D:Overnutrition

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Disease Term
Synonyms Dieting, EXCESS EATING, WEIGHT LOSS
Documents 119
Hot Single Events 71
Hot Interactions 9

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Overnutrition. They are ordered first by their relevance to Overnutrition and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87 95.40
2 INT314623 Ex Positive_regulation of INS 1 0.10 1.46 0 94.64
3 INT284311 RPS6KB1 Positive_regulation of Phosphorylation of IRS1 1 0.18 0.24 0 88.20
4 INT183784 INS Negative_regulation of Binding of TBK1 1 0.01 1.81 0.34 88.12
5 INT183783 INS Negative_regulation of TBK1 1 0.01 1.81 0.34 88.12
6 INT183793 INS Negative_regulation of Binding of Ros1 1 0.16 1.66 0.34 88.12
7 INT183785 INS Positive_regulation of Gene_expression of NFKBIB 1 0.03 1.83 0.34 88.12
8 INT183780 INS Negative_regulation of Gene_expression of CYBB 1 0.02 1.74 0.34 88.12
9 INT183782 INS Negative_regulation of Gene_expression of TBK1 1 0.01 1.81 0.34 88.12
10 INT314624 Ex Regulation of GCG 1 0.01 0.67 0 70.96
11 INT314621 Ex Regulation of INS 1 0.06 0.67 0 70.96
12 INT183786 IL6 Negative_regulation of INS 1 0.09 1.61 0.35 54.24
13 INT326625 Binding of ALB and Trf 1 0.01 0.64 0.04 49.40
14 INT314620 Ex Positive_regulation of GLP1R Positive_regulation of Gene_expression of INS 1 0.03 0.3 0.11 29.28
15 INT314625 Ex Positive_regulation of GLP1R 1 0.03 0.3 0.11 26.72
16 INT284313 Binding of IRS1 and SART3 1 0.07 0.32 0 19.76
17 INT284312 Negative_regulation of Binding of IRS1 and SART3 1 0.08 0.32 0 19.76
18 INT354790 MMP3 Negative_regulation of Gene_expression of OSM 1 0.00 0.27 0.31 5.00
19 INT187361 Binding of Gabrg1 and Kcnn3 1 0.36 0.13 0.3 5.00
20 INT336379 TIMP1 Negative_regulation of FADS1 1 0.01 0.52 0.2 5.00
21 INT217661 LEP Positive_regulation of INS 2 0.25 1.85 0.19 5.00
22 INT217665 ADIPOQ Positive_regulation of INS 2 0.06 1.8 0.19 5.00
23 INT217667 LEP Negative_regulation of Localization of INS 1 0.15 1.18 0.14 5.00
24 INT217664 LEP Negative_regulation of INS 1 0.15 1.18 0.14 5.00
25 INT288219 Cigs1 Regulation of Nrgn 1 0.00 0.87 0.1 5.00
26 INT336383 TIMP1 Positive_regulation of Ppara 1 0.08 0.77 0.07 5.00
27 INT336380 Gene_expression of Adipoq Positive_regulation of Ppara 1 0.06 1.77 0.07 5.00
28 INT217666 ADIPOQ Regulation of Gene_expression of INS 1 0.03 1.99 0.05 5.00
29 INT323056 LDLR Regulation of HSD11B1 1 0.01 1.2 0.05 5.00
30 INT314622 Binding of INS and Ex 1 0.08 0.44 0.04 5.00
31 INT299889 Binding of MAT1A and MPP6 1 0.03 0.39 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Overnutrition. They are ordered first by their pain relevance and then by number of times they were reported in Overnutrition. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT62681 Negative_regulation of LEP 93 0.59 66.97 15.77 100.00
2 INT65356 Localization of LEP 46 0.79 41.17 5.43 100.00
3 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 99.84
4 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 99.84
5 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 99.78
6 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 99.78
7 INT49844 Negative_regulation of Bmc1 16 0.24 4.53 1.42 99.76
8 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 99.64
9 INT251 Regulation of INS 398 0.62 232.47 55.04 99.50
10 INT812 Localization of INS 1026 0.81 515.6 145.31 99.50
11 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 99.44
12 INT1530 Regulation of Gh 382 0.61 115.96 112.47 99.16
13 INT2122 Negative_regulation of Localization of Gnrh1 226 0.59 26.92 92.04 99.16
14 INT439 Localization of Gnrh1 976 0.81 100.96 363.25 98.72
15 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 97.60
16 INT126743 Positive_regulation of Gene_expression of LEP 61 0.66 50.02 11.17 97.04
17 INT183791 Positive_regulation of Phosphorylation of TNF 6 0.49 4.72 1.56 96.92
18 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 96.68
19 INT4494 Regulation of GCG 41 0.45 18.38 9.68 96.52
20 INT51265 Phosphorylation of TNF 32 0.81 25.33 10.75 96.52
21 INT162 Regulation of Prl 794 0.62 165.01 322.24 96.48
22 INT4563 Positive_regulation of Regulation of Prl 20 0.70 4.2 8.1 96.48
23 INT215844 Gene_expression of Ex 12 0.65 9.24 0.54 96.48
24 INT40216 Positive_regulation of Alas1 11 0.65 6.08 1.8 96.32
25 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 96.08
26 INT12042 Regulation of MIA3 28 0.23 17.33 5.79 96.00
27 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61 95.84
28 INT14572 Binding of INS 205 0.48 175.43 13.38 95.56
29 INT86437 Binding of IL6 154 0.48 121.22 29.3 95.40
30 INT284321 Gene_expression of PIK3R2 1 0.20 0.97 0.09 95.28
31 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 95.08
32 INT284334 Gene_expression of IRS1 10 0.49 5.81 0.59 94.72
33 INT284324 Positive_regulation of Gene_expression of IRS1 1 0.31 0.24 0 94.72
34 INT1472 Positive_regulation of Ins1 349 0.69 146.2 86.36 94.60
35 INT1114 Localization of Ins1 748 0.80 192.95 165.48 94.60
36 INT186709 Regulation of HCA1 5 0.39 1.91 0.21 94.24
37 INT314619 Gene_expression of ZGLP1 4 0.29 3.75 0.1 93.76
38 INT17625 Localization of GCG 210 0.80 55.69 24.97 93.72
39 INT14681 Negative_regulation of GCG 31 0.57 13.55 4.98 93.72
40 INT1646 Negative_regulation of Localization of FSHR 17 0.58 7.36 3.46 92.80
41 INT912 Localization of FSHR 91 0.79 23.61 15.58 92.48
42 INT207570 Phosphorylation of IRS1 45 0.71 33.27 3.42 91.28
43 INT240031 Positive_regulation of Phosphorylation of IRS1 15 0.46 13.17 1.53 91.28
44 INT89407 Positive_regulation of IRS1 10 0.51 9.67 0.81 91.28
45 INT284333 Positive_regulation of PIK3R2 1 0.12 0.42 0.05 91.12
46 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 89.40
47 INT143357 Binding of Ros1 48 0.36 27.76 6 87.48
48 INT4486 Regulation of TSHB 5 0.28 0.99 1.42 87.28
49 INT146594 Negative_regulation of Gene_expression of LEP 25 0.42 18.88 5.71 86.80
50 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 86.40
51 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 85.76
52 INT159806 Binding of HCA1 4 0.32 1.57 0.24 85.60
53 INT116433 Gene_expression of CYBB 93 0.70 50.44 11.91 85.56
54 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 85.28
55 INT92335 Gene_expression of TBK1 11 0.28 8.98 3 85.00
56 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 84.32
57 INT79928 Positive_regulation of Localization of ALB 10 0.60 8.96 1.05 84.32
58 INT18773 Localization of ALB 117 0.80 69.18 13.8 84.04
59 INT183790 Binding of TBK1 2 0.04 2.97 1.16 83.88
60 INT3041 Positive_regulation of MIA3 34 0.56 21.11 6.49 83.64
61 INT15528 Positive_regulation of GCG 38 0.63 20.47 6.14 83.64
62 INT90825 Gene_expression of NFKBIB 3 0.17 4.13 1.41 82.96
63 INT134716 Gene_expression of Rs1 3 0.16 0.39 0.92 82.92
64 INT259786 Gene_expression of Fpr-rs4 1 0.01 0.38 0 82.32
65 INT215845 Localization of Ex 2 0.20 5.16 0.36 82.20
66 INT169591 Gene_expression of FAT1 23 0.67 10.73 0.77 81.60
67 INT217731 Positive_regulation of Phosphorylation of MTOR 3 0.40 0.54 0 81.52
68 INT11937 Localization of Il6 228 0.81 139.83 64.39 81.08
69 INT284331 Positive_regulation of Phosphorylation of RPS6KB1 5 0.32 0.7 0.05 80.72
70 INT263820 Phosphorylation of RPS6KB1 6 0.52 1.43 0.42 80.20
71 INT156204 Phosphorylation of MTOR 15 0.82 3.99 0.21 80.20
72 INT75907 Binding of LEP 53 0.46 46.65 8.44 79.84
73 INT77416 Localization of ZGLP1 3 0.79 1.79 0.36 78.80
74 INT217683 Localization of BMI1 7 0.68 6.28 0.87 77.84
75 INT120656 Localization of HMBS 3 0.16 2.6 0.23 77.32
76 INT112054 Negative_regulation of Negative_regulation of DMD 12 0.44 5.02 0.45 76.48
77 INT32795 Positive_regulation of Hypism 17 0.15 20.16 1.73 76.12
78 INT134651 Binding of TLR4 89 0.48 66.96 23.19 75.60
79 INT16608 Positive_regulation of FFAR1 40 0.37 18.48 3.59 75.40
80 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 74.60
81 INT1894 Negative_regulation of Localization of Gh 168 0.58 64.12 43.56 72.80
82 INT1893 Localization of Gh 1041 0.79 340.23 256.58 72.80
83 INT314612 Positive_regulation of Localization of Ex 1 0.11 0.65 0 70.96
84 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 70.40
85 INT17626 Positive_regulation of Localization of GCG 36 0.69 13.94 4.06 70.36
86 INT144755 Negative_regulation of INSR 5 0.41 2.09 0.36 70.00
87 INT215863 Positive_regulation of Ex 3 0.16 2.46 0 69.80
88 INT89403 Negative_regulation of PIK3CA 19 0.57 11.74 0.35 67.04
89 INT196506 Localization of AL 1 0.16 0.07 0 65.76
90 INT15837 Binding of CGA 31 0.41 12.06 3.17 61.52
91 INT105457 Regulation of Binding of CGA 2 0.45 0.48 0.33 61.52
92 INT62689 Negative_regulation of PPOX 7 0.58 4.66 0.28 61.44
93 INT7035 Regulation of CGA 87 0.45 29.04 28.45 60.88
94 INT3866 Positive_regulation of Positive_regulation of INS 30 0.59 21.58 1.86 59.20
95 INT3315 Negative_regulation of Positive_regulation of INS 31 0.57 14.73 2.27 58.80
96 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 52.40
97 INT3179 Positive_regulation of SCT 15 0.50 4.79 1.98 52.36
98 INT125066 Negative_regulation of HDAC4 56 0.49 41.55 5.42 51.64
99 INT2132 Localization of SCT 29 0.81 8.39 5.43 50.56
100 INT75908 Regulation of LEP 77 0.60 60.16 15.19 50.00
101 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75 50.00
102 INT54044 Negative_regulation of EDA 7 0.42 2.54 1.14 50.00
103 INT136037 Positive_regulation of LOC691170 2 0.62 0.33 0.56 50.00
104 INT119271 Positive_regulation of BCS1L 13 0.50 7.56 0.39 50.00
105 INT207293 Negative_regulation of Negative_regulation of INS 12 0.49 6 0.26 50.00
106 INT133858 Negative_regulation of BCS1L 13 0.51 8.65 0.2 50.00
107 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 49.92
108 INT314610 Binding of Ex 1 0.08 2.16 0.05 47.16
109 INT284325 Positive_regulation of Gene_expression of DAG1 3 0.13 1.08 0.36 46.88
110 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 46.24
111 INT546 Binding of ALB 311 0.48 85.98 60.14 46.12
112 INT326623 Binding of Ttr 2 0.35 4.76 0.46 46.12
113 INT189771 Gene_expression of DAG1 5 0.27 4.14 1.12 45.28
114 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 43.80
115 INT117731 Binding of MYP1 7 0.30 10.61 0.67 43.76
116 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 43.40
117 INT860 Regulation of ALB 48 0.60 25.11 8.95 41.12
118 INT48912 Localization of NOS1 52 0.77 24.14 10.92 40.88
119 INT48911 Binding of NOS1 24 0.40 11.21 5.89 40.88
120 INT96047 Positive_regulation of Localization of NOS1 6 0.38 4.24 1.47 40.88
121 INT6323 Positive_regulation of Gabrg1 213 0.70 45.08 124.34 40.72
122 INT7133 Negative_regulation of MME 85 0.59 29.22 33.1 40.12
123 INT110638 Negative_regulation of COMT 43 0.59 21.03 21.05 39.40
124 INT89394 Phosphorylation of INS 37 0.82 35.84 3.9 39.20
125 INT183789 Positive_regulation of Phosphorylation of INS 5 0.50 4.87 0.64 39.20
126 INT215866 Regulation of Ex 2 0.10 2.25 0.24 35.92
127 INT213400 Regulation of SELPLG 4 0.14 3.53 0.05 34.20
128 INT213399 Negative_regulation of SELPLG 3 0.16 3.23 0.03 34.20
129 INT3933 Positive_regulation of PLOD1 128 0.70 30.76 42.03 28.56
130 INT13064 Positive_regulation of GNRHR 2 0.36 0.93 0.35 28.24
131 INT61363 Positive_regulation of TFAM 43 0.69 26.43 8.14 26.60
132 INT77417 Negative_regulation of ZGLP1 3 0.42 0.71 0.16 26.28
133 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 26.08
134 INT11361 Gene_expression of SERPINE1 183 0.78 136.45 27.97 26.08
135 INT9951 Gene_expression of ANGPTL5 45 0.53 37.2 6.44 26.08
136 INT119606 Regulation of Gene_expression of LEP 17 0.45 17.96 3.75 26.00
137 INT59365 Gene_expression of HTR1A 41 0.75 16.31 16.57 25.48
138 INT213923 Positive_regulation of MTOR 16 0.65 9.28 0.7 25.08
139 INT228901 Positive_regulation of RPS6KB1 5 0.55 2.44 0.18 25.08
140 INT82854 Gene_expression of MRGPRX1 61 0.75 10.14 10.65 24.36
141 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 21.36
142 INT172084 Positive_regulation of Binding of TNF 21 0.50 15.31 6.06 20.84
143 INT239436 Localization of PPOX 3 0.54 0.67 0 20.84
144 INT264798 Binding of GLP1R 9 0.40 2.95 1.27 20.48
145 INT6481 Binding of TNF 624 0.48 510.2 214.82 20.20
146 INT284330 Positive_regulation of Positive_regulation of RPS6KB1 1 0.23 0.24 0 19.12
147 INT314618 Binding of ZGLP1 2 0.16 1.7 0.59 16.40
148 INT121037 Positive_regulation of Positive_regulation of TFAM 5 0.42 2.56 1.02 15.08
149 INT217684 Positive_regulation of LIPG 3 0.04 1.9 0.12 13.60
150 INT7994 Gene_expression of Lta 113 0.67 69.81 19.59 13.32
151 INT207565 Negative_regulation of LIPG 8 0.10 7.83 0.76 11.76
152 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22 11.44
153 INT6484 Binding of IL1B 122 0.47 75.84 35.07 10.92
154 INT16178 Gene_expression of Clcn1 20 0.69 8.67 1.46 10.16
155 INT306058 Positive_regulation of ZGLP1 5 0.21 2.1 0.51 9.72
156 INT239437 Transcription of PPOX 1 0.42 0.62 0 8.40
157 INT86591 Positive_regulation of Positive_regulation of PKIB 2 0.09 0.48 1.43 7.84
158 INT15898 Positive_regulation of Prkaca 199 0.70 50.89 87.54 7.40
159 INT86592 Positive_regulation of PKIB 3 0.09 0.54 2.75 7.40
160 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 5.00
161 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
162 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 5.00
163 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
164 INT7506 Negative_regulation of Ltp 267 0.46 91.01 176.8 5.00
165 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
166 INT4768 Positive_regulation of OPRM1 212 0.70 31.09 164.28 5.00
167 INT7628 Gene_expression of Ltp 273 0.77 70.21 147.87 5.00
168 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
169 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 5.00
170 INT252 Localization of GH1 529 0.80 227.4 122.05 5.00
171 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
172 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
173 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
174 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
175 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 5.00
176 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 5.00
177 INT84546 Positive_regulation of Ppara 481 0.70 334.21 83.45 5.00
178 INT2289 Gene_expression of PENK 203 0.78 55.62 79.49 5.00
179 INT3657 Gene_expression of Ins1 514 0.78 321.69 75.76 5.00
180 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
181 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 5.00
182 INT6849 Localization of IL1B 229 0.81 112.56 69.63 5.00
183 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
184 INT18981 Gene_expression of ABAT 78 0.68 38.35 61.36 5.00
185 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 5.00
186 INT1200 Negative_regulation of Ins1 274 0.58 155.17 56.14 5.00
187 INT52692 Gene_expression of Ptgs2 160 0.78 85.06 55.73 5.00
188 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 5.00
189 INT19488 Localization of ABAT 56 0.69 21.51 50.56 5.00
190 INT9210 Regulation of IL6 166 0.62 125.61 49.95 5.00
191 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 5.00
192 INT4862 Localization of PENK 62 0.81 11.57 40.28 5.00
193 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 5.00
194 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 5.00
195 INT255 Regulation of Localization of GH1 89 0.62 18.71 35.3 5.00
196 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
197 INT67613 Positive_regulation of PPARG 94 0.70 69.15 34.38 5.00
198 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 5.00
199 INT84825 Gene_expression of CD36 121 0.78 43.73 33.23 5.00
200 INT234 Binding of Alb 151 0.48 52.34 32.97 5.00
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