D:Otitis Media With Effusion

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Disease Term
Synonyms Ear Effusion Middle, Ear Effusions Middle, Effusion Middle Ear, Effusions Middle Ear, Middle Ear Effusion, Middle Ear Effusions, OTITIS MEDIA SECRETORY, OTITIS MEDIA SEROUS, Secretory Otitis Media, Serous Otitis Media
Documents 185
Hot Single Events 101
Hot Interactions 16

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Otitis Media With Effusion. They are ordered first by their relevance to Otitis Media With Effusion and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT267585 TNF Regulation of IL6 2 0.16 2.44 0.37 99.52
2 INT267625 Binding of KNG1 and Klk1 2 0.21 2.23 0.61 99.04
3 INT267624 Klk1 Positive_regulation of KNG1 1 0.05 0.52 0.25 99.04
4 INT267592 IL6 Positive_regulation of Localization of MUC1 1 0.00 1.24 0.07 96.40
5 INT267593 IL8 Positive_regulation of Localization of MUC1 1 0.00 1.06 0.06 95.20
6 INT267587 PTAFR Positive_regulation of Localization of PTPRC 1 0.00 2.04 0.09 92.68
7 INT267618 Il1 Positive_regulation of Vcam1 1 0.00 0.81 0.09 89.36
8 INT151849 IL10 Negative_regulation of Gene_expression of IL8 4 0.14 3.26 1.54 88.40
9 INT267588 IL10 Negative_regulation of Gene_expression of IL6 1 0.01 2.25 1.11 87.68
10 INT267597 IL10 Negative_regulation of Gene_expression of TNF 1 0.03 2.24 1.1 86.72
11 INT267626 Il1 Positive_regulation of ICAM1 1 0.00 0.79 0.09 86.32
12 INT267596 KNG1 Positive_regulation of Gene_expression of PLA2G6 1 0.01 0.87 0.25 84.92
13 INT267591 CYSLTR1 Positive_regulation of Gene_expression of PLA2G6 1 0.00 0.87 0.25 84.92
14 INT267584 TNF Positive_regulation of Gene_expression of PLA2G6 1 0.08 0.87 0.25 84.92
15 INT267632 Il1 Positive_regulation of Gene_expression of PLA2G6 1 0.00 0.86 0.25 84.92
16 INT267631 IRF6 Positive_regulation of Gene_expression of Il1 1 0.00 0.96 0.25 81.72
17 INT267595 IL12A Positive_regulation of IFN1@ 1 0.03 0.69 0.36 79.44
18 INT267623 IL6 Positive_regulation of Crp 1 0.00 1.6 0.24 74.16
19 INT267589 IL2 Positive_regulation of Gene_expression of IL12A 1 0.01 0.69 0.34 72.04
20 INT267586 IL4 Positive_regulation of IGHE 1 0.00 1.42 0.27 66.52
21 INT267628 IL4 Positive_regulation of IgG 1 0.00 1.42 0.27 66.52
22 INT267629 PTAFR Positive_regulation of Localization of Il1 1 0.00 1.32 0.18 61.44
23 INT171905 TNF Positive_regulation of Gene_expression of Il1 2 0.23 1.08 0.54 56.32
24 INT267630 Il1 Regulation of Gene_expression of IL8 1 0.00 0.44 0.71 26.96
25 INT267627 Il1 Positive_regulation of Gene_expression of TNF 1 0.02 0.45 0.17 5.00
26 INT277890 Binding of Ids and Tas2r111-ps2 1 0.08 0.5 0.09 5.00
27 INT277889 Regulation of Binding of Ids and Tas2r111-ps2 1 0.09 0.5 0.09 5.00
28 INT277892 IDS Regulation of Ids 1 0.18 0.41 0 5.00
29 INT277891 Binding of TPBG and M6pr-ps 1 0.02 0.06 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Otitis Media With Effusion. They are ordered first by their pain relevance and then by number of times they were reported in Otitis Media With Effusion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT173021 Localization of MUC5AC 14 0.70 10.73 0.91 100.00
2 INT257450 Localization of MUC5B 2 0.62 1.14 0.09 100.00
3 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 99.98
4 INT10506 Gene_expression of PTAFR 86 0.76 37.57 28.58 99.92
5 INT236711 Gene_expression of Bcl6 15 0.30 12.98 0.58 99.84
6 INT24895 Positive_regulation of LYZ 25 0.70 17.92 2.64 99.84
7 INT258953 Negative_regulation of Gene_expression of Bcl6 1 0.19 1.53 0.14 99.84
8 INT11659 Gene_expression of COL2A1 164 0.78 78.49 22.58 99.72
9 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 99.68
10 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 99.68
11 INT236693 Positive_regulation of Gene_expression of Bcl6 3 0.15 2.06 0.14 99.68
12 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 99.60
13 INT53021 Positive_regulation of COL2A1 29 0.55 27.75 3.47 99.60
14 INT100938 Positive_regulation of Il13 47 0.69 42.11 14.36 99.56
15 INT9660 Regulation of TNF 363 0.62 312.94 139.99 99.52
16 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 99.48
17 INT117232 Localization of COL2A1 11 0.72 7.34 1.3 99.48
18 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 99.44
19 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 99.42
20 INT56301 Positive_regulation of IL4 68 0.56 54.51 18.65 99.42
21 INT96693 Binding of COL2A1 45 0.46 37.11 2.61 99.40
22 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 99.32
23 INT52107 Transcription of IL8 63 0.72 41.66 16.06 99.32
24 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 99.12
25 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 99.04
26 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 99.00
27 INT3165 Gene_expression of LYZ 25 0.65 16.72 5.16 98.96
28 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 98.88
29 INT9210 Regulation of IL6 166 0.62 125.61 49.95 98.80
30 INT10836 Negative_regulation of IL8 95 0.59 52.59 24.71 98.68
31 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 98.66
32 INT19432 Positive_regulation of Gene_expression of CD79A 14 0.45 13.49 1.49 98.56
33 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 98.56
34 INT9884 Localization of CD79A 41 0.78 21.75 3.06 98.32
35 INT20129 Regulation of Il1 53 0.53 44.14 19.89 98.32
36 INT78899 Gene_expression of CCL5 155 0.77 84.02 55.09 98.12
37 INT62042 Positive_regulation of Gene_expression of IL4 67 0.56 42.05 20.39 98.04
38 INT99586 Binding of IRF6 60 0.36 27.87 13.2 98.00
39 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 97.68
40 INT179168 Regulation of Transcription of IL8 4 0.43 1.88 0.63 97.48
41 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 97.04
42 INT261093 Positive_regulation of Gene_expression of PLA2G6 2 0.31 0.93 0.1 96.76
43 INT49802 Localization of MUC1 75 0.81 44.74 8.87 96.40
44 INT78774 Gene_expression of PLA2G6 15 0.61 8.39 1.56 96.40
45 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 96.32
46 INT23635 Positive_regulation of MMP12 31 0.59 28.19 17.95 96.20
47 INT49142 Gene_expression of SELP 94 0.75 54.61 11.64 95.92
48 INT63425 Positive_regulation of Gene_expression of SELP 23 0.67 15.34 3.48 95.92
49 INT179169 Transcription of IL13 11 0.15 4.22 1.37 95.72
50 INT56299 Transcription of IL4 15 0.64 10.2 5.44 95.72
51 INT145650 Localization of PLA2G6 15 0.76 8.87 2.06 95.48
52 INT184798 Positive_regulation of Localization of PLA2G6 2 0.16 2.41 0.05 95.48
53 INT132163 Positive_regulation of Localization of MUC1 9 0.19 8.96 1.54 95.32
54 INT12339 Localization of IL8 437 0.81 251.87 117.39 95.20
55 INT274704 Localization of GPT 5 0.73 3.91 0.29 94.74
56 INT9012 Localization of Vip 283 0.81 31.71 106.16 94.20
57 INT20380 Gene_expression of Il5 172 0.78 104.75 34.78 93.84
58 INT38266 Localization of PTPRC 30 0.68 17.05 1.68 93.48
59 INT23344 Gene_expression of Alox5 60 0.75 28.2 13.82 93.44
60 INT20551 Negative_regulation of COL2A1 31 0.55 21.98 2.66 93.44
61 INT8413 Gene_expression of Ptgs1 248 0.78 110.17 108.58 93.36
62 INT17886 Negative_regulation of Il1 95 0.57 70.91 31.25 93.04
63 INT187095 Negative_regulation of Positive_regulation of Il1 8 0.14 6.17 1.82 93.04
64 INT13303 Positive_regulation of PTAFR 40 0.69 16.27 11.56 92.48
65 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 92.08
66 INT104263 Regulation of Positive_regulation of NOS1 5 0.28 3.15 2.15 91.96
67 INT49805 Positive_regulation of MUC1 56 0.70 44.5 4.56 91.64
68 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 91.56
69 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2 91.44
70 INT6852 Localization of TNF 883 0.81 705.95 270.84 91.36
71 INT72747 Localization of IgG 55 0.53 30.88 4.19 90.96
72 INT62829 Positive_regulation of VCAM1 39 0.70 38.42 9.15 90.24
73 INT64743 Positive_regulation of olt 19 0.40 16.46 3.86 90.04
74 INT19775 Localization of Il1 183 0.78 145.5 50.91 90.00
75 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 89.68
76 INT81443 Positive_regulation of Vcam1 29 0.63 28.4 6.35 89.60
77 INT6478 Negative_regulation of Binding of TNF 36 0.58 30.42 13.31 89.52
78 INT45253 Positive_regulation of Ltf 20 0.69 10.22 2.77 89.04
79 INT6481 Binding of TNF 624 0.48 510.2 214.82 88.72
80 INT186273 Negative_regulation of Il13 33 0.46 22.88 8.65 88.40
81 INT118615 Negative_regulation of IL4 20 0.41 13.79 3.49 88.40
82 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 87.20
83 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 87.20
84 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 87.20
85 INT62827 Positive_regulation of ICAM1 184 0.70 180.95 36.28 86.48
86 INT26312 Positive_regulation of PLA2G6 26 0.70 7.41 3.2 85.84
87 INT4021 Positive_regulation of PLA2G1B 35 0.70 23.27 8.2 85.84
88 INT75832 Positive_regulation of Positive_regulation of IL8 30 0.70 20.77 6.05 85.44
89 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57 84.76
90 INT267615 Positive_regulation of Localization of PTPRC 3 0.01 3.41 0.46 84.48
91 INT3971 Positive_regulation of Alb 175 0.70 98.46 36.45 84.36
92 INT91667 Localization of IL12A 39 0.74 25.51 7.36 83.64
93 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 83.40
94 INT181304 Binding of CD48 3 0.08 2.43 0.34 83.04
95 INT258955 Localization of Bcl6 1 0.23 0.83 0.11 82.12
96 INT267608 Positive_regulation of MUC2 1 0.11 0.86 0.04 81.96
97 INT267609 Positive_regulation of Transcription of MUC2 1 0.11 0.86 0.04 81.96
98 INT9732 Regulation of COL2A1 9 0.58 6.93 0.44 81.00
99 INT173005 Transcription of MUC1 11 0.63 10.15 2.24 80.88
100 INT173007 Transcription of MUC2 2 0.64 0.98 0.04 80.88
101 INT22383 Binding of IL2 59 0.48 39.06 8.56 80.84
102 INT267606 Protein_catabolism of CCL5 2 0.48 1.39 0.43 78.84
103 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 78.48
