D:Parakeratosis

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Disease Term
Synonyms PARAKERATOSES
Documents 38
Hot Single Events 6
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Parakeratosis. They are ordered first by their relevance to Parakeratosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT329801 Binding of CAMP and IFNA1 1 0.03 1.48 0.4 64.60
2 INT313915 Binding of Il12a and Il23a 2 0.16 0.44 0.31 25.64
3 INT313914 Binding of Il12a and Il23r 1 0.14 0.44 0.13 25.64
4 INT313913 Binding of Il23a and Il23r 1 0.24 0.43 0.13 25.00
5 INT306732 Il17a Positive_regulation of Gene_expression of Il2 1 0.09 1.07 0.46 23.24
6 INT306731 Il22 Positive_regulation of Gene_expression of Il2 1 0.12 1.07 0.46 22.84
7 INT306745 Binding of Il12a and IL23A 1 0.10 3.25 1.56 5.00
8 INT329794 TLR2 Positive_regulation of Positive_regulation of IL12A 1 0.01 1.05 0.44 5.00
9 INT329803 TLR2 Positive_regulation of Positive_regulation of IL6 1 0.01 0.94 0.41 5.00
10 INT329800 TLR2 Positive_regulation of Positive_regulation of IL8 1 0.01 0.99 0.41 5.00
11 INT329799 Binding of CD14 and LY96 2 0.04 1.02 0.39 5.00
12 INT325028 TNF Negative_regulation of Ptgs1 1 0.00 1.79 0.23 5.00
13 INT325008 TNF Negative_regulation of Gene_expression of NOSTRIN 1 0.00 1.78 0.23 5.00
14 INT325007 TNF Negative_regulation of NOSTRIN 1 0.00 1.78 0.23 5.00
15 INT306714 IL23A Positive_regulation of TNF 1 0.29 0.5 0.21 5.00
16 INT306746 Il12a Positive_regulation of TNF 1 0.24 0.5 0.21 5.00
17 INT306744 IL23A Positive_regulation of Il12a 1 0.13 0.59 0.2 5.00
18 INT329795 IL6 Positive_regulation of Transcription of CCL5 1 0.02 0.59 0.17 5.00
19 INT306747 IL23A Positive_regulation of Il17a 1 0.05 0.51 0.16 5.00
20 INT329796 TICAM1 Positive_regulation of IFNA1 2 0.02 0.89 0.15 5.00
21 INT329797 Positive_regulation of TLR2 Positive_regulation of Gene_expression of IL6 1 0.02 1.67 0.11 5.00
22 INT329802 Positive_regulation of TLR2 Regulation of Gene_expression of IL6 1 0.01 1.67 0.11 5.00
23 INT329798 Binding of MYD88 and TICAM1 2 0.01 0.24 0.1 5.00
24 INT325027 Apoc3 Negative_regulation of Pnlip 1 0.01 1.02 0.04 5.00
25 INT325026 Apoc3 Negative_regulation of Lpl 1 0.03 1.01 0.04 5.00
26 INT325025 Apoa2 Positive_regulation of Hdl1 1 0.05 1.03 0.04 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Parakeratosis. They are ordered first by their pain relevance and then by number of times they were reported in Parakeratosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT39244 Gene_expression of TMPO 137 0.77 14.55 11.83 88.48
2 INT310442 Gene_expression of POLA1 1 0.30 0.97 0 88.48
3 INT72651 Gene_expression of TH1L 114 0.75 80.15 35.15 87.92
4 INT118381 Gene_expression of Il17a 405 0.76 306.97 112.06 87.20
5 INT296054 Positive_regulation of Il22 13 0.33 17.97 4.06 84.96
6 INT160564 Gene_expression of Il22 64 0.55 59.29 20.9 84.96
7 INT756 Gene_expression of C3 138 0.75 100.6 19.2 67.04
8 INT310439 Regulation of POLA1 1 0.24 2.21 0 65.92
9 INT79413 Gene_expression of CAMP 13 0.75 8.3 4.02 65.16
10 INT79412 Positive_regulation of Gene_expression of CAMP 5 0.49 3.73 1.55 65.16
11 INT48066 Binding of CAMP 3 0.36 2.69 0.93 64.60
12 INT133028 Gene_expression of TLR2 209 0.73 131.92 36.17 62.72
13 INT133030 Positive_regulation of Gene_expression of TLR2 53 0.65 38.15 10.65 62.72
14 INT204529 Positive_regulation of TLR9 18 0.62 15.62 3.99 61.56
15 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 60.16
16 INT175312 Positive_regulation of Gene_expression of IL23A 17 0.45 14.8 5.05 58.68
17 INT285489 Positive_regulation of Gene_expression of Il22 9 0.32 10.97 3.63 58.68
18 INT161515 Positive_regulation of Gene_expression of Il17a 50 0.64 41.52 13.82 58.68
19 INT226463 Positive_regulation of IL23A 23 0.45 21.58 9.18 58.68
20 INT306735 Positive_regulation of Positive_regulation of IL23A 4 0.26 3.25 1.04 58.68
21 INT306727 Positive_regulation of Positive_regulation of Il22 1 0.12 1.26 0.3 58.68
22 INT168263 Gene_expression of IL23A 57 0.58 47.1 17.67 58.08
23 INT104045 Regulation of Hand1 65 0.35 51.32 16.26 55.44
24 INT285510 Regulation of Localization of Hand1 6 0.14 6.13 1.61 55.44
25 INT20378 Localization of Hand1 53 0.71 41.96 13.31 53.92
26 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 52.44
27 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33 51.08
28 INT246031 Gene_expression of IL22 10 0.40 9.48 5.11 51.08
29 INT6852 Localization of TNF 883 0.81 705.95 270.84 47.96
30 INT306726 Localization of Il22 4 0.57 5.52 2.57 47.96
31 INT310443 Negative_regulation of POLA1 1 0.16 0.31 0 41.08
32 INT224648 Gene_expression of Il21 15 0.39 18.71 7.47 39.28
33 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 38.16
34 INT9656 Regulation of Gene_expression of Il6 57 0.62 33.3 17.71 38.16
35 INT135411 Gene_expression of Il23a 76 0.72 72.87 26.15 36.80
36 INT9660 Regulation of TNF 363 0.62 312.94 139.99 35.68
37 INT285470 Regulation of Il22 4 0.11 4.18 1.21 35.68
38 INT39243 Regulation of TMPO 20 0.61 5.66 2.67 32.48
39 INT163269 Binding of Il23a 11 0.44 7.2 3.14 31.04
40 INT160565 Gene_expression of Il23r 6 0.56 10.01 4.51 27.88
41 INT235510 Binding of Il17a 14 0.34 10.67 3.99 23.24
42 INT306723 Binding of Il22 3 0.11 2.44 0.97 22.84
43 INT11807 Gene_expression of Il2 266 0.78 112 64.97 21.52
44 INT11804 Positive_regulation of Gene_expression of Il2 70 0.70 33 21.63 21.52
45 INT91667 Localization of IL12A 39 0.74 25.51 7.36 15.72
46 INT100540 Localization of SOAT1 9 0.78 2.67 1.42 12.56
47 INT174553 Localization of Stat1 17 0.80 6.62 0.73 11.60
48 INT192965 Localization of Stat3 15 0.74 7.05 1.68 11.32
49 INT313912 Localization of Stat4 1 0.24 0.33 0.08 11.04
50 INT313905 Localization of Stat5a 1 0.21 0.33 0.08 10.60
51 INT269406 Binding of TMPO 35 0.31 1.43 1.82 9.52
52 INT306739 Positive_regulation of Gene_expression of IL22 2 0.28 2.2 1.36 7.88
53 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
54 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
55 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
56 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
57 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
58 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
