D:Pancreatic Ductal Carcinoma

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Disease Term
Synonyms Carcinoma Pancreas Duct Cell, Carcinomas Pancreas Duct Cell, Carcinomas Pancreatic Ductal, Duct Cell Carcinoma Of The Pancreas, Duct Cell Carcinoma Pancreas, Duct Cell Carcinomas Pancreas, Ductal Carcinoma Of The Pancreas, Ductal Carcinoma Pancreatic, DUCTAL CARCINOMAS PANCREATIC, PANCREAS DUCT CELL CARCINOMA, Pancreas Duct Cell Carcinomas
Documents 43
Hot Single Events 62
Hot Interactions 7

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Pancreatic Ductal Carcinoma. They are ordered first by their relevance to Pancreatic Ductal Carcinoma and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT75486 Binding of Tgfbr1 and Tgfbr2 1 0.10 1.94 1.02 98.84
2 INT75489 Binding of SGCG and Tgfbr2 1 0.23 0.83 0.41 91.76
3 INT75487 Binding of TGFB1 and Tgfbr2 1 0.31 0.83 0.41 91.76
4 INT75488 Binding of TGFB1 and Tgfbr1 1 0.23 0.78 0.41 90.72
5 INT75483 Binding of SGCG and TGFB1 1 0.52 2.27 1.19 89.20
6 INT318192 MUC5AC Negative_regulation of Gene_expression of VEGFA 1 0.20 0.98 0.1 83.28
7 INT318210 MUC5AC Negative_regulation of Phosphorylation of Flt1 1 0.07 0.98 0.09 82.36
8 INT20959 Binding of PTPRC and Pak1 1 0.01 0.76 0.09 76.80
9 INT20958 Binding of In(10)7H and Pak2 1 0.00 0.7 0.09 69.12
10 INT318185 MUC5AC Positive_regulation of Gene_expression of MMP3 1 0.09 0.86 0.13 68.88
11 INT84751 Binding of HRAS and TWIST1 1 0.29 2.6 0.07 66.56
12 INT84752 Binding of HRAS and DCPS 1 0.18 2.61 0.07 66.56
13 INT20957 Binding of Pak1 and Pak2 1 0.27 0.65 0.08 62.40
14 INT325952 Gene_expression of Ezr Positive_regulation of Mapk1 1 0.02 1.69 0.15 51.76
15 INT318211 MUC5AC Positive_regulation of Muc4 1 0.17 1.12 0.17 50.04
16 INT318188 MUC5AC Positive_regulation of MUC1 1 0.16 1.12 0.17 50.04
17 INT318209 Sis Negative_regulation of VEGFA 1 0.00 1.09 0.14 33.32
18 INT318189 MUC5AC Regulation of Gene_expression of VEGFA 1 0.21 1.17 0.22 7.44
19 INT304187 Ang Negative_regulation of Gene_expression of VEGFA 1 0.05 0.16 0.13 5.00
20 INT304188 Agtr2 Negative_regulation of Gene_expression of VEGFA 1 0.06 0.6 0.12 5.00
21 INT185279 Binding of CCND1 and CDK4 4 0.13 2.05 0.08 5.00
22 INT185278 Binding of CCND1 and CDK6 3 0.13 1.62 0.08 5.00
23 INT325954 Binding of Cttn and Ezr 1 0.22 1.61 0.07 5.00
24 INT304186 Ang Positive_regulation of Gene_expression of VEGFA 2 0.05 2.5 0.06 5.00
25 INT318186 MUC5AC Positive_regulation of Gene_expression of VEGFA 1 0.22 1.01 0.04 5.00
26 INT318191 INCENP Negative_regulation of Gene_expression of VEGFA 1 0.00 1.05 0.03 5.00
27 INT318190 Negative_regulation of MUC5AC Negative_regulation of Gene_expression of VEGFA 1 0.23 1.06 0.03 5.00
28 INT318187 Binding of INCENP and MUC5AC 1 0.00 1.03 0.03 5.00
29 INT325945 Binding of Cd44 and Ezr 1 0.25 0.39 0 5.00
30 INT325942 Binding of Icam1 and Ezr 1 0.15 0.39 0 5.00
31 INT325949 Binding of Spn and Ezr 1 0.14 0.39 0 5.00
32 INT185281 Binding of CDK6 and CDKN2A 1 0.29 0.87 0 5.00
33 INT325948 Ezr Regulation of Pcx 1 0.00 0.84 0 5.00
34 INT304185 Mapk1 Positive_regulation of Positive_regulation of Egf 1 0.09 0.71 0 5.00
35 INT185277 CDK6 Negative_regulation of Binding of CDK4 and CDK6 1 0.20 0.87 0 5.00
36 INT185280 Binding of CDK4 and CDK6 1 0.20 0.87 0 5.00
37 INT325953 Ezr Positive_regulation of Mapk1 1 0.02 0.4 0 5.00
38 INT325955 Ezr Regulation of Mia1 1 0.09 1.68 0 5.00
