D:Parathyroid Cancer

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Disease Term
Synonyms ADENOMA PARATHYROID, Adenomas Parathyroid, Cancer Of Parathyroid, Cancer Of The Parathyroid, CANCER PARATHYROID, CANCERS PARATHYROID, Carcinoma Parathyroid, Carcinomas Parathyroid, Neoplasm Parathyroid, Neoplasms Parathyroid, Parathyroid Adenoma
Documents 228
Hot Single Events 76
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Parathyroid Cancer. They are ordered first by their relevance to Parathyroid Cancer and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT156668 Gh Positive_regulation of Igf1 5 0.22 2.07 0.57 5.00
2 INT263917 Binding of SST and Sstr5 2 0.02 0.56 0.45 5.00
3 INT215037 Ghrh Regulation of Localization of Igf2 1 0.04 2.12 0.24 5.00
4 INT197811 Binding of SMS and SST 1 0.00 0.98 0.21 5.00
5 INT75057 Binding of POMC and Msx1 2 0.39 0.6 0.2 5.00
6 INT263901 Binding of Ighg1 and Slc3a2 1 0.00 0.89 0.16 5.00
7 INT215034 Gh Regulation of Igf1 1 0.13 0.27 0.13 5.00
8 INT215036 Gh Positive_regulation of Gene_expression of Trh 1 0.08 1.4 0.06 5.00
9 INT270330 Binding of HYAL1 and TIMP1 1 0.00 0.2 0.04 5.00
10 INT197808 Binding of MEN1 and NME1 1 0.00 1.81 0 5.00
11 INT197809 Binding of MEN1 and VIM 1 0.04 0.52 0 5.00
12 INT186689 Binding of ACHE and Edn1 1 0.28 0 0 5.00
13 INT186685 Edn1 Regulation of Gene_expression of Il6 1 0.11 1.1 0 5.00
14 INT197810 Binding of MEN1 and MUC1 1 0.06 0.47 0 5.00
15 INT263900 Binding of Col1a1 and Cea 1 0.01 0.63 0 5.00
16 INT197816 Binding of MEN1 and NFKB1 1 0.05 0.07 0 5.00
17 INT197813 Binding of AMBP and MEN1 1 0.00 0.51 0 5.00
18 INT197812 Binding of AMBP and RDBP 1 0.00 0.51 0 5.00
19 INT197817 Binding of JUND and MEN1 1 0.18 0.14 0 5.00
20 INT263918 Binding of PTPRC and Cea 1 0.00 0.37 0 5.00
21 INT197844 Binding of MEN1 and Nfkb1 1 0.06 0.26 0 5.00
22 INT215035 Trh Positive_regulation of Gh 1 0.07 0.89 0 5.00
23 INT197815 Binding of MEN1 and TGFB1 1 0.16 0.13 0 5.00
24 INT263899 Binding of PTPRC and TMED7-TICAM2 1 0.00 0.85 0 5.00
25 INT197814 Binding of MEN1 and RELA 1 0.42 0.07 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Parathyroid Cancer. They are ordered first by their pain relevance and then by number of times they were reported in Parathyroid Cancer. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT122448 Regulation of Gene_expression of ABCB1 13 0.62 3.67 3.5 100.00
2 INT1767 Positive_regulation of PROC 83 0.67 54.14 17 100.00
3 INT4097 Localization of Pth 66 0.81 47.17 4.36 99.96
4 INT122449 Localization of SMUG1 10 0.67 7.97 1.47 99.96
5 INT2867 Gene_expression of CALCA 247 0.78 78.78 138.47 99.96
6 INT22500 Negative_regulation of Pth 6 0.43 3.41 2.83 99.96
7 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 99.90
8 INT52457 Gene_expression of ABCB1 129 0.78 38.68 19.88 99.80
9 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 99.76
10 INT34777 Localization of IGF1 82 0.80 42.68 8.62 99.76
11 INT19395 Negative_regulation of Localization of Pth 11 0.58 10.16 0.55 99.68
12 INT72024 Localization of EDNRA 11 0.57 8.22 0.96 99.68
13 INT6514 Positive_regulation of Gene_expression of PTH 28 0.67 30.28 1.37 99.52
14 INT62570 Binding of Pth 48 0.48 26.45 4.85 99.50
15 INT109007 Positive_regulation of Ccnd1 23 0.53 9.5 0.86 99.50
16 INT6625 Negative_regulation of Pth 96 0.58 57.6 8.24 99.44
17 INT64849 Gene_expression of Ret 24 0.75 14.36 9.1 99.32
18 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 99.14
19 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33 99.12
20 INT93399 Gene_expression of Ccnd1 38 0.58 21 3.65 99.08
21 INT93396 Positive_regulation of Gene_expression of Ccnd1 13 0.52 8.59 2.26 99.00
22 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54 98.96
23 INT22715 Positive_regulation of Gene_expression of Pth 29 0.64 22.53 2.31 98.96
24 INT144427 Transcription of Ccnd1 10 0.41 7.89 1.07 98.60
25 INT258835 Localization of Ccnd1 3 0.53 2.7 0.5 98.16
26 INT2544 Localization of PTH 39 0.81 30.55 2.22 98.16
27 INT39500 Positive_regulation of Positive_regulation of Pth 14 0.48 9.75 1.28 98.08
28 INT215750 Transcription of Ccnd1 2 0.14 2.23 0.09 98.00
29 INT12564 Localization of Pthlh 23 0.81 4.37 5.82 97.84
30 INT36770 Positive_regulation of Localization of Pth 14 0.70 10.42 0.46 97.68
31 INT101047 Localization of Epgn 2 0.23 1.41 0.1 97.44
32 INT196424 Binding of Ccnd1 5 0.29 3.34 0.47 97.28
33 INT144432 Positive_regulation of Transcription of Ccnd1 4 0.36 2.36 0.63 97.24
34 INT258832 Regulation of Transcription of Ccnd1 1 0.16 1.57 0.03 97.24
35 INT22813 Gene_expression of PTRH1 1 0.11 0.42 0.08 97.04
36 INT197839 Negative_regulation of PHPT1 1 0.04 2.88 0.06 96.80
37 INT197828 Negative_regulation of MEN1 1 0.43 5.06 0.06 96.80
38 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 96.64
39 INT300621 Localization of Men1 1 0.56 4.63 0.52 96.56
40 INT46615 Negative_regulation of Gene_expression of PTH 8 0.57 5.1 0.4 96.12
41 INT300623 Positive_regulation of Men1 1 0.35 10.65 0.57 95.84
42 INT1792 Positive_regulation of CGA 123 0.70 64.73 20.79 95.76
43 INT219876 Positive_regulation of PHPT1 1 0.01 1.25 0 95.42
44 INT16235 Positive_regulation of CGB 27 0.70 15.71 4.06 95.36
45 INT7082 Gene_expression of CRH 180 0.78 64.66 31.74 94.60
46 INT219980 Positive_regulation of THRA 4 0.49 1.17 0.96 94.44
47 INT102572 Gene_expression of Ccnd1 79 0.69 56.37 7.34 94.32
48 INT197842 Gene_expression of PHPT1 1 0.06 5.89 0.16 94.20
49 INT197835 Positive_regulation of Gene_expression of PHPT1 1 0.04 3.17 0.07 94.20
50 INT5454 Localization of CRH 124 0.79 79.18 41.53 94.20
51 INT61102 Gene_expression of MEN1 12 0.78 17.7 0.43 93.88
52 INT197836 Positive_regulation of Gene_expression of MEN1 1 0.50 3.16 0.07 93.88
53 INT4096 Regulation of Localization of Pth 7 0.58 3.97 0.95 93.28
54 INT425 Localization of PRL 455 0.81 189.64 144.8 92.96
55 INT22812 Positive_regulation of PTRH1 4 0.49 3.06 0.43 92.80
56 INT62067 Negative_regulation of Gene_expression of Pth 13 0.41 8.24 0.61 92.24
57 INT75718 Positive_regulation of Cxadr 2 0.32 0.31 0.62 91.92
58 INT155036 Localization of NT5E 6 0.73 4.1 1.35 91.32
59 INT101048 Negative_regulation of Epgn 1 0.14 1.06 0 91.00
60 INT268701 Negative_regulation of SLC25A5 2 0.31 2.61 0.08 90.88
61 INT158796 Positive_regulation of SMUG1 67 0.70 38.97 8.98 89.96
62 INT186142 Gene_expression of Ghrh 45 0.66 34.04 6.94 89.52
63 INT114159 Binding of PHPT1 1 0.30 1.21 0.14 88.40
64 INT285 Positive_regulation of Salpa1 73 0.68 61.47 9.19 87.44
65 INT246502 Negative_regulation of Men1 2 0.30 8.9 0.33 87.36
66 INT151032 Localization of Igf1 49 0.76 26.32 5.71 87.28
67 INT252 Localization of GH1 529 0.80 227.4 122.05 86.92
68 INT3343 Regulation of PTH 24 0.62 11.18 1.62 86.64
69 INT23030 Positive_regulation of Pth 13 0.61 9.24 0.97 86.56
70 INT70905 Positive_regulation of EDNRA 49 0.67 24.33 11.79 86.32
71 INT62784 Gene_expression of NT5E 46 0.65 15.95 3.72 86.12
72 INT5865 Positive_regulation of Localization of Gh 282 0.69 84.86 93.5 84.68
73 INT1893 Localization of Gh 1041 0.79 340.23 256.58 84.68
74 INT146801 Regulation of Ccnd1 5 0.34 2.4 0.19 84.56
75 INT4860 Positive_regulation of CALCA 148 0.00 73.35 97.61 84.24
76 INT90 Localization of Gast 400 0.81 137.67 113 83.76
77 INT78281 Gene_expression of Krt7 28 0.70 26.77 0.97 79.52
78 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 79.04
79 INT105021 Binding of GOPC 187 0.40 60.39 20.38 79.04
80 INT170601 Positive_regulation of Gene_expression of GOPC 122 0.43 42.79 11.68 79.04
81 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 75.96
82 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 75.96
83 INT22083 Regulation of Pth 55 0.62 22.32 8.9 75.00
84 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 73.76
85 INT349546 Negative_regulation of Binding of CASR 1 0.07 1.11 0 72.72
86 INT67093 Binding of CASR 3 0.41 3.32 0.64 72.72
87 INT142060 Positive_regulation of Ghrh 15 0.66 7.21 1.83 71.88
88 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 70.96
89 INT3777 Positive_regulation of NARFL 256 0.56 302.43 25.74 70.92
90 INT192808 Negative_regulation of Localization of PTH 6 0.59 7.31 0.45 70.28
91 INT54978 Binding of EDNRA 36 0.41 14.97 7.86 69.64
92 INT3824 Negative_regulation of PTH 40 0.59 28.58 3.39 67.16
93 INT175652 Positive_regulation of BPHL 9 0.44 17.98 1.14 65.12
94 INT115423 Gene_expression of Men1 4 0.47 14.08 0.64 64.08
95 INT23031 Positive_regulation of Bglap 2 0.08 1.34 0.17 63.68
96 INT2244 Positive_regulation of Localization of GAST 7 0.68 5.28 0.73 55.76
97 INT2243 Localization of GAST 67 0.81 34.54 16.19 55.24
98 INT16303 Negative_regulation of Localization of GH1 89 0.59 37.31 22.15 52.32
99 INT197827 Regulation of PHPT1 1 0.03 2.54 0.08 51.56
100 INT170604 Negative_regulation of Gene_expression of GOPC 50 0.35 12.71 4.51 50.00
101 INT64797 Regulation of ALPP 18 0.24 9.71 2.24 50.00
102 INT75719 Regulation of Cxadr 2 0.21 0.06 0.66 50.00
103 INT261585 Positive_regulation of Localization of MRS2 1 0.01 0.66 0 50.00
104 INT261586 Positive_regulation of MRS2 1 0.01 0.27 0 50.00
105 INT261584 Positive_regulation of Regulation of Cxadr 1 0.02 0.06 0 50.00
106 INT261587 Localization of MRS2 1 0.01 0.66 0 50.00
107 INT15148 Gene_expression of Vip 51 0.77 25.61 18.33 45.36
108 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 43.08
109 INT184418 Negative_regulation of Positive_regulation of GOPC 15 0.26 5.47 0.87 43.08
110 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 42.88
111 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 42.72
112 INT65058 Binding of Nfkb1 36 0.45 19.87 10.02 42.24
113 INT300622 Binding of Jund 1 0.04 1.57 0 42.24
114 INT90350 Gene_expression of Gast 27 0.78 14.07 4.74 42.00
115 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 40.64
116 INT276148 Negative_regulation of Positive_regulation of SLC25A5 1 0.08 0.68 0.03 39.60
117 INT5010 Gene_expression of Calca 197 0.78 85.76 118.75 38.80
118 INT276150 Positive_regulation of SLC25A5 1 0.13 0.68 0.03 38.44
119 INT40249 Regulation of Regulation of Ren 4 0.36 0.83 1.05 38.12
120 INT1116 Regulation of Ren 103 0.62 27.66 33.26 36.44
121 INT145594 Gene_expression of Mtx1 64 0.57 35.33 30.35 28.08
122 INT846 Positive_regulation of B2M 42 0.70 29.78 8.06 25.00
123 INT53927 Positive_regulation of Localization of PTH 8 0.69 5.33 0.09 25.00
124 INT227515 Regulation of Gene_expression of Mtx1 5 0.38 4.34 3.24 23.68
125 INT42530 Gene_expression of Lct 11 0.66 9.37 1.37 19.68
126 INT159561 Positive_regulation of Gene_expression of Lct 4 0.49 4.11 0.4 19.68
127 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 16.40
128 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 16.40
129 INT2093 Gene_expression of GAST 50 0.78 32.32 7.98 16.40
130 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 6.32
131 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 6.32
132 INT158 Localization of Prl 2431 0.81 378.96 952.2 5.00
133 INT443 Localization of POMC 1020 0.81 284.52 443.17 5.00
134 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
135 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 5.00
136 INT626 Localization of CALCA 289 0.81 125.39 221.15 5.00
137 INT159 Negative_regulation of Localization of Prl 416 0.59 55.34 171.8 5.00
138 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 5.00
139 INT2640 Gene_expression of Pomc 424 0.78 120.72 155.37 5.00
140 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
141 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
142 INT695 Binding of POMC 304 0.48 56.66 126.85 5.00
143 INT5008 Localization of Calca 204 0.81 80.35 125.16 5.00
144 INT1438 Localization of Pomc 360 0.81 101.26 116.47 5.00
145 INT1530 Regulation of Gh 382 0.61 115.96 112.47 5.00
146 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 5.00
147 INT397 Localization of SST 232 0.81 58.05 101.19 5.00
148 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 5.00
149 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 5.00
150 INT3214 Localization of Ins1 527 0.80 196.9 79.26 5.00
151 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 5.00
152 INT253 Regulation of PRL 184 0.62 47.27 65.79 5.00
153 INT3950 Gene_expression of Ptger2 293 0.77 122.28 62.42 5.00
154 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
155 INT48891 Positive_regulation of Il10 143 0.70 101.42 56.72 5.00
156 INT249 Localization of GHRH 215 0.80 78.02 51.87 5.00
157 INT921 Regulation of GH1 172 0.60 52.88 51.04 5.00
158 INT5781 Gene_expression of Edn1 190 0.78 99.1 46 5.00
159 INT1894 Negative_regulation of Localization of Gh 168 0.58 64.12 43.56 5.00
160 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 5.00
161 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52 5.00
162 INT918 Positive_regulation of Localization of PRL 90 0.70 23.97 40.3 5.00
163 INT173693 Localization of Gopc 249 0.65 70.49 38.81 5.00
164 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
165 INT916 Regulation of Localization of PRL 92 0.62 22.98 38.13 5.00
166 INT70437 Negative_regulation of Mdk 115 0.57 41.03 35.72 5.00
167 INT255 Regulation of Localization of GH1 89 0.62 18.71 35.3 5.00
168 INT129686 Gene_expression of FSCN1 46 0.15 18.91 34.47 5.00
169 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 5.00
170 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 5.00
171 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92 5.00
172 INT13897 Localization of Sst 65 0.81 14.91 32.24 5.00
173 INT13186 Positive_regulation of Il4 113 0.68 71.22 31.4 5.00
174 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
175 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 5.00
176 INT23937 Gene_expression of EDNRA 103 0.65 55.63 24.67 5.00
177 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07 5.00
178 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04 5.00
179 INT956 Negative_regulation of PRL 94 0.59 42.72 23.01 5.00
180 INT11346 Binding of Mtx1 39 0.41 24.88 21.21 5.00
181 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 5.00
182 INT5048 Binding of Edn1 55 0.47 18.86 19.16 5.00
183 INT13454 Positive_regulation of Positive_regulation of Gh 49 0.68 14.53 18.49 5.00
184 INT1578 Negative_regulation of Localization of PRL 52 0.59 20.62 17.18 5.00
185 INT10841 Positive_regulation of Gene_expression of Gh 101 0.59 45.39 16.96 5.00
186 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65 5.00
187 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 5.00
188 INT1981 Negative_regulation of NARFL 219 0.47 223.48 16.41 5.00
189 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 5.00
190 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 5.00
191 INT49532 Regulation of Gene_expression of Il6 43 0.61 25.8 14.99 5.00
192 INT65263 Positive_regulation of Gene_expression of Igf1 61 0.69 25.69 14.49 5.00
193 INT1982 Regulation of NARFL 119 0.49 116.2 14.35 5.00
194 INT35029 Positive_regulation of Gene_expression of Ptger2 66 0.43 26.37 13.99 5.00
195 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99 5.00
196 INT5806 Regulation of Edn1 63 0.62 23.46 13.88 5.00
197 INT6365 Localization of Edn1 56 0.81 18.84 13.83 5.00
198 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61 5.00
199 INT22000 Positive_regulation of Sst 25 0.70 14.82 13.6 5.00
200 INT2005 Positive_regulation of Gene_expression of PRL 55 0.70 21.4 13.44 5.00
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