D:Oxidative Phosphorylation Disease

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Disease Term
Synonyms Alexander Disease, Autosomal Dominant Chronic Progressive External Ophthalmoplegia, Autosomal Recessive Chronic Progressive External Ophthalmoplegia, Fahrs Syndrome Variants, Familial Spastic Paraplegia, Friedreich Ataxia, Hereditary Spastic Paraplegia, Kearns Sayre Syndrome, Lebers Familial Optic Neuropathy, LEBERS HEREDITARY OPTIC NEUROPATHY, Leighs Disease
Documents 26
Hot Single Events 17
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Oxidative Phosphorylation Disease. They are ordered first by their relevance to Oxidative Phosphorylation Disease and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT256706 Binding of Hsp90b1 and Wfs1 1 0.43 5.02 0.2 85.28
2 INT256707 Eif2ak3 Regulation of Gene_expression of Wfs1 1 0.10 0.78 0.03 48.56
3 INT302676 Binding of OPA1 and MFN2 1 0.46 1.12 0.14 5.00
4 INT256703 Negative_regulation of Hsp90b1 Positive_regulation of Wfs1 1 0.42 0.24 0 5.00
5 INT256700 Negative_regulation of Binding of Hsp90b1 and Wfs1 1 0.52 0 0 5.00
6 INT256701 Binding of Hsp90aa1 and Hsp90b1 1 0.12 0.34 0 5.00
7 INT302675 Binding of OPA1 and PLAA 1 0.15 0.73 0 5.00
8 INT256705 Binding of Wfs1 and Xbp1 1 0.19 0.39 0 5.00
9 INT256704 Xbp1 Positive_regulation of Positive_regulation of Wfs1 1 0.26 0.4 0 5.00
10 INT256702 Binding of Wfs1 and Tmed4 1 0.01 0.61 0 5.00
11 INT251822 Binding of POLG and C10orf2 1 0.42 0.29 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Oxidative Phosphorylation Disease. They are ordered first by their pain relevance and then by number of times they were reported in Oxidative Phosphorylation Disease. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT251830 Binding of TYMP 2 0.13 4.36 0.37 99.76
2 INT15367 Gene_expression of OPA1 35 0.67 24.9 5.45 98.64
3 INT120722 Gene_expression of TYMP 35 0.75 19.26 1.31 97.80
4 INT138556 Positive_regulation of TYMP 23 0.58 12.9 0.28 97.80
5 INT12250 Negative_regulation of Mtr 19 0.50 6.9 5.35 95.84
6 INT274268 Localization of OPA2 1 0.12 1.48 0 95.68
7 INT97624 Positive_regulation of Adc 13 0.69 5.56 4.87 91.76
8 INT287528 Gene_expression of WFS1 1 0.75 2.74 1.55 88.08
9 INT222077 Regulation of Hsp90b1 9 0.37 4.78 0.45 87.04
10 INT256681 Regulation of Wfs1 8 0.43 4.72 0.36 87.04
11 INT154101 Gene_expression of Ide 1 0.11 1.48 0.19 86.76
12 INT256696 Positive_regulation of Wfs1 1 0.66 9.14 0.17 85.16
13 INT256687 Positive_regulation of Transcription of Wfs1 1 0.44 1.95 0.09 83.88
14 INT256693 Transcription of Wfs1 1 0.68 2.44 0.08 83.56
15 INT147088 Gene_expression of HHEX 5 0.65 4.86 0.99 83.08
16 INT287524 Regulation of WFS1 1 0.40 1.34 0.78 81.44
17 INT334578 Binding of SLC26A4 1 0.21 0.83 0 80.08
18 INT138555 Negative_regulation of Tymp 3 0.39 3.31 0.74 75.00
19 INT138554 Positive_regulation of Negative_regulation of Tymp 1 0.13 0.7 0.28 75.00
20 INT161702 Gene_expression of GJB2 3 0.65 2.19 0.14 74.68
21 INT256366 Gene_expression of GJB6 2 0.50 0.8 0 74.68
22 INT256695 Regulation of Regulation of Hsp90b1 1 0.22 1.69 0.07 72.96
23 INT282213 Negative_regulation of Regulation of Mtr 1 0.01 0.82 0.27 70.12