39 INT185276 CDK4 Negative_regulation of Binding of CDK4 and CDK6 1 0.20 0.87 0 5.00
40 INT325946 Gene_expression of Ezr Positive_regulation of Positive_regulation of Mapk1 1 0.02 0.28 0 5.00
41 INT325947 Ezr Regulation of Zfp369 1 0.00 0.84 0 5.00
42 INT325950 Binding of Icam2 and Ezr 1 0.17 0.39 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Pancreatic Ductal Carcinoma. They are ordered first by their pain relevance and then by number of times they were reported in Pancreatic Ductal Carcinoma. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT185299 Gene_expression of PNKD 5 0.22 6.35 0 100.00
2 INT185296 Negative_regulation of Gene_expression of PNKD 1 0.11 1.73 0 100.00
3 INT185298 Positive_regulation of Gene_expression of PNKD 1 0.12 1.67 0 100.00
4 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49 100.00
5 INT15419 Gene_expression of IL31RA 6 0.65 5.02 1.19 100.00
6 INT185301 Regulation of PNKD 1 0.07 1.12 0 100.00
7 INT341468 Positive_regulation of Gene_expression of IL31RA 1 0.00 0.44 0 100.00
8 INT325930 Gene_expression of Ezr 75 0.77 59.77 4.06 99.84
9 INT24042 Gene_expression of MUC5AC 98 0.77 74.99 6.18 99.84
10 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99 99.84
11 INT325931 Negative_regulation of Gene_expression of Ezr 1 0.58 3.57 0.04 99.84
12 INT185302 Gene_expression of SNORD4A 1 0.03 2.33 0 99.80
13 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 99.64
14 INT7125 Gene_expression of PLA2G2A 47 0.78 42.12 7.83 99.60
15 INT156796 Gene_expression of DUP18PDEL18Q 1 0.08 0.39 0.19 99.60
16 INT28216 Gene_expression of HRAS 173 0.75 93.97 20.78 99.52
17 INT166171 Negative_regulation of Gene_expression of HRAS 5 0.07 3.98 1.11 99.52
18 INT80175 Positive_regulation of Gene_expression of HRAS 24 0.67 14.69 3.97 99.52
19 INT75485 Gene_expression of Tgfbr2 10 0.57 10.98 3.76 99.42
20 INT79270 Gene_expression of MKI67 113 0.77 63.52 3.38 99.32
21 INT74019 Regulation of TSC1 27 0.35 23.61 0.79 99.28
22 INT48202 Gene_expression of Tgfb1 146 0.78 89.93 27.76 99.08
23 INT75484 Gene_expression of Tgfbr1 21 0.64 13.36 3.15 98.94
24 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 98.68
25 INT325940 Positive_regulation of Gene_expression of Ezr 42 0.69 27.79 1.56 98.68
26 INT198453 Negative_regulation of MUC5AC 12 0.58 12.96 1.38 98.68
27 INT185297 Regulation of Gene_expression of RASL12 1 0.03 1.43 0 98.66
28 INT185295 Gene_expression of RASL12 2 0.13 2.02 0 98.66
29 INT61120 Positive_regulation of Gene_expression of Tgfb1 34 0.70 21.15 6.93 98.56
30 INT93885 Positive_regulation of Gene_expression of MKI67 8 0.60 4.4 0.18 98.24
31 INT185283 Regulation of SAI1 3 0.14 2.3 0.05 97.36
32 INT7130 Localization of PLA2G2A 32 0.80 20.4 5.05 96.92
33 INT43948 Localization of PLA2G1B 17 0.78 6.92 2.99 96.68
34 INT13499 Gene_expression of Agtr2 68 0.76 35.64 10.59 96.00
35 INT16654 Gene_expression of Insrr 138 0.46 58.96 75.68 96.00
36 INT38173 Gene_expression of Ang 40 0.75 32.63 8.86 96.00
37 INT164259 Gene_expression of H19 8 0.75 27.5 0.97 95.84
38 INT113705 Gene_expression of Egfr 228 0.78 149.05 7.59 95.16
39 INT120563 Positive_regulation of Gene_expression of Egfr 56 0.70 46.19 1.82 95.16
40 INT219108 Negative_regulation of Gene_expression of MUC5AC 11 0.31 9.74 1.08 92.80
41 INT6510 Gene_expression of AFP 130 0.78 119.2 9.19 92.68
42 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 92.64
