D:Ovarian Hyperstimulation Syndrome

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Disease Term
Synonyms Hyperstimulation Syndrome Ovarian, HYPERSTIMULATION SYNDROMES OVARIAN, Ovarian Hyperstimulation Syndromes
Documents 80
Hot Single Events 58
Hot Interactions 9

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Ovarian Hyperstimulation Syndrome. They are ordered first by their relevance to Ovarian Hyperstimulation Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT254640 CGA Positive_regulation of REN 1 0.07 1.51 0.08 96.56
2 INT254641 CGA Positive_regulation of AGT 1 0.17 1.51 0.08 96.56
3 INT254639 CGA Positive_regulation of Gene_expression of AGT 1 0.18 1.51 0.08 96.56
4 INT335275 Binding of AGRP and TFPT 1 0.00 0.51 0 94.64
5 INT335276 Binding of AGRP and TSPAN33 1 0.03 0.5 0 93.52
6 INT147936 CGA Regulation of Gene_expression of FSHR 1 0.31 0.71 0.1 90.96
7 INT295430 BRD2 Positive_regulation of PLOD1 1 0.02 0.33 0.22 89.84
8 INT295431 FSHR Positive_regulation of CGA 1 0.29 0.27 0 88.44
9 INT319170 Casp3 Regulation of Hdac1 1 0.01 0.27 0 88.28
10 INT295433 Binding of PLOD1 and SCN5A 1 0.07 0.25 0.16 59.52
11 INT295434 BRD2 Positive_regulation of Gene_expression of GNRH1 1 0.02 0.07 0.2 19.60
12 INT187676 Binding of CYP19A1 and SHBG 1 0.01 0.63 0.03 17.60
13 INT187732 Binding of CYP19A1 and Cyp11a1 1 0.01 0.68 0.04 11.48
14 INT186240 Binding of AGRP and SCN5A 2 0.13 1.19 0.1 7.08
15 INT45780 GNRH1 Positive_regulation of PLOD1 3 0.07 1.02 0.63 5.00
16 INT65677 Binding of CGA and FSHR 2 0.25 0.29 0.16 5.00
17 INT65676 Binding of CGA and PLOD1 3 0.23 1.68 0.1 5.00
18 INT272439 Binding of ARAF and Prokr2 1 0.01 0.59 0.09 5.00
19 INT187671 CGA Negative_regulation of Gene_expression of GNRH1 1 0.01 0 0.06 5.00
20 INT272417 Binding of PROK1 and Positive_regulation of MAPK1 1 0.01 0.08 0.05 5.00
21 INT319171 Binding of Cgn and Hdac1 1 0.00 0 0 5.00
22 INT187672 Binding of DBT and SCN5A 1 0.00 0.2 0 5.00
23 INT187677 Negative_regulation of FSHR Positive_regulation of DBT 1 0.03 0 0 5.00
24 INT187675 DBT Positive_regulation of Gene_expression of LEP 1 0.04 0.27 0 5.00
25 INT272418 CGA Regulation of Gene_expression of PROK1 1 0.01 0.34 0 5.00
26 INT187674 FSHR Positive_regulation of Gene_expression of CYP19A1 1 0.24 0 0 5.00
27 INT187667 DBT Positive_regulation of Localization of LEP 1 0.05 0.55 0 5.00
28 INT272416 PROK1 Positive_regulation of Gene_expression of VEGFA 1 0.26 0 0 5.00
29 INT295432 FSHR Positive_regulation of PCOS1 1 0.06 1.24 0 5.00
30 INT187669 FSHR Positive_regulation of DBT 1 0.03 0 0 5.00
31 INT187673 GNRH1 Regulation of Localization of PLOD1 1 0.06 0.09 0 5.00
32 INT187670 Gene_expression of FSHR Positive_regulation of Gene_expression of CYP19A1 1 0.16 0 0 5.00
33 INT187668 Negative_regulation of GNRH1 Positive_regulation of PLOD1 1 0.06 0.07 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Ovarian Hyperstimulation Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Ovarian Hyperstimulation Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT6782 Gene_expression of SCN5A 156 0.78 33.13 17.88 99.64
2 INT252612 Regulation of Gene_expression of SCN5A 5 0.35 0.56 0.53 99.64
3 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 99.46
4 INT27644 Gene_expression of BRD2 23 0.65 6.97 2.23 99.38
