D:Pagets Disease

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pChart

Disease Term
Synonyms Osteitis Deformans, Paget Disease Bone, Paget Disease Of Bone, Paget S Disease Of Bone, Pagets Disease Bone
Documents 43
Hot Single Events 3
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Pagets Disease. They are ordered first by their relevance to Pagets Disease and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT318305 Binding of NOD2 and NLRP3 1 0.08 1.76 0.15 5.00
2 INT318306 Binding of DPEP1 and NLRP3 1 0.03 1.77 0.15 5.00
3 INT311083 DST Regulation of FOS 1 0.03 0.15 0.08 5.00
4 INT311082 DST Regulation of MAPK8 1 0.02 0.07 0.04 5.00
5 INT332159 Gh Positive_regulation of Gene_expression of Igfbp3 1 0.07 1.11 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Pagets Disease. They are ordered first by their pain relevance and then by number of times they were reported in Pagets Disease. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT95669 Regulation of TNFRSF11A 7 0.56 10.01 0.94 98.68
2 INT155201 Gene_expression of VCP 4 0.75 8.25 0.31 82.00
3 INT2867 Gene_expression of CALCA 247 0.78 78.78 138.47 81.16
4 INT155200 Protein_catabolism of VCP 1 0.70 1.18 0.06 75.00
5 INT425 Localization of PRL 455 0.81 189.64 144.8 70.24
6 INT211969 Positive_regulation of Best1 34 0.11 14.92 1.44 49.52
7 INT1578 Negative_regulation of Localization of PRL 52 0.59 20.62 17.18 29.36
8 INT956 Negative_regulation of PRL 94 0.59 42.72 23.01 16.32
9 INT912 Localization of FSHR 91 0.79 23.61 15.58 6.24
10 INT1646 Negative_regulation of Localization of FSHR 17 0.58 7.36 3.46 6.24
11 INT920 Localization of PLOD1 223 0.81 42.25 78.7 5.60
12 INT1642 Negative_regulation of Localization of PLOD1 40 0.58 10.67 17.95 5.60
13 INT1893 Localization of Gh 1041 0.79 340.23 256.58 5.00
14 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 5.00
15 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 5.00
16 INT5865 Positive_regulation of Localization of Gh 282 0.69 84.86 93.5 5.00
17 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 5.00
18 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
19 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 5.00
20 INT20462 Binding of ESR1 210 0.44 102.7 26.34 5.00
21 INT756 Gene_expression of C3 138 0.75 100.6 19.2 5.00
22 INT65260 Positive_regulation of Col7a1 95 0.69 61.73 18.42 5.00
23 INT17024 Gene_expression of COL1A2 69 0.77 36.38 8.29 5.00
24 INT15687 Regulation of ESR1 91 0.60 40.42 7.95 5.00
25 INT10094 Negative_regulation of ALPP 36 0.37 20.45 6.45 5.00
26 INT65265 Positive_regulation of Gene_expression of Col7a1 48 0.69 23.81 6.16 5.00
27 INT134966 Localization of Col7a1 23 0.42 16.4 5.24 5.00
28 INT157805 Negative_regulation of Gene_expression of Col7a1 22 0.34 12.85 3.51 5.00
29 INT10353 Positive_regulation of PGR 34 0.70 21.84 3.28 5.00
30 INT34830 Regulation of PGR 14 0.45 6.99 2.32 5.00
31 INT211970 Negative_regulation of Best1 49 0.14 37.33 2.32 5.00
32 INT53434 Positive_regulation of T 7 0.07 3.67 2.09 5.00
33 INT9466 Binding of APOB 27 0.41 19.36 1.56 5.00
34 INT28647 Binding of CTD 13 0.31 14.2 1.5 5.00
35 INT36777 Gene_expression of CTD 12 0.41 11.47 1.42 5.00
36 INT61068 Gene_expression of Igfbp3 15 0.75 8.48 1.41 5.00
37 INT139725 Binding of CDCP1 3 0.01 2.1 1.4 5.00
38 INT65261 Regulation of Col7a1 18 0.55 8.7 1.33 5.00
39 INT101027 Binding of DST 20 0.41 10.9 1.17 5.00
40 INT70496 Positive_regulation of EFS 3 0.29 0.2 0.84 5.00
41 INT187418 Positive_regulation of Gene_expression of MTTP 5 0.18 4.83 0.76 5.00
42 INT149485 Regulation of Gene_expression of C3 5 0.60 3.39 0.75 5.00
43 INT150165 Gene_expression of MTTP 21 0.75 10.1 0.73 5.00
44 INT187090 Positive_regulation of Localization of Col7a1 4 0.07 3.16 0.51 5.00
45 INT110777 Regulation of CTD 4 0.23 3.17 0.42 5.00
46 INT311092 Positive_regulation of CPT1A 2 0.36 0.8 0.28 5.00
47 INT211045 Positive_regulation of CD6 1 0.49 0.56 0.26 5.00
48 INT187422 Negative_regulation of MTTP 23 0.57 11.75 0.24 5.00
49 INT311096 Positive_regulation of GPR153 1 0.49 0.55 0.08 5.00
50 INT207433 Positive_regulation of MTTP 5 0.14 2.47 0.08 5.00
51 INT311095 Regulation of GPR153 1 0.26 0.55 0.08 5.00
52 INT332156 Positive_regulation of Ppib 1 0.05 0.3 0 5.00
53 INT311091 Positive_regulation of Gene_expression of CTD 1 0.25 0.17 0 5.00
54 INT207428 Binding of MTTP 5 0.38 2.06 0 5.00
55 INT332158 Positive_regulation of Crtap 1 0.49 0.3 0 5.00
56 INT311093 Regulation of Gene_expression of CTD 1 0.22 0.17 0 5.00
57 INT311097 Negative_regulation of Gene_expression of CTD 1 0.21 0.17 0 5.00
58 INT332157 Positive_regulation of Lepre1 1 0.17 0.3 0 5.00
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