation of Gene_expression of TNFRSF11A 13 0.68 7.19 2.9 100.00
80 INT170033 Positive_regulation of Gene_expression of Fig4 59 0.43 20.99 16.69 100.00
81 INT145009 Positive_regulation of Negative_regulation of VDR 2 0.41 1.18 0.25 100.00
82 INT256567 Regulation of Ptprv 1 0.20 0.26 0 100.00
83 INT262109 Positive_regulation of Mgp 2 0.63 42.44 0.9 100.00
84 INT262051 Positive_regulation of Transcription of Mgp 1 0.11 0.7 0 100.00
85 INT262083 Transcription of Mgp 1 0.12 0.69 0 100.00
86 INT242988 Positive_regulation of Transcription of Spp1 4 0.28 3.28 0.92 100.00
87 INT262124 Positive_regulation of Transcription of Tnfrsf11b 1 0.07 0.69 0 100.00
88 INT262055 Transcription of Tnfrsf11b 1 0.11 0.69 0 100.00
89 INT209397 Transcription of ALPI 2 0.55 1.18 0.24 100.00
90 INT319131 Positive_regulation of Lrp5 1 0.43 0.36 0.03 100.00
91 INT319135 Positive_regulation of Sp7 1 0.41 0.36 0.03 100.00
92 INT243655 Positive_regulation of Gene_expression of IL-17 11 0.58 3.06 1.45 100.00
93 INT312604 Gene_expression of Lrp4 2 0.71 1.48 0.21 100.00
94 INT135993 Regulation of Gene_expression of Npw 2 0.55 0.32 0.81 100.00
95 INT164029 Regulation of Gene_expression of Npbwr1 1 0.45 0.32 0.34 100.00
96 INT61068 Gene_expression of Igfbp3 15 0.75 8.48 1.41 100.00
97 INT349060 Regulation of Negative_regulation of HHIP 1 0.10 1.33 0 100.00
98 INT313932 Positive_regulation of Positive_regulation of Vms1 1 0.16 2.13 0 100.00
99 INT26860 Positive_regulation of Vms1 7 0.41 3.21 1.18 100.00
100 INT36588 Protein_catabolism of Calca 7 0.87 1.98 1.31 100.00
101 INT15490 Negative_regulation of Gene_expression of COL7A1 40 0.58 25.97 7.18 100.00
102 INT56193 Binding of Ifnar1 4 0.31 1.94 0.71 100.00
103 INT19775 Localization of Il1 183 0.78 145.5 50.91 100.00
104 INT256568 Regulation of Localization of Bglap 1 0.22 0.57 0 100.00
105 INT316800 Regulation of Col1a2 2 0.25 0.34 0.03 100.00
106 INT66718 Positive_regulation of BDKRB2 21 0.64 9.89 11.6 100.00
107 INT12083 Regulation of TGFB1 22 0.53 15.4 3.6 100.00
108 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23 100.00
109 INT341291 Positive_regulation of Negative_regulation of Tnfrsf11b 1 0.09 1.34 0.45 100.00
110 INT341289 Positive_regulation of Localization of Tnfsf11 1 0.13 1.26 0.44 100.00
111 INT75431 Binding of CRG 6 0.28 1.91 0.39 100.00
112 INT270143 Negative_regulation of Gene_expression of BPs 1 0.03 0.1 0.08 100.00
113 INT294996 Localization of Use1 1 0.04 0.76 0.04 100.00
114 INT64185 Gene_expression of TNFRSF11A 131 0.76 75.15 24.73 99.98
115 INT129883 Gene_expression of Dkk1 56 0.77 45.42 12.52 99.98
116 INT89484 Gene_expression of TNFRSF11B 119 0.76 53.57 19.67 99.98
117 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 99.98
118 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 99.98
119 INT24670 Gene_expression of FGF2 121 0.78 85.64 15.12 99.98
120 INT223959 Localization of Bglap 10 0.77 11.25 1.74 99.98
121 INT250351 Positive_regulation of Gene_expression of Best1 5 0.27 3.14 0.65 99.98
122 INT4096 Regulation of Localization of Pth 7 0.58 3.97 0.95 99.98
123 INT335864 Gene_expression of Sost 4 0.77 2.36 0.2 99.98
124 INT220436 Binding of IL19 4 0.36 1.92 0.41 99.98
125 INT341290 Localization of Tnfrsf11b 1 0.14 1.28 0.45 99.98
126 INT340265 Localization of Tnfsf11 2 0.30 1.65 0.44 99.98
127 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 99.96
128 INT129832 Positive_regulation of Positive_regulation of PTH 5 0.50 3.4 0.14 99.96
129 INT114263 Negative_regulation of Negative_regulation of Trpv1 6 0.43 2.71 2.92 99.96
130 INT109967 Gene_expression of Mmv7 21 0.35 15.66 1.7 99.96
131 INT344977 Negative_regulation of Localization of Dkk1 2 0.42 2.57 0.3 99.96
132 INT89858 Positive_regulation of STAT6 10 0.66 7.81 1.47 99.96
133 INT101441 Positive_regulation of FTH1 15 0.54 7.03 3.22 99.96
134 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 99.92
135 INT130867 Gene_expression of TNFSF11 106 0.77 45.15 10.34 99.92
136 INT13397 Localization of DMD 21 0.78 7.96 1.08 99.92
137 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 99.92
138 INT130866 Positive_regulation of Gene_expression of TNFSF11 25 0.69 7.11 1.82 99.92
139 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 99.92
140 INT4683 Negative_regulation of PDXK 17 0.55 12.81 4.39 99.92
141 INT171998 Binding of DMD 58 0.47 38.13 3.35 99.88
142 INT178766 Negative_regulation of HHIP 19 0.28 11.1 0.43 99.88
143 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 99.88
144 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 99.88
145 INT70503 Regulation of Gene_expression of Nos2 71 0.62 44 24.01 99.88
146 INT129901 Gene_expression of Nr1i2 60 0.73 22.44 6.04 99.88
147 INT13416 Positive_regulation of Pthlh 19 0.60 14.78 3.74 99.88
148 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 99.84
149 INT93533 Positive_regulation of Tnfsf11 53 0.50 36.93 10.53 99.84
150 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 99.84
151 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 99.84
152 INT136555 Negative_regulation of Tnfsf11 31 0.55 22.23 6.23 99.84
153 INT81987 Gene_expression of ODF1 1 0.07 2.08 0.54 99.84
154 INT171962 Gene_expression of Tnfrsf11a 40 0.72 31.1 7.84 99.84
155 INT16445 Gene_expression of IL1A 60 0.78 44.46 19.19 99.84
156 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 99.84
157 INT81982 Gene_expression of Bmpr2 36 0.60 14.58 1.55 99.84
158 INT22082 Localization of Ceacam1 13 0.80 2.44 2.48 99.84
159 INT48202 Gene_expression of Tgfb1 146 0.78 89.93 27.76 99.84
160 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 99.84
161 INT81231 Gene_expression of LGALS3 26 0.74 9.38 3.66 99.84
162 INT176519 Regulation of Gene_expression of Spp1 7 0.58 8.54 0.35 99.84
163 INT81986 Negative_regulation of Gene_expression of ODF1 1 0.05 0.52 0.15 99.84
164 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46 99.84
165 INT65260 Positive_regulation of Col7a1 95 0.69 61.73 18.42 99.84
166 INT171963 Positive_regulation of Positive_regulation of Tnfsf11 3 0.42 2.44 0.93 99.84
167 INT52696 Positive_regulation of Ptgs2 48 0.70 27.65 14.44 99.84
168 INT52695 Regulation of Ptgs2 20 0.42 8.72 5.71 99.84
169 INT52697 Regulation of Positive_regulation of Ptgs2 2 0.27 0.34 0.13 99.84
170 INT61120 Positive_regulation of Gene_expression of Tgfb1 34 0.70 21.15 6.93 99.84
171 INT140795 Positive_regulation of Gene_expression of Smad3 3 0.48 3.16 0.3 99.84
172 INT140794 Gene_expression of Smad3 22 0.64 9.41 0.83 99.84
173 INT207379 Regulation of Negative_regulation of Tnfsf11 2 0.28 1.7 0.5 99.84
174 INT104551 Gene_expression of Il18 156 0.76 115.51 36.95 99.84
175 INT266819 Regulation of Localization of Grxcr1 2 0.06 1.28 0 99.84
176 INT173655 Binding of LRP5 10 0.39 3.06 0.22 99.84
177 INT171995 Binding of PTH1R 8 0.35 1.16 0.31 99.84
178 INT13396 Gene_expression of DMD 125 0.75 57.81 5.45 99.82
179 INT211970 Negative_regulation of Best1 49 0.14 37.33 2.32 99.82
180 INT93534 Gene_expression of Tnfsf11 185 0.77 119.26 33.66 99.80
181 INT355352 Gene_expression of NOG 1 0.36 24.11 1.23 99.80
182 INT3214 Localization of Ins1 527 0.80 196.9 79.26 99.80
183 INT227759 Gene_expression of Best1 26 0.42 20.36 1.73 99.80
184 INT355346 Negative_regulation of Gene_expression of NOG 1 0.20 5.87 0.33 99.80
185 INT46619 Gene_expression of CSF1 80 0.73 36.63 12.94 99.80
186 INT10237 Binding of EDN1 40 0.48 16 8.48 99.80
187 INT334924 Binding of MEHMO 1 0.01 9.69 0.26 99.80
188 INT296901 Positive_regulation of Gene_expression of Tmie 2 0.29 1.29 0 99.80
189 INT8246 Positive_regulation of IL36RN 13 0.43 9.15 3.16 99.80
190 INT170503 Positive_regulation of Localization of Tmie 11 0.29 3.27 0.61 99.80
191 INT270543 Binding of Get4 1 0.25 0.52 0 99.80
192 INT63113 Positive_regulation of HRAS 30 0.67 22.85 4.28 99.80
193 INT23524 Positive_regulation of VCF 7 0.57 4.25 1.16 99.80
194 INT96965 Positive_regulation of PLF 4 0.49 4.37 1.45 99.78
195 INT181110 Gene_expression of Cks1b 2 0.56 0.43 0 99.78
196 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33 99.76
197 INT112054 Negative_regulation of Negative_regulation of DMD 12 0.44 5.02 0.45 99.76
198 INT76095 Positive_regulation of ISYNA1 117 0.55 79.73 25.86 99.76
199 INT2541 Binding of Calca 200 0.48 67.14 134.62 99.76
200 INT70970 Binding of COPD 144 0.42 180.34 18.29 99.76
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