D:Paraparesis

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Disease Term
Synonyms Cerebral Paraparesis, CHRONIC PROGRESSIVE PARAPARESIS, HYPOTONIC PARAPARESIS, Parapareses, Paraparesis Cerebral, PARAPARESIS CHRONIC PROGRESSIVE, PARAPARESIS HYPOTONIC, Paraparesis Spinal, Progressive Paraparesis Chronic, Spinal Paraparesis
Documents 452
Hot Single Events 48
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Paraparesis. They are ordered first by their relevance to Paraparesis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT282712 Binding of MUC5AC and Csf2 1 0.01 2.63 1.07 5.00
2 INT93063 Binding of gr and Jun 3 0.14 0.79 0.57 5.00
3 INT282711 Binding of Csf2 and Mmp9 1 0.16 1.35 0.54 5.00
4 INT282713 Binding of MUC5AC and Mmp9 1 0.02 1.27 0.52 5.00
5 INT206538 Trem2 Regulation of Gene_expression of Cd80 1 0.17 1.26 0.44 5.00
6 INT206536 Trem2 Positive_regulation of Gene_expression of Cd80 1 0.30 1.26 0.44 5.00
7 INT288162 Igh-Dex Positive_regulation of Gopc 1 0.02 0.63 0.41 5.00
8 INT355018 Binding of FAS and Faslg 1 0.12 1.34 0.37 5.00
9 INT288168 Binding of Jun and Ugcg Negative_regulation of Gene_expression of Mmp13 1 0.01 0.52 0.36 5.00
10 INT288164 Jun Regulation of Gene_expression of Mmp13 1 0.02 0.41 0.35 5.00
11 INT288167 Ugcg Negative_regulation of Gene_expression of Mmp13 1 0.06 0.46 0.35 5.00
12 INT288165 Binding of Jun and Ugcg 1 0.02 0.45 0.32 5.00
13 INT288166 Binding of gr and Ugcg 1 0.07 0.45 0.31 5.00
14 INT288163 Binding of gr and Igh-Dex 1 0.03 0.18 0.27 5.00
15 INT206535 Binding of Trem2 and Tg(CAG-EGFP)D4Nagy 1 0.03 0.5 0.27 5.00
16 INT206540 mc Positive_regulation of Gene_expression of Cd80 1 0.01 0.62 0.22 5.00
17 INT206541 mc Regulation of Gene_expression of Cd80 1 0.00 0.62 0.22 5.00
18 INT282710 Mmp9 Regulation of Gene_expression of Csf2 1 0.15 0.16 0.2 5.00
19 INT206539 Trem2 Positive_regulation of Phosphorylation of Mapk1 1 0.22 0.62 0.2 5.00
20 INT355023 Phosphorylation of Rtn4r Negative_regulation of Binding of Mag and Rtn4r 1 0.00 0.38 0.11 5.00
21 INT353230 MOG Positive_regulation of Eae1 1 0.07 1.09 0.1 5.00
22 INT355008 Binding of Mag and Rtn4r 1 0.02 0.36 0.1 5.00
23 INT355019 Lif Positive_regulation of JAK1 1 0.00 0.69 0.08 5.00
24 INT355021 Cntf Positive_regulation of SOAT1 1 0.02 0.7 0.08 5.00
25 INT355022 Cntf Positive_regulation of JAK1 1 0.00 0.69 0.08 5.00
26 INT355009 Cntf Positive_regulation of Il6st 1 0.02 0.69 0.08 5.00
27 INT355020 Lif Positive_regulation of SOAT1 1 0.02 0.7 0.08 5.00
28 INT355010 Lif Positive_regulation of Il6st 1 0.02 0.69 0.08 5.00
29 INT206537 Eae1 Regulation of Trem2 1 0.06 0.45 0.06 5.00
30 INT225230 Ad Positive_regulation of Nf2 1 0.04 1.37 0.04 5.00
31 INT225228 Binding of Cdk4 and Cdkn2a 1 0.21 1.24 0 5.00
32 INT225229 Binding of Cdk6 and Cdkn2a 1 0.19 1.25 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Paraparesis. They are ordered first by their pain relevance and then by number of times they were reported in Paraparesis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT90291 Gene_expression of LMNB1 6 0.38 7.75 0.86 100.00
2 INT156 Negative_regulation of Prl 542 0.59 131.97 192.24 99.82
3 INT1990 Positive_regulation of Ean5 35 0.41 38.05 28.8 99.60
4 INT173967 Gene_expression of Mri1 26 0.43 16.67 6.45 98.84
5 INT58208 Negative_regulation of Ctsl 8 0.53 3.49 1.91 98.64
6 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 98.04
7 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 97.52
8 INT28362 Gene_expression of REG1A 29 0.75 9.69 5.95 97.52
9 INT28363 Gene_expression of NRSN1 8 0.45 8.66 0.53 97.52
10 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 97.52
11 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 97.52
12 INT28360 Gene_expression of PSMD10 1 0.36 0.79 0.17 97.52
13 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 97.44
14 INT16150 Positive_regulation of NKG7 10 0.69 10.26 1.73 97.44
15 INT202848 Gene_expression of Nf2 5 0.59 4.93 0.63 97.12
16 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 97.04