24 INT10006 Regulation of Mtr 9 0.23 3.56 5.42 69.72
25 INT256684 Positive_regulation of Gene_expression of Wfs1 1 0.66 3.62 0.16 69.56
26 INT256682 Gene_expression of Wfs1 1 0.74 6.63 0.25 69.00
27 INT256675 Regulation of Gene_expression of Wfs1 1 0.43 2.33 0.09 65.48
28 INT42104 Regulation of Cdkn2a 4 0.44 5.67 1.06 65.28
29 INT246905 Regulation of Cdkal1 2 0.24 1.29 0.12 62.88
30 INT159409 Gene_expression of PLAA 2 0.54 6.14 0.89 61.60
31 INT206031 Regulation of Adc 7 0.33 6.85 1.48 58.32
32 INT97623 Negative_regulation of Adc 17 0.56 3.81 8.14 50.04
33 INT282214 Negative_regulation of Gene_expression of Adc 2 0.07 1.34 0.21 50.04
34 INT282215 Negative_regulation of Regulation of Adc 1 0.07 0.39 0.04 50.04
35 INT51083 Gene_expression of Adc 14 0.53 8.24 2.25 50.00
36 INT134902 Positive_regulation of Tymp 11 0.37 3.06 0.53 50.00
37 INT354726 Binding of Tymp 1 0.30 1.08 0.23 50.00
38 INT211375 Regulation of Gene_expression of TYMP 2 0.43 2.44 0.22 50.00
39 INT142587 Regulation of TYMP 2 0.51 2 0 50.00
40 INT175738 Regulation of ARNTL 4 0.28 0.29 0 50.00
41 INT137338 Regulation of Eif2ak3 8 0.45 5.5 1.07 46.84
42 INT109034 Gene_expression of Eif2ak3 37 0.77 17.11 14.19 42.64
43 INT256671 Regulation of Positive_regulation of Wfs1 1 0.59 1.77 0 41.92
44 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 39.28
45 INT14281 Gene_expression of Hspa5 44 0.63 34.19 3.31 27.24
46 INT195978 Gene_expression of Hsp90b1 26 0.65 11.28 2.88 27.24
47 INT118558 Gene_expression of Xbp1 13 0.72 7.98 0.91 27.24
48 INT256679 Gene_expression of Aatf 1 0.65 0.71 0 27.24
49 INT125066 Negative_regulation of HDAC4 56 0.49 41.55 5.42 26.96
50 INT666 Gene_expression of Jun 124 0.78 54.61 33.67 15.44
51 INT15756 Positive_regulation of Gene_expression of Jun 29 0.69 16.58 12.06 15.44
52 INT256677 Regulation of Transcription of Wfs1 1 0.59 0.5 0 12.96
53 INT167929 Gene_expression of Kcnq1 2 0.65 1.04 0.37 11.28
54 INT302683 Negative_regulation of PLAA 1 0.15 0.4 0.13 8.56
55 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
56 INT4658 Binding of OPRM1 188 0.48 25.96 136.24 5.00
57 INT6323 Positive_regulation of Gabrg1 213 0.70 45.08 124.34 5.00
58 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
59 INT6490 Negative_regulation of ADCY1 145 0.58 26.25 70.96 5.00
60 INT22454 Regulation of Crp 213 0.62 160.67 49.24 5.00
61 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 5.00
62 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 5.00
63 INT2774 Binding of Crp 241 0.48 195.89 44.39 5.00
64 INT37296 Binding of Esr1 117 0.43 62.51 27.33 5.00
65 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 5.00
66 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 5.00
67 INT11161 Gene_expression of HLA-DRB1 121 0.78 75.33 20.96 5.00
68 INT49774 Binding of DRD2 48 0.48 17.42 20.73 5.00
69 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 5.00
70 INT68267 Gene_expression of CACNA1A 22 0.75 11.39 8.65 5.00
71 INT64815 Binding of Jun 49 0.48 21.47 8.59 5.00
72 INT25585 Positive_regulation of DNAH8 39 0.70 17.96 7.85 5.00
73 INT6596 Positive_regulation of HLA-DRB1 33 0.61 27.01 7.26 5.00
74 INT17041 Gene_expression of PER1 24 0.66 5.31 7.12 5.00
75 INT32107 Gene_expression of PTPLA 14 0.47 8.06 6.76 5.00
76 INT27118 Regulation of Binding of OPRM1 10 0.62 1.18 5.97 5.00
77 INT23401 Gene_expression of HLA-DOA 91 0.30 38.21 5.52 5.00
78 INT84909 Positive_regulation of SUGT1 22 0.08 22.01 5.43 5.00
79 INT8959 Binding of Gnb5 17 0.40 31.38 5.1 5.00
80 INT33854 Localization of OPA1 19 0.65 10.55 5.04 5.00
81 INT34870 Positive_regulation of OPA1 18 0.59 10.66 5 5.00
82 INT10374 Gene_expression of RARA 39 0.75 22.59 4.28 5.00
83 INT83035 Binding of INSR 16 0.47 9.29 4.11 5.00
84 INT32933 Gene_expression of GNAS 57 0.32 10.58 4.03 5.00
85 INT287526 Negative_regulation of Gene_expression of CACNA1A 1 0.42 4.25 3.81 5.00
86 INT98624 Regulation of Aqp4 27 0.62 30.76 3.77 5.00
87 INT24883 Regulation of OPA1 14 0.45 9.73 3.44 5.00
88 INT178631 Phosphorylation of ESR1 21 0.75 9.16 3.36 5.00
89 INT186507 Localization of ATP1A2 2 0.74 3.35 3.04 5.00
90 INT111263 Gene_expression of Gnb5 8 0.75 8.51 3 5.00
91 INT5913 Binding of OPA1 12 0.41 9.33 2.92 5.00
92 INT287525 Localization of CAV2 5 0.47 5.32 2 5.00
93 INT13544 Localization of LTA 9 0.78 6.34 1.8 5.00
94 INT17094 Negative_regulation of SLC25A4 3 0.41 3.82 1.52 5.00
95 INT178890 Localization of CHDH 12 0.62 15.76 1.49 5.00
96 INT195977 Transcription of Hsp90b1 5 0.56 1.74 1.27 5.00
97 INT57425 Binding of MYH14 12 0.11 2.33 1.26 5.00
98 INT74550 Negative_regulation of SUCLA2 5 0.41 3.6 1.24 5.00
99 INT119827 Gene_expression of PTPN11 31 0.75 24.21 1.22 5.00
100 INT184696 Positive_regulation of Xbp1 12 0.60 13.6 1.06 5.00
101 INT52460 Localization of SUCLA2 5 0.67 2.5 0.86 5.00
102 INT17246 Negative_regulation of POLG 16 0.56 9.69 0.79 5.00
103 INT260501 Positive_regulation of AKR1B1 5 0.67 4.31 0.71 5.00
104 INT109964 Binding of AKR1B1 4 0.31 3.95 0.7 5.00
105 INT256673 Positive_regulation of Hsp90b1 12 0.49 8.49 0.68 5.00
106 INT287529 Negative_regulation of Positive_regulation of AKR1B1 2 0.41 2.1 0.63 5.00
107 INT192235 Binding of Hsp90aa1 6 0.19 1.46 0.6 5.00
108 INT19047 Localization of SLC25A4 5 0.73 2.73 0.57 5.00
109 INT127480 Negative_regulation of Hsp90aa1 20 0.57 10.67 0.56 5.00
110 INT256690 Binding of Hsp90b1 11 0.30 5.94 0.55 5.00
111 INT251828 Negative_regulation of C10orf2 3 0.37 2.87 0.41 5.00
112 INT239084 Localization of KAT2B 4 0.73 3.08 0.36 5.00
113 INT33569 Gene_expression of MYLK 6 0.25 2.56 0.34 5.00
114 INT222080 Regulation of Gene_expression of Hsp90b1 3 0.50 1.22 0.34 5.00
115 INT284528 Negative_regulation of POLG2 2 0.17 2.19 0.33 5.00
116 INT224340 Localization of TYMP 3 0.62 2.86 0.3 5.00
117 INT155170 Negative_regulation of Localization of SUCLA2 2 0.38 1.26 0.28 5.00
118 INT301935 Gene_expression of UCK2 5 0.13 4.4 0.27 5.00
119 INT138715 Gene_expression of POLG 12 0.66 6.97 0.23 5.00
120 INT173979 Gene_expression of Cap1 3 0.42 2.17 0.22 5.00
121 INT185443 Regulation of ROCK1 4 0.18 3.32 0.21 5.00
122 INT285702 Negative_regulation of Tpmt 2 0.28 1.4 0.19 5.00
123 INT172530 Gene_expression of THRB 5 0.04 4.62 0.18 5.00
124 INT194332 Localization of MFN2 2 0.74 1.45 0.15 5.00
125 INT302703 Binding of PLAA 1 0.13 0.87 0.15 5.00
126 INT184693 Positive_regulation of Gene_expression of Xbp1 3 0.47 4.42 0.13 5.00
127 INT302682 Localization of POLG2 1 0.67 1 0.11 5.00
128 INT302693 Localization of C10orf2 1 0.59 1 0.11 5.00
129 INT302695 Negative_regulation of Localization of C10orf2 1 0.33 1 0.11 5.00
130 INT302706 Negative_regulation of Localization of POLG2 1 0.38 1 0.11 5.00
131 INT302679 Negative_regulation of Localization of POLG 1 0.39 0.99 0.11 5.00
132 INT302699 Negative_regulation of Localization of SLC25A4 1 0.38 1.01 0.11 5.00
133 INT302692 Localization of POLG 1 0.69 0.99 0.1 5.00
134 INT302684 Negative_regulation of RRM2B 1 0.17 0.73 0.08 5.00
135 INT302698 Negative_regulation of MPV17 1 0.16 0.67 0.08 5.00
136 INT320460 Regulation of Positive_regulation of DNAH8 1 0.01 2.04 0.08 5.00
137 INT251829 Positive_regulation of POLG 1 0.53 1.5 0.08 5.00
138 INT251831 Positive_regulation of C10orf2 1 0.50 1.23 0.08 5.00
139 INT302686 Negative_regulation of Localization of RRM2B 1 0.38 0.73 0.08 5.00
140 INT302690 Negative_regulation of Localization of MPV17 1 0.37 0.67 0.08 5.00
141 INT302697 Negative_regulation of DGUOK 1 0.38 0.65 0.07 5.00
142 INT302696 Negative_regulation of Localization of TK2 1 0.37 0.65 0.07 5.00
143 INT256683 Negative_regulation of Gene_expression of Hsp90b1 2 0.35 0.67 0.07 5.00
144 INT302700 Localization of TK2 1 0.65 0.65 0.07 5.00
145 INT302681 Negative_regulation of Localization of DGUOK 1 0.38 0.65 0.07 5.00
146 INT302689 Negative_regulation of TK2 1 0.16 0.65 0.07 5.00
147 INT302704 Negative_regulation of Localization of TYMP 1 0.35 0.64 0.07 5.00
148 INT302694 Localization of RRM2B 1 0.66 0.73 0.07 5.00
149 INT211378 Negative_regulation of TYMP 2 0.56 1.45 0.07 5.00
150 INT302680 Localization of DGUOK 1 0.66 0.65 0.07 5.00
151 INT302705 Localization of SUCLG1 1 0.65 0.66 0.07 5.00
152 INT302702 Negative_regulation of SUCLG1 1 0.16 0.66 0.07 5.00
153 INT302685 Localization of MPV17 1 0.65 0.67 0.07 5.00
154 INT302691 Negative_regulation of Localization of SUCLG1 1 0.37 0.66 0.07 5.00
155 INT193687 Gene_expression of TIMM8A 2 0.49 1.27 0.04 5.00
156 INT251827 Regulation of POLG 3 0.59 2.94 0.04 5.00
157 INT256691 Binding of Xbp1 4 0.32 1.63 0.03 5.00
158 INT256676 Regulation of Binding of Wfs1 1 0.43 0.35 0 5.00
159 INT302701 Positive_regulation of PLAA 1 0.18 0 0 5.00
160 INT256692 Negative_regulation of Wfs1 1 0.41 0 0 5.00
161 INT302688 Transcription of OPA1 1 0.68 0.3 0 5.00
162 INT251833 Binding of C10orf2 1 0.37 0.47 0 5.00
163 INT256686 Binding of Wfs1 1 0.46 0.91 0 5.00
164 INT256689 Positive_regulation of Regulation of Hsp90b1 1 0.38 0.45 0 5.00
165 INT302687 Regulation of PLAA 1 0.19 0.24 0 5.00
166 INT251832 Positive_regulation of Positive_regulation of POLG 1 0.35 0.28 0 5.00
167 INT256685 Positive_regulation of Negative_regulation of Hsp90b1 1 0.41 0.24 0 5.00
168 INT256680 Negative_regulation of Hsp90b1 4 0.47 1.43 0 5.00
169 INT334577 Binding of KCNE1L 1 0.27 1.33 0 5.00
170 INT256674 Regulation of Binding of Hsp90b1 1 0.37 0.35 0 5.00
171 INT251826 Gene_expression of C10orf2 1 0.67 0.28 0 5.00
172 INT219498 Gene_expression of TBL1X 2 0.49 1.03 0 5.00
173 INT256672 Positive_regulation of Positive_regulation of Wfs1 1 0.44 0.24 0 5.00
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