5 INT4145 Gene_expression of FSHR 124 0.77 44.98 13.04 99.36
6 INT1792 Positive_regulation of CGA 123 0.70 64.73 20.79 99.04
7 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 99.00
8 INT662 Gene_expression of ATP6AP2 3 0.28 2.06 0.35 99.00
9 INT1793 Localization of CGA 379 0.81 67.38 114.69 98.92
10 INT4612 Positive_regulation of Localization of CGA 64 0.64 8.51 22.39 98.92
11 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26 98.68
12 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 98.44
13 INT656 Positive_regulation of ATP6AP2 10 0.18 2.89 0.58 98.44
14 INT111958 Regulation of Thim 4 0.16 3.34 1.67 98.20
15 INT12033 Binding of PLOD1 15 0.48 8.04 2.3 98.16
16 INT3589 Positive_regulation of SCN5A 101 0.57 46.01 21.73 98.08
17 INT7035 Regulation of CGA 87 0.45 29.04 28.45 98.04
18 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 97.84
19 INT3104 Negative_regulation of CGA 76 0.54 29.81 12.23 97.16
20 INT7970 Gene_expression of PLOD1 120 0.71 44.42 15.54 96.24
21 INT15888 Positive_regulation of Nbr1 42 0.69 35.76 10.48 96.04
22 INT35539 Positive_regulation of Positive_regulation of Nbr1 2 0.47 2.52 0.41 95.76
23 INT1647 Negative_regulation of FSHR 54 0.45 13.44 8.87 94.80
24 INT23104 Positive_regulation of Cga 20 0.70 10.35 8.03 94.72
25 INT23054 Binding of Cga 4 0.36 2.17 0.78 94.72
26 INT5131 Gene_expression of GNRH1 109 0.78 28.79 23.94 94.72
27 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 94.32
28 INT188844 Gene_expression of AES 44 0.58 33.94 5.85 94.28
29 INT23010 Positive_regulation of CYP19A1 28 0.58 24.18 5.37 93.92
30 INT171105 Positive_regulation of Positive_regulation of CYP19A1 5 0.39 4.02 0.58 93.92
31 INT187718 Negative_regulation of Positive_regulation of CYP19A1 1 0.33 0.61 0.05 93.92
32 INT15887 Gene_expression of Nbr1 39 0.77 23.91 7.34 93.52
33 INT1794 Regulation of Localization of CGA 136 0.57 13.39 59.07 93.48
34 INT41892 Gene_expression of HBM 48 0.64 28.32 5.64 93.16
35 INT1644 Regulation of FSHR 77 0.55 15.62 21.49 91.32
36 INT272438 Gene_expression of PROK1 32 0.63 15.06 1.01 90.32
37 INT7033 Binding of FSHR 19 0.37 6.66 1.52 89.60
38 INT319157 Gene_expression of Kat2a 1 0.56 0.78 0 89.32
39 INT31116 Gene_expression of Casp3 192 0.78 78.21 57.43 89.32
40 INT196917 Gene_expression of Hdac1 15 0.71 3.66 0.28 89.32
41 INT118952 Gene_expression of Hist1h3f 13 0.21 3.58 1.05 89.32
42 INT15837 Binding of CGA 31 0.41 12.06 3.17 89.16
43 INT67468 Regulation of SCN5A 27 0.44 4.4 3.47 88.24
44 INT39443 Positive_regulation of Positive_regulation of F2 6 0.70 4.31 1.3 88.04
45 INT1190 Positive_regulation of F2 53 0.70 46.41 11.64 87.68
46 INT119904 Regulation of CYP19A1 25 0.62 9.36 8.34 87.52
47 INT37005 Regulation of Nbr1 6 0.24 6.33 1.56 84.96
48 INT35540 Negative_regulation of Positive_regulation of Nbr1 1 0.25 1.03 0.31 84.64
49 INT22456 Localization of Nbr1 4 0.70 2.71 0.95 83.92
50 INT71046 Localization of CYP19A1 2 0.78 1.38 0.48 83.16
51 INT187725 Positive_regulation of Localization of CYP19A1 1 0.39 0.23 0 83.16
52 INT187719 Negative_regulation of Localization of CYP19A1 1 0.33 0.78 0 83.16
53 INT319160 Regulation of Hist1h3f 1 0.07 0.7 0 83.08
54 INT249661 Positive_regulation of Phosphorylation of SCN5A 1 0.06 0.74 0.09 82.24