17 INT63814 Gene_expression of NKG7 3 0.58 2.76 0.54 97.04
18 INT72370 Gene_expression of Timp1 82 0.65 57.52 24.16 95.04
19 INT107653 Gene_expression of ACAT1 9 0.60 4.74 1.03 94.80
20 INT107652 Gene_expression of C7 4 0.60 2.06 0.56 94.80
21 INT68975 Gene_expression of Mmp9 111 0.78 79.57 38.55 94.76
22 INT125896 Negative_regulation of Gene_expression of Mmp9 15 0.43 13.73 4.18 94.76
23 INT80305 Gene_expression of IGKV2-30 6 0.04 3.68 1.01 94.76
24 INT163396 Negative_regulation of Gene_expression of IGKV2-30 1 0.00 1.24 0.8 94.76
25 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 94.60
26 INT44717 Gene_expression of TNFSF14 12 0.75 13.44 3.72 94.44
27 INT55924 Negative_regulation of IGKV2-30 3 0.07 2.26 1.8 94.20
28 INT124834 Negative_regulation of fh 1 0.00 1.03 0.54 94.08
29 INT105162 Gene_expression of Ad 47 0.12 46.53 1.83 93.48
30 INT125247 Negative_regulation of Mmp9 42 0.43 23.68 9.37 93.40
31 INT118343 Positive_regulation of Eae1 121 0.39 136.06 34.87 91.44
32 INT188674 Negative_regulation of Positive_regulation of Eae1 9 0.15 7.54 2.34 91.44
33 INT211700 Negative_regulation of Mri1 5 0.29 2.06 1.04 90.52
34 INT70265 Regulation of MRI1 42 0.39 30.95 14.18 90.12
35 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 89.16
36 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 89.16
37 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 87.44
38 INT66753 Negative_regulation of Positive_regulation of Tnf 45 0.59 35.28 22.33 87.08
39 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 86.96
40 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 85.92
41 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 84.96
42 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1 84.44
43 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 83.20
44 INT82846 Negative_regulation of CRX 9 0.37 5.93 3.64 83.00
45 INT70027 Positive_regulation of Gene_expression of C6orf25 10 0.62 7.21 0.83 82.08
46 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 81.72
47 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01 80.80
48 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 80.08
49 INT11292 Gene_expression of Mme 77 0.78 20.98 35.85 79.52
50 INT95767 Negative_regulation of Mmp9 72 0.57 49.14 17.1 79.24
51 INT9695 Negative_regulation of Csf2 41 0.57 31.65 6.28 79.24
52 INT374 Positive_regulation of Ldha 212 0.70 107.08 47.43 75.00
53 INT59909 Binding of ATF7IP 4 0.36 2.83 0.9 75.00
54 INT6557 Gene_expression of Eno2 65 0.77 54.42 8.17 74.84
55 INT79439 Gene_expression of XCL1 9 0.65 5.18 3.84 74.72
56 INT116091 Regulation of XCL1 1 0.00 1.61 1.06 74.72
57 INT225221 Negative_regulation of Nf2 1 0.57 18.06 0.83 73.56
58 INT46721 Regulation of Csf2 26 0.45 20.4 6.18 72.20
59 INT129115 Negative_regulation of Cdkn2a 16 0.50 17.03 0.76 71.72
60 INT162247 Positive_regulation of Hist1h2aa 2 0.09 2.6 2.03 70.68
61 INT162248 Positive_regulation of Gene_expression of Foxp3 2 0.68 1.87 1.53 70.68
62 INT80905 Regulation of Ean5 1 0.15 2.08 1.54 70.40
63 INT162249 Gene_expression of Hist1h2aa 8 0.12 6.46 4.35 70.28
64 INT25 Positive_regulation of LAMC2 19 0.67 8.64 7.06 69.76
65 INT156896 Gene_expression of Foxp3 11 0.76 7.62 2.92 69.60
66 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 68.76
67 INT156892 Positive_regulation of Foxp3 3 0.50 3.49 2.74 68.76
68 INT97825 Negative_regulation of Dhodh 2 0.57 1.21 0.64 65.36
69 INT19768 Negative_regulation of LAMC2 11 0.57 10.54 5.32 59.84
70 INT259041 Binding of D18Tlj1e 1 0.03 1.98 0.57 54.76
71 INT132997 Localization of Mmp9 59 0.80 45.9 17.61 54.64
72 INT132994 Positive_regulation of Localization of Mmp9 12 0.42 9.4 3.75 53.80
73 INT23147 Negative_regulation of MRI1 26 0.38 14.33 8.96 53.68
74 INT225219 Positive_regulation of Gene_expression of Nf2 1 0.43 1.27 0.27 52.24
75 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 50.00
76 INT96588 Gene_expression of MOG 18 0.75 11.41 1.89 48.32
77 INT75932 Binding of Csf2 45 0.37 33.2 8.01 44.64
78 INT11802 Gene_expression of KLF1 11 0.65 6.81 1.41 44.48
