D:Paraganglioma

From wiki-pain
Jump to: navigation, search

pChart

Disease Term
Synonyms Cancer Of The Paraganglion, Gangliocytic Paraganglioma, Gangliocytic Paragangliomas, Neoplasm Of Paraganglion, Paraganglioma Disorder, PARAGANGLIOMA GANGLIOCYTIC, Paragangliomas, PARAGANGLIOMAS GANGLIOCYTIC, Paraganglionic Cancer, PARAGANGLIONIC NEOPLASM, PARAGANGLIONIC NEOPLASMS
Documents 314
Hot Single Events 103
Hot Interactions 6

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Paraganglioma. They are ordered first by their relevance to Paraganglioma and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT156661 Binding of Pgls and Sdhb 1 0.01 1.43 0.25 100.00
2 INT200213 PAH Positive_regulation of SDHD 1 0.21 2.43 0.1 100.00
3 INT348637 Binding of TLE4 and OLFM1 1 0.01 1.67 0.24 100.00
4 INT354469 Binding of SDHC and Sdhb 1 0.08 1.82 0 100.00
5 INT311666 Binding of BCL2 and TP53 1 0.19 1.26 0.14 95.36
6 INT200212 Binding of EPAS1 and VHL 3 0.06 4.1 0.05 85.40
7 INT241119 Binding of Sdhc and Sdhb 1 0.00 1.29 0 62.92
8 INT241120 Binding of Sdhc and Sdhd 1 0.00 1.28 0 61.96
9 INT74015 Binding of VHL and XRCC1 1 0.07 3.51 0.09 33.04
10 INT229635 SPINK5 Positive_regulation of NF1 1 0.01 2.17 0.3 5.00
11 INT229634 GOPC Positive_regulation of GAST 1 0.09 0.47 0.19 5.00
12 INT249962 Binding of KIT and KITLG 6 0.19 3.69 0.17 5.00
13 INT218784 Binding of TCEB2 and VHL 1 0.04 3.81 0.1 5.00
14 INT241500 Binding of Kit and Kitl 1 0.08 0.92 0 5.00
15 INT243373 Binding of CASP8 and SERPINH1 1 0.28 1.49 0 5.00
16 INT243374 SERPINH1 Positive_regulation of Gene_expression of CAMK4 1 0.07 1.01 0 5.00
17 INT251983 XRCC1 Regulation of Binding of MET 1 0.05 0.4 0 5.00
18 INT295426 Binding of KIT and PDGFRB 1 0.24 0.4 0 5.00
19 INT218785 Binding of FN1 and VHL 1 0.06 1.12 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Paraganglioma. They are ordered first by their pain relevance and then by number of times they were reported in Paraganglioma. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT200218 Localization of SDHD 1 0.69 48.58 4.57 100.00
2 INT200222 Positive_regulation of Localization of SDHD 1 0.43 7.07 0.84 100.00
3 INT171435 Gene_expression of SDHD 14 0.58 26.55 0.91 100.00
4 INT200216 Binding of SDHD 3 0.37 4.51 0.71 100.00
5 INT200221 Positive_regulation of SDHD 3 0.43 6.59 0.42 100.00
6 INT156655 Positive_regulation of Pgls 2 0.38 3.11 0.35 100.00
7 INT8960 Binding of SDHB 9 0.36 9.2 1.68 100.00
8 INT149200 Binding of SDHC 2 0.36 1.82 0.18 100.00
9 INT329915 Gene_expression of Pgls 1 0.51 1.21 0.04 100.00
10 INT661 Gene_expression of REN 100 0.78 48.21 11.36 100.00
11 INT200215 Transcription of SDHD 1 0.59 1.35 0.15 100.00
12 INT329916 Localization of Pgls 1 0.61 1.33 0.07 100.00
13 INT348638 Binding of OLFM1 1 0.07 1.09 0.21 100.00
14 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 99.98
15 INT200217 Localization of PAH 10 0.36 15.51 2.46 99.96
16 INT9110 Binding of PAH 32 0.41 42.1 3.1 99.96
17 INT61993 Gene_expression of NF1 29 0.78 34.47 1.23 99.92
18 INT63333 Gene_expression of RET 24 0.76 30.09 2.41 99.92
19 INT19158 Gene_expression of PAH 35 0.65 35.81 3.88 99.92
20 INT68216 Binding of NF1 40 0.48 51.24 4.59 99.92
21 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 99.88
22 INT311668 Regulation of Regulation of TP53 2 0.36 3.58 0.04 99.84
23 INT60585 Regulation of TP53 59 0.59 54.55 5.21 99.84
24 INT45730 Transcription of PAH 3 0.68 2.4 0.33 99.80
25 INT127458 Positive_regulation of PAH 24 0.58 27.25 2.53 99.78
26 INT79784 Positive_regulation of RET 15 0.57 17.43 0.71 99.76
27 INT64700 Binding of Nf1 14 0.45 15.24 2.29 99.76
28 INT16277 Regulation of CHGA 16 0.44 11.31 4.43 99.68
29 INT56817 Regulation of Eno2 16 0.61 10.64 1.99 99.68
30 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 99.68
31 INT22707 Positive_regulation of Eno2 36 0.69 27.31 5.07 99.68
32 INT18898 Positive_regulation of CHGA 38 0.67 28.99 4.86 99.68
33 INT68665 Binding of Vhl 9 0.48 10.3 0.82 99.56
34 INT238507 Regulation of Regulation of BCL2 3 0.44 5.14 0.16 99.56
35 INT84685 Regulation of BCL2 67 0.60 72.96 6.65 99.56
36 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 99.38
37 INT4988 Gene_expression of KRT1 64 0.77 43.4 4.12 99.04
38 INT156827 Localization of MRI1 25 0.65 16.06 8.33 99.00
39 INT51066 Binding of S100B 24 0.48 13.5 0.97 99.00
40 INT225811 Binding of Erbb2 1 0.42 4.26 0 98.88
41 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 98.72
42 INT6810 Gene_expression of ENO2 70 0.78 54.8 8.35 98.68
43 INT241102 Transcription of FH 2 0.59 2 0.14 98.60
44 INT15652 Positive_regulation of ENO2 37 0.68 33.39 5.02 98.56
45 INT85284 Negative_regulation of ENO2 8 0.58 7.86 2.28 98.56
46 INT140116 Binding of Sdhd 2 0.04 2.78 0.3 98.48
47 INT60279 Gene_expression of VHL 70 0.78 75.21 2.21 98.24
48 INT6868 Gene_expression of GFAP 136 0.78 84.65 22.7 98.14
49 INT105546 Gene_expression of Tpo 2 0.76 9.29 0.28 98.06
50 INT9397 Regulation of MET 17 0.60 8.36 7.04 97.84
51 INT241115 Regulation of Vhl 5 0.15 8.36 0.11 97.84
52 INT484 Negative_regulation of ADRB2 13 0.59 2.85 3.94 97.78
53 INT8224 Gene_expression of CHGA 73 0.75 53.63 12.31 97.76
54 INT52052 Positive_regulation of SDHB 14 0.68 14.07 2.27 97.64
55 INT156656 Gene_expression of Sdhb 1 0.05 1.57 0.3 97.52
56 INT11551 Localization of VHL 12 0.65 22.76 0.68 97.48
57 INT114842 Localization of RET 3 0.71 5.98 0.71 97.48
58 INT30 Gene_expression of Gast 158 0.78 99 41.45 97.44
59 INT8159 Binding of ELL 7 0.36 12.62 0.84 97.38
60 INT64849 Gene_expression of Ret 24 0.75 14.36 9.1 96.92
61 INT24891 Gene_expression of SYP 55 0.75 45.76 7.53 96.80
62 INT58918 Gene_expression of SDHB 5 0.75 2.93 1.27 96.76
63 INT5843 Positive_regulation of Gfap 184 0.70 108.2 70.21 96.64
64 INT212652 Gene_expression of SDHC 1 0.40 0.73 0.43 96.64