55 INT48499 Transcription of GNRH1 11 0.67 0.74 3.48 80.68
56 INT174297 Positive_regulation of MOS 6 0.51 3.26 0.42 80.56
57 INT249663 Negative_regulation of Phosphorylation of SCN5A 1 0.05 0.74 0.09 80.56
58 INT249660 Phosphorylation of SCN5A 1 0.10 0.73 0.09 80.56
59 INT920 Localization of PLOD1 223 0.81 42.25 78.7 79.12
60 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21 78.76
61 INT319164 Negative_regulation of Gene_expression of Kat2a 1 0.42 0.24 0 78.12
62 INT912 Localization of FSHR 91 0.79 23.61 15.58 77.04
63 INT1646 Negative_regulation of Localization of FSHR 17 0.58 7.36 3.46 77.04
64 INT21873 Positive_regulation of Gene_expression of Nbr1 5 0.50 2.09 0.51 73.40
65 INT319156 Negative_regulation of Gene_expression of Hdac1 1 0.39 0.22 0 72.56
66 INT187721 Transcription of PLOD1 4 0.49 4.69 0.51 72.08
67 INT5345 Positive_regulation of BRD2 14 0.67 6.72 3.43 69.84
68 INT7972 Positive_regulation of Gene_expression of PLOD1 15 0.42 5.73 1.96 68.84
69 INT88237 Gene_expression of Gbp1 9 0.65 5.46 0.61 66.80
70 INT243713 Positive_regulation of Gene_expression of Gbp1 2 0.12 2.58 0 66.80
71 INT318002 Gene_expression of Dmrta1 1 0.70 1.18 0 65.84
72 INT26538 Positive_regulation of FSHR 103 0.69 30.95 15.33 63.52
73 INT812 Localization of INS 1026 0.81 515.6 145.31 63.24
74 INT318005 Negative_regulation of Dmrta1 1 0.39 1.13 0 62.64
75 INT251 Regulation of INS 398 0.62 232.47 55.04 61.80
76 INT187728 Regulation of PCOS1 1 0.02 0.84 0.13 61.80
77 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 60.56
78 INT187711 Transcription of BRD2 1 0.67 0.06 0 58.16
79 INT5130 Regulation of GNRH1 139 0.62 31.95 42.08 57.80
80 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 57.40
81 INT187713 Gene_expression of PCOS1 1 0.04 2.09 0.19 56.68
82 INT318001 Gene_expression of Nobox 1 0.48 1.03 0 56.08
83 INT206389 Positive_regulation of HIST1H2AI 1 0.08 0.2 0 51.76
84 INT2982 Positive_regulation of Gene_expression of CGA 17 0.59 9.08 1.99 50.72
85 INT37068 Regulation of Gene_expression of Nbr1 1 0.41 0.76 0.47 49.96
86 INT187717 Regulation of Negative_regulation of CYP19A1 11 0.42 2.85 0.45 45.60
87 INT187720 Negative_regulation of Negative_regulation of CYP19A1 5 0.34 0.99 0 44.64
88 INT105457 Regulation of Binding of CGA 2 0.45 0.48 0.33 44.28
89 INT81795 Negative_regulation of AGRP 23 0.41 10.93 0.87 42.92
90 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 36.60
91 INT7971 Regulation of Gene_expression of GNRH1 12 0.58 1.72 2.43 35.04
92 INT15609 Positive_regulation of Gene_expression of GNRH1 17 0.49 5.15 3.34 34.16
93 INT140515 Positive_regulation of TSPAN33 2 0.44 0.63 0.51 34.16
94 INT224165 Positive_regulation of Gene_expression of TSPAN33 3 0.30 0.07 0.16 34.16
95 INT113263 Gene_expression of TSPAN33 5 0.65 1.19 1.3 33.40
96 INT141665 Gene_expression of AGRP 83 0.67 43.43 4.24 28.80
97 INT23598 Binding of SCN5A 32 0.40 16 5.35 27.28
98 INT187722 Positive_regulation of Gene_expression of BRD2 3 0.49 0.43 0.23 24.80
99 INT5868 Positive_regulation of GNRH1 122 0.69 20.96 32.8 24.20
100 INT917 Positive_regulation of Localization of PLOD1 51 0.69 8.53 22.87 24.12
101 INT3180 Positive_regulation of PPY 39 0.63 25.57 10.15 22.00
102 INT272436 Negative_regulation of Gene_expression of PROK1 3 0.40 2.3 0.17 21.76
