D:Paranasal Sinus Disease

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Disease Term
Synonyms Disease Of Accessory Sinus, DISEASE OF NASAL SINUS, Disease Paranasal Sinus, Disease Syndrome Of The Paranasal Sinuses, DISEASES PARANASAL SINUS, Disorder Of Paranasal Sinuses, Paranasal Sinus, Paranasal Sinus Diseases, Sinus Disease Paranasal, SINUS DISEASES PARANASAL
Documents 209
Hot Single Events 19
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Paranasal Sinus Disease. They are ordered first by their relevance to Paranasal Sinus Disease and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT199436 Binding of Capns1 and Cysltr1 1 0.00 0.79 0.1 33.16
2 INT193218 Binding of PTGER1 and PTGER2 3 0.12 2.31 0.66 5.00
3 INT193219 Binding of LTC4S and CYSLTR2 2 0.28 2.2 0.44 5.00
4 INT193217 Binding of PTGER2 and PTGER3 2 0.10 1.31 0.43 5.00
5 INT304098 Binding of Il13 and Aia1 1 0.01 5.78 0.41 5.00
6 INT304102 Il13 Positive_regulation of Gene_expression of IGHE 1 0.25 2.65 0.4 5.00
7 INT304099 Binding of IGHE and Il13 1 0.17 4.13 0.38 5.00
8 INT299557 Binding of CRS and SQLE 1 0.00 0.7 0.29 5.00
9 INT299592 SQLE Regulation of RatNP-3b 1 0.01 0.99 0.22 5.00
10 INT193215 Binding of CYSLTR1 and CYSLTR2 2 0.09 1.7 0.21 5.00
11 INT304104 Il13 Positive_regulation of Positive_regulation of AHR 1 0.14 2.6 0.19 5.00
12 INT193214 Binding of PTGER2 and PTGER4 2 0.08 2.51 0.18 5.00
13 INT193216 Binding of LTC4S and CYSLTR1 1 0.04 0.71 0.16 5.00
14 INT304094 Binding of AHR and SNRNP70 1 0.00 2.64 0.14 5.00
15 INT304100 Binding of CCL11 and Il13 1 0.05 0.86 0.08 5.00
16 INT304103 Il13 Positive_regulation of Gene_expression of CCL11 1 0.64 0.69 0.04 5.00
17 INT304101 Il13 Positive_regulation of CCL11 1 0.43 0.69 0.04 5.00
18 INT299556 SQLE Regulation of CRS 1 0.00 0.77 0.03 5.00
19 INT304093 Binding of IL10 and TGFB1 1 0.02 1.21 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Paranasal Sinus Disease. They are ordered first by their pain relevance and then by number of times they were reported in Paranasal Sinus Disease. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT71308 Gene_expression of CCL11 33 0.76 25.66 7.83 98.80
2 INT55114 Gene_expression of CRS 42 0.58 26.86 4.69 98.40
3 INT77652 Negative_regulation of Gene_expression of IL8 99 0.59 67.57 30.21 97.72
4 INT63839 Binding of CRS 31 0.41 34.05 4.7 97.36
5 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 97.32
6 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57 92.64
7 INT39196 Localization of Aia1 2 0.04 2.63 0.41 91.92
8 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 90.08
9 INT10836 Negative_regulation of IL8 95 0.59 52.59 24.71 87.52
10 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05 86.60
11 INT168373 Gene_expression of Capns1 4 0.58 4.55 1.34 85.04
12 INT1760 Gene_expression of PTGER2 524 0.57 226.94 96.4 83.40
13 INT27018 Gene_expression of PTGER1 68 0.75 31.76 20.12 83.40
14 INT107619 Gene_expression of PTGER3 42 0.75 15 5.61 83.40
15 INT80712 Gene_expression of PTGER4 21 0.65 13.08 5.03 83.40
16 INT193263 Transcription of CYSLTR2 1 0.19 1.11 0.12 83.40
17 INT193259 Transcription of LTB4R2 1 0.24 1.11 0.12 83.40
18 INT193252 Transcription of LTB4R 1 0.33 1.11 0.12 83.40
19 INT193262 Transcription of CYSLTR1 1 0.36 1.11 0.12 83.40
20 INT74507 Protein_catabolism of PRTN3 4 0.87 1.14 0.52 78.20
21 INT51685 Gene_expression of LTB4R 87 0.58 68.69 31.72 78.04
22 INT4808 Gene_expression of LTC4S 37 0.73 18.36 9.62 78.04
23 INT144292 Binding of Ppt1 9 0.37 2.02 1.71 75.52
24 INT13634 Gene_expression of CYSLTR1 19 0.75 11.24 2.88 68.12
25 INT37895 Positive_regulation of Gene_expression of CYSLTR1 4 0.48 2.97 0.44 68.12
26 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 65.20
27 INT193257 Positive_regulation of CYSLTR2 4 0.18 1.81 0.27 62.96
28 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 58.92
29 INT211181 Protein_catabolism of IGHE 1 0.07 1.28 0.25 51.32
30 INT16966 Positive_regulation of CRS 23 0.60 22.5 3.49 48.88
31 INT8775 Binding of IGHE 167 0.48 102.61 23.54 47.04
32 INT145801 Negative_regulation of Binding of Cysltr1 2 0.39 1.89 0.35 46.48
33 INT100892 Positive_regulation of GCLC 8 0.68 3.44 1.08 40.96
34 INT101819 Positive_regulation of Positive_regulation of GCLC 2 0.59 1.47 0.15 40.96
35 INT40104 Binding of Cysltr1 11 0.38 4.56 1.95 40.64
36 INT49436 Binding of TRPV1 145 0.48 38.35 55.08 38.80
37 INT49325 Gene_expression of Cd34 102 0.78 82.75 8.97 36.64
38 INT21679 Negative_regulation of PTGER1 10 0.26 4.59 2.85 33.84
39 INT128937 Negative_regulation of PTGER3 8 0.23 4.49 1.01 33.84
40 INT14166 Positive_regulation of Ahr 32 0.61 20.78 7.47 25.60
41 INT311687 Binding of 119L04aR 2 0.01 0.61 0 24.32
42 INT22875 Regulation of CRS 16 0.39 14.33 2.69 18.56
43 INT192653 Binding of Capns1 8 0.26 9.94 0.51 18.32
44 INT171878 Binding of SQLE 8 0.04 4 0.63 16.48
45 INT37907 Positive_regulation of Capns1 9 0.41 3.55 4.1 14.32
46 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
47 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
48 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
49 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
50 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
51 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
52 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
53 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
54 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
55 INT100939 Gene_expression of Il13 176 0.73 125.1 43.38 5.00
56 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
57 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
58 INT16323 Gene_expression of pr 62 0.66 36.14 38.26 5.00
59 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
60 INT79060 Gene_expression of NOS2 116 0.78 69.25 34.84 5.00
61 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 5.00
62 INT169180 Binding of SNRNP70 204 0.47 119.1 29.3 5.00
63 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