79 INT225226 Positive_regulation of Negative_regulation of Ccnd1 1 0.14 1.18 0.03 42.12
80 INT128987 Negative_regulation of Ccnd1 24 0.52 15.78 1.15 41.72
81 INT114875 Negative_regulation of Cdk4 4 0.35 4.01 0.86 41.72
82 INT169911 Phosphorylation of Rb1 35 0.73 18.58 0.79 39.12
83 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 36.56
84 INT86751 Negative_regulation of Il10 62 0.59 40.1 20.51 35.36
85 INT225215 Negative_regulation of Positive_regulation of Ccnd1 2 0.13 1.33 0 32.12
86 INT236839 Positive_regulation of CXCL13 14 0.44 19.27 5.81 31.12
87 INT225220 Positive_regulation of Positive_regulation of Ccnd1 1 0.14 1.2 0 30.52
88 INT25906 Negative_regulation of Cish 6 0.29 5.41 3.17 30.36
89 INT109007 Positive_regulation of Ccnd1 23 0.53 9.5 0.86 30.00
90 INT28088 Binding of Alb 34 0.47 11.06 5.48 29.96
91 INT182240 Gene_expression of CXCL13 25 0.59 22.77 11.96 26.76
92 INT236842 Positive_regulation of Gene_expression of CXCL13 6 0.32 3.91 2.55 26.76
93 INT182215 Regulation of CXCR5 4 0.27 4.49 2.18 24.52
94 INT156827 Localization of MRI1 25 0.65 16.06 8.33 24.12
95 INT206518 Gene_expression of Trem2 1 0.78 16.79 6.92 21.76
96 INT137767 Gene_expression of Eae1 74 0.34 89.32 20.48 18.48
97 INT215922 Negative_regulation of Gene_expression of Eae1 3 0.06 1.96 1.1 18.48
98 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68 16.28
99 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
100 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 5.00
101 INT5680 Gene_expression of Ngf 530 0.78 264.29 310.56 5.00
102 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
103 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 5.00
104 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71 5.00
105 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
106 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
107 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 5.00
108 INT5842 Gene_expression of Gfap 372 0.78 153.71 127.71 5.00
109 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
110 INT118381 Gene_expression of Il17a 405 0.76 306.97 112.06 5.00
111 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
112 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 5.00
113 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46 5.00
114 INT75999 Gene_expression of BDNF 344 0.78 114.19 83.12 5.00
115 INT16254 Positive_regulation of Gene_expression of Ngf 144 0.70 80.61 82.08 5.00
116 INT12001 Regulation of Ngf 97 0.62 54.64 76.25 5.00
117 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 5.00
118 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
119 INT3034 Localization of Ngf 126 0.81 50.81 72.84 5.00
120 INT11937 Localization of Il6 228 0.81 139.83 64.39 5.00
121 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
122 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01 5.00
123 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 5.00
124 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 5.00
125 INT62543 Gene_expression of Icam1 231 0.78 187.58 52.71 5.00
126 INT83199 Gene_expression of Nos3 193 0.78 100.72 51.57 5.00
127 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
128 INT60695 Positive_regulation of Gene_expression of Il10 154 0.70 120.28 43.07 5.00
129 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 5.00
130 INT97596 Localization of S100a8 94 0.78 90.69 40.41 5.00
131 INT92437 Positive_regulation of Phosphorylation of Mapk1 113 0.70 32.19 40.29 5.00
132 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 5.00
133 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
134 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 5.00
135 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 5.00
136 INT2732 Gene_expression of VIP 74 0.78 24.57 33.72 5.00
137 INT29503 Gene_expression of Mmp2 95 0.77 56.92 31.68 5.00
138 INT29743 Negative_regulation of App 91 0.59 65.56 31.26 5.00
139 INT90792 Localization of Il10 144 0.80 87.88 30.03 5.00
140 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 5.00
141 INT15174 Gene_expression of Itgam 238 0.73 104.92 29.26 5.00
142 INT66200 Gene_expression of Gfap 215 0.78 88.04 28.25 5.00
143 INT14690 Localization of CSF2 124 0.80 85.17 27.26 5.00
144 INT59449 Negative_regulation of Timp1 76 0.42 54.86 26.99 5.00
145 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 5.00
146 INT13995 Gene_expression of gr 96 0.74 48.21 26.54 5.00
147 INT61953 Transcription of Nos2 101 0.72 46.64 25.49 5.00
148 INT73670 Gene_expression of Vcam1 128 0.78 123.79 24.96 5.00
149 INT172458 Regulation of Gopc 155 0.53 62.57 24.86 5.00
150 INT44954 Gene_expression of APP 191 0.78 105.86 23.9 5.00
151 INT74423 Localization of IL10 91 0.80 61.6 22.95 5.00
152 INT6868 Gene_expression of GFAP 136 0.78 84.65 22.7 5.00
153 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 5.00
154 INT35711 Positive_regulation of Sdcbp 110 0.60 50.45 22.11 5.00
155 INT150022 Positive_regulation of Il17a 69 0.64 70.04 21.87 5.00
156 INT74682 Positive_regulation of Mmp2 72 0.69 40.46 21.73 5.00
157 INT170313 Gene_expression of Mmp1a 50 0.65 38.53 21.36 5.00
158 INT7561 Positive_regulation of gr 70 0.57 31.92 20.22 5.00
159 INT116282 Gene_expression of Mmp13 83 0.75 45.4 20.18 5.00
160 INT48663 Negative_regulation of Gene_expression of Gfap 45 0.59 18.34 19.84 5.00
161 INT103469 Positive_regulation of Gene_expression of BDNF 59 0.67 24.39 18.36 5.00
162 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 5.00
163 INT11938 Positive_regulation of Localization of Il6 61 0.70 35.72 18.25 5.00
164 INT96155 Gene_expression of Cd86 134 0.77 50.56 17.13 5.00
165 INT12922 Gene_expression of Atp9a 115 0.75 50.95 17.01 5.00
166 INT24225 Gene_expression of Alms1 93 0.62 52.75 16.93 5.00
167 INT23657 Positive_regulation of APP 64 0.70 39.76 16.68 5.00
168 INT10187 Gene_expression of Il2ra 91 0.78 52.67 16.66 5.00
169 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 5.00
170 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 5.00
171 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 5.00
172 INT152730 Positive_regulation of S100a8 48 0.68 47.67 15.4 5.00
173 INT113606 Positive_regulation of Gene_expression of Mmp9 46 0.64 44 15.07 5.00
174 INT49219 Gene_expression of Hrh1 28 0.75 13.77 14.99 5.00
175 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89 5.00
176 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 5.00
177 INT35120 Gene_expression of Sdcbp 68 0.67 21.33 13.96 5.00
178 INT36177 Binding of Alms1 70 0.31 35.47 13.81 5.00
179 INT5207 Negative_regulation of Alms1 70 0.41 41.56 13.68 5.00
180 INT20378 Localization of Hand1 53 0.71 41.96 13.31 5.00
181 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 5.00
182 INT100655 Regulation of BDNF 51 0.60 21.49 13.14 5.00
183 INT28420 Gene_expression of Ptgds 59 0.78 31.72 12.67 5.00
184 INT107916 Protein_catabolism of App 114 1.00 66.71 12.38 5.00
185 INT3104 Negative_regulation of CGA 76 0.54 29.81 12.23 5.00
186 INT87239 Localization of Il12a 51 0.75 31.95 12.05 5.00
187 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63 5.00
188 INT50933 Transcription of Il6 38 0.72 24.31 11.58 5.00
189 INT74681 Positive_regulation of Gene_expression of Mmp2 23 0.55 15.58 10.74 5.00
190 INT72579 Localization of BDNF 56 0.80 14.84 10.65 5.00
191 INT53201 Negative_regulation of gr 35 0.50 17.76 10.62 5.00
192 INT85048 Regulation of NGF 19 0.62 11.61 10.5 5.00
193 INT50196 Transcription of Il1b 25 0.69 19.08 10.43 5.00
194 INT16404 Regulation of CD4 54 0.61 33.05 10.29 5.00
195 INT140338 Negative_regulation of Gene_expression of Il17a 34 0.46 23.82 9.87 5.00
196 INT96157 Gene_expression of Cd80 74 0.77 31.19 9.78 5.00
197 INT140191 Positive_regulation of Gene_expression of Mmp13 25 0.67 13.47 9.71 5.00
198 INT70850 Positive_regulation of Transcription of Nos2 30 0.70 18.95 9.68 5.00
199 INT41569 Regulation of APP 32 0.62 17.15 9.4 5.00
200 INT155944 Gene_expression of Foxp3 66 0.66 24.37 9.12 5.00
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