D:Papillary Adenocarcinoma

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pChart

Disease Term
Synonyms Adenocarcinomas Papillary, Papillary Adenocarcinomas
Documents 89
Hot Single Events 21
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Papillary Adenocarcinoma. They are ordered first by their relevance to Papillary Adenocarcinoma and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT246360 Binding of Cea and Muc6 1 0.00 1.09 0.12 96.96
2 INT246362 Binding of MUC2 and Cea 1 0.00 1.08 0.12 96.16
3 INT179872 Binding of HGF and MET 7 0.09 4.69 0.07 5.00
4 INT219875 Binding of KRT7 and Krt20 1 0.01 1.32 0.04 5.00
5 INT219857 Binding of Krt20 and Nbr1 1 0.00 1.31 0.04 5.00
6 INT334322 Binding of RB1 and TP53 1 0.34 2 0 5.00
7 INT334320 EGFR Positive_regulation of RASGRP1 1 0.05 0.76 0 5.00
8 INT334321 EGFR Positive_regulation of MAPK1 1 0.25 0.76 0 5.00
9 INT334323 IL8 Positive_regulation of EGFR 1 0.50 1.29 0 5.00
10 INT319320 Binding of EGI and IGF1R 1 0.02 0.85 0 5.00
11 INT335526 SPHK1 Regulation of Gene_expression of SGCB 1 0.27 0.86 0 5.00
12 INT335525 Binding of SGCB and SPHK1 1 0.22 1.61 0 5.00
13 INT319319 Binding of EGFR and KRAS 1 0.22 0.27 0 5.00
14 INT334319 IL8 Positive_regulation of MAPK1 1 0.25 1.29 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Papillary Adenocarcinoma. They are ordered first by their pain relevance and then by number of times they were reported in Papillary Adenocarcinoma. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT49802 Localization of MUC1 75 0.81 44.74 8.87 99.82
2 INT23767 Positive_regulation of SERPINA7 6 0.67 1.96 1.2 99.60
3 INT8546 Positive_regulation of MUC16 99 0.69 74.98 11.26 97.60
4 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 97.44
5 INT280594 Gene_expression of SPHK1 2 0.78 71.47 0.19 95.20
6 INT23766 Binding of SERPINA7 3 0.36 1.66 0.2 95.08
7 INT57157 Gene_expression of TDGF1 5 0.75 3.97 4.02 94.04
8 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 92.68
9 INT160736 Negative_regulation of KRT7 9 0.41 10.08 0.68 92.24
10 INT671 Positive_regulation of Cea 221 0.69 164.5 47.79 91.56
11 INT335530 Positive_regulation of Gene_expression of SPHK1 1 0.69 21.31 0 91.52
12 INT2139 Negative_regulation of Cea 55 0.43 43.59 9.14 91.52
13 INT16323 Gene_expression of pr 62 0.66 36.14 38.26 91.32
14 INT8224 Gene_expression of CHGA 73 0.75 53.63 12.31 90.12
15 INT37722 Gene_expression of NCAM1 103 0.75 81.57 14.18 88.92
16 INT24891 Gene_expression of SYP 55 0.75 45.76 7.53 88.92
17 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19 88.04
18 INT21609 Positive_regulation of RASGRP1 58 0.50 40.78 5.47 87.84
19 INT8669 Positive_regulation of Afp 66 0.70 58.21 7.67 86.84
20 INT335539 Regulation of Gene_expression of SPHK1 1 0.62 4.55 0 86.08
21 INT335535 Positive_regulation of SPHK1 1 0.69 12.71 0 80.52
22 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 78.76
23 INT8066 Binding of RASGRP1 10 0.36 4.65 0.58 77.68
24 INT84894 Gene_expression of Calb2 45 0.73 24.65 7.81 77.36
25 INT280589 Localization of SPHK1 2 0.75 2.61 0.13 76.44
26 INT95652 Gene_expression of Krt20 54 0.61 53.69 3.31 75.24
27 INT85831 Positive_regulation of CA9 5 0.60 8.29 1.02 75.00
28 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55 59.60
29 INT63701 Localization of KRIT1 11 0.78 2.02 9.17 52.72
30 INT179888 Localization of KRT7 3 0.39 2.85 0.22 52.04
31 INT214630 Localization of KRT10 1 0.73 0.56 0 51.44
32 INT129312 Gene_expression of SGCB 24 0.76 18.25 3.75 49.16
33 INT335536 Positive_regulation of Gene_expression of SGCB 1 0.26 1.46 0 49.16
34 INT100622 Localization of CD68 16 0.73 6.58 2.2 47.96
