D:Papular Skin Disease

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Disease Term
Synonyms Folicular Keratotic Papules, Lichen Planus, PAPULE, PITYRIASSI ROSEA, Piyriasis Rubra Pilaris, Psoriasis
Documents 85
Hot Single Events 7
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Papular Skin Disease. They are ordered first by their relevance to Papular Skin Disease and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT334529 Pax3 Positive_regulation of Gene_expression of Ngf 1 0.03 0.31 0.91 33.32
2 INT334532 Sema3a Negative_regulation of Gene_expression of Nrp1 1 0.19 7.58 2 5.00
3 INT334537 Sema3a Negative_regulation of Gene_expression of Plxna1 1 0.08 3.76 1 5.00
4 INT94331 IFNG Positive_regulation of CXCL10 4 0.11 1.31 0.82 5.00
5 INT334526 Trpv1 Positive_regulation of Gene_expression of Sema3a 1 0.31 0.92 0.55 5.00
6 INT334533 Binding of Foxq1 and Ngf 1 0.05 0.8 0.38 5.00
7 INT172004 IL17A Positive_regulation of Gene_expression of IL6 2 0.14 1.35 0.34 5.00
8 INT171293 TNF Positive_regulation of CXCL10 2 0.09 0.97 0.31 5.00
9 INT171723 IL4 Positive_regulation of Positive_regulation of TNF 1 0.01 0.67 0.28 5.00
10 INT171719 IL4 Positive_regulation of TNF Positive_regulation of CXCL10 1 0.01 0.67 0.28 5.00
11 INT171720 IL4 Positive_regulation of Positive_regulation of IFNG 1 0.01 0.67 0.28 5.00
12 INT171722 IL4 Positive_regulation of Positive_regulation of CXCL10 1 0.04 0.67 0.28 5.00
13 INT171721 IL4 Positive_regulation of Positive_regulation of CXCL9 1 0.04 0.67 0.28 5.00
14 INT171724 TNF Positive_regulation of CXCL9 1 0.03 0.6 0.27 5.00
15 INT171726 TNF Positive_regulation of IFNG 1 0.01 0.6 0.27 5.00
16 INT171725 IFNG Positive_regulation of CXCL9 1 0.02 0.6 0.27 5.00
17 INT334522 Ngf Positive_regulation of Nrp1 1 0.19 0.93 0.22 5.00
18 INT334525 Ngf Positive_regulation of Gene_expression of Nrp1 1 0.19 0.93 0.22 5.00
19 INT334531 Nrp1 Negative_regulation of Gene_expression of Il4 1 0.08 0.48 0.14 5.00
20 INT334527 Sema3a Negative_regulation of Gene_expression of Il4 1 0.15 0.48 0.14 5.00
21 INT334534 Nrp1 Negative_regulation of Gene_expression of Sema3a 1 0.17 0.48 0.14 5.00
22 INT334530 Sema3a Regulation of Il18 1 0.18 1.61 0.13 5.00
23 INT334528 Nrp1 Negative_regulation of Sema3a 1 0.17 0.47 0.13 5.00
24 INT334524 Sema3a Regulation of Foxq1 1 0.04 1.61 0.13 5.00
25 INT171727 Gene_expression of CSH1 Positive_regulation of Gene_expression of CCL17 1 0.04 0.49 0.11 5.00
26 INT333095 Localization of IL2 Negative_regulation of Negative_regulation of CD8A 1 0.10 0.8 0.09 5.00
27 INT333099 Localization of IL2 Negative_regulation of Negative_regulation of CD4 1 0.14 0.8 0.09 5.00
28 INT333094 HIVEP1 Regulation of CD4 1 0.00 0.22 0.09 5.00
29 INT333121 Pol Positive_regulation of CD8A 1 0.00 0.08 0.09 5.00
30 INT181845 Binding of CD8A and IFN1@ 2 0.13 0.65 0.09 5.00
31 INT333089 CD4 Positive_regulation of ERVW-1 1 0.05 0.07 0.08 5.00
32 INT333097 ERVW-1 Positive_regulation of CD8A 1 0.02 0.08 0.08 5.00
33 INT333096 Binding of CD4 and IFN1@ 1 0.12 0.17 0.07 5.00
34 INT333092 Binding of CD4 and IL2 1 0.01 0.17 0.07 5.00
35 INT333098 Binding of CD8A and IL2 1 0.01 0.17 0.07 5.00
36 INT333091 Localization of IFN1@ Negative_regulation of Negative_regulation of CD4 1 0.14 0.4 0.05 5.00
37 INT333090 Localization of IFN1@ Negative_regulation of Negative_regulation of CD8A 1 0.10 0.4 0.05 5.00