103 INT200438 Negative_regulation of Gene_expression of SCN5A 6 0.36 1.93 0.71 21.60
104 INT111113 Binding of CYP19A1 15 0.36 9.17 2.12 17.60
105 INT15604 Gene_expression of FSHB 30 0.56 9.7 2.45 15.68
106 INT23491 Positive_regulation of FSHB 14 0.65 7.2 1.79 15.28
107 INT175209 Regulation of DBT 9 0.12 2.03 0.2 13.68
108 INT5128 Positive_regulation of Lhb 232 0.69 44.23 71.26 8.96
109 INT295437 Negative_regulation of Protein_catabolism of CGA 1 0.36 0.05 0.19 6.48
110 INT30209 Localization of SCN5A 24 0.72 7.95 5.35 5.32
111 INT2867 Gene_expression of CALCA 247 0.78 78.78 138.47 5.00
112 INT7395 Localization of GNRH1 399 0.81 62.88 117.68 5.00
113 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
114 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
115 INT6761 Binding of CALCA 100 0.48 26.71 62.05 5.00
116 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 5.00
117 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
118 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 5.00
119 INT3933 Positive_regulation of PLOD1 128 0.70 30.76 42.03 5.00
120 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52 5.00
121 INT48933 Gene_expression of Mapk3 93 0.75 44.39 37.92 5.00
122 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
123 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79 5.00
124 INT48924 Positive_regulation of Mapk3 107 0.67 50.53 34.05 5.00
125 INT913 Regulation of Localization of PLOD1 71 0.62 8.64 32.72 5.00
126 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81 5.00
127 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
128 INT7975 Regulation of PLOD1 97 0.62 20.9 30.51 5.00
129 INT7397 Negative_regulation of Localization of GNRH1 86 0.59 15.45 29.78 5.00
130 INT23463 Positive_regulation of Gene_expression of CALCA 47 0.70 18.14 28.76 5.00
131 INT5135 Negative_regulation of GNRH1 106 0.58 36.63 27.71 5.00
132 INT1638 Negative_regulation of PLOD1 92 0.59 21.69 26.61 5.00
133 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 5.00
134 INT2261 Gene_expression of Lhb 121 0.77 42.78 26.04 5.00
135 INT7113 Negative_regulation of Localization of CGA 71 0.51 17.7 23.42 5.00
136 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52 5.00
137 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 5.00
138 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22 5.00
139 INT1642 Negative_regulation of Localization of PLOD1 40 0.58 10.67 17.95 5.00
140 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 5.00
141 INT62681 Negative_regulation of LEP 93 0.59 66.97 15.77 5.00
142 INT75908 Regulation of LEP 77 0.60 60.16 15.19 5.00
143 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 5.00
144 INT2129 Positive_regulation of F2 83 0.70 58.95 12.63 5.00
145 INT7234 Binding of GNRH1 43 0.47 21.59 12.36 5.00
146 INT73959 Positive_regulation of NOSTRIN 49 0.61 31.1 11.27 5.00
147 INT126743 Positive_regulation of Gene_expression of LEP 61 0.66 50.02 11.17 5.00
148 INT62895 Gene_expression of NOSTRIN 51 0.75 28.8 10.68 5.00
149 INT62919 Regulation of Gnas 22 0.43 5.61 9.55 5.00
150 INT75907 Binding of LEP 53 0.46 46.65 8.44 5.00
151 INT135578 Gene_expression of Prokr1 22 0.70 11.71 8.31 5.00
152 INT15687 Regulation of ESR1 91 0.60 40.42 7.95 5.00
153 INT8684 Positive_regulation of ANGPTL5 45 0.69 36.29 7.47 5.00
154 INT6906 Negative_regulation of SCN5A 64 0.43 20.64 7.3 5.00
155 INT31226 Localization of PPY 20 0.78 9.93 6.8 5.00
156 INT146594 Negative_regulation of Gene_expression of LEP 25 0.42 18.88 5.71 5.00
157 INT38556 Gene_expression of DBT 47 0.50 12.52 5.6 5.00
158 INT65356 Localization of LEP 46 0.79 41.17 5.43 5.00
159 INT81796 Binding of AGRP 62 0.36 37.19 5.3 5.00
160 INT5126 Positive_regulation of Positive_regulation of Lhb 16 0.48 2.12 5.23 5.00
161 INT199383 Gene_expression of Prokr2 8 0.59 7.37 5.21 5.00
162 INT57064 Positive_regulation of APC 72 0.66 48.5 5.08 5.00
163 INT924 Regulation of Localization of FSHR 15 0.45 1.4 5.07 5.00
164 INT22022 Regulation of PPY 8 0.26 5.52 5.02 5.00
165 INT63121 Binding of APC 29 0.41 23.02 3.8 5.00
166 INT17620 Positive_regulation of Gnrh1 23 0.70 9.77 3.79 5.00
167 INT57252 Negative_regulation of PGR 22 0.43 12.95 3.33 5.00
168 INT239083 Binding of PPY 9 0.32 7.59 2.9 5.00
169 INT7976 Regulation of Gene_expression of CGA 8 0.19 1.09 2.71 5.00
170 INT188756 Positive_regulation of AGRP 43 0.60 23.67 2.51 5.00
171 INT15607 Localization of GNRHR 14 0.62 7.56 2.3 5.00
172 INT31118 Localization of Casp3 17 0.73 11.55 2.3 5.00
173 INT83236 Localization of PGR 14 0.73 8.26 2.23 5.00
174 INT7974 Regulation of Gene_expression of PLOD1 6 0.42 0.41 1.99 5.00
175 INT5344 Negative_regulation of BRD2 12 0.56 4.71 1.89 5.00
176 INT33496 Positive_regulation of Gene_expression of FSHR 14 0.46 6.05 1.66 5.00
177 INT136523 Binding of Prokr1 2 0.48 0.85 1.47 5.00
178 INT1641 Positive_regulation of Negative_regulation of FSHR 3 0.41 1.7 1.43 5.00
179 INT52589 Positive_regulation of Gene_expression of SCN5A 14 0.49 3.84 1.33 5.00
180 INT25032 Negative_regulation of Gene_expression of FSHR 11 0.39 1.99 1.2 5.00
181 INT268379 Gene_expression of ARAF 22 0.16 9.34 1.07 5.00
182 INT172529 Negative_regulation of Gene_expression of PGR 24 0.48 16.69 1.04 5.00
183 INT60286 Gene_expression of PKLR 5 0.65 2.14 1.04 5.00
184 INT175280 Binding of DBT 19 0.08 6.37 0.98 5.00
185 INT38557 Positive_regulation of Gene_expression of DBT 8 0.37 2.05 0.92 5.00
186 INT97021 Gene_expression of PTPRH 2 0.02 0 0.86 5.00
187 INT38558 Positive_regulation of DBT 9 0.31 1.59 0.86 5.00
188 INT32963 Negative_regulation of Localization of GNRHR 3 0.29 2.48 0.84 5.00
189 INT187709 Regulation of Gene_expression of DBT 3 0.04 0.63 0.8 5.00
190 INT57062 Regulation of APC 24 0.58 14.3 0.7 5.00
191 INT130194 Positive_regulation of PROK1 9 0.65 0.97 0.7 5.00
192 INT180149 Positive_regulation of SRA1 7 0.40 2.65 0.65 5.00
193 INT187712 Negative_regulation of DBT 11 0.19 2.99 0.65 5.00
194 INT16102 Negative_regulation of Gene_expression of GNRH1 5 0.39 0.85 0.64 5.00
195 INT146563 Gene_expression of PROK2 15 0.75 4.12 0.61 5.00
196 INT188754 Localization of AGRP 15 0.74 8.88 0.6 5.00
197 INT27643 Negative_regulation of Gene_expression of BRD2 2 0.42 0.19 0.51 5.00
198 INT187714 Regulation of Negative_regulation of PLOD1 1 0.09 0 0.51 5.00
199 INT127890 Positive_regulation of Negative_regulation of CYP19A1 6 0.50 1.41 0.45 5.00
200 INT187726 Positive_regulation of Localization of LEP 5 0.50 5.31 0.41 5.00
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