D:Paraproteinemias

From wiki-pain
Jump to: navigation, search

pChart

Disease Term
Synonyms Gammapathy Monoclonal, Gammopathy Monoclonal, Monoclonal Gammapathies, Monoclonal Gammopathies, Paraimmunoglobulinemia, Paraimmunoglobulinemias, PARAPROTEINEMIA, Plasma Cell Dyscrasias
Documents 67
Hot Single Events 30
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Paraproteinemias. They are ordered first by their relevance to Paraproteinemias and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT332588 Binding of RAPH1 and MND1 1 0.01 3.88 0.07 81.64
2 INT332587 MND1 Positive_regulation of Binding of RAPH1 and MND1 1 0.00 2.21 0.03 73.68
3 INT221068 Cd79a Regulation of Gene_expression of IgG 1 0.01 0.93 0.1 5.00
4 INT221067 Cd79a Regulation of IgG 1 0.01 0.93 0.1 5.00
5 INT221066 Cd79a Regulation of Gene_expression of Ighm 1 0.01 0.93 0.1 5.00
6 INT273136 Binding of CHED1 and VSX1 1 0.15 0.12 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Paraproteinemias. They are ordered first by their pain relevance and then by number of times they were reported in Paraproteinemias. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT156130 Binding of SERPING1 29 0.42 26.16 2.52 100.00
2 INT43907 Binding of CD79A 28 0.48 28.11 3.04 99.96
3 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 99.76
4 INT240281 Positive_regulation of IGFALS 11 0.31 10.44 0.56 99.76
5 INT16449 Binding of IGHG3 67 0.48 39.55 10.59 99.68
6 INT39516 Gene_expression of Alb 81 0.75 30.08 6.59 99.64
7 INT2280 Negative_regulation of TNFAIP1 70 0.43 69.43 8.36 98.84
8 INT332592 Binding of MND1 1 0.08 9.21 0.16 98.60
9 INT17326 Binding of Plg 14 0.43 11.72 1.94 98.50
10 INT121335 Localization of SCD 10 0.68 6.81 1.51 97.52
11 INT273154 Positive_regulation of Localization of SCD 1 0.03 0.94 0 97.52
12 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 96.44
13 INT28647 Binding of CTD 13 0.31 14.2 1.5 94.52
14 INT273148 Localization of LCAT 1 0.38 0.91 0 92.32
15 INT273152 Positive_regulation of Localization of LCAT 1 0.26 0.91 0 92.32
16 INT45753 Localization of CD40LG 45 0.79 32.31 5.28 92.08
17 INT67138 Gene_expression of Gc 19 0.31 17.11 4.1 90.92
18 INT149404 Positive_regulation of MAG 1 0.01 1.65 0.12 89.00
19 INT75648 Negative_regulation of CTD 4 0.07 3.91 0.25 88.16
20 INT240280 Gene_expression of IGFALS 14 0.42 20.38 0.95 88.04
21 INT41610 Positive_regulation of IGHD@ 2 0.42 1.5 0.23 85.96
22 INT1127 Negative_regulation of IGHG3 32 0.28 21.1 7.37 84.52
23 INT1124 Negative_regulation of CD40LG 53 0.57 36.26 7 84.52
24 INT1126 Negative_regulation of CD79A 46 0.59 31.07 6 84.52
25 INT126719 Gene_expression of EBVS1 1 0.01 1.34 0.07 84.00
26 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 82.40
27 INT73731 Binding of RAPH1 9 0.33 14.58 0.5 81.64
28 INT264689 Negative_regulation of IGFALS 10 0.33 12.58 0.45 80.40
29 INT36777 Gene_expression of CTD 12 0.41 11.47 1.42 80.04
30 INT105569 Binding of IGFALS 13 0.25 17.31 1.36 80.04
31 INT160799 Regulation of IGFALS 11 0.29 9.09 0.7 79.04
32 INT14666 Negative_regulation of Slc3a2 2 0.12 0.62 0.39 78.96
33 INT128649 Positive_regulation of Itgae 3 0.04 4.3 0.21 77.76
34 INT24816 Binding of CD40LG 68 0.47 45.48 11.56 75.60
35 INT900 Localization of SLC3A2 3 0.70 2.43 0.29 75.00
36 INT16618 Negative_regulation of SERPING1 81 0.59 86.28 7.17 73.84
37 INT149405 Binding of MAG 1 0.01 1.65 0.13 65.92
38 INT64982 Positive_regulation of Ifnb1 10 0.48 6.16 2.35 56.16
39 INT16478 Positive_regulation of Plg 29 0.45 18.07 4.07 54.92
40 INT31317 Positive_regulation of PHGDH 6 0.49 4.45 1.22 54.48
41 INT42715 Positive_regulation of Slc3a2 1 0.13 0.51 0.34 54.48
42 INT47949 Positive_regulation of ELOVL1 19 0.42 29.78 3.3 54.12
43 INT66423 Binding of ELOVL1 52 0.40 61.63 5.16 51.68
44 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 50.56
45 INT19492 Regulation of B2M 16 0.60 10.97 2.55 28.76
46 INT1168 Binding of PROC 62 0.38 44.15 9.04 25.00
47 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33 18.96
48 INT3796 Gene_expression of Ighm 130 0.77 69.61 13.78 12.08
49 INT39416 Gene_expression of Cd79a 81 0.64 45.17 6.08 12.08
50 INT240278 Localization of IGFALS 11 0.53 9.44 0.29 11.60
51 INT332589 Localization of MND1 1 0.12 2.01 0 11.60
52 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
53 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
54 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
55 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
56 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
57 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
58 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
59 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
60 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
61 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
62 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
63 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
64 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 5.00
65 INT5356 Positive_regulation of FOS 153 0.69 54.21 56.74 5.00
66 INT9210 Regulation of IL6 166 0.62 125.61 49.95 5.00
67 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 5.00
68 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
69 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 5.00
70 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
71 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
72 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 5.00
73 INT10763 Localization of IL2 157 0.80 81.11 33.21 5.00
74 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 5.00
75 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 5.00
76 INT8775 Binding of IGHE 167 0.48 102.61 23.54 5.00
77 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 5.00
78 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
79 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 5.00
80 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44 5.00
81 INT38056 Localization of Crp 71 0.78 53.14 17.03 5.00
82 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3 5.00
83 INT10000 Regulation of Gene_expression of IL2 56 0.45 15.33 16.2 5.00
84 INT11508 Positive_regulation of TGFBI 24 0.70 19.81 15.78 5.00
85 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54 5.00
86 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 5.00
87 INT701 Localization of IGHE 87 0.80 40.5 10.62 5.00
88 INT15888 Positive_regulation of Nbr1 42 0.69 35.76 10.48 5.00
89 INT98130 Positive_regulation of CASP8 79 0.67 65.29 10.08 5.00
90 INT35164 Negative_regulation of IGHE 96 0.58 76.3 9.74 5.00
91 INT108202 Positive_regulation of PIK3CG 47 0.67 25.83 8.25 5.00
92 INT2971 Regulation of IGHE 42 0.61 28.81 7.87 5.00
93 INT167052 Gene_expression of Cr2 43 0.56 25.7 7.76 5.00
94 INT15887 Gene_expression of Nbr1 39 0.77 23.91 7.34 5.00
95 INT53189 Gene_expression of VSX1 32 0.69 10.59 7.21 5.00
96 INT3757 Positive_regulation of Gene_expression of ALB 45 0.69 23.73 6.85 5.00
97 INT16389 Gene_expression of Plg 80 0.67 36.88 6.74 5.00
98 INT38672 Binding of KRT20 69 0.39 48.01 6.31 5.00
99 INT55655 Gene_expression of DCN 17 0.75 7.98 5.98 5.00
100 INT87470 Gene_expression of SDC1 27 0.78 24.86 5.81 5.00
101 INT2132 Localization of SCT 29 0.81 8.39 5.43 5.00
102 INT76313 Gene_expression of CD38 30 0.64 20.74 5.27 5.00
103 INT78515 Negative_regulation of Mag 10 0.54 9.4 5.06 5.00
104 INT4988 Gene_expression of KRT1 64 0.77 43.4 4.12 5.00
105 INT52678 Positive_regulation of VSX1 15 0.42 3.94 3.64 5.00
106 INT2886 Gene_expression of SCT 13 0.78 4.55 3.57 5.00
107 INT9999 Regulation of Gene_expression of IGHE 32 0.60 15.75 3.53 5.00
108 INT2117 Regulation of VSX1 15 0.30 3.38 3.38 5.00
109 INT118035 Positive_regulation of JAK1 23 0.67 10.57 3.29 5.00
110 INT4596 Positive_regulation of SCD 18 0.42 22.59 3.26 5.00
111 INT44873 Negative_regulation of LCAT 16 0.59 6.92 3.13 5.00
112 INT9884 Localization of CD79A 41 0.78 21.75 3.06 5.00
113 INT569 Negative_regulation of C4a 13 0.42 9.48 2.85 5.00
114 INT129358 Gene_expression of ELOVL1 23 0.66 29.39 2.83 5.00
115 INT34830 Regulation of PGR 14 0.45 6.99 2.32 5.00
116 INT31994 Negative_regulation of Nbr1 7 0.41 5.54 2.29 5.00
117 INT9995 Localization of C6orf25 13 0.69 6.48 2.29 5.00
118 INT39453 Negative_regulation of TCN2 12 0.59 3.98 2.13 5.00
119 INT15580 Gene_expression of TCN2 16 0.44 7.59 1.97 5.00
120 INT2409 Binding of SCT 7 0.48 2.69 1.94 5.00
121 INT2116 Negative_regulation of VSX1 29 0.36 10.67 1.89 5.00
122 INT3911 Gene_expression of TNFAIP1 29 0.65 21.68 1.85 5.00
123 INT85084 Gene_expression of KRT19 66 0.73 42.56 1.82 5.00
124 INT167692 Binding of NCAM1 11 0.36 6.73 1.59 5.00
125 INT67006 Positive_regulation of TTPA 5 0.49 2.31 1.29 5.00
126 INT126370 Localization of VSX1 6 0.56 1.7 1.28 5.00
127 INT87988 Gene_expression of ASAH1 9 0.77 9.75 1.18 5.00
128 INT186483 Negative_regulation of MYOM2 3 0.04 2.92 0.79 5.00
129 INT59175 Localization of TNMD 4 0.70 4.14 0.71 5.00
130 INT173508 Negative_regulation of Fgfr1 4 0.55 5.08 0.66 5.00
131 INT230410 Negative_regulation of Gene_expression of TNFAIP1 3 0.16 3.67 0.63 5.00
132 INT194794 Binding of TTPA 7 0.08 2.56 0.57 5.00
133 INT4597 Regulation of SCD 5 0.39 2.25 0.5 5.00
134 INT136074 Regulation of ELOVL1 5 0.23 3.6 0.49 5.00
135 INT189634 Regulation of DCN 3 0.25 1.69 0.49 5.00
136 INT185621 Positive_regulation of Gene_expression of SCT 4 0.14 2.14 0.49 5.00
137 INT266786 Binding of ASAH1 2 0.11 3.87 0.44 5.00
138 INT165342 Gene_expression of TGFBI 13 0.59 5.81 0.39 5.00
139 INT320118 Positive_regulation of Localization of CD79A 1 0.49 0.25 0.25 5.00
140 INT273158 Binding of COL8A2 1 0.33 2.02 0.22 5.00
141 INT36479 Binding of NR0B2 2 0.36 3.5 0.21 5.00
142 INT15045 Gene_expression of Car15 2 0.26 1.67 0.21 5.00
143 INT218762 Localization of ZEB1 2 0.65 0.09 0.2 5.00
144 INT34479 Gene_expression of IFNK 1 0.75 0.88 0.18 5.00
145 INT229301 Gene_expression of NR0B2 3 0.18 3.49 0.16 5.00
146 INT155302 Positive_regulation of Car15 1 0.59 0.84 0.13 5.00
147 INT175556 Regulation of Positive_regulation of PTH 3 0.39 2.34 0.12 5.00
148 INT172101 Negative_regulation of Binding of ELOVL1 1 0.36 0.78 0.12 5.00
149 INT194253 Positive_regulation of FIG4 2 0.27 1.39 0.12 5.00
150 INT155303 Negative_regulation of Car15 1 0.36 0.81 0.12 5.00
151 INT172100 Binding of TOP1 2 0.14 1.31 0.11 5.00
152 INT283245 Gene_expression of MND1 2 0.11 1.94 0.07 5.00
153 INT273145 Negative_regulation of COL8A2 1 0.40 0.83 0.06 5.00
154 INT332590 Negative_regulation of Gene_expression of TCN2 1 0.05 1.2 0.06 5.00
155 INT273155 Gene_expression of COL8A2 1 0.53 0.74 0.05 5.00
156 INT273142 Gene_expression of Smc3 1 0.09 0.35 0 5.00
157 INT273144 Binding of CHED1 1 0.19 1.7 0 5.00
158 INT273157 Localization of COL8A2 1 0.26 0.09 0 5.00
159 INT273150 Regulation of CHED1 1 0.24 0.09 0 5.00
160 INT273143 Negative_regulation of Tat 1 0.01 2.3 0 5.00
161 INT232980 Binding of KRT3 2 0.29 0.43 0 5.00
162 INT178941 Transcription of Sdc1 1 0.67 0.92 0 5.00
163 INT245872 Positive_regulation of HLA-G 1 0.02 0.78 0 5.00
164 INT273146 Positive_regulation of Binding of TNMD 1 0.02 0.21 0 5.00
165 INT232943 Binding of KRT12 3 0.47 0.88 0 5.00
166 INT273156 Gene_expression of SLC4A11 1 0.41 0.84 0 5.00
167 INT273147 Binding of TBCD 1 0.05 0 0 5.00
168 INT273160 Binding of TNMD 4 0.42 1.72 0 5.00
169 INT273151 Binding of GCDH 1 0.04 0.25 0 5.00
170 INT273153 Positive_regulation of CHED1 1 0.27 1.53 0 5.00
171 INT332591 Positive_regulation of MND1 1 0.11 1.56 0 5.00
172 INT273159 Gene_expression of CHED1 1 0.36 1.83 0 5.00
173 INT320119 Gene_expression of FBLN5 1 0.01 0.35 0 5.00
174 INT273149 Localization of GCDH 1 0.06 0.77 0 5.00
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox