D:Paragonimiasis

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Disease Term
Synonyms Endemic Hemoptysis, Oriental Lung Fluke, ORIENTAL LUNG FLUKES, PARAGONIMIASES
Documents 37
Hot Single Events 2
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Paragonimiasis. They are ordered first by their relevance to Paragonimiasis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT279131 LTF Positive_regulation of CALR 1 0.03 2.39 0 51.12
2 INT226371 IL18 Positive_regulation of IL4 4 0.05 2.49 0.79 5.00
3 INT300551 TBX21 Regulation of Hand1 2 0.10 0.44 0.48 5.00
4 INT300751 Binding of IGHE and Hand2 1 0.04 0 0.34 5.00
5 INT300727 IL25 Positive_regulation of IL33 Positive_regulation of IL13 1 0.00 0 0.34 5.00
6 INT300732 IL33 Positive_regulation of IL13 1 0.00 0 0.34 5.00
7 INT300728 IL33 Positive_regulation of IL4 1 0.00 0 0.33 5.00
8 INT300729 IL18 Positive_regulation of IL13 1 0.00 0 0.33 5.00
9 INT300742 Stat6 Regulation of Hand2 1 0.01 0.06 0.3 5.00
10 INT300752 GATA3 Regulation of Hand2 1 0.01 0.06 0.3 5.00
11 INT300753 Binding of Cd28 and Positive_regulation of Transcription of IL13 1 0.00 0 0.17 5.00
12 INT304169 Il33 Positive_regulation of Gene_expression of Itgam 1 0.02 1.18 0.15 5.00
13 INT300731 IL10 Negative_regulation of Gene_expression of IGHE 1 0.03 0.23 0.13 5.00
14 INT304172 Il5 Positive_regulation of Bcl2l1 1 0.02 0.91 0.05 5.00
15 INT304170 Binding of Apaf1 and Positive_regulation of Casp9 1 0.01 0.51 0 5.00
16 INT304175 IL1B Positive_regulation of Gene_expression of Vcam1 1 0.02 0.96 0 5.00
17 INT304135 Binding of CEL and Positive_regulation of CASP8 1 0.00 0.52 0 5.00
18 INT285291 TNF Positive_regulation of Gene_expression of Vcam1 2 0.10 3.1 0 5.00
19 INT304176 Binding of IL1B and Il13 1 0.00 0.96 0 5.00
20 INT304167 Il4 Positive_regulation of Gene_expression of Vcam1 1 0.04 0.94 0 5.00
21 INT304168 Binding of Gata1 and Sfpi1 1 0.08 0.07 0 5.00
22 INT304171 Il13 Positive_regulation of Gene_expression of Vcam1 1 0.04 0.89 0 5.00
23 INT304174 Binding of IL1B and Il4 1 0.00 0.96 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Paragonimiasis. They are ordered first by their pain relevance and then by number of times they were reported in Paragonimiasis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT246513 Regulation of IL4I1 2 0.10 2.06 0.15 100.00
2 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 96.46
3 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 77.72
4 INT9081 Positive_regulation of Positive_regulation of IGHE 5 0.42 7.13 1 77.72
5 INT20380 Gene_expression of Il5 172 0.78 104.75 34.78 65.92
6 INT248744 Negative_regulation of STH 2 0.41 1.02 0 59.44
7 INT10303 Regulation of STH 16 0.60 16.14 0.95 51.04
8 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 39.68
9 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 39.68
10 INT147113 Binding of LTF 14 0.29 18.24 0.98 15.24
11 INT80939 Positive_regulation of PDR 8 0.55 5.43 0.67 13.08
12 INT246512 Positive_regulation of IL4I1 2 0.26 1.05 0 13.08
13 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05 6.80
14 INT93046 Positive_regulation of Gene_expression of Hand2 27 0.47 24.54 7.01 6.80
15 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
16 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
17 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
18 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
19 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03 5.00
20 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 5.00
21 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
22 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
23 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
24 INT31116 Gene_expression of Casp3 192 0.78 78.21 57.43 5.00
25 INT110023 Negative_regulation of Mapk14 127 0.59 84.27 45.42 5.00
26 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
27 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 5.00
28 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 5.00
29 INT54302 Positive_regulation of Gene_expression of Il4 126 0.68 86.18 30.75 5.00
30 INT65597 Negative_regulation of Casp3 69 0.59 39.19 29.32 5.00
31 INT15174 Gene_expression of Itgam 238 0.73 104.92 29.26 5.00
32 INT69157 Gene_expression of IL5 127 0.77 102.58 26.81 5.00
33 INT73670 Gene_expression of Vcam1 128 0.78 123.79 24.96 5.00
34 INT4465 Gene_expression of CEL 116 0.77 98.35 23.58 5.00
35 INT8775 Binding of IGHE 167 0.48 102.61 23.54 5.00
36 INT84732 Positive_regulation of Hand2 81 0.69 62.07 22 5.00
37 INT96156 Gene_expression of Cd40 144 0.77 56.95 21.7 5.00
38 INT56301 Positive_regulation of IL4 68 0.56 54.51 18.65 5.00
39 INT112017 Regulation of Hand2 77 0.36 62.23 18.04 5.00
40 INT80755 Gene_expression of CD40 88 0.75 53.68 17.86 5.00
41 INT104045 Regulation of Hand1 65 0.35 51.32 16.26 5.00
42 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 5.00
43 INT109511 Gene_expression of Bax 133 0.78 113.22 14.36 5.00
44 INT3796 Gene_expression of Ighm 130 0.77 69.61 13.78 5.00
45 INT173505 Localization of Hand2 63 0.57 45.32 13.66 5.00
46 INT36263 Positive_regulation of CEL 53 0.69 34.88 12.87 5.00
47 INT69158 Localization of IL4 48 0.71 31.3 11.98 5.00
48 INT701 Localization of IGHE 87 0.80 40.5 10.62 5.00
49 INT15804 Gene_expression of ISG20 83 0.75 44.33 10.58 5.00
50 INT98130 Positive_regulation of CASP8 79 0.67 65.29 10.08 5.00
51 INT35164 Negative_regulation of IGHE 96 0.58 76.3 9.74 5.00
52 INT70134 Negative_regulation of TXK 124 0.23 81.96 9.59 5.00
53 INT85966 Gene_expression of Cd40lg 50 0.73 30.9 9.11 5.00
54 INT2241 Negative_regulation of CEL 56 0.58 29.32 8.83 5.00
55 INT81444 Positive_regulation of Gene_expression of Vcam1 40 0.70 46.38 8.58 5.00
56 INT2971 Regulation of IGHE 42 0.61 28.81 7.87 5.00
57 INT78226 Gene_expression of Mbp 43 0.75 22.14 7.79 5.00
58 INT58365 Gene_expression of LTF 51 0.78 44.14 7.25 5.00
59 INT93003 Binding of CD40 28 0.47 20.25 7.13 5.00
60 INT126984 Positive_regulation of Gene_expression of Il5 29 0.69 20.61 6.72 5.00
61 INT132822 Localization of IL13 26 0.67 22.85 6.66 5.00
62 INT73499 Positive_regulation of IL13 23 0.39 20.03 6.53 5.00
63 INT304151 Gene_expression of Siglec5 2 0.74 17.33 6.03 5.00
64 INT113101 Gene_expression of Ccl11 41 0.76 22.36 5.47 5.00
65 INT56299 Transcription of IL4 15 0.64 10.2 5.44 5.00
66 INT171562 Regulation of IL4 19 0.36 12.12 5.33 5.00
67 INT177526 Negative_regulation of Il5 17 0.36 11.13 5.31 5.00
68 INT117004 Gene_expression of Sfpi1 21 0.75 15.95 5.29 5.00
69 INT62041 Negative_regulation of Gene_expression of IGHE 37 0.58 37.86 5.27 5.00
70 INT18995 Binding of CEL 23 0.47 14.46 4.5 5.00
71 INT108342 Negative_regulation of EPHB2 18 0.57 9.48 4.46 5.00
72 INT72385 Phosphorylation of Shc1 11 0.52 1.62 4.1 5.00
73 INT123752 Regulation of Bax 19 0.60 16.45 4 5.00
74 INT112692 Localization of Bax 31 0.80 20.97 3.98 5.00
75 INT4464 Localization of CEL 21 0.80 8.09 3.88 5.00
76 INT146946 Gene_expression of Lyn 16 0.76 8.9 3.75 5.00
77 INT170528 Negative_regulation of Gene_expression of CD4 25 0.41 17.98 3.6 5.00
78 INT70919 Binding of Il4 19 0.36 6.58 3.59 5.00
79 INT9999 Regulation of Gene_expression of IGHE 32 0.60 15.75 3.53 5.00
80 INT73500 Regulation of IL13 12 0.36 10.37 3.53 5.00
81 INT89966 Negative_regulation of Fas 26 0.58 24.83 3.5 5.00
82 INT188355 Binding of Cd28 25 0.34 8.29 3.38 5.00
83 INT85971 Positive_regulation of Gene_expression of Cd40lg 14 0.66 7.61 3.29 5.00
84 INT64234 Regulation of Bcl2 41 0.54 31.88 3.16 5.00
85 INT114276 Gene_expression of Nr4a1 20 0.77 7.71 3.14 5.00
86 INT98226 Negative_regulation of Cd79a 5 0.49 3.99 2.66 5.00
87 INT28815 Gene_expression of Ighd 18 0.65 11.02 2.48 5.00
88 INT118871 Negative_regulation of JAK2 15 0.57 11.4 2.16 5.00
89 INT98225 Regulation of Il5 8 0.45 5.07 2.06 5.00
90 INT221431 Negative_regulation of FOXP3 8 0.40 9.92 1.98 5.00
91 INT38268 Positive_regulation of BEST1 16 0.17 14.54 1.93 5.00
92 INT129240 Positive_regulation of Stat6 6 0.67 1.96 1.92 5.00
93 INT20377 Gene_expression of Il3 8 0.65 0.82 1.77 5.00
94 INT186269 Binding of Il13 9 0.39 7.7 1.64 5.00
95 INT113340 Phosphorylation of JAK2 17 0.78 5.69 1.6 5.00
96 INT114279 Positive_regulation of Nr4a1 9 0.59 3.37 1.59 5.00
97 INT114862 Gene_expression of BEST1 16 0.65 12.14 1.53 5.00
98 INT114270 Gene_expression of Plscr1 6 0.47 1.33 1.49 5.00
99 INT100672 Transcription of Hand2 9 0.42 2.84 1.47 5.00
100 INT152223 Binding of BEST1 10 0.29 6.67 1.46 5.00
101 INT179169 Transcription of IL13 11 0.15 4.22 1.37 5.00
102 INT254666 Positive_regulation of Map2k2 37 0.56 23.85 1.35 5.00
103 INT112695 Negative_regulation of Protein_catabolism of Bax 3 0.36 1.72 1.3 5.00
104 INT102200 Gene_expression of Nr4a2 9 0.72 3.69 1.28 5.00
105 INT167056 Gene_expression of CALR 29 0.75 20.05 1.25 5.00
106 INT112693 Protein_catabolism of Bax 5 0.74 3.17 1.2 5.00
107 INT114272 Regulation of Gene_expression of Nr4a1 5 0.45 1.82 1.14 5.00
108 INT117002 Negative_regulation of Sfpi1 16 0.58 9.72 1 5.00
109 INT73450 Gene_expression of Pilra 7 0.05 2.87 0.97 5.00
110 INT21940 Positive_regulation of CALR 15 0.40 17.42 0.95 5.00
111 INT123948 Positive_regulation of Plscr1 4 0.42 1.02 0.93 5.00
112 INT228727 Transcription of Il5 4 0.27 5.13 0.9 5.00
113 INT160830 Gene_expression of Siglece 6 0.39 2.37 0.85 5.00
114 INT150165 Gene_expression of MTTP 21 0.75 10.1 0.73 5.00
115 INT94300 Negative_regulation of Gene_expression of Mbp 6 0.44 1.79 0.7 5.00
116 INT304148 Gene_expression of Csf2ra 1 0.36 2.09 0.65 5.00
117 INT59792 Gene_expression of STH 14 0.75 15.2 0.61 5.00
118 INT147554 Gene_expression of Birc2 11 0.75 10.93 0.6 5.00
119 INT162801 Localization of CALR 7 0.73 8.69 0.6 5.00
120 INT73524 Positive_regulation of Ear1 7 0.27 4.82 0.54 5.00
121 INT125821 Regulation of Positive_regulation of IGHE 6 0.40 5.38 0.53 5.00
122 INT163925 Localization of Epx 3 0.51 2.23 0.39 5.00
123 INT98745 Regulation of Ear1 2 0.51 0.36 0.38 5.00
124 INT181020 Positive_regulation of Gene_expression of Sfpi1 2 0.67 1.11 0.31 5.00
125 INT304143 Negative_regulation of Transcription of Il5 1 0.08 1 0.3 5.00
126 INT280707 Gene_expression of Cebpg 4 0.75 0.37 0.29 5.00
127 INT304144 Localization of Csf2ra 1 0.32 0.3 0.27 5.00
128 INT263492 Positive_regulation of Regulation of Hand2 3 0.19 4.76 0.21 5.00
129 INT181036 Positive_regulation of Sfpi1 3 0.49 0.96 0.21 5.00
130 INT304142 Negative_regulation of Phosphorylation of Lyn 1 0.12 1.11 0.2 5.00
131 INT199771 Localization of Ahr 8 0.70 4.86 0.2 5.00
132 INT261820 Phosphorylation of Lyn 5 0.30 1.41 0.2 5.00
133 INT304145 Phosphorylation of Grb2 1 0.03 0.72 0.2 5.00
134 INT284968 Positive_regulation of CDA 2 0.05 0.34 0.15 5.00
135 INT304137 Regulation of Localization of Bax 2 0.24 1.7 0.09 5.00
136 INT304139 Gene_expression of Ccl26 1 0.36 1.33 0.08 5.00
137 INT304149 Positive_regulation of Transcription of Il5 1 0.09 1.81 0.08 5.00
138 INT300743 Regulation of MS4A2 1 0.00 0.62 0.06 5.00
139 INT304173 Binding of SIGLEC8 1 0.07 1.18 0.06 5.00
140 INT304136 Positive_regulation of Fip1l1 1 0.24 1.7 0.05 5.00
141 INT241509 Negative_regulation of Gene_expression of Lyn 2 0.20 1.02 0.05 5.00
142 INT182438 Localization of MPG 3 0.30 1.43 0.04 5.00
143 INT275621 Positive_regulation of Atcay 3 0.06 2.15 0.04 5.00
144 INT201641 Binding of Apaf1 3 0.16 2.36 0.03 5.00
145 INT304150 Regulation of Irf8 1 0.17 0.07 0.03 5.00
146 INT300746 Gene_expression of MS4A2 1 0.01 0.25 0 5.00
147 INT304140 Regulation of Negative_regulation of Casp3 1 0.05 0.67 0 5.00
148 INT300748 Negative_regulation of Negative_regulation of IGHE 1 0.38 0.55 0 5.00
149 INT304141 Positive_regulation of Localization of Epx 1 0.22 0.72 0 5.00
150 INT300749 Binding of MS4A2 1 0.00 0.38 0 5.00
151 INT304147 Gene_expression of Fip1l1 1 0.32 2.07 0 5.00
152 INT300747 Positive_regulation of Negative_regulation of IGHE 1 0.41 0.63 0 5.00
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