59 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
60 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
61 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
62 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
63 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 5.00
64 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 5.00
65 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
66 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
67 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
68 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
69 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 5.00
70 INT84546 Positive_regulation of Ppara 481 0.70 334.21 83.45 5.00
71 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 5.00
72 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 5.00
73 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
74 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 5.00
75 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 5.00
76 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42 5.00
77 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 5.00
78 INT9210 Regulation of IL6 166 0.62 125.61 49.95 5.00
79 INT20345 Gene_expression of Dbi 136 0.78 56.41 46.2 5.00
80 INT18522 Positive_regulation of Gene_expression of IFNA1 248 0.67 160.85 44.87 5.00
81 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 5.00
82 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 5.00
83 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 5.00
84 INT6484 Binding of IL1B 122 0.47 75.84 35.07 5.00
85 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 5.00
86 INT52350 Gene_expression of CD14 184 0.75 71.37 33.13 5.00
87 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2 5.00
88 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 5.00
89 INT122039 Positive_regulation of Gene_expression of Ppara 144 0.68 113.55 28.55 5.00
90 INT133876 Positive_regulation of Gene_expression of Ros1 141 0.32 75.55 27.45 5.00
91 INT116861 Gene_expression of Apoe 182 0.78 100.41 27.26 5.00
92 INT69036 Gene_expression of IL18 99 0.77 77.92 25.95 5.00
93 INT9886 Gene_expression of Ptgs1 92 0.77 40.66 25.31 5.00
94 INT10836 Negative_regulation of IL8 95 0.59 52.59 24.71 5.00
95 INT10835 Regulation of IL8 79 0.49 53.04 24.14 5.00
96 INT55583 Localization of IFNA1 135 0.78 85.07 24.13 5.00
97 INT69322 Negative_regulation of MAPK14 70 0.54 42.92 22.71 5.00
98 INT18322 Negative_regulation of Ins1 132 0.58 88.49 22.59 5.00
99 INT150022 Positive_regulation of Il17a 69 0.64 70.04 21.87 5.00
100 INT60690 Positive_regulation of Gene_expression of Il12a 69 0.63 41.41 20.85 5.00
101 INT14701 Negative_regulation of IFNA1 118 0.54 84.19 20.08 5.00
102 INT88949 Positive_regulation of Il12a 79 0.60 47.68 19.98 5.00
103 INT117220 Positive_regulation of TLR4 64 0.69 53.61 17.33 5.00
104 INT34057 Negative_regulation of Gene_expression of IFNA1 65 0.58 43.46 17.25 5.00
105 INT94467 Positive_regulation of Hand1 71 0.58 59 16.96 5.00
106 INT45142 Gene_expression of DCPS 109 0.56 84.71 16.87 5.00