43 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19 91.08
44 INT129756 Regulation of MUC5AC 7 0.34 6.45 0.7 90.28
45 INT6511 Positive_regulation of AFP 76 0.70 70.15 7.28 89.88
46 INT20956 Gene_expression of Pak2 1 0.55 1.25 0.07 88.96
47 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 88.84
48 INT3041 Positive_regulation of MIA3 34 0.56 21.11 6.49 88.84
49 INT20954 Gene_expression of Pak1 3 0.58 1.47 0.07 88.56
50 INT185300 Positive_regulation of SNORD4A 1 0.02 3.84 0.43 88.32
51 INT69769 Positive_regulation of Pscs 61 0.56 39.32 15.93 87.36
52 INT85829 Gene_expression of CA9 14 0.68 12.59 1.4 84.96
53 INT85830 Positive_regulation of Gene_expression of CA9 4 0.41 5.47 1.02 84.96
54 INT85831 Positive_regulation of CA9 5 0.60 8.29 1.02 84.96
55 INT112124 Positive_regulation of Egfr 71 0.70 47.82 5.61 84.32
56 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 83.44
57 INT111545 Phosphorylation of VEGFA 50 0.76 22.19 5.88 82.72
58 INT341470 Regulation of H19 1 0.44 6.44 0 82.36
59 INT315145 Phosphorylation of Flt1 4 0.40 2.88 0.09 82.36
60 INT78199 Gene_expression of Neu1 65 0.75 62.88 7.16 81.72
61 INT120562 Negative_regulation of Egfr 108 0.59 79.38 3.11 80.56
62 INT185287 Transcription of VHL 2 0.60 3.77 0 80.40
63 INT69768 Negative_regulation of Pscs 7 0.51 4.76 2.82 79.76
64 INT185286 Transcription of MLH1 1 0.06 1.12 0 79.76
65 INT185303 Positive_regulation of MUC6 2 0.36 2.59 0.17 79.20
66 INT147149 Transcription of CDKN2A 8 0.67 6.85 0.15 79.20
67 INT185285 Negative_regulation of Transcription of CDKN2A 1 0.43 1.12 0 79.20
68 INT14705 Binding of Grem1 2 0.21 0.39 0.08 78.80
69 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61 78.64
70 INT14439 Regulation of GAL 12 0.61 2.25 4.02 77.64
71 INT20955 Binding of Pak1 1 0.30 0.76 0.09 76.80
72 INT73465 Transcription of TSC1 4 0.07 3.47 0.96 76.24
73 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 76.08
74 INT91754 Gene_expression of Cp 42 0.77 21.97 5.38 75.84
75 INT195106 Positive_regulation of Gene_expression of Cp 5 0.50 2.96 0.49 75.84
76 INT13063 Binding of RHCE 16 0.38 6.54 1.22 75.00
77 INT13064 Positive_regulation of GNRHR 2 0.36 0.93 0.35 75.00
78 INT173023 Gene_expression of MUC6 13 0.69 9.77 0.46 73.84
79 INT20981 Binding of HRAS 42 0.48 24.49 4.23 73.00
80 INT164260 Positive_regulation of Gene_expression of H19 2 0.67 4.29 0.43 72.56
81 INT29496 Gene_expression of MMP3 136 0.75 49.49 41.78 65.16
82 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58 65.16
83 INT325939 Regulation of Gene_expression of Ezr 1 0.61 5.27 0.19 64.96
84 INT34864 Binding of Cp 23 0.47 5.17 1.78 63.68
85 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62 62.96
86 INT318207 Negative_regulation of Negative_regulation of MUC5AC 1 0.34 0.75 0 61.88
87 INT289505 Negative_regulation of Ezr 2 0.43 3.04 0.35 61.76
88 INT157135 Positive_regulation of MKI67 10 0.60 7.51 0.28 60.40
89 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 59.68
90 INT49805 Positive_regulation of MUC1 56 0.70 44.5 4.56 58.80
91 INT39986 Regulation of Agtr2 13 0.45 10.39 3.55 58.08
92 INT44147 Positive_regulation of Gene_expression of Agtr2 11 0.50 9.02 1.28 57.60
93 INT15506 Localization of Cp 11 0.80 4.26 1.9 56.96
94 INT325934 Localization of Ezr 1 0.80 3.78 0.27 56.48
95 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48 55.80