35 INT70021 Localization of BCL2 23 0.74 21.6 1.09 47.96
36 INT87819 Localization of CD34 21 0.81 7.69 0.47 47.96
37 INT134223 Localization of CD99 4 0.73 4.42 0.16 47.96
38 INT335534 Regulation of Positive_regulation of SGCB 1 0.23 0.86 0 46.24
39 INT57785 Positive_regulation of SGCB 25 0.69 5.01 1.49 45.08
40 INT172996 Gene_expression of MUC2 14 0.69 11.01 0.42 42.48
41 INT156595 Gene_expression of CDX2 10 0.69 7.8 0.25 42.48
42 INT24042 Gene_expression of MUC5AC 98 0.77 74.99 6.18 33.52
43 INT173023 Gene_expression of MUC6 13 0.69 9.77 0.46 33.52
44 INT280581 Regulation of SPHK1 2 0.45 1.33 0.13 19.76
45 INT115982 Positive_regulation of KRT7 18 0.50 19.81 1.14 13.84
46 INT130889 Regulation of KRT7 4 0.07 3.74 0.39 13.84
47 INT15888 Positive_regulation of Nbr1 42 0.69 35.76 10.48 13.04
48 INT37005 Regulation of Nbr1 6 0.24 6.33 1.56 13.04
49 INT257455 Binding of PDLIM5 2 0.08 1.72 0.64 11.96
50 INT2386 Gene_expression of Pgr 112 0.78 45.46 22.19 8.24
51 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
52 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
53 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
54 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 5.00
55 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
56 INT14823 Gene_expression of MET 103 0.75 51.92 32.48 5.00
57 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
58 INT8097 Gene_expression of EGF 122 0.77 75.94 28.47 5.00
59 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44 5.00
60 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79 5.00
61 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59 5.00
62 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42 5.00
63 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
64 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57 5.00
65 INT103154 Gene_expression of FLT1 138 0.76 58.5 7.41 5.00
66 INT120401 Positive_regulation of PIK3CD 33 0.45 14.89 7.37 5.00
67 INT15376 Positive_regulation of Gene_expression of ERBB2 215 0.70 168.54 5.23 5.00
68 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93 5.00
69 INT105336 Regulation of AKT1 52 0.56 32.53 4.89 5.00
70 INT37652 Positive_regulation of Pgr 29 0.59 9.09 4.67 5.00
71 INT96492 Gene_expression of NGFR 24 0.00 12.3 4.59 5.00
72 INT103155 Gene_expression of KDR 78 0.66 50.53 4.38 5.00
73 INT138872 Gene_expression of SPINK5 21 0.58 30.11 4.12 5.00
74 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 5.00
75 INT15375 Gene_expression of AXL 21 0.65 18.5 3.74 5.00
76 INT62784 Gene_expression of NT5E 46 0.65 15.95 3.72 5.00
77 INT200670 Gene_expression of AKT2 25 0.75 16.25 3 5.00
78 INT63333 Gene_expression of RET 24 0.76 30.09 2.41 5.00
79 INT25208 Gene_expression of IGF2 43 0.74 30.64 2.31 5.00
80 INT65545 Localization of EGFR 35 0.79 20.8 1.88 5.00
81 INT123130 Positive_regulation of Positive_regulation of AKT1 22 0.49 11.77 1.83 5.00
82 INT71788 Gene_expression of MAP3K1 13 0.70 4.9 1.66 5.00
83 INT28300 Gene_expression of GHR 10 0.78 4.29 1.5 5.00
84 INT243799 Gene_expression of PIK3CD 15 0.45 6.63 1.5 5.00
85 INT131457 Gene_expression of FCGR1A 11 0.75 4.88 1.45 5.00
86 INT41719 Gene_expression of MTOR 27 0.77 19.43 1.44 5.00
87 INT49128 Gene_expression of IGF1R 35 0.63 23.48 1.39 5.00
88 INT119062 Negative_regulation of BRCA1 12 0.49 13.7 1.36 5.00
89 INT92383 Gene_expression of KRAS 38 0.65 32.94 1.32 5.00
90 INT210399 Gene_expression of IGF2R 22 0.65 17.1 1.23 5.00
91 INT60060 Positive_regulation of KRAS 17 0.67 11.68 1.21 5.00
92 INT22455 Binding of Nbr1 8 0.21 10.57 0.93 5.00
93 INT122813 Binding of Krt20 11 0.32 13.77 0.88 5.00
94 INT71784 Positive_regulation of Gene_expression of MAP3K1 4 0.34 4.8 0.82 5.00
95 INT84726 Gene_expression of NKX3-1 4 0.75 2.1 0.75 5.00
96 INT79784 Positive_regulation of RET 15 0.57 17.43 0.71 5.00
97 INT44614 Gene_expression of FCGR2C 7 0.29 5.6 0.68 5.00
98 INT44478 Negative_regulation of PTEN 32 0.57 27.45 0.63 5.00
99 INT79432 Positive_regulation of Calb2 7 0.23 6.59 0.61 5.00
100 INT105782 Positive_regulation of Krt20 9 0.20 9.62 0.53 5.00
101 INT290303 Localization of HPCAL1 1 0.04 1.2 0.52 5.00
102 INT94165 Negative_regulation of RB1 30 0.52 27.29 0.51 5.00
103 INT131931 Binding of KRT7 13 0.36 19.24 0.5 5.00
104 INT158019 Positive_regulation of Gene_expression of FLT1 20 0.68 9.73 0.44 5.00
105 INT71019 Negative_regulation of SMAD4 12 0.42 6.88 0.43 5.00
106 INT90681 Binding of SGCB 4 0.18 2.24 0.38 5.00
107 INT117564 Gene_expression of SMAD4 12 0.71 8.7 0.37 5.00
108 INT250284 Gene_expression of AQP5 4 0.61 5.68 0.29 5.00
109 INT143489 Gene_expression of Ggt6 3 0.24 1.67 0.28 5.00
110 INT41720 Positive_regulation of Gene_expression of MTOR 2 0.49 1.54 0.28 5.00
111 INT173091 Transcription of KDR 3 0.55 1.39 0.27 5.00
112 INT201638 Positive_regulation of Cdk4 5 0.58 3.38 0.24 5.00
113 INT280593 Negative_regulation of Gene_expression of SPHK1 2 0.43 3.92 0.19 5.00
114 INT183242 Negative_regulation of Gene_expression of PTEN 6 0.55 3.81 0.16 5.00
115 INT201656 Positive_regulation of Positive_regulation of Cdk4 2 0.06 2.34 0.15 5.00
116 INT302261 Regulation of PIK3CD 7 0.29 5.34 0.15 5.00
117 INT92590 Positive_regulation of Gene_expression of IGF1R 3 0.57 2.31 0.12 5.00
118 INT170849 Binding of Cdk4 3 0.16 2.44 0.1 5.00
119 INT290301 Regulation of Localization of JMJD6 1 0.03 1.25 0.08 5.00
120 INT290302 Localization of JMJD6 1 0.05 1.25 0.08 5.00
121 INT246361 Positive_regulation of Gene_expression of SPINK5 1 0.07 2.55 0.06 5.00
122 INT176533 Positive_regulation of Gene_expression of MET 13 0.67 7.17 0.06 5.00
123 INT319330 Transcription of IGF2R 1 0.33 1.34 0.04 5.00
124 INT290297 Binding of Cq2 1 0.08 1.16 0.03 5.00
125 INT319335 Transcription of FLT4 1 0.18 0.99 0.03 5.00
126 INT290298 Positive_regulation of Binding of Cq2 1 0.11 1.16 0.03 5.00
127 INT319329 Positive_regulation of EGI 1 0.04 0.95 0 5.00
128 INT297045 Gene_expression of CLIC4 3 0.65 0.94 0 5.00
129 INT335533 Negative_regulation of SPHK1 1 0.59 2.38 0 5.00
130 INT219856 Binding of Msln 1 0.02 2.52 0 5.00
131 INT319333 Transcription of IGF1R 1 0.31 0.85 0 5.00
132 INT335531 Phosphorylation of SPHK1 1 0.81 1 0 5.00
133 INT335538 Positive_regulation of Transcription of SGCB 1 0.24 0.74 0 5.00
134 INT335529 Transcription of SPHK1 1 0.53 0.74 0 5.00
135 INT258231 Phosphorylation of S1PR1 2 0.45 0.95 0 5.00
136 INT191352 Regulation of SHC1 2 0.14 1.46 0 5.00
137 INT334324 Positive_regulation of Negative_regulation of PTEN 1 0.41 0.81 0 5.00
138 INT319328 Regulation of EGI 1 0.02 0 0 5.00
139 INT304076 Regulation of Localization of KRAS 2 0.36 2.39 0 5.00
140 INT335540 Transcription of SGCB 1 0.28 0.74 0 5.00
141 INT284329 Regulation of Gene_expression of MTOR 2 0.20 1.63 0 5.00
142 INT315882 Regulation of Negative_regulation of PTEN 2 0.44 1.39 0 5.00
143 INT319331 Regulation of Localization of EGFR 2 0.32 1.85 0 5.00
144 INT246178 Gene_expression of EIF4EBP1 3 0.61 1.82 0 5.00
145 INT334327 Regulation of SMAD4 2 0.35 1.73 0 5.00
146 INT117563 Negative_regulation of Gene_expression of SMAD4 6 0.54 3.87 0 5.00
147 INT180396 Localization of KRAS 3 0.69 2.89 0 5.00
148 INT175421 Positive_regulation of Positive_regulation of KRAS 2 0.34 1.45 0 5.00
149 INT319332 Gene_expression of EGI 1 0.06 2.08 0 5.00
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