38 INT334538 Il18 Positive_regulation of Localization of IFN1@ 1 0.34 0.65 0 5.00
39 INT172011 IgG Regulation of Ighm 1 0.00 0.77 0 5.00
40 INT333093 AD5 Regulation of CD8A 1 0.00 0.25 0 5.00
41 INT285399 Binding of DEFB1 and HLA-B 1 0.01 1.33 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Papular Skin Disease. They are ordered first by their pain relevance and then by number of times they were reported in Papular Skin Disease. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT155153 Binding of S100a1 15 0.35 6.42 1.63 98.98
2 INT155154 Binding of CD1D 2 0.36 1.7 0.12 98.98
3 INT155152 Negative_regulation of Lch 1 0.32 1.05 0.09 96.96
4 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 96.80
5 INT94628 Gene_expression of CD1D 12 0.75 5.58 2.13 94.08
6 INT143850 Gene_expression of S100a1 19 0.73 9.52 1.54 93.36
7 INT3364 Binding of SGCG 87 0.47 31.93 17.24 90.32
8 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 72.80
9 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31 68.48
10 INT3795 Positive_regulation of Ighm 46 0.68 22.43 6.47 67.40
11 INT3797 Positive_regulation of Gene_expression of Ighm 16 0.47 9.4 2.01 67.40
12 INT3796 Gene_expression of Ighm 130 0.77 69.61 13.78 66.80
13 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71 61.20
14 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19 58.36
15 INT17275 Gene_expression of HIVEP1 267 0.75 232.07 24.06 51.68
16 INT217875 Gene_expression of AD5 41 0.40 19.85 2.28 50.64
17 INT83607 Positive_regulation of CSAD 13 0.59 14.24 8.07 38.40
18 INT67048 Gene_expression of ITGA4 58 0.75 28.93 10.16 31.52
19 INT89293 Positive_regulation of Gene_expression of CCR5 29 0.70 22.14 15 29.12
20 INT171749 Positive_regulation of Gene_expression of CXCR3 18 0.58 11.03 6.51 29.12
21 INT105403 Positive_regulation of Gene_expression of CCR3 10 0.60 7.99 4.74 29.12
22 INT100398 Positive_regulation of Gene_expression of CCL17 6 0.53 2.26 1.19 29.12
23 INT88322 Gene_expression of CCR5 111 0.78 77.36 39.84 27.16
24 INT121663 Gene_expression of CXCR3 76 0.77 50.96 30.62 27.16
25 INT102525 Gene_expression of CCR3 24 0.71 16.19 10 27.16
26 INT100399 Gene_expression of CCL17 22 0.77 9.38 2.43 27.16
27 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 26.64
28 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 26.64
29 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 26.00
30 INT88195 Gene_expression of ZAK 15 0.74 4.79 1.55 25.36
31 INT55886 Negative_regulation of Gene_expression of Il4 47 0.57 26.04 11.42 21.96
32 INT27955 Negative_regulation of Gene_expression of Ngf 16 0.59 10.43 10.17 21.96
33 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 21.36
34 INT170438 Negative_regulation of Gene_expression of Pax3 4 0.04 1.03 3.42 10.64
35 INT14624 Gene_expression of Pax3 100 0.38 33.22 69.47 10.00
36 INT14737 Gene_expression of FN1 117 0.78 78.74 18.99 5.60
37 INT227973 Gene_expression of Gm2404 9 0.10 4.21 0 5.48
38 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
39 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 5.00
40 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
41 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
42 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 5.00
43 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
44 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
45 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 5.00
46 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
47 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
48 INT21793 Positive_regulation of Ngf 154 0.70 94.78 85.27 5.00
49 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
50 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
51 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
52 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 5.00
53 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
54 INT46637 Gene_expression of CXCL10 172 0.78 121.94 57.74 5.00
55 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 5.00
56 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 5.00
57 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05 5.00
58 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33 5.00
59 INT100939 Gene_expression of Il13 176 0.73 125.1 43.38 5.00
60 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
61 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 5.00
62 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 5.00
63 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
64 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
65 INT20210 Localization of Ngf 69 0.79 46.22 38.57 5.00
66 INT104551 Gene_expression of Il18 156 0.76 115.51 36.95 5.00
67 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
68 INT72651 Gene_expression of TH1L 114 0.75 80.15 35.15 5.00
69 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 5.00
70 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 5.00
71 INT10763 Localization of IL2 157 0.80 81.11 33.21 5.00
72 INT88318 Gene_expression of CXCR4 208 0.77 189.67 31.72 5.00
73 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 5.00
74 INT34729 Positive_regulation of IFN1@ 233 0.67 128.04 30.38 5.00
75 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 5.00
76 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 5.00
77 INT20462 Binding of ESR1 210 0.44 102.7 26.34 5.00
78 INT63769 Regulation of Ngf 44 0.62 21.82 25.84 5.00
79 INT5055 Positive_regulation of IFNG 89 0.69 64.03 23.05 5.00
80 INT94335 Positive_regulation of CXCL10 71 0.58 50.69 23 5.00
81 INT74423 Localization of IL10 91 0.80 61.6 22.95 5.00
82 INT49196 Gene_expression of SELE 105 0.78 107.29 22.92 5.00
83 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52 5.00
84 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 5.00
85 INT15796 Regulation of IL2 66 0.61 25.43 20.62 5.00
86 INT49103 Positive_regulation of Vcam1 71 0.69 59.52 19.85 5.00
87 INT157463 Gene_expression of CX3CL1 55 0.62 69.05 19.75 5.00
88 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 5.00
89 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 5.00
90 INT116978 Gene_expression of CCR6 53 0.78 56 17.73 5.00
91 INT38056 Localization of Crp 71 0.78 53.14 17.03 5.00
92 INT94467 Positive_regulation of Hand1 71 0.58 59 16.96 5.00
93 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 5.00
94 INT170754 Localization of IFN1@ 121 0.78 66.78 15.6 5.00
95 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89 5.00
96 INT107585 Gene_expression of CCR2 35 0.71 26.44 14.75 5.00
97 INT100938 Positive_regulation of Il13 47 0.69 42.11 14.36 5.00
98 INT120901 Positive_regulation of Gene_expression of Il13 36 0.57 31.63 13.36 5.00
99 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
100 INT141014 Positive_regulation of Gene_expression of Il18 46 0.68 47.63 13.3 5.00
101 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 5.00
102 INT10016 Negative_regulation of CD8A 81 0.42 56.68 13.15 5.00
103 INT4137 Positive_regulation of C3 73 0.69 48.57 12.63 5.00
104 INT36287 Binding of CD4 96 0.47 58.93 11.88 5.00
105 INT65713 Localization of ICAM1 42 0.81 39.55 11.49 5.00
106 INT701 Localization of IGHE 87 0.80 40.5 10.62 5.00
107 INT58904 Localization of TH1L 40 0.68 27.11 10.52 5.00
108 INT16404 Regulation of CD4 54 0.61 33.05 10.29 5.00
109 INT137181 Gene_expression of CXCL9 25 0.65 13.09 9.56 5.00
110 INT76860 Gene_expression of HSPG2 32 0.65 37.14 9.06 5.00
111 INT141502 Positive_regulation of CX3CL1 21 0.55 25.8 8.88 5.00
112 INT15687 Regulation of ESR1 91 0.60 40.42 7.95 5.00
113 INT71308 Gene_expression of CCL11 33 0.76 25.66 7.83 5.00
114 INT573 Negative_regulation of C3 60 0.59 41.37 7.78 5.00
115 INT177759 Negative_regulation of IFN1@ 51 0.57 31.81 7.76 5.00
116 INT171742 Positive_regulation of CXCR3 17 0.58 12.26 7.72 5.00
117 INT81399 Regulation of Vcam1 24 0.46 23.53 7.68 5.00
118 INT39417 Gene_expression of Fcer2a 65 0.76 32.1 7.37 5.00
119 INT91667 Localization of IL12A 39 0.74 25.51 7.36 5.00
120 INT121752 Gene_expression of IL11 54 0.62 18.05 7.16 5.00
121 INT1123 Positive_regulation of CD79A 74 0.70 51.96 7.14 5.00
122 INT75382 Negative_regulation of HSPG2 20 0.57 15.18 7.03 5.00
123 INT17049 Localization of CD4 57 0.75 35.33 6.89 5.00
124 INT160562 Localization of Cd4 49 0.71 27.58 6.78 5.00
125 INT13520 Binding of HLA-DRB4 30 0.42 32.65 6.74 5.00
126 INT110987 Transcription of ESR1 45 0.71 24.16 6.72 5.00
127 INT132822 Localization of IL13 26 0.67 22.85 6.66 5.00
128 INT22128 Positive_regulation of HIVEP1 61 0.43 70.52 6.07 5.00
129 INT122653 Positive_regulation of Gene_expression of CD4 48 0.68 22.5 5.96 5.00
130 INT45275 Gene_expression of CSH1 39 0.62 9.39 5.85 5.00
131 INT56149 Localization of CD8A 56 0.74 30.41 5.75 5.00
132 INT77281 Negative_regulation of HIVEP1 132 0.49 102.78 5.36 5.00
133 INT16405 Regulation of CD8A 38 0.45 19.04 5.31 5.00
134 INT62525 Positive_regulation of SELE 38 0.70 46 5.25 5.00
135 INT62832 Negative_regulation of Gene_expression of SELE 16 0.49 10.6 5.12 5.00
136 INT137179 Positive_regulation of CXCL9 11 0.65 7.73 5.11 5.00
137 INT130290 Positive_regulation of Localization of IL10 16 0.47 9.38 4.75 5.00
138 INT104549 Localization of Il18 16 0.78 13.01 4.64 5.00
139 INT133630 Negative_regulation of Gene_expression of ESR1 42 0.52 23.89 4.57 5.00
140 INT153189 Gene_expression of Sema3a 19 0.75 14.37 4.21 5.00
141 INT57273 Positive_regulation of Gene_expression of FN1 26 0.47 17.83 4.2 5.00
142 INT63977 Positive_regulation of Sele 28 0.68 18.49 4.17 5.00
143 INT91333 Gene_expression of CXCL11 11 0.65 10.96 4.1 5.00
144 INT57157 Gene_expression of TDGF1 5 0.75 3.97 4.02 5.00
145 INT170455 Gene_expression of Atp8a1 66 0.75 24.63 3.94 5.00
146 INT54701 Localization of Ptafr 19 0.49 18.68 3.82 5.00
147 INT63979 Regulation of Sele 13 0.54 10.64 3.7 5.00
148 INT122323 Positive_regulation of NOTCH1 36 0.70 35.63 3.7 5.00
149 INT10188 Positive_regulation of Il2ra 19 0.45 11.6 3.37 5.00
150 INT120067 Positive_regulation of Gene_expression of CCR2 10 0.46 5.13 3.02 5.00
151 INT50765 Positive_regulation of Fcer2a 23 0.68 10.22 2.92 5.00
152 INT177760 Negative_regulation of Gene_expression of IFN1@ 21 0.57 16.61 2.89 5.00
153 INT123910 Gene_expression of CXCL16 5 0.49 3.81 2.82 5.00
154 INT62487 Localization of HIVEP1 35 0.73 36.24 2.72 5.00
155 INT24129 Positive_regulation of ZAK 13 0.70 2.29 2.39 5.00
156 INT165841 Gene_expression of BPIFA4P 17 0.65 6.48 2.38 5.00
157 INT240113 Gene_expression of Nrp1 11 0.30 10.88 2.24 5.00
158 INT179256 Positive_regulation of Localization of IL13 7 0.42 7.04 2.14 5.00
159 INT140650 Positive_regulation of Gene_expression of CCL11 10 0.68 5.43 2.08 5.00
160 INT58691 Positive_regulation of Gene_expression of CD8A 26 0.50 15.19 1.97 5.00
161 INT141002 Negative_regulation of Fcer2a 15 0.12 7.17 1.88 5.00
162 INT95650 Negative_regulation of Positive_regulation of Ngf 6 0.43 4.41 1.84 5.00
163 INT153190 Negative_regulation of Sema3a 7 0.56 7.94 1.76 5.00
164 INT63812 Gene_expression of H1FNT 14 0.06 8.41 1.67 5.00
165 INT62839 Negative_regulation of SEMA6A 5 0.42 0.31 1.52 5.00
166 INT80295 Gene_expression of CCL13 6 0.58 3.63 1.48 5.00
167 INT79357 Binding of ERVW-1 32 0.43 16.06 1.35 5.00
168 INT247904 Localization of ICAM2 1 0.07 5.72 1.32 5.00
169 INT247903 Localization of ITGA1 1 0.06 5.69 1.32 5.00
170 INT79358 Gene_expression of ERVW-1 65 0.75 29.9 1.31 5.00
171 INT221531 Gene_expression of Plxna1 7 0.75 4.51 1.31 5.00
172 INT190335 Negative_regulation of Positive_regulation of IFN1@ 16 0.42 4.6 1.29 5.00
173 INT149292 Localization of NOTCH1 7 0.54 6.11 1.14 5.00
174 INT108559 Gene_expression of Pol 46 0.45 30.07 1.14 5.00
175 INT62959 Positive_regulation of CCR2 4 0.61 1.47 1.13 5.00
176 INT295694 Localization of DNAI1 4 0.15 3.28 1.09 5.00
177 INT184384 Gene_expression of DNAI1 8 0.66 5.45 1.05 5.00
178 INT171746 Gene_expression of CCR8 4 0.40 1.29 0.88 5.00
179 INT295611 Regulation of DNAI1 5 0.23 2.41 0.87 5.00
180 INT189171 Positive_regulation of Localization of CD4 7 0.49 5.88 0.79 5.00
181 INT171741 Localization of CXCR3 2 0.44 2.38 0.79 5.00
182 INT171750 Positive_regulation of Gene_expression of CCL13 3 0.33 2.38 0.74 5.00
183 INT250281 Positive_regulation of Positive_regulation of CD40LG 3 0.23 3.19 0.73 5.00
184 INT171740 Gene_expression of CCL27 3 0.38 2.71 0.71 5.00
185 INT82808 Positive_regulation of ITGA4 7 0.44 5.19 0.71 5.00
186 INT158295 Transcription of CD8A 11 0.53 4.02 0.7 5.00
187 INT3536 Positive_regulation of Nrp1 2 0.19 0.93 0.7 5.00
188 INT24128 Negative_regulation of ZAK 3 0.39 0 0.7 5.00
189 INT196155 Binding of Nrp1 5 0.16 2.38 0.69 5.00
190 INT171747 Gene_expression of ACD 4 0.57 4.44 0.68 5.00
191 INT145949 Gene_expression of CCL24 2 0.54 2.39 0.68 5.00
192 INT260823 Positive_regulation of Gene_expression of Nrp1 3 0.19 2.14 0.65 5.00
193 INT88987 Gene_expression of HMGA2 8 0.77 10.46 0.64 5.00
194 INT108558 Transcription of Pol 5 0.35 4.67 0.64 5.00
195 INT297286 Positive_regulation of Foxp3 7 0.58 3.05 0.63 5.00
196 INT158486 Negative_regulation of Gene_expression of Sema3a 4 0.41 2.49 0.57 5.00
197 INT171739 Positive_regulation of Gene_expression of CCL27 2 0.25 1.64 0.56 5.00
198 INT217864 Positive_regulation of Gene_expression of AD5 4 0.30 3.51 0.53 5.00
199 INT221545 Binding of Sema3a 2 0.33 1.4 0.53 5.00
200 INT176649 Negative_regulation of Localization of Cd4 5 0.32 2.41 0.51 5.00
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