D:Paraneoplastic Syndromes

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Disease Term
Synonyms Paraneoplastic Syndrome, Syndrome Paraneoplastic, Syndromes Paraneoplastic
Documents 187
Hot Single Events 44
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Paraneoplastic Syndromes. They are ordered first by their relevance to Paraneoplastic Syndromes and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT266837 Dmp1 Negative_regulation of Gene_expression of Fgf23 1 0.48 2.41 0 92.00
2 INT244116 ELAVL3 Negative_regulation of MUC1 1 0.09 3.41 0.15 34.96
3 INT313886 RPS6KB1 Positive_regulation of Gene_expression of XRCC1 1 0.01 0.8 0.05 5.00
4 INT313890 Akt1 Positive_regulation of Gene_expression of XRCC1 1 0.00 0.79 0.05 5.00
5 INT331172 Binding of IFNA1 and IL2 1 0.00 0.46 0.04 5.00
6 INT199159 Binding of RET and Pheo 1 0.04 1.42 0.03 5.00
7 INT266835 Pth Regulation of Slc34a3 1 0.19 0.07 0 5.00
8 INT313885 XRCC1 Positive_regulation of Localization of PTEN 1 0.00 0.65 0 5.00
9 INT266836 Pth Regulation of Slc34a1 1 0.09 0.07 0 5.00
10 INT266839 Fgf23 Negative_regulation of Slc34a1 1 0.21 0.88 0 5.00
11 INT266834 Pth Negative_regulation of Positive_regulation of Grxcr1 1 0.04 0.51 0 5.00
12 INT266833 Phex Regulation of Gene_expression of Fgf23 1 0.23 0.46 0 5.00
13 INT266838 Fgf23 Regulation of Slc34a1 1 0.13 0.3 0 5.00
14 INT313884 XRCC1 Positive_regulation of Localization of HIF1A 1 0.00 0.65 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Paraneoplastic Syndromes. They are ordered first by their pain relevance and then by number of times they were reported in Paraneoplastic Syndromes. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT156997 Localization of NPC1 19 0.64 30 0.42 99.50
2 INT9647 Gene_expression of PROC 163 0.65 89.76 26.75 99.44
3 INT54565 Binding of SCLC1 12 0.31 20.41 0.81 99.40
4 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 99.04
5 INT2843 Gene_expression of Epo 100 0.78 62.01 14.66 98.96
6 INT5095 Localization of Ghrh 185 0.81 28.09 62.08 98.52
7 INT59342 Negative_regulation of NPC1 20 0.44 20.21 2.79 98.26
8 INT46530 Gene_expression of Pthlh 15 0.78 11.23 1.7 98.24
9 INT59900 Binding of MATN3 13 0.42 17.19 3.59 98.08
10 INT78199 Gene_expression of Neu1 65 0.75 62.88 7.16 97.52
11 INT80174 Positive_regulation of Gene_expression of Neu1 23 0.37 17.82 1.12 97.52
12 INT67624 Gene_expression of Phex 3 0.26 4.15 1.67 97.36
13 INT98645 Gene_expression of FGF23 9 0.78 10.07 0.8 97.36
14 INT66041 Positive_regulation of NTRK1 24 0.70 16.12 8.42 97.24
15 INT98642 Binding of FGF23 1 0.22 1.46 0.09 96.92
16 INT102659 Gene_expression of CSF3 32 0.77 21.93 2.39 96.80
17 INT212362 Positive_regulation of Gene_expression of CSF3 3 0.32 4.85 0.26 96.80
18 INT76227 Binding of NPC1 30 0.41 32.31 4.05 96.40
19 INT18012 Gene_expression of EPO 169 0.78 108.36 13.75 96.12
20 INT98640 Binding of Phex 1 0.13 1.44 0.09 95.64
21 INT118371 Positive_regulation of Fgf23 15 0.69 25.34 0.85 95.04
22 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 94.52
23 INT66941 Localization of NTRK1 8 0.78 5.89 1.96 94.24
24 INT131844 Gene_expression of MATN3 12 0.78 9.65 0.92 93.92
25 INT118373 Gene_expression of Fgf23 16 0.77 29.62 1.04 92.00
26 INT50555 Regulation of Pthlh 3 0.16 2.07 0.52 91.20
27 INT2541 Binding of Calca 200 0.48 67.14 134.62 90.60
28 INT126726 Binding of Pthlh 1 0.03 1.05 0.09 90.16
29 INT20631 Positive_regulation of CHKB 166 0.69 109.86 17.92 90.00
30 INT3364 Binding of SGCG 87 0.47 31.93 17.24 89.44
31 INT91013 Binding of IFNAR1 9 0.46 8.7 2.74 89.44
32 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 89.04
33 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 89.04
34 INT214 Localization of AVP 370 0.81 208.51 91.09 88.04
35 INT4860 Positive_regulation of CALCA 148 0.00 73.35 97.61 86.36
36 INT23257 Regulation of CRP 127 0.62 100.05 21.87 86.16
37 INT21631 Positive_regulation of Gene_expression of Adh1 4 0.70 12.56 0.39 85.28
38 INT44550 Positive_regulation of Gene_expression of AVP 38 0.70 22.27 8.62 85.28
39 INT21032 Gene_expression of Adh1 23 0.78 22.1 6.14 84.92
40 INT3679 Gene_expression of AVP 171 0.78 72.9 35.23 84.92
41 INT12082 Localization of IL6 365 0.81 241.78 105.78 83.68
42 INT6852 Localization of TNF 883 0.81 705.95 270.84 83.68
43 INT98641 Transcription of Phex 1 0.23 2.89 0.17 80.44
44 INT70602 Regulation of Phex 3 0.13 1.51 1.06 80.44
45 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 79.08
46 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35 79.08
47 INT9656 Regulation of Gene_expression of Il6 57 0.62 33.3 17.71 79.08
48 INT48078 Regulation of Gene_expression of Il1b 15 0.62 14.78 9.53 79.08
49 INT48312 Gene_expression of NTRK1 72 0.78 38.21 22.24 77.96
50 INT51028 Regulation of Il1b 28 0.60 21.15 12.47 77.60
51 INT812 Localization of INS 1026 0.81 515.6 145.31 77.20
52 INT14572 Binding of INS 205 0.48 175.43 13.38 77.20
53 INT136964 Gene_expression of Dmp1 10 0.75 3.69 2.83 77.12
54 INT16003 Gene_expression of Phex 3 0.65 4.68 0.77 77.12
55 INT9655 Regulation of Il6 98 0.62 70.92 31.95 77.08
56 INT98644 Transcription of FGF23 1 0.41 2.83 0.17 76.48
57 INT95767 Negative_regulation of Mmp9 72 0.57 49.14 17.1 75.00
58 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 71.40
59 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93 71.40
60 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 70.00
61 INT13907 Gene_expression of SCLC1 16 0.59 16.58 1.89 67.48
62 INT37193 Negative_regulation of BDNF-AS 21 0.37 15.06 3.12 66.16
63 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 62.48
64 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 61.12
65 INT135880 Positive_regulation of Gene_expression of Fgf23 4 0.46 7.52 0.29 57.04
66 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 54.88
67 INT98643 Positive_regulation of Gene_expression of FGF23 2 0.47 2.16 0.13 53.48
68 INT98639 Positive_regulation of Gene_expression of Phex 1 0.24 1.26 0.06 53.48
69 INT212058 Positive_regulation of Psmb10 1 0.01 11.89 0.4 53.32
70 INT175453 Binding of Sftpd 2 0.23 2.04 0.15 53.04
71 INT9473 Binding of MUC1 66 0.48 46.77 2.36 52.04
72 INT266828 Negative_regulation of Fgf23 3 0.42 5.63 0.04 51.92
73 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17 51.08
74 INT131929 Positive_regulation of Gene_expression of S100B 25 0.67 12.61 2.83 51.08
75 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 50.68
76 INT62763 Binding of GFER 3 0.48 0.66 0.06 50.00
77 INT87963 Regulation of Tg 3 0.45 2.7 0.32 46.72
78 INT241118 Negative_regulation of Vhl 3 0.11 4.01 0.08 41.56
79 INT121493 Gene_expression of XRCC1 55 0.65 73.43 2.76 37.56
80 INT175449 Gene_expression of Sftpd 30 0.55 25.7 3.15 36.40
81 INT241115 Regulation of Vhl 5 0.15 8.36 0.11 35.48
82 INT285 Positive_regulation of Salpa1 73 0.68 61.47 9.19 30.80
83 INT100375 Gene_expression of Vhl 14 0.15 22.3 1.69 30.68
84 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 30.20
85 INT1921 Gene_expression of CEACAM7 47 0.78 43.23 2.53 29.00
86 INT105390 Positive_regulation of Gene_expression of HIF1A 27 0.49 26.3 2.88 28.60
87 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66 28.40
88 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 25.00
89 INT11069 Positive_regulation of Pf4 35 0.68 27.7 13.96 25.00
90 INT19399 Gene_expression of Rf 43 0.36 33.39 13.53 25.00
91 INT11071 Positive_regulation of PPBP 43 0.68 26.85 13.43 25.00
92 INT650 Gene_expression of Afp 13 0.78 7.44 1.47 25.00
93 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 24.16
94 INT109396 Negative_regulation of RET 12 0.42 14.92 1.06 24.08
95 INT14360 Positive_regulation of DDC 7 0.70 2.97 2.02 22.48
96 INT294726 Positive_regulation of Lts1 5 0.49 4.06 0.87 20.04
97 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 19.20
98 INT245648 Gene_expression of SEPHS1 5 0.49 4.53 0.59 18.48
99 INT153782 Localization of SEPHS1 2 0.62 0.9 0.12 18.48
100 INT244117 Binding of ELAVL3 1 0.15 5.2 0.42 18.16
101 INT158796 Positive_regulation of SMUG1 67 0.70 38.97 8.98 16.52
102 INT122449 Localization of SMUG1 10 0.67 7.97 1.47 16.52
103 INT78478 Negative_regulation of TOP1 3 0.21 1.75 0.06 8.88
104 INT75932 Binding of Csf2 45 0.37 33.2 8.01 5.44
105 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 5.00
106 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
107 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 5.00
108 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
109 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 5.00
110 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
111 INT1893 Localization of Gh 1041 0.79 340.23 256.58 5.00
112 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 5.00
113 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
114 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 5.00
115 INT2867 Gene_expression of CALCA 247 0.78 78.78 138.47 5.00
116 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
117 INT17459 Positive_regulation of Gene_expression of FOS 182 0.67 53.45 96.38 5.00
118 INT7180 Negative_regulation of Trib3 180 0.51 68.48 88.01 5.00
119 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
120 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
121 INT18981 Gene_expression of ABAT 78 0.68 38.35 61.36 5.00
122 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 5.00
123 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
124 INT48891 Positive_regulation of Il10 143 0.70 101.42 56.72 5.00
125 INT8490 Negative_regulation of CALCA 87 0.59 29.73 51.34 5.00
126 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 5.00
127 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
128 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
129 INT30 Gene_expression of Gast 158 0.78 99 41.45 5.00
130 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
131 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 5.00
132 INT67613 Positive_regulation of PPARG 94 0.70 69.15 34.38 5.00
133 INT10763 Localization of IL2 157 0.80 81.11 33.21 5.00
134 INT8915 Gene_expression of Igf1 199 0.78 78.58 32.51 5.00
135 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
136 INT48202 Gene_expression of Tgfb1 146 0.78 89.93 27.76 5.00
137 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 5.00
138 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19 5.00
139 INT55583 Localization of IFNA1 135 0.78 85.07 24.13 5.00
140 INT5055 Positive_regulation of IFNG 89 0.69 64.03 23.05 5.00
141 INT85952 Positive_regulation of AR 168 0.67 64.36 20.66 5.00
142 INT5096 Positive_regulation of Gtf3a 79 0.60 42.26 20.62 5.00
143 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 5.00
144 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 5.00
145 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3 5.00
146 INT3793 Regulation of CEBPZ 59 0.61 20.91 15.83 5.00
147 INT42810 Gene_expression of CALCRL 53 0.77 10.87 15.42 5.00
148 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 5.00
149 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
150 INT63104 Negative_regulation of CALCRL 29 0.37 13.62 12.42 5.00
151 INT107033 Gene_expression of Slc37a4 66 0.62 27.34 12.35 5.00
152 INT8224 Gene_expression of CHGA 73 0.75 53.63 12.31 5.00
153 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 5.00
154 INT48203 Positive_regulation of Tgfb1 67 0.70 41.31 11.07 5.00
155 INT2792 Gene_expression of Mb 91 0.76 41.56 10.25 5.00
156 INT20166 Negative_regulation of Mtor 32 0.56 10.64 10.25 5.00
157 INT5465 Positive_regulation of CALCRL 25 0.49 7.24 9.8 5.00
158 INT70134 Negative_regulation of TXK 124 0.23 81.96 9.59 5.00
159 INT56985 Gene_expression of MEFV 56 0.71 46.71 9.47 5.00
160 INT49325 Gene_expression of Cd34 102 0.78 82.75 8.97 5.00
161 INT59165 Binding of fc 67 0.36 37.51 8.68 5.00
162 INT77794 Binding of Gdnf 15 0.48 8.38 8.22 5.00
163 INT6557 Gene_expression of Eno2 65 0.77 54.42 8.17 5.00
164 INT162393 Gene_expression of SMUG1 58 0.75 38.78 7.7 5.00
165 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49 5.00
166 INT15872 Positive_regulation of EPO 74 0.70 45.35 6.67 5.00
167 INT49212 Negative_regulation of GAD1 23 0.59 22.15 6.54 5.00
168 INT48313 Binding of NTRK1 19 0.47 14.44 6.12 5.00
169 INT91657 Negative_regulation of IL18 20 0.48 15.97 6.12 5.00
170 INT9495 Negative_regulation of Gene_expression of Igf1 31 0.59 11.87 6.1 5.00
171 INT55733 Negative_regulation of VTN 47 0.58 47.22 5.68 5.00
172 INT21609 Positive_regulation of RASGRP1 58 0.50 40.78 5.47 5.00
173 INT23611 Gene_expression of Mtor 23 0.66 3.57 5.02 5.00
174 INT49805 Positive_regulation of MUC1 56 0.70 44.5 4.56 5.00
175 INT72747 Localization of IgG 55 0.53 30.88 4.19 5.00
176 INT17324 Negative_regulation of Plg 26 0.38 13.5 4.05 5.00
177 INT84891 Gene_expression of PPARD 10 0.78 6.8 3.64 5.00
178 INT170528 Negative_regulation of Gene_expression of CD4 25 0.41 17.98 3.6 5.00
179 INT105537 Regulation of Gene_expression of Igf1 15 0.58 6.97 3.23 5.00
180 INT66077 Regulation of CHPT1 12 0.38 6.1 3.23 5.00
181 INT35143 Negative_regulation of ANGPTL5 28 0.54 18.59 3.14 5.00
182 INT84890 Negative_regulation of PPARD 7 0.59 3.27 3.1 5.00
183 INT22500 Negative_regulation of Pth 6 0.43 3.41 2.83 5.00
184 INT8112 Regulation of EPO 38 0.58 22.04 2.76 5.00
185 INT149314 Negative_regulation of CAV2 5 0.42 1.21 2.76 5.00
186 INT27652 Gene_expression of TG 36 0.78 22.36 2.74 5.00
187 INT237655 Binding of Sfn 1 0.42 3.62 2.55 5.00
188 INT63333 Gene_expression of RET 24 0.76 30.09 2.41 5.00
189 INT237653 Gene_expression of Sfn 6 0.59 5.54 2.26 5.00
190 INT151878 Gene_expression of CAV2 18 0.66 9.26 2.17 5.00
191 INT108710 Gene_expression of HAL 36 0.58 14.75 2.16 5.00
192 INT109327 Negative_regulation of KIT 42 0.57 43.2 2.15 5.00
193 INT287525 Localization of CAV2 5 0.47 5.32 2 5.00
194 INT64709 Gene_expression of VTN 11 0.67 11.01 1.97 5.00
195 INT184410 Gene_expression of ASF1A 6 0.11 5.51 1.94 5.00
196 INT136503 Negative_regulation of KDR 46 0.48 43.1 1.86 5.00
197 INT169862 Regulation of NPC1 13 0.53 13.61 1.84 5.00
198 INT60337 Positive_regulation of THBS1 8 0.46 4.69 1.83 5.00
199 INT199146 Gene_expression of Pheo 3 0.18 3.57 1.63 5.00
200 INT120519 Localization of XRCC1 15 0.78 17.03 1.51 5.00
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