96 INT318205 Regulation of Negative_regulation of MUC5AC 1 0.19 0.44 0.09 52.72
97 INT156795 Gene_expression of FCER1A 1 0.31 0 0 50.00
98 INT31925 Negative_regulation of Agtr2 13 0.43 7.59 2.94 49.44
99 INT230483 Protein_catabolism of Akt1 2 0.10 1.11 0.2 49.28
100 INT37380 Negative_regulation of Sis 31 0.55 19.89 3.92 48.88
101 INT310369 Protein_catabolism of Trib3 2 0.01 0.43 0.2 48.64
102 INT183399 Gene_expression of Cyp2b10 17 0.39 18.39 0.71 47.28
103 INT225225 Negative_regulation of Gene_expression of Cyp2b10 2 0.29 2.43 0.27 47.28
104 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44 47.04
105 INT102572 Gene_expression of Ccnd1 79 0.69 56.37 7.34 45.12
106 INT112867 Positive_regulation of Gene_expression of Ccnd1 15 0.56 13.22 1.77 45.12
107 INT26314 Positive_regulation of MMP3 48 0.67 22.14 16.17 42.40
108 INT134973 Binding of Ts1 2 0.31 2.51 0.09 32.36
109 INT185350 Negative_regulation of Gene_expression of Egfr 24 0.59 13.21 0.35 32.32
110 INT78470 Negative_regulation of Gene_expression of CDKN2A 14 0.59 14.44 1.38 31.68
111 INT49803 Negative_regulation of MUC1 37 0.58 26.37 2.06 28.80
112 INT94196 Negative_regulation of Phosphorylation of MAPK1 60 0.59 31.64 9.16 28.64
113 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17 26.96
114 INT279188 Regulation of Localization of Egfr 1 0.45 0.76 0 26.56
115 INT279196 Regulation of SYCP3 1 0.26 0.81 0 25.20
116 INT169355 Localization of Egfr 6 0.75 3.24 0.43 24.64
117 INT279195 Binding of SYCP3 4 0.47 1.52 0.24 24.52
118 INT43727 Negative_regulation of Gene_expression of MMP3 16 0.40 4.81 7.18 23.72
119 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 19.48
120 INT9473 Binding of MUC1 66 0.48 46.77 2.36 19.48
121 INT147151 Positive_regulation of Negative_regulation of CDKN2A 2 0.47 1.74 0 19.04
122 INT279189 Regulation of Positive_regulation of Egfr 1 0.45 0.96 0 12.36
123 INT111607 Gene_expression of CDH1 103 0.75 90.45 7.77 11.52
124 INT152771 Gene_expression of TJP1 19 0.75 14.95 1.98 11.52
125 INT217506 Gene_expression of Tjp2 8 0.32 5.26 0.89 11.52
126 INT318208 Transcription of TJP1 1 0.02 0.38 0.17 11.52
127 INT318193 Transcription of Tjp2 1 0.02 0.38 0.17 11.52
128 INT254701 Transcription of CDH1 6 0.67 2.5 0.17 11.52
129 INT287270 Binding of Ezr 8 0.36 1.78 0.76 8.36
130 INT65055 Negative_regulation of Nfkb1 83 0.58 44.85 34.94 8.08
131 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 5.00
132 INT287 Localization of Cck 518 0.81 86.84 364.04 5.00
133 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
134 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 5.00
135 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
136 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
137 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46 5.00
138 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
139 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
140 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
141 INT12471 Regulation of Insrr 52 0.35 17.8 48.31 5.00
142 INT62426 Gene_expression of Mc1r 127 0.78 42.99 48.01 5.00
143 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 5.00
144 INT671 Positive_regulation of Cea 221 0.69 164.5 47.79 5.00
145 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 5.00
146 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 5.00
147 INT666 Gene_expression of Jun 124 0.78 54.61 33.67 5.00
148 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81 5.00
149 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
150 INT55737 Positive_regulation of MMP2 101 0.68 59.11 27.71 5.00
151 INT16428 Positive_regulation of Gtf3a 135 0.20 106.44 26.67 5.00
152 INT95788 Positive_regulation of Positive_regulation of Mapk1 83 0.69 24.75 25.84 5.00
153 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
154 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14 5.00
155 INT74286 Regulation of Il10 42 0.44 28.06 19.44 5.00
156 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01 5.00
157 INT95790 Regulation of Mapk1 55 0.61 21.17 16.31 5.00
158 INT98647 Positive_regulation of Mdk 65 0.59 32.93 15.67 5.00
159 INT31990 Positive_regulation of SOD1 124 0.69 67.79 12.52 5.00
160 INT75137 Regulation of Akt1 74 0.48 37.89 9.7 5.00
161 INT107291 Positive_regulation of Ghrl 58 0.67 44.6 9.68 5.00
162 INT20205 Binding of IgG 108 0.46 66.68 8.57 5.00
163 INT91667 Localization of IL12A 39 0.74 25.51 7.36 5.00
164 INT5308 Regulation of Il1a 17 0.44 10.8 7.31 5.00
165 INT134624 Gene_expression of Flt1 77 0.66 48.86 7.27 5.00
166 INT1123 Positive_regulation of CD79A 74 0.70 51.96 7.14 5.00
167 INT11154 Binding of EGFR 149 0.48 96.23 6.29 5.00
168 INT269144 Gene_expression of Mia1 8 0.59 11.84 6.16 5.00
169 INT114882 Positive_regulation of Gene_expression of Akt1 45 0.69 21.29 6.06 5.00
170 INT19916 Gene_expression of GPHA2 18 0.48 9.78 6.04 5.00
171 INT125467 Positive_regulation of Gene_expression of CDKN2A 35 0.63 39.07 5.56 5.00
172 INT89794 Positive_regulation of CDKN2A 58 0.67 50.18 5.38 5.00
173 INT12104 Positive_regulation of PLG 45 0.68 28.94 4.81 5.00
174 INT128746 Negative_regulation of Gsk3a 11 0.52 8.43 4.61 5.00
175 INT98251 Binding of IL12A 20 0.37 16.03 4.51 5.00
176 INT103155 Gene_expression of KDR 78 0.66 50.53 4.38 5.00
177 INT103914 Phosphorylation of Egfr 35 0.82 16.98 4.31 5.00
178 INT23653 Binding of Egf 22 0.36 11.34 4.12 5.00
179 INT18515 Gene_expression of Lipg 18 0.66 9.3 3.72 5.00
180 INT60933 Positive_regulation of Apcs 16 0.67 11.69 3.68 5.00
181 INT31758 Positive_regulation of Egf 32 0.66 19.42 3.64 5.00
182 INT157687 Regulation of Gene_expression of Akt1 9 0.62 4.96 3.27 5.00
183 INT117348 Regulation of EGFR 75 0.61 47.73 3.09 5.00
184 INT9884 Localization of CD79A 41 0.78 21.75 3.06 5.00
185 INT43907 Binding of CD79A 28 0.48 28.11 3.04 5.00
186 INT78467 Negative_regulation of IL12A 18 0.38 11.29 2.98 5.00
187 INT90875 Negative_regulation of CCND1 31 0.42 26.22 2.66 5.00
188 INT4560 Protein_catabolism of PLG 18 0.96 11.64 2.32 5.00
189 INT103917 Positive_regulation of Phosphorylation of Egfr 12 0.68 7.23 2.18 5.00
190 INT63081 Localization of Itpr3 13 0.67 1.08 2.12 5.00
191 INT17268 Localization of PLG 9 0.78 11.71 2.06 5.00
192 INT102176 Transcription of FAS 3 0.60 3.22 2.05 5.00
193 INT4691 Regulation of Lipg 10 0.61 4.7 1.99 5.00
194 INT77656 Gene_expression of Hsp90aa1 12 0.78 24.27 1.81 5.00
195 INT172961 Localization of Egf 26 0.71 16.74 1.81 5.00
196 INT116114 Phosphorylation of EID1 8 0.12 3.99 1.75 5.00
197 INT102178 Gene_expression of CD97 10 0.73 6.68 1.7 5.00
198 INT150602 Gene_expression of Capza3 2 0.19 1.2 1.47 5.00
199 INT58963 Gene_expression of Gda 7 0.76 2.49 1.41 5.00
200 INT134338 Gene_expression of CD55 23 0.65 13.01 1.38 5.00
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