104 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 78.04
105 INT25610 Positive_regulation of Gene_expression of Il1 136 0.67 104.43 43.86 76.72
106 INT63340 Positive_regulation of Gene_expression of ICAM1 109 0.70 90.82 20.61 76.48
107 INT10763 Localization of IL2 157 0.80 81.11 33.21 76.08
108 INT25076 Negative_regulation of Gene_expression of Il1 41 0.52 30.58 13.85 75.56
109 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 74.88
110 INT139840 Positive_regulation of Negative_regulation of MAPK14 2 0.21 1.55 0.67 74.80
111 INT267610 Negative_regulation of Negative_regulation of MAPK14 1 0.03 1.08 0.15 74.52
112 INT69322 Negative_regulation of MAPK14 70 0.54 42.92 22.71 74.32
113 INT117920 Regulation of MAPK14 14 0.38 8.75 4.31 74.32
114 INT61624 Positive_regulation of Gene_expression of IL12A 50 0.56 33.07 13.07 74.28
115 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 74.16
116 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 72.16
117 INT5160 Localization of PTAFR 61 0.80 42.6 19.16 71.96
118 INT267616 Positive_regulation of Positive_regulation of MUC5AC 1 0.14 1.15 0.16 70.80
119 INT170754 Localization of IFN1@ 121 0.78 66.78 15.6 70.56
120 INT724 Negative_regulation of Alb 151 0.59 93.57 29.65 70.44
121 INT215183 Positive_regulation of MUC5AC 4 0.45 2.78 0.6 70.24
122 INT70048 Positive_regulation of Gene_expression of IL10 90 0.55 71.34 25.66 69.92
123 INT70050 Negative_regulation of IL10 56 0.58 37.45 12.39 66.96
124 INT81498 Positive_regulation of Gene_expression of CCL2 107 0.70 53.89 45.22 66.64
125 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 65.16
126 INT76095 Positive_regulation of ISYNA1 117 0.55 79.73 25.86 64.68
127 INT49804 Negative_regulation of Localization of MUC1 7 0.59 5.84 1.19 59.40
128 INT109913 Positive_regulation of MAP3K14 2 0.67 0.51 0.37 51.20
129 INT238021 Negative_regulation of NNT 1 0.04 0.39 0.13 51.16
130 INT168418 Positive_regulation of RCT 32 0.55 20.2 4.07 50.00
131 INT64499 Positive_regulation of IRF6 123 0.49 52.73 27.51 35.68
132 INT756 Gene_expression of C3 138 0.75 100.6 19.2 19.12
133 INT150540 Binding of TLR2 50 0.45 35.86 10.43 9.52
134 INT230758 Positive_regulation of Gene_expression of PTPRC 11 0.49 6.04 2.45 9.04
135 INT76227 Binding of NPC1 30 0.41 32.31 4.05 8.88
136 INT106952 Positive_regulation of NPC1 23 0.43 22.9 0.94 8.84
137 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 5.00
138 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
139 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
140 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
141 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
142 INT26500 Gene_expression of MMP2 201 0.78 110.57 46.9 5.00
143 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
144 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
145 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 5.00
146 INT9199 Positive_regulation of CEBPZ 111 0.67 30.99 28.45 5.00
147 INT55737 Positive_regulation of MMP2 101 0.68 59.11 27.71 5.00
148 INT151758 Gene_expression of PYCARD 91 0.63 14.54 24.27 5.00
149 INT8775 Binding of IGHE 167 0.48 102.61 23.54 5.00
150 INT49196 Gene_expression of SELE 105 0.78 107.29 22.92 5.00
151 INT4535 Localization of PROC 106 0.73 76.24 21.1 5.00