107 INT93948 Negative_regulation of Gene_expression of Il12a 48 0.55 27.77 16.87 5.00
108 INT103757 Negative_regulation of Il12a 37 0.55 21.62 16.38 5.00
109 INT52107 Transcription of IL8 63 0.72 41.66 16.06 5.00
110 INT7475 Positive_regulation of Hdl1 138 0.67 175.81 15.05 5.00
111 INT61624 Positive_regulation of Gene_expression of IL12A 50 0.56 33.07 13.07 5.00
112 INT117222 Positive_regulation of Gene_expression of TLR4 80 0.70 51.6 12.9 5.00
113 INT94464 Negative_regulation of Hand1 44 0.41 31.5 12.39 5.00
114 INT8547 Gene_expression of MUC16 116 0.78 75.97 12.18 5.00
115 INT87239 Localization of Il12a 51 0.75 31.95 12.05 5.00
116 INT111476 Gene_expression of TP63 88 0.76 61.08 11.64 5.00
117 INT102272 Regulation of TH1L 41 0.44 30.89 11.63 5.00
118 INT8546 Positive_regulation of MUC16 99 0.69 74.98 11.26 5.00
119 INT6515 Gene_expression of BGLAP 110 0.75 45.13 10.81 5.00
120 INT62895 Gene_expression of NOSTRIN 51 0.75 28.8 10.68 5.00
121 INT133172 Gene_expression of Il12b 98 0.75 52.16 10.68 5.00
122 INT58904 Localization of TH1L 40 0.68 27.11 10.52 5.00
123 INT150540 Binding of TLR2 50 0.45 35.86 10.43 5.00
124 INT159631 Positive_regulation of DCPS 60 0.27 43.23 10.3 5.00
125 INT95565 Positive_regulation of IL12A 47 0.56 33.96 10.16 5.00
126 INT123142 Gene_expression of DEFB4A 54 0.76 36.14 10.02 5.00
127 INT6516 Positive_regulation of BGLAP 45 0.67 26.61 9.9 5.00
128 INT81929 Negative_regulation of Gene_expression of IL10 41 0.57 27.99 9.87 5.00
129 INT107307 Transcription of IFNA1 30 0.52 18.16 9.61 5.00
130 INT13467 Positive_regulation of ABCB1 36 0.68 9.68 8.95 5.00
131 INT82839 Negative_regulation of ABCB1 61 0.59 16.09 8.83 5.00
132 INT17686 Negative_regulation of Hdl1 72 0.36 81.85 7.74 5.00
133 INT39242 Negative_regulation of TMPO 29 0.58 5.15 7.04 5.00
134 INT111377 Positive_regulation of Ifih1 16 0.60 11.22 6.99 5.00
135 INT142264 Positive_regulation of Apoe 47 0.50 26.35 6.94 5.00
136 INT81493 Transcription of CCL2 20 0.65 13.63 6.78 5.00
137 INT194479 Phosphorylation of Ppara 47 0.81 30.36 6.6 5.00
138 INT228469 Negative_regulation of Il17a 19 0.54 18.76 6.43 5.00
139 INT31582 Gene_expression of Hdl1 103 0.66 118.95 6.42 5.00
140 INT77945 Regulation of Gene_expression of Il12a 19 0.58 6.55 6.4 5.00
141 INT137206 Positive_regulation of TLR2 47 0.65 33.36 6.4 5.00
142 INT56803 Positive_regulation of Bcl2a1a 12 0.47 7.29 5.65 5.00
143 INT35536 Negative_regulation of CAT 26 0.57 14.39 5.38 5.00
144 INT106189 Regulation of Il12a 18 0.44 12.4 5.3 5.00
145 INT170470 Binding of CD14 27 0.35 14.89 5.16 5.00
146 INT135291 Positive_regulation of Positive_regulation of Mapk8 24 0.64 19.37 5.16 5.00
147 INT180379 Gene_expression of Olr1 31 0.36 36.46 4.84 5.00
148 INT24889 Negative_regulation of CABIN1 36 0.48 16.76 4.73 5.00
149 INT181886 Gene_expression of Apoa1 40 0.64 40.53 4.56 5.00
150 INT230810 Phosphorylation of Ins1 59 0.69 41.15 4.51 5.00
151 INT98251 Binding of IL12A 20 0.37 16.03 4.51 5.00
152 INT178751 Positive_regulation of TMPO 51 0.44 1.47 4.41 5.00
153 INT24332 Regulation of Hdl1 28 0.45 45.45 4.26 5.00
154 INT97131 Positive_regulation of CD14 25 0.67 12.03 4.21 5.00
155 INT11230 Regulation of MUC16 23 0.60 19.54 3.93 5.00
156 INT173519 Positive_regulation of Localization of IFNA1 27 0.49 24.48 3.9 5.00
157 INT176208 Gene_expression of Nr1h2 27 0.59 22.75 3.84 5.00
158 INT103281 Transcription of CCL5 10 0.67 5.95 3.7 5.00
159 INT144231 Gene_expression of Il12b 18 0.75 12.93 3.65 5.00
160 INT133169 Positive_regulation of Il12b 25 0.49 13 3.64 5.00
161 INT174160 Binding of Il12a 19 0.24 12.61 3.4 5.00
162 INT12844 Binding of TP63 15 0.47 10.57 3.38 5.00
163 INT167478 Positive_regulation of Gene_expression of DCPS 23 0.27 14.75 3.37 5.00
164 INT97138 Positive_regulation of Gene_expression of CD14 17 0.48 9.07 3.35 5.00
165 INT250884 Binding of IL23A 5 0.19 7.17 3.17 5.00
166 INT174117 Gene_expression of Cd1d1 26 0.75 12.07 3.07 5.00
167 INT186805 Transcription of TLR2 12 0.63 9.66 3.04 5.00
168 INT11775 Gene_expression of Ema 39 0.65 38.12 2.99 5.00
169 INT181848 Negative_regulation of CD14 16 0.43 8.14 2.95 5.00
170 INT133174 Positive_regulation of Gene_expression of Il12b 29 0.15 13.04 2.92 5.00
171 INT1631 Binding of Hdl1 42 0.36 49.22 2.92 5.00
172 INT114181 Negative_regulation of Positive_regulation of Il12a 7 0.34 3.65 2.82 5.00
173 INT8545 Negative_regulation of MUC16 19 0.57 15.96 2.81 5.00
174 INT139562 Transcription of IL18 10 0.68 6.14 2.73 5.00
175 INT181880 Positive_regulation of Apoa1 19 0.66 21.19 2.43 5.00
176 INT207852 Positive_regulation of Olr1 9 0.12 9.76 2.26 5.00
177 INT250888 Negative_regulation of IL23A 4 0.30 6.13 2.15 5.00
178 INT105378 Regulation of IL12A 6 0.26 8.82 2.15 5.00
179 INT186893 Binding of BGLAP 10 0.37 6.19 2.02 5.00
180 INT258780 Regulation of Il23a 6 0.13 4.77 1.96 5.00
181 INT190883 Gene_expression of Apoc3 16 0.38 14.18 1.93 5.00
182 INT222903 Gene_expression of TLR1 20 0.60 8.77 1.9 5.00
183 INT11033 Positive_regulation of Gene_expression of MUC16 21 0.69 15.75 1.89 5.00
184 INT120014 Transcription of CCL3 5 0.69 3.03 1.82 5.00
185 INT102751 Positive_regulation of polymerase 7 0.10 3.06 1.81 5.00
186 INT38266 Localization of PTPRC 30 0.68 17.05 1.68 5.00
187 INT113985 Positive_regulation of TP63 9 0.50 8.79 1.62 5.00
188 INT157769 Binding of LY96 8 0.47 2.5 1.59 5.00
189 INT163666 Localization of Cat 8 0.80 5.84 1.57 5.00
190 INT193823 Positive_regulation of Gene_expression of TP63 7 0.18 7.74 1.57 5.00
191 INT110028 Transcription of Il12a 6 0.49 1.48 1.51 5.00
192 INT194461 Positive_regulation of Chol1 11 0.67 6.46 1.45 5.00
193 INT217388 Negative_regulation of Gene_expression of Apoe 11 0.59 6.07 1.4 5.00
194 INT285482 Negative_regulation of Il22 3 0.30 3.02 1.37 5.00
195 INT35271 Negative_regulation of Apcs 12 0.59 8.05 1.36 5.00
196 INT157817 Negative_regulation of Il23a 6 0.39 3.34 1.33 5.00
197 INT37253 Negative_regulation of PTPRC 12 0.37 6.13 1.26 5.00
198 INT11887 Localization of MUC16 16 0.80 10.66 1.26 5.00
199 INT146914 Negative_regulation of TLR2 12 0.53 7.41 1.23 5.00
200 INT118817 Positive_regulation of Apoc4 6 0.45 6.44 1.23 5.00
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