D:Pachyonychia Congenita

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pChart

Disease Term
Synonyms Congenita Pachyonychia, Jackson Lawler Type Pachyonychia Congenita, Jadassohn Lewandowsky Syndrome, Pachyonychia Congenita Jackson Lawler Type, Pachyonychia Congenita Jadassohn Lewandowsky Type, Pachyonychia Congenita Tarda Type 1, PACHYONYCHIA CONGENITA TYPE 1, PACHYONYCHIA CONGENITA TYPE 2, Type 1 Pachyonychia Congenita, Type 2 Pachyonychia Congenita
Documents 23
Hot Single Events 10
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Pachyonychia Congenita. They are ordered first by their relevance to Pachyonychia Congenita and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT131130 Binding of PKD1 and Krt16 1 0.01 1 0.08 100.00
2 INT146181 Kdm6a Negative_regulation of Gene_expression of KRT6A 1 0.03 0.31 0.11 75.00
3 INT232917 Binding of KRT8 and KRT19 2 0.16 1.04 0.08 5.00
4 INT232914 Binding of KRT2 and KRT7 1 0.15 0.63 0.05 5.00
5 INT232916 Binding of KRT2 and KRT19 1 0.21 0.62 0.05 5.00
6 INT232907 Binding of KRT7 and KRT8 1 0.09 0.63 0.05 5.00
7 INT232918 Binding of KRT2 and KRT8 1 0.17 0.59 0 5.00
8 INT322607 Binding of RRM2 and TF 1 0.02 0.09 0 5.00
9 INT232912 Binding of KRT4 and KRT13 1 0.07 0.06 0 5.00
10 INT232910 Binding of KRT12 and KRT76 1 0.39 0.2 0 5.00
11 INT232911 Binding of KRT18 and PLAT 1 0.05 1.3 0 5.00
12 INT322608 Binding of PAEP and TF 1 0.01 0.09 0 5.00
13 INT232915 Binding of KRT8 and PLAT 1 0.04 1.3 0 5.00
14 INT232909 Binding of KRT1 and KRT9 1 0.16 0.5 0 5.00
15 INT232913 Binding of KRT3 and NBPF14 1 0.01 0.21 0 5.00
16 INT232908 Binding of KRT19 and PLAT 1 0.05 1.31 0 5.00
17 INT232906 Binding of KRT1 and KRT10 1 0.18 0.51 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Pachyonychia Congenita. They are ordered first by their pain relevance and then by number of times they were reported in Pachyonychia Congenita. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT162474 Negative_regulation of Transcription of THOP1 2 0.27 0.29 0 99.36
2 INT162476 Transcription of THOP1 3 0.43 0.92 0 99.36
3 INT161702 Gene_expression of GJB2 3 0.65 2.19 0.14 96.40
4 INT41721 Negative_regulation of MTOR 40 0.58 32.49 2.83 95.20
5 INT162480 Negative_regulation of KRT6B 1 0.41 0.17 0 93.76
6 INT162477 Negative_regulation of KRT6A 1 0.41 0.17 0 93.76
7 INT163253 Binding of Flg 3 0.31 3.6 0.32 91.08
8 INT146179 Gene_expression of KRT6A 23 0.75 9.39 0.52 89.48
9 INT86639 Gene_expression of KRT16 19 0.68 12.44 7.79 89.48
10 INT227017 Gene_expression of KRT17 2 0.45 14.84 0.41 87.84
11 INT142740 Gene_expression of Trpv6 15 0.78 6.1 2.06 78.48
12 INT146178 Gene_expression of Neb 1 0.18 0.38 0.11 78.48
13 INT146180 Positive_regulation of Gene_expression of KRT6A 2 0.49 1.43 0.16 75.56
14 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 75.00
15 INT233003 Negative_regulation of Gene_expression of KRT17 1 0.25 2.13 0.1 62.96
16 INT162478 Gene_expression of KRT6B 2 0.75 1.39 0.08 50.00
17 INT162479 Negative_regulation of Gene_expression of KRT6A 1 0.57 0 0 50.00
18 INT162475 Regulation of Gene_expression of KRT6A 1 0.60 0 0 50.00
19 INT186810 Positive_regulation of TLR3 13 0.65 6.37 1.37 49.76
20 INT265417 Positive_regulation of Positive_regulation of TLR3 2 0.16 1.1 0 49.76
21 INT322621 Regulation of Positive_regulation of TLR3 1 0.04 0.41 0 49.76
22 INT233005 Gene_expression of CAPN9 1 0.02 1.76 0.1 49.12
23 INT4988 Gene_expression of KRT1 64 0.77 43.4 4.12 34.60
24 INT232994 Gene_expression of KRT10 6 0.40 8.2 0.03 34.52
25 INT233006 Binding of KRT17 1 0.28 0.8 0.04 32.72
26 INT159190 Gene_expression of KRT5 31 0.65 26.67 0.56 20.00
27 INT187628 Gene_expression of KRT14 15 0.75 11.54 0.1 20.00
28 INT225959 Gene_expression of KRT15 7 0.48 2.01 0 20.00
29 INT189228 Positive_regulation of KRT16 5 0.44 1.89 0.41 12.00
30 INT232997 Positive_regulation of KRT6A 1 0.40 0.82 0 12.00
31 INT232977 Gene_expression of KRT77 1 0.75 3.41 0 11.72
32 INT86640 Positive_regulation of Gene_expression of KRT16 5 0.61 2.5 2.99 5.04
33 INT232981 Positive_regulation of Gene_expression of KRT17 1 0.25 1.06 0.05 5.04
34 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
35 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
36 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
37 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
38 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 5.00
39 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 5.00
40 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 5.00
41 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 5.00
42 INT25022 Binding of PAEP 66 0.42 22.83 6.59 5.00
43 INT38672 Binding of KRT20 69 0.39 48.01 6.31 5.00
44 INT38671 Positive_regulation of KRT20 62 0.53 40.17 5.6 5.00
45 INT38670 Positive_regulation of Gene_expression of KRT20 68 0.69 23.25 5.55 5.00
46 INT60585 Regulation of TP53 59 0.59 54.55 5.21 5.00
47 INT103155 Gene_expression of KDR 78 0.66 50.53 4.38 5.00
48 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 5.00
49 INT52047 Gene_expression of APOE 50 0.78 34.75 3.52 5.00
50 INT87314 Gene_expression of Htt 112 0.78 55.82 3.03 5.00
51 INT38673 Negative_regulation of KRT20 38 0.42 22.49 2.77 5.00
52 INT221269 Binding of BRCA1 14 0.40 31.77 2.7 5.00
53 INT111143 Regulation of Gene_expression of KRT20 22 0.26 5.65 1.93 5.00
54 INT85084 Gene_expression of KRT19 66 0.73 42.56 1.82 5.00
55 INT233010 Gene_expression of PERP 5 0.26 6.04 1.66 5.00
56 INT137382 Negative_regulation of Gene_expression of KRT20 22 0.58 12.29 1.29 5.00
57 INT90670 Positive_regulation of KRT1 10 0.44 6.25 1.16 5.00
58 INT128987 Negative_regulation of Ccnd1 24 0.52 15.78 1.15 5.00
59 INT127064 Gene_expression of KRT76 7 0.75 1.71 1.1 5.00
60 INT281849 Binding of RRM2 5 0.17 0.43 1.07 5.00
61 INT148121 Gene_expression of KRT8 35 0.65 29.07 1.05 5.00
62 INT5006 Transcription of KRT20 9 0.46 7.11 1.03 5.00
63 INT83479 Gene_expression of KRT18 30 0.65 27.29 1 5.00
64 INT206467 Gene_expression of IARS 11 0.33 6.65 0.93 5.00
65 INT127633 Localization of KRT18 5 0.52 5.93 0.75 5.00
66 INT160736 Negative_regulation of KRT7 9 0.41 10.08 0.68 5.00
67 INT206139 Phosphorylation of KRT20 8 0.48 9.1 0.66 5.00
68 INT117437 Protein_catabolism of KRT18 3 0.46 4.64 0.61 5.00
69 INT95692 Negative_regulation of KRT19 4 0.24 4.07 0.51 5.00
70 INT131931 Binding of KRT7 13 0.36 19.24 0.5 5.00
71 INT70445 Binding of KRT1 10 0.35 5.38 0.47 5.00
72 INT233007 Negative_regulation of VIM 6 0.41 3.46 0.36 5.00
73 INT174112 Positive_regulation of Gene_expression of KRT19 4 0.44 4.28 0.31 5.00
74 INT151793 Gene_expression of KRT3 36 0.75 2.32 0.26 5.00
75 INT162564 Gene_expression of KRT2 5 0.59 1.75 0.24 5.00
76 INT232945 Positive_regulation of Gene_expression of KRT18 2 0.49 3.54 0.23 5.00
77 INT232970 Localization of KRT19 4 0.41 3.41 0.23 5.00
78 INT232982 Localization of KRT8 2 0.44 2.65 0.23 5.00
79 INT232967 Positive_regulation of Gene_expression of KRT8 2 0.29 3.54 0.23 5.00
80 INT232944 Transcription of KRT75 1 0.43 0.59 0.18 5.00
81 INT232962 Binding of KRT18 4 0.26 2.38 0.18 5.00
82 INT232989 Gene_expression of KRT71 1 0.46 0.45 0.17 5.00
83 INT216395 Negative_regulation of Gene_expression of KRT7 4 0.41 3.57 0.16 5.00
84 INT71389 Positive_regulation of KRT19 3 0.38 4.91 0.13 5.00
85 INT232955 Gene_expression of KRT38 1 0.47 0.12 0.13 5.00
86 INT232964 Gene_expression of KRT28 4 0.48 3.88 0.13 5.00
87 INT232987 Gene_expression of KRT85 1 0.10 1.2 0.11 5.00
88 INT233008 Gene_expression of KRT75 1 0.56 1.07 0.11 5.00
89 INT232951 Gene_expression of KRT81 1 0.39 0.31 0.11 5.00
90 INT145490 Binding of KRT76 2 0.36 0.29 0.09 5.00
91 INT70450 Binding of KRT5 6 0.47 5.72 0.08 5.00
92 INT164348 Positive_regulation of KRT14 5 0.49 2 0.08 5.00
93 INT232996 Gene_expression of KRT27 1 0.44 0 0.07 5.00
94 INT232974 Gene_expression of KRT25 1 0.36 0 0.06 5.00
95 INT230117 Binding of KRT8 6 0.31 2.44 0.05 5.00
96 INT232972 Gene_expression of KRT34 1 0.30 0 0.05 5.00
97 INT232971 Negative_regulation of KRT17 1 0.22 0.45 0.05 5.00
98 INT175895 Negative_regulation of KRT1 5 0.37 3.23 0.05 5.00
99 INT232957 Binding of KRT19 3 0.23 0.97 0.05 5.00
100 INT232984 Gene_expression of KRT36 1 0.14 0 0.05 5.00
101 INT232986 Negative_regulation of KRT81 1 0.18 0 0.04 5.00
102 INT232991 Localization of KRT5 1 0.33 1.36 0.04 5.00
103 INT232952 Gene_expression of KRT40 1 0.27 0 0.04 5.00
104 INT232920 Regulation of Gene_expression of Krt27 1 0.00 0.11 0.04 5.00
105 INT232919 Gene_expression of Krt27 1 0.01 0.11 0.04 5.00
106 INT233000 Negative_regulation of KRT86 1 0.23 0 0.04 5.00
107 INT232999 Positive_regulation of Localization of KRT16 1 0.32 0.37 0 5.00
108 INT233002 Binding of KRT2 1 0.29 0 0 5.00
109 INT232953 Binding of RBPJP3 1 0.03 0.26 0 5.00
110 INT233004 Localization of KRT17 1 0.36 0.19 0 5.00
111 INT232978 Localization of KRT4 1 0.35 0.2 0 5.00
112 INT232948 Positive_regulation of Phosphorylation of KRT20 1 0.41 0.67 0 5.00
113 INT232975 Binding of KRT9 2 0.14 0.8 0 5.00
114 INT225958 Gene_expression of KRT12 13 0.68 1.57 0 5.00
115 INT232949 Positive_regulation of KRT10 1 0.25 0.38 0 5.00
116 INT232980 Binding of KRT3 2 0.29 0.43 0 5.00
117 INT232947 Positive_regulation of RBPJP3 1 0.05 0.19 0 5.00
118 INT232990 Localization of KRT6A 1 0.43 0.37 0 5.00
119 INT232922 Gene_expression of Krt71 1 0.65 0 0 5.00
120 INT232983 Negative_regulation of KRT13 1 0.26 2.44 0 5.00
121 INT232979 Gene_expression of RBPJP3 1 0.06 0.24 0 5.00
122 INT232985 Positive_regulation of Localization of KRT6A 1 0.29 0.37 0 5.00
123 INT232965 Binding of KRT10 3 0.19 1.66 0 5.00
124 INT233009 Binding of KRT13 1 0.16 1.13 0 5.00
125 INT232943 Binding of KRT12 3 0.47 0.88 0 5.00
126 INT322619 Gene_expression of NUSAP1 1 0.15 0.23 0 5.00
127 INT232921 Gene_expression of Krt6b 2 0.65 1.5 0 5.00
128 INT227013 Positive_regulation of KRT17 2 0.27 2.4 0 5.00
129 INT232992 Localization of KRT9 1 0.29 0.47 0 5.00
130 INT232961 Localization of KRT13 1 0.38 0.2 0 5.00
131 INT322622 Localization of SCPEP1 1 0.07 0.27 0 5.00
132 INT232954 Binding of KRT15 1 0.17 0 0 5.00
133 INT232988 Binding of KRT77 1 0.20 0.79 0 5.00
134 INT322618 Binding of KRT6A 1 0.36 0.56 0 5.00
135 INT232956 Localization of KRT16 1 0.47 0.37 0 5.00
136 INT233001 Binding of KRT14 2 0.36 0.77 0 5.00
137 INT232923 Negative_regulation of Krt27 1 0.00 0.62 0 5.00
138 INT225960 Gene_expression of KRT13 4 0.39 2.47 0 5.00
139 INT232960 Negative_regulation of Binding of KRT5 1 0.20 1.68 0 5.00
140 INT232946 Positive_regulation of Gene_expression of KRT5 1 0.23 0.33 0 5.00
141 INT232969 Positive_regulation of KRT5 1 0.27 1.24 0 5.00
142 INT232950 Negative_regulation of Gene_expression of KRT8 1 0.25 0.79 0 5.00
143 INT232942 Negative_regulation of KRT10 3 0.21 1.19 0 5.00
144 INT187627 Gene_expression of KRT4 5 0.37 4.54 0 5.00
145 INT232968 Negative_regulation of Gene_expression of KRT13 1 0.22 0.11 0 5.00
146 INT232995 Negative_regulation of Gene_expression of KRT15 1 0.32 0.37 0 5.00
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