152 INT10833 Regulation of Gene_expression of IL8 68 0.62 38.74 18.46 5.00
153 INT10000 Regulation of Gene_expression of IL2 56 0.45 15.33 16.2 5.00
154 INT26501 Positive_regulation of Gene_expression of MMP2 51 0.67 39 15.16 5.00
155 INT184853 Gene_expression of ADHD1 87 0.65 89.2 11.8 5.00
156 INT79656 Positive_regulation of NR3C1 14 0.68 6.38 10.83 5.00
157 INT701 Localization of IGHE 87 0.80 40.5 10.62 5.00
158 INT35164 Negative_regulation of IGHE 96 0.58 76.3 9.74 5.00
159 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 5.00
160 INT4228 Gene_expression of CAT 50 0.75 20.62 7.18 5.00
161 INT137052 Positive_regulation of PYCARD 30 0.43 4.72 6.17 5.00
162 INT96234 Localization of Il13 11 0.62 10.94 5.48 5.00
163 INT28145 Binding of PAPPA 26 0.48 7.4 4.96 5.00
164 INT1285 Localization of Mmp13 12 0.78 8.98 4.93 5.00
165 INT2725 Positive_regulation of FCER2 23 0.69 23.08 4.7 5.00
166 INT133231 Regulation of PYCARD 18 0.39 5.02 4.44 5.00
167 INT233945 Positive_regulation of Expi 5 0.04 2.53 3.46 5.00
168 INT124954 Gene_expression of Egfr 26 0.75 15.08 3.12 5.00
169 INT59342 Negative_regulation of NPC1 20 0.44 20.21 2.79 5.00
170 INT168188 Gene_expression of PLXNA2 13 0.58 9 2.73 5.00
171 INT32421 Gene_expression of FCER2 19 0.73 17.23 2.53 5.00
172 INT105993 Gene_expression of IDS 26 0.78 10.83 2.41 5.00
173 INT135744 Positive_regulation of Id1 4 0.49 3.08 2.02 5.00
174 INT169862 Regulation of NPC1 13 0.53 13.61 1.84 5.00
175 INT124953 Negative_regulation of Gene_expression of Egfr 6 0.42 1.97 1.75 5.00
176 INT55979 Protein_catabolism of PROC 8 0.22 2.8 1.49 5.00
177 INT18114 Gene_expression of NPC1 45 0.66 57.85 1.44 5.00
178 INT105991 Negative_regulation of IDS 12 0.38 6.31 1.04 5.00
179 INT200462 Binding of IDS 13 0.31 4.95 1 5.00
180 INT19084 Negative_regulation of NRG1 5 0.42 4.9 0.96 5.00
181 INT213739 Gene_expression of Expi 7 0.47 1.05 0.63 5.00
182 INT137221 Gene_expression of Sh2d1b2 6 0.47 1.99 0.6 5.00
183 INT137222 Positive_regulation of Sh2d1b2 5 0.30 1.26 0.6 5.00
184 INT125821 Regulation of Positive_regulation of IGHE 6 0.40 5.38 0.53 5.00
185 INT217723 Regulation of IDS 15 0.25 2.12 0.49 5.00
186 INT277886 Localization of Ids 3 0.73 1.09 0.48 5.00
187 INT248346 Binding of PLXNA2 4 0.29 1.38 0.46 5.00
188 INT156997 Localization of NPC1 19 0.64 30 0.42 5.00
189 INT202349 Positive_regulation of Map2k3 3 0.52 1.26 0.36 5.00
190 INT88374 Gene_expression of DPP3 3 0.75 1.2 0.32 5.00
191 INT317746 Positive_regulation of Gene_expression of FCER2 2 0.01 4.09 0.3 5.00
192 INT277882 Gene_expression of Ids 5 0.71 1.6 0.26 5.00
193 INT277878 Binding of Ids 4 0.34 0.8 0.24 5.00
194 INT277884 Binding of Tas2r111-ps2 1 0.09 0.95 0.19 5.00
195 INT153233 Negative_regulation of Ids 5 0.40 2.1 0.12 5.00
196 INT277879 Positive_regulation of Gene_expression of Ids 3 0.44 0.14 0.11 5.00
197 INT354592 Positive_regulation of Gene_expression of PLXNA2 1 0.04 0.37 0.07 5.00
198 INT354590 Regulation of Gene_expression of Expi 1 0.02 0.34 0.05 5.00
199 INT250505 Positive_regulation of Negative_regulation of COL2A1 1 0.41 0.57 0.05 5.00
200 INT354591 Negative_regulation of Positive_regulation of PYCARD 1 0.05 0.34 0.05 5.00
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