64 INT1765 Positive_regulation of Gene_expression of PTGER2 140 0.51 68.68 27 5.00
65 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 5.00
66 INT1761 Positive_regulation of PTGER2 135 0.49 90.17 26.26 5.00
67 INT73670 Gene_expression of Vcam1 128 0.78 123.79 24.96 5.00
68 INT79061 Positive_regulation of NOS2 92 0.65 58.89 23.96 5.00
69 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14 5.00
70 INT1764 Negative_regulation of Gene_expression of PTGER2 81 0.34 34.74 19.45 5.00
71 INT10833 Regulation of Gene_expression of IL8 68 0.62 38.74 18.46 5.00
72 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42 5.00
73 INT17442 Gene_expression of ALOX5 110 0.75 51.55 18.29 5.00
74 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 5.00
75 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 5.00
76 INT3400 Positive_regulation of pr 57 0.68 36.9 16.24 5.00
77 INT52107 Transcription of IL8 63 0.72 41.66 16.06 5.00
78 INT100938 Positive_regulation of Il13 47 0.69 42.11 14.36 5.00
79 INT7997 Gene_expression of Ltc4s 51 0.76 34.28 13.8 5.00
80 INT120901 Positive_regulation of Gene_expression of Il13 36 0.57 31.63 13.36 5.00
81 INT33358 Gene_expression of Cysltr1 46 0.62 24.18 13.36 5.00
82 INT39046 Positive_regulation of PTGER1 28 0.69 18.18 13.21 5.00
83 INT10870 Regulation of IgG 67 0.59 43.27 12.74 5.00
84 INT22030 Negative_regulation of Cysltr1 31 0.39 21.83 12.49 5.00
85 INT79545 Positive_regulation of Gene_expression of ESR1 82 0.64 39.42 12.18 5.00
86 INT73829 Positive_regulation of Gene_expression of VCAM1 41 0.61 35.96 11.92 5.00
87 INT16772 Gene_expression of MPO 81 0.78 90.98 11.9 5.00
88 INT1762 Negative_regulation of PTGER2 64 0.43 28.21 11.27 5.00
89 INT701 Localization of IGHE 87 0.80 40.5 10.62 5.00
90 INT18833 Positive_regulation of LTB4R 19 0.69 27.61 10.17 5.00
91 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 5.00
92 INT81444 Positive_regulation of Gene_expression of Vcam1 40 0.70 46.38 8.58 5.00
93 INT22481 Gene_expression of CADM1 28 0.65 30.26 8.5 5.00
94 INT13539 Gene_expression of LTA 39 0.62 22.55 8.07 5.00
95 INT5822 Gene_expression of Ltb4r1 51 0.76 37.43 7.2 5.00
96 INT10505 Gene_expression of Ptafr 18 0.62 10.7 6.83 5.00
97 INT35486 Regulation of PTGER2 39 0.36 19.03 6.75 5.00
98 INT34767 Gene_expression of PTGIR 36 0.42 14.79 6.69 5.00
99 INT16068 Gene_expression of SERPINB1 27 0.60 20.51 6.56 5.00
100 INT181525 Localization of Il13 24 0.66 21.51 6.55 5.00
101 INT7205 Positive_regulation of HBG1 65 0.69 40.35 6.37 5.00
102 INT127062 Positive_regulation of Gene_expression of LTB4R 18 0.34 15.9 5.64 5.00
103 INT96234 Localization of Il13 11 0.62 10.94 5.48 5.00
104 INT89104 Binding of TGFB1 29 0.44 13.67 5.12 5.00
105 INT17489 Regulation of F13A1 28 0.45 15.79 4.93 5.00
106 INT142162 Binding of IL10 30 0.37 21.9 4.84 5.00
107 INT10605 Positive_regulation of Ltc4s 21 0.68 17.22 4.8 5.00
108 INT8773 Gene_expression of HBG1 58 0.76 37.6 4.59 5.00
109 INT29668 Regulation of PTGER1 9 0.45 5.52 4.5 5.00
110 INT170988 Positive_regulation of CYSLTR1 15 0.34 6.23 4.44 5.00
111 INT50595 Positive_regulation of HRASLS 16 0.49 9.65 4.24 5.00
112 INT14165 Negative_regulation of Ahr 14 0.51 8.35 4.17 5.00
113 INT20743 Positive_regulation of Gene_expression of Ltc4s 13 0.60 12.3 3.86 5.00
114 INT76339 Positive_regulation of Ltb4r1 23 0.45 22.78 3.58 5.00
115 INT85130 Regulation of IL5 14 0.27 8.37 3.55 5.00
116 INT115921 Positive_regulation of AHR 22 0.49 12.03 3.53 5.00
117 INT79270 Gene_expression of MKI67 113 0.77 63.52 3.38 5.00
118 INT16969 Negative_regulation of CRS 28 0.37 14.77 3.35 5.00
119 INT84020 Positive_regulation of RNASE3 17 0.47 11.92 2.92 5.00
120 INT4811 Positive_regulation of Gene_expression of LTC4S 5 0.65 3.29 2.92 5.00
121 INT85078 Positive_regulation of PCNA 36 0.49 17.06 2.81 5.00
122 INT104035 Gene_expression of LTB4R2 12 0.66 7.41 2.76 5.00
123 INT78702 Positive_regulation of CCL11 13 0.68 12.94 2.74 5.00
124 INT11235 Positive_regulation of IFNA2 27 0.69 15.32 2.57 5.00
125 INT193251 Binding of CYSLTR1 13 0.32 8.32 2.57 5.00
126 INT36338 Gene_expression of NRP2 29 0.67 6.47 2.4 5.00
127 INT96876 Gene_expression of AHR 20 0.77 10.43 2.39 5.00
128 INT55952 Transcription of TP53 16 0.61 12.14 2.36 5.00
129 INT77651 Negative_regulation of Transcription of IL8 8 0.43 4.48 2.16 5.00
130 INT140650 Positive_regulation of Gene_expression of CCL11 10 0.68 5.43 2.08 5.00
131 INT177778 Gene_expression of SQLE 28 0.40 16.42 2.08 5.00
132 INT13544 Localization of LTA 9 0.78 6.34 1.8 5.00
133 INT196158 Binding of NRP2 16 0.06 7.03 1.73 5.00
134 INT164275 Gene_expression of Alox5ap 3 0.55 3.79 1.72 5.00
135 INT113676 Gene_expression of NRP1 22 0.72 10.81 1.71 5.00
136 INT15996 Binding of Ltc4s 9 0.35 5.66 1.64 5.00
137 INT186269 Binding of Il13 9 0.39 7.7 1.64 5.00
138 INT65684 Gene_expression of MDM2 30 0.62 24.94 1.55 5.00
139 INT304095 Binding of Aia1 2 0.03 3.93 1.5 5.00
140 INT36389 Binding of AHR 18 0.45 7.22 1.46 5.00
141 INT78704 Binding of CCL11 10 0.37 11.38 1.44 5.00
142 INT74178 Gene_expression of HMBS 24 0.76 9.62 1.36 5.00
143 INT29693 Binding of Ahr 11 0.31 13.27 1.23 5.00
144 INT168374 Negative_regulation of Capns1 2 0.50 5.09 1.1 5.00
145 INT115802 Positive_regulation of Positive_regulation of HRASLS 2 0.12 3.06 1.03 5.00
146 INT193256 Positive_regulation of PTGER4 6 0.19 4.38 0.99 5.00
147 INT19084 Negative_regulation of NRG1 5 0.42 4.9 0.96 5.00
148 INT8772 Positive_regulation of Gene_expression of HBG1 16 0.68 6.93 0.95 5.00
149 INT13543 Positive_regulation of LTC4S 5 0.58 2.26 0.88 5.00
150 INT103389 Negative_regulation of Negative_regulation of IL8 3 0.39 2.2 0.86 5.00
151 INT13545 Negative_regulation of Gene_expression of LTA 5 0.34 3.23 0.86 5.00
152 INT95917 Gene_expression of CYSLTR2 10 0.64 6.1 0.82 5.00
153 INT119102 Gene_expression of PDGFRA 13 0.75 11.99 0.81 5.00
154 INT32418 Binding of NCS1 10 0.40 8.93 0.81 5.00
155 INT196182 Localization of NRP2 9 0.46 3.61 0.8 5.00
156 INT65286 Binding of ARIH1 10 0.48 4.3 0.76 5.00
157 INT193261 Positive_regulation of Regulation of PTGER2 3 0.28 2.14 0.76 5.00
158 INT199430 Regulation of LTA 4 0.11 2.48 0.75 5.00
159 INT199433 Negative_regulation of LTA 5 0.17 3.84 0.74 5.00
160 INT122725 Regulation of PTGER3 4 0.39 2.74 0.72 5.00
161 INT139205 Binding of NRP1 27 0.45 4.34 0.71 5.00
162 INT265800 Localization of NRP1 14 0.75 3.66 0.69 5.00
163 INT145384 Binding of LTA 10 0.32 4.4 0.66 5.00
164 INT88124 Regulation of Positive_regulation of PTGER2 4 0.17 2 0.63 5.00
165 INT199424 Negative_regulation of Gene_expression of Cysltr1 2 0.35 0.71 0.59 5.00
166 INT194379 Localization of CRS 7 0.64 8.58 0.57 5.00
167 INT125821 Regulation of Positive_regulation of IGHE 6 0.40 5.38 0.53 5.00
168 INT128363 Negative_regulation of Gene_expression of Ltb4r1 5 0.50 2.53 0.52 5.00
169 INT92592 Transcription of PTGER2 6 0.32 4.52 0.47 5.00
170 INT147960 Negative_regulation of GCLC 8 0.28 4.4 0.45 5.00
171 INT193254 Binding of CYSLTR2 4 0.15 0.93 0.38 5.00
172 INT193255 Transcription of PTGER4 2 0.19 1.4 0.38 5.00
173 INT233007 Negative_regulation of VIM 6 0.41 3.46 0.36 5.00
174 INT193258 Regulation of Positive_regulation of PTGER1 1 0.12 0.72 0.34 5.00
175 INT21349 Binding of Ltb4r1 4 0.07 2.9 0.34 5.00
176 INT299574 Localization of SQLE 1 0.10 1.41 0.32 5.00
177 INT75504 Gene_expression of CDK4 9 0.72 7.43 0.3 5.00
178 INT156411 Gene_expression of Pdgfra 8 0.75 5.5 0.3 5.00
179 INT188093 Regulation of Gene_expression of Ltb4r1 4 0.60 3.73 0.28 5.00
180 INT199434 Negative_regulation of Cysltr2 1 0.04 0.52 0.26 5.00
181 INT141617 Regulation of Cysltr1 2 0.10 1.33 0.26 5.00
182 INT156410 Positive_regulation of Pdgfra 3 0.08 1.51 0.25 5.00
183 INT199432 Regulation of Localization of LTA 1 0.03 0.79 0.24 5.00
184 INT38790 Regulation of CYSLTR1 3 0.18 0.25 0.2 5.00
185 INT192652 Regulation of Capns1 2 0.32 1.3 0.18 5.00
186 INT159231 Positive_regulation of PDGFRA 3 0.47 2.39 0.18 5.00
187 INT299575 Positive_regulation of Positive_regulation of CRS 1 0.04 1.12 0.18 5.00
188 INT299579 Gene_expression of RatNP-3b 2 0.09 0.39 0.17 5.00
189 INT193253 Binding of RNASE3 1 0.02 0.49 0.15 5.00
190 INT95918 Regulation of Gene_expression of CYSLTR2 2 0.24 0.39 0.13 5.00
191 INT193264 Regulation of Gene_expression of CYSLTR1 2 0.30 0.96 0.12 5.00
192 INT311689 Positive_regulation of 119L04aR 2 0.01 1.09 0.1 5.00
193 INT299578 Localization of RatNP-3b 1 0.07 0.77 0.08 5.00
194 INT177775 Negative_regulation of SQLE 7 0.06 5.97 0.04 5.00
195 INT281008 Negative_regulation of Gene_expression of Capns1 1 0.03 1.79 0.04 5.00
196 INT95919 Regulation of CYSLTR2 2 0.24 0.08 0.04 5.00
197 INT311690 Regulation of 119L04aR 1 0.01 0.39 0.03 5.00
198 INT299572 Gene_expression of PRR5 1 0.01 0.8 0.03 5.00
199 INT299573 Regulation of Gene_expression of SQLE 1 0.05 0.21 0 5.00
200 INT311688 Gene_expression of 119L04aR 2 0.02 0.16 0 5.00
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