65 INT124870 Gene_expression of SDHAF2 4 0.57 1.37 0.03 96.56
66 INT159232 Negative_regulation of SYP 4 0.41 4.45 0.38 96.40
67 INT4991 Positive_regulation of Vim 74 0.69 69.84 8.33 96.40
68 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 96.20
69 INT171434 Positive_regulation of Gene_expression of SDHD 2 0.10 3.87 0.08 96.12
70 INT82374 Binding of SYP 13 0.36 13.69 0.85 95.88
71 INT52053 Positive_regulation of Positive_regulation of SDHB 2 0.49 3.11 0.14 95.68
72 INT13507 Gene_expression of Erbb2 17 0.77 34.23 7.58 95.48
73 INT93503 Positive_regulation of Gene_expression of Erbb2 3 0.69 6.22 0.45 95.48
74 INT1429 Gene_expression of PDYN 308 0.78 61.33 175.65 95.04
75 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 95.04
76 INT15752 Positive_regulation of Ema 15 0.40 14.57 2.34 94.80
77 INT66940 Regulation of RET 7 0.52 5.61 0.69 94.16
78 INT119818 Negative_regulation of CHGA 10 0.57 8.21 2.04 93.84
79 INT79270 Gene_expression of MKI67 113 0.77 63.52 3.38 93.60
80 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42 93.60
81 INT30868 Binding of Lrrc23 2 0.17 1.17 0.43 93.40
82 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 92.60
83 INT24160 Gene_expression of TRIM13 7 0.65 1.42 3.46 92.60
84 INT4993 Gene_expression of Lrrc23 13 0.66 11.04 1.99 92.00
85 INT348639 Gene_expression of OLFM1 1 0.12 1.57 0.19 92.00
86 INT20055 Gene_expression of CRTAC1 19 0.58 15.49 4.73 92.00
87 INT132885 Regulation of SYP 4 0.44 3.92 0.44 91.68
88 INT18897 Binding of CHGA 11 0.36 10.12 1.17 91.40
89 INT140542 Gene_expression of SSTR2 18 0.65 13.58 3.94 91.20
90 INT55736 Transcription of MMP2 11 0.68 5.78 2.28 90.88
91 INT31317 Positive_regulation of PHGDH 6 0.49 4.45 1.22 89.04
92 INT5842 Gene_expression of Gfap 372 0.78 153.71 127.71 88.64
93 INT185017 Gene_expression of TOP2B 7 0.75 4.84 1.67 88.56
94 INT6557 Gene_expression of Eno2 65 0.77 54.42 8.17 87.68
95 INT99549 Gene_expression of CDKN1B 30 0.75 17 5.15 86.24
96 INT232566 Gene_expression of FHIT 1 0.58 2.97 0.08 86.24
97 INT121496 Gene_expression of TERT 107 0.78 45.6 7.42 86.16
98 INT164294 Negative_regulation of Gene_expression of ENO2 2 0.41 1.36 0.27 84.40
99 INT15584 Binding of S100A12 14 0.48 15.14 3 83.08
100 INT200219 Positive_regulation of VHL 18 0.50 15.38 0.67 80.40
101 INT152215 Binding of FH 10 0.41 14.13 0.19 80.32
102 INT200223 Positive_regulation of EPAS1 21 0.17 21.95 1.7 80.16
103 INT183672 Gene_expression of EPAS1 37 0.35 28.68 0.72 80.16
104 INT4740 Gene_expression of Th 298 0.78 61.27 154.03 79.96
105 INT8571 Gene_expression of B3GAT1 54 0.75 36.85 15.98 79.76
106 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17 78.64
107 INT99961 Positive_regulation of SYP 13 0.67 15.13 2.79 78.52
108 INT7412 Positive_regulation of SST 71 0.70 24.44 29.48 78.52
109 INT56032 Positive_regulation of NCAM1 38 0.49 26.01 4.68 78.52
110 INT14515 Positive_regulation of Lrrc23 8 0.28 8.51 0.97 78.08
111 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45 78.08
112 INT109403 Regulation of Gene_expression of BCL2 31 0.60 31.22 3.4 78.08
113 INT102813 Regulation of Gene_expression of TP53 25 0.59 25.95 0.75 78.08
114 INT235467 Negative_regulation of Gene_expression of VHL 9 0.43 8.67 0 78.08
115 INT7362 Gene_expression of Sst 185 0.78 41.73 111.37 77.28
116 INT27935 Binding of Vim 21 0.36 15.65 2.61 77.24
117 INT88070 Binding of Ema 7 0.18 7.39 0.31 77.24
118 INT1634 Gene_expression of Gcg 25 0.75 14.98 4.42 75.00
119 INT3657 Gene_expression of Ins1 514 0.78 321.69 75.76 75.00
120 INT19520 Negative_regulation of SDHB 4 0.37 1.57 1.24 74.64
121 INT88278 Binding of Kit 33 0.37 24.45 4.13 73.88
122 INT241113 Negative_regulation of Binding of Vhl 1 0.07 3.31 0.03 72.52
123 INT691 Binding of SST 67 0.48 24.66 32.67 71.28
124 INT100375 Gene_expression of Vhl 14 0.15 22.3 1.69 71.12
125 INT67195 Negative_regulation of Gene_expression of SST 7 0.42 6.98 4.88 70.92
126 INT200220 Positive_regulation of Positive_regulation of EPAS1 2 0.09 2 0.16 70.60
127 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 70.24
128 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39 70.24
129 INT124191 Localization of SDHB 3 0.74 2.4 0.32 70.20
130 INT23650 Positive_regulation of Sdhb 2 0.17 1.34 0.43 68.88
131 INT143601 Positive_regulation of Erbb2 2 0.46 1.44 0.39 67.24
132 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 62.08
133 INT650 Gene_expression of Afp 13 0.78 7.44 1.47 61.72
134 INT6510 Gene_expression of AFP 130 0.78 119.2 9.19 60.96
135 INT327414 Transcription of TFE3 1 0.68 3.33 0 60.92
136 INT137135 Gene_expression of THBS1 28 0.75 11.55 2.45 60.80
137 INT15543 Gene_expression of CASP8 32 0.75 25.6 2.61 60.56
138 INT243390 Gene_expression of HIC1 1 0.62 2.72 0.06 60.28
139 INT190280 Gene_expression of DICER1 12 0.65 9.54 2.67 60.04
140 INT116978 Gene_expression of CCR6 53 0.78 56 17.73 59.80
141 INT23246 Gene_expression of HLA-DRB4 37 0.64 36.79 6.61 59.44
142 INT59955 Gene_expression of RASSF1 3 0.60 3.43 0.13 59.12
143 INT241104 Gene_expression of FH 7 0.66 20.35 0.31 58.24
144 INT241100 Negative_regulation of Binding of FH 1 0.11 2.76 0.05 57.16
145 INT96141 Gene_expression of ASPSCR1 9 0.68 11.46 1.29 56.20
146 INT327415 Gene_expression of TFE3 1 0.52 1.79 0 56.20
147 INT185287 Transcription of VHL 2 0.60 3.77 0 55.68
148 INT251997 Negative_regulation of Transcription of VHL 1 0.37 1.32 0 55.68
149 INT124944 Regulation of KIT 15 0.60 11.84 0.24 52.20
150 INT86368 Gene_expression of TEP1 31 0.50 16.36 1.63 50.08
151 INT67097 Gene_expression of MIB1 20 0.75 21.06 1.03 50.08
152 INT167692 Binding of NCAM1 11 0.36 6.73 1.59 50.00
153 INT173080 Positive_regulation of Gene_expression of VHL 3 0.50 9.58 0.1 46.72
154 INT74017 Regulation of VHL 4 0.43 7.59 0.16 45.52
155 INT8725 Gene_expression of Mln 32 0.77 14.9 12.22 40.24
156 INT40753 Gene_expression of GLI1 9 0.75 5.98 0.33 39.44
157 INT15529 Gene_expression of GCG 51 0.75 18.55 8.35 39.04
158 INT241099 Positive_regulation of Gene_expression of FH 3 0.43 5.17 0.11 36.24
159 INT225812 Localization of EIF3A 1 0.08 1.24 0 34.64
160 INT1636 Gene_expression of Sct 58 0.77 16.14 11.57 34.16
161 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 34.08
162 INT249062 Positive_regulation of Positive_regulation of DES 1 0.49 1.29 0.03 32.64
163 INT1902 Gene_expression of Cck 348 0.78 70.33 241.92 32.24
164 INT51607 Positive_regulation of DES 33 0.67 32.24 3.29 32.12
165 INT241114 Transcription of Vhl 1 0.11 2.3 0.05 31.68
166 INT121493 Gene_expression of XRCC1 55 0.65 73.43 2.76 29.28
167 INT85280 Positive_regulation of FH 2 0.45 3.53 0.09 29.04
168 INT120519 Localization of XRCC1 15 0.78 17.03 1.51 28.64
169 INT148702 Positive_regulation of UPF1 29 0.31 12.9 1.91 25.76
170 INT241101 Negative_regulation of Gene_expression of FH 2 0.42 3.16 0 21.92
171 INT100376 Positive_regulation of Gene_expression of Vhl 4 0.10 6.47 1.47 18.44
172 INT173086 Negative_regulation of VHL 14 0.59 12.54 0.29 16.92
173 INT49128 Gene_expression of IGF1R 35 0.63 23.48 1.39 11.12
174 INT73223 Gene_expression of UPF1 78 0.41 31.44 9.94 8.32
175 INT241117 Regulation of Gene_expression of Vhl 1 0.06 2.5 0.07 5.52
176 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
177 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
178 INT5780 Regulation of Gene_expression of Calca 90 0.62 59.52 85.03 5.00
179 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 5.00
180 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
181 INT5118 Regulation of SST 97 0.62 34.35 51.74 5.00
182 INT1726 Positive_regulation of Kitl 65 0.70 38.81 44.85 5.00
183 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
184 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
185 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 5.00
186 INT16428 Positive_regulation of Gtf3a 135 0.20 106.44 26.67 5.00
187 INT151758 Gene_expression of PYCARD 91 0.63 14.54 24.27 5.00
188 INT55583 Localization of IFNA1 135 0.78 85.07 24.13 5.00
189 INT3593 Gene_expression of ADRA1D 70 0.75 29.48 20.87 5.00
190 INT14737 Gene_expression of FN1 117 0.78 78.74 18.99 5.00
191 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45 5.00
192 INT68681 Transcription of VEGFA 132 0.71 80.47 17.03 5.00
193 INT2243 Localization of GAST 67 0.81 34.54 16.19 5.00
194 INT37722 Gene_expression of NCAM1 103 0.75 81.57 14.18 5.00
195 INT12464 Binding of MET 38 0.47 10.3 13.15 5.00
196 INT12156 Positive_regulation of MET 43 0.67 17.75 12.64 5.00
197 INT111476 Gene_expression of TP63 88 0.76 61.08 11.64 5.00
198 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 5.00
199 INT70134 Negative_regulation of TXK 124 0.23 81.96 9.59 5.00
200 INT62919 Regulation of Gnas 22 0.43 5.61 9.55 5.00
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox