D:Parkinsonian Disorders

From wiki-pain
Jump to: navigation, search

pChart

Disease Term
Synonyms AUTOSOMAL DOMINANT JUVENILE PARKINSON DISEASE, AUTOSOMAL DOMINANT JUVENILE PARKINSONISM, AUTOSOMAL DOMINANT PARKINSONISM, Autosomal Recessive Juvenile Parkinson Disease, Autosomal Recessive Parkinsonism, Autosomal Recesssive Juvenile Parkinsonism, Chromosome 6 Linked Autosomal Recessive Parkinsonism, Diseases Experimental Parkinson, DOMINANT PARKINSONISM AUTOSOMAL, Experimental Parkinson Disease, Experimental Parkinson Diseases
Documents 62
Hot Single Events 50
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Parkinsonian Disorders. They are ordered first by their relevance to Parkinsonian Disorders and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT326587 GYPA Regulation of DDC 1 0.08 0.83 0.33 92.68
2 INT336561 Binding of DDC and DIO2 1 0.04 0.27 0.24 90.80
3 INT326585 Binding of GYPA and SLC6A3 1 0.13 0.86 2.64 82.40
4 INT160971 Gm2111 Positive_regulation of Grm7 1 0.01 0.16 0.41 75.00
5 INT326586 SLC18A2 Negative_regulation of DDC 1 0.28 0.91 0.66 73.08
6 INT326583 GYPA Negative_regulation of Binding of GYPA and SLC6A3 1 0.03 0.22 0.22 68.92
7 INT277433 Wibg Positive_regulation of Gdnf 1 0.01 0.6 0.13 67.32
8 INT277430 Wibg Positive_regulation of Gene_expression of Gdnf 1 0.01 0.6 0.13 67.32
9 INT336556 SLC6A3 Positive_regulation of Gene_expression of GOPC 1 0.08 1.87 1.76 5.00
10 INT336559 SLC6A3 Positive_regulation of GOPC 1 0.08 1 1.15 5.00
11 INT339291 Casp1 Positive_regulation of Il1 2 0.12 1.63 0.8 5.00
12 INT336557 SLC6A3 Positive_regulation of Binding of GOPC 1 0.08 0.5 0.58 5.00
13 INT354820 Creb1 Negative_regulation of Transcription of Cpox 1 0.03 0.59 0.38 5.00
14 INT336573 Ptpn2 Regulation of INSR 1 0.00 1.36 0.36 5.00
15 INT345421 IFNA1 Positive_regulation of Eif2ak2 2 0.03 1.25 0.3 5.00
16 INT354821 Nos2 Positive_regulation of Eif2ak2 1 0.06 0.64 0.3 5.00
17 INT277434 Cd5 Regulation of Gdnf 1 0.01 0 0.21 5.00
18 INT354819 Binding of Cpox and Ptgs2 1 0.02 0.45 0.16 5.00
19 INT258812 Sugt1 Positive_regulation of Ace 1 0.05 1.26 0.16 5.00
20 INT354823 IFNA1 Positive_regulation of Racgap1 1 0.00 1.4 0.15 5.00
21 INT347868 Ntf3 Negative_regulation of Negative_regulation of Chat 1 0.03 0.22 0.13 5.00
22 INT277431 Positive_regulation of Grm3 Positive_regulation of Gene_expression of Gdnf 1 0.18 0 0.07 5.00
23 INT277432 Ptpn2 Positive_regulation of Gdnf 1 0.29 1.41 0.06 5.00
24 INT354822 Negative_regulation of Stat3 Negative_regulation of Positive_regulation of IFNA1 1 0.02 0.85 0.06 5.00
25 INT277435 Ptpn2 Positive_regulation of Ptpn2 Positive_regulation of Gdnf 1 0.20 0.94 0.05 5.00
26 INT277429 Ptpn2 Regulation of Gdnf 1 0.34 0.47 0.03 5.00
27 INT277427 Ptpn2 Positive_regulation of Gene_expression of Gdnf 1 0.32 0.47 0.03 5.00
28 INT277428 Positive_regulation of Ptpn2 Positive_regulation of Gdnf 1 0.29 0.47 0.03 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Parkinsonian Disorders. They are ordered first by their pain relevance and then by number of times they were reported in Parkinsonian Disorders. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT27627 Binding of Rac1 41 0.41 22.88 13.68 100.00
2 INT10980 Gene_expression of GYPA 40 0.78 15.32 5.51 99.64
3 INT110961 Binding of GYPA 14 0.36 6.66 2.03 99.64
4 INT90461 Negative_regulation of DRD2 21 0.53 8.35 6.55 99.04
5 INT51635 Negative_regulation of LRTOMT 5 0.41 1.17 1.49 98.96
6 INT53062 Gene_expression of Ddc 31 0.77 11.59 9.63 98.88
7 INT15744 Localization of GYPA 12 0.64 7.19 2.61 98.68
8 INT75682 Regulation of Chrna7 14 0.45 10.24 5.25 98.56
9 INT6042 Binding of Oprm1 248 0.48 31.77 154.34 98.48
10 INT18021 Positive_regulation of Binding of Oprm1 16 0.70 2.53 8.38 98.48
11 INT18391 Positive_regulation of GYPA 41 0.40 16.47 8.69 98.20
12 INT160994 Negative_regulation of St13 9 0.20 4.83 3.71 97.92
13 INT125399 Negative_regulation of Nat2 1 0.01 1.84 0.72 97.60
14 INT89425 Positive_regulation of HLA-DRB3 2 0.59 2.38 0.42 97.52
15 INT36491 Gene_expression of mn 2 0.52 2.22 0.89 97.46
16 INT48144 Gene_expression of Fgf2 117 0.78 43 20.48 97.12
17 INT71633 Negative_regulation of SLC6A3 25 0.59 10.5 10.69 97.00
18 INT96504 Negative_regulation of SLC18A2 5 0.36 2.07 4.62 97.00
19 INT195535 Positive_regulation of Grm3 8 0.25 3.37 1.67 96.92
20 INT50895 Regulation of GYPA 10 0.60 4.05 1.95 96.76
21 INT102897 Positive_regulation of Gene_expression of Gdnf 34 0.69 11.13 13.28 96.40
22 INT90823 Positive_regulation of Ptpn2 25 0.59 22.97 3.59 96.40
23 INT121136 Negative_regulation of DDC 4 0.57 2.98 1.32 95.96
24 INT326597 Negative_regulation of Localization of GYPA 1 0.16 1.51 0.1 95.68
25 INT60032 Negative_regulation of Pla2g2a 29 0.58 12.42 5.75 95.64
26 INT144735 Gene_expression of DDC 8 0.75 3.21 5.31 95.60
27 INT51819 Negative_regulation of MSMB 8 0.49 4.5 4 95.56
28 INT5648 Negative_regulation of Mptp1 7 0.37 6.64 3.08 95.44
29 INT48890 Gene_expression of Gdnf 91 0.77 28.62 31.49 95.40
30 INT18390 Positive_regulation of Positive_regulation of GYPA 2 0.40 1.42 0.39 95.04
31 INT64687 Regulation of Gene_expression of Fgf2 7 0.62 2.29 1.89 93.88
32 INT326598 Negative_regulation of Negative_regulation of SLC6A3 1 0.28 0.65 0.24 93.84
33 INT1169 Negative_regulation of Bche 322 0.59 149.22 61.27 93.00
34 INT71634 Gene_expression of SLC6A3 45 0.78 13.48 15.23 92.56
35 INT103880 Positive_regulation of DRD2 9 0.67 5.57 5.93 91.36
36 INT202581 Positive_regulation of Gene_expression of DRD2 2 0.49 0.81 0.47 91.36
37 INT63773 Gene_expression of DRD2 25 0.78 10.41 10.8 90.96
38 INT86713 Positive_regulation of Mip 10 0.67 6.44 2.63 90.56
39 INT166881 Positive_regulation of Ccr1 31 0.69 18.14 7.9 90.16
40 INT3439 Localization of Abat 1017 0.78 112.39 727.06 89.76
41 INT96269 Positive_regulation of Mcpt1 71 0.61 52.38 20.4 89.52
42 INT9027 Positive_regulation of Ddc 24 0.66 6.04 10.19 88.56
43 INT326599 Positive_regulation of Binding of GYPA 1 0.14 0.88 0.03 87.44
44 INT61547 Regulation of Fgf2 21 0.47 7.23 3.24 86.16
45 INT150155 Binding of TPO 3 0.30 3.98 0.58 86.00
46 INT67488 Binding of Pc 8 0.31 4.6 1.13 84.24
47 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 83.44
48 INT16428 Positive_regulation of Gtf3a 135 0.20 106.44 26.67 82.76
49 INT47425 Localization of Chrna7 11 0.81 6.7 1.86 81.72
50 INT4781 Gene_expression of TH 68 0.73 26.92 24.01 80.08
51 INT170238 Negative_regulation of Gene_expression of GYPA 5 0.42 1.74 0.88 79.48
52 INT4829 Positive_regulation of Localization of Abat 199 0.55 20.91 150.48 79.36
53 INT597 Positive_regulation of PON1 26 0.62 19.14 2.87 79.04
54 INT119053 Positive_regulation of SLC6A3 15 0.65 2.51 4 78.08
55 INT76142 Positive_regulation of Regulation of Fgf2 2 0.47 0.34 0.64 76.96
56 INT326602 Negative_regulation of Gene_expression of SLC18A2 1 0.25 0.93 0.67 76.80
57 INT326601 Gene_expression of SLC18A2 2 0.42 1.31 0.92 76.40
58 INT1771 Positive_regulation of Ace 31 0.68 10.47 7.46 75.88
59 INT8652 Protein_catabolism of Ace 10 0.94 4.7 2.74 75.88
60 INT61548 Positive_regulation of Fgf2 72 0.70 32.18 14.49 75.60
61 INT23676 Gene_expression of Chrna7 47 0.75 23.66 9.51 75.00
62 INT2211 Negative_regulation of Abat 267 0.59 66.51 200.98 75.00
63 INT79680 Binding of Grm7 6 0.47 2.83 3.58 75.00
64 INT57549 Gene_expression of GNPTAB 49 0.65 57.5 9.05 70.64
65 INT15745 Negative_regulation of GYPA 18 0.43 8.01 2.74 68.92
66 INT64689 Positive_regulation of Gene_expression of Fgf2 30 0.70 12.05 6.2 67.84
67 INT82950 Positive_regulation of Gdnf 36 0.51 11.72 10.5 65.36
68 INT18190 Regulation of DRD2 11 0.60 9.01 7.63 64.88
69 INT326603 Regulation of Positive_regulation of DRD2 1 0.44 0.8 0.69 64.88
70 INT161404 Negative_regulation of Pc 3 0.49 0.95 0.2 63.44
71 INT93182 Binding of Gdnf 7 0.35 1.96 1.64 62.00
72 INT326600 Negative_regulation of Gene_expression of DRD2 1 0.53 0.35 0.23 62.00
73 INT388 Positive_regulation of Gene_expression of Ace 4 0.42 1.04 2.13 57.96
74 INT389 Gene_expression of Ace 21 0.67 10.31 8.1 57.48
75 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 53.52
76 INT49567 Regulation of DRD1 5 0.35 1.02 1.54 52.40
77 INT798 Positive_regulation of Gene_expression of Penk 394 0.70 78.53 203.07 49.24
78 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59 48.76
79 INT35467 Gene_expression of DIO2 37 0.65 9.56 12.61 46.08
80 INT336571 Gene_expression of DRD5 1 0.06 0.73 1.41 46.08
81 INT144366 Negative_regulation of Positive_regulation of Gdnf 4 0.41 1.43 2.41 45.52
82 INT277419 Positive_regulation of Positive_regulation of Gdnf 1 0.47 0 0.12 45.52
83 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 45.36
84 INT49975 Binding of SLC6A3 34 0.47 9.86 12.41 43.20
85 INT309257 Transcription of LMOD1 3 0.36 1.71 1.57 41.92
86 INT342722 Gene_expression of Lrrk2 2 0.41 1.81 0.03 41.44
87 INT65207 Positive_regulation of Positive_regulation of Fgf2 10 0.70 3.5 2.08 39.04
88 INT68332 Positive_regulation of GRM1 7 0.67 2.11 3.83 36.16
89 INT43902 Binding of Ptpn2 6 0.29 3.59 0.93 30.52
90 INT354815 Transcription of Ptpn2 1 0.29 0.61 0.27 30.52
91 INT110445 Phosphorylation of Gtf3a 15 0.09 5.58 3.07 27.68
92 INT130696 Positive_regulation of Phosphorylation of Gtf3a 2 0.01 1.37 0.91 27.68
93 INT98017 Protein_catabolism of Gtf3a 10 0.11 6.16 0.83 27.68
94 INT354812 Positive_regulation of Protein_catabolism of Gtf3a 1 0.01 0.56 0.44 27.68
95 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 27.48
96 INT128269 Positive_regulation of Slc17a7 3 0.50 1.06 1.82 21.20
97 INT261850 Regulation of Positive_regulation of Slc17a7 1 0.10 0.49 0.58 21.20
98 INT107930 Gene_expression of Slc17a7 39 0.78 6.53 18.86 20.08
99 INT129505 Regulation of Slc17a7 5 0.37 1.09 2.11 20.08
100 INT128273 Regulation of Gene_expression of Slc17a7 3 0.62 0.82 1.72 20.08
101 INT96533 Gene_expression of Slc1a3 72 0.78 26.85 55.31 19.52
102 INT268616 Positive_regulation of Gene_expression of Ptpn2 7 0.43 8.14 2.08 19.00
103 INT161107 Gene_expression of Ptpn2 58 0.58 49.92 7.4 18.24
104 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 13.72
105 INT43901 Negative_regulation of Ptpn2 65 0.37 56.32 7.48 12.24
106 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94 10.40
107 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 8.64
108 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 8.64
109 INT53083 Gene_expression of Ptgs2 153 0.78 90.04 50.39 8.64
110 INT120477 Gene_expression of Sugt1 2 0.06 1.07 0.69 6.64
111 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 5.00
112 INT16260 Gene_expression of Bdnf 671 0.78 283.44 339.1 5.00
113 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 5.00
114 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
115 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 5.00
116 INT626 Localization of CALCA 289 0.81 125.39 221.15 5.00
117 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07 5.00
118 INT16259 Positive_regulation of Bdnf 336 0.70 183.48 209.82 5.00
119 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 5.00
120 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71 5.00
121 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
122 INT49441 Negative_regulation of Cpox 494 0.59 303.22 177.46 5.00
123 INT7506 Negative_regulation of Ltp 267 0.46 91.01 176.8 5.00
124 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
125 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 5.00
126 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
127 INT49134 Gene_expression of Grin1 270 0.78 84.78 148.61 5.00
128 INT7628 Gene_expression of Ltp 273 0.77 70.21 147.87 5.00
129 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
130 INT49439 Gene_expression of Cpox 508 0.73 326.97 130.17 5.00
131 INT5842 Gene_expression of Gfap 372 0.78 153.71 127.71 5.00
132 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 5.00
133 INT7341 Positive_regulation of Grin1 169 0.70 65.86 118.38 5.00
134 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
135 INT16253 Positive_regulation of Gene_expression of Bdnf 196 0.70 92.67 113.01 5.00
136 INT7627 Negative_regulation of Positive_regulation of Ltp 162 0.50 41.2 106.27 5.00
137 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
138 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
139 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
140 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
141 INT74058 Gene_expression of Nos1 260 0.78 80.04 95.71 5.00
142 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
143 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 5.00
144 INT13036 Positive_regulation of Positive_regulation of Ltp 105 0.51 23.71 77.66 5.00
145 INT79506 Gene_expression of Grin2b 122 0.78 43.71 73.42 5.00
146 INT39565 Gene_expression of Ptger2 424 0.75 229.28 72.68 5.00
147 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 5.00
148 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 5.00
149 INT5843 Positive_regulation of Gfap 184 0.70 108.2 70.21 5.00
150 INT6849 Localization of IL1B 229 0.81 112.56 69.63 5.00
151 INT13276 Regulation of Ltp 107 0.53 30.78 69.13 5.00
152 INT47690 Regulation of Bdnf 118 0.62 53.02 64.5 5.00
153 INT6894 Gene_expression of CNR1 168 0.78 74.07 62.84 5.00
154 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 5.00
155 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 5.00
156 INT6623 Gene_expression of NA 231 0.78 45.78 59.36 5.00
157 INT3920 Localization of Ldha 241 0.81 83.08 58.72 5.00
158 INT119528 Positive_regulation of Camk2a 135 0.70 26.13 54.7 5.00
159 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 5.00
160 INT4957 Negative_regulation of Grin1 87 0.59 24.51 53.21 5.00
161 INT52611 Negative_regulation of Ptgs2 142 0.59 66.31 52.71 5.00
162 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 5.00
163 INT19775 Localization of Il1 183 0.78 145.5 50.91 5.00
164 INT51627 Gene_expression of Grin2a 82 0.76 25.09 47.6 5.00
165 INT374 Positive_regulation of Ldha 212 0.70 107.08 47.43 5.00
166 INT18522 Positive_regulation of Gene_expression of IFNA1 248 0.67 160.85 44.87 5.00
167 INT25610 Positive_regulation of Gene_expression of Il1 136 0.67 104.43 43.86 5.00
168 INT11406 Positive_regulation of Localization of CALCA 49 0.70 20.64 42.8 5.00
169 INT16261 Transcription of Bdnf 101 0.72 49.41 40.64 5.00
170 INT20210 Localization of Ngf 69 0.79 46.22 38.57 5.00
171 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2 5.00
172 INT82054 Positive_regulation of Grin2b 56 0.70 17.45 37.14 5.00
173 INT12608 Regulation of CNR1 62 0.60 24.36 36.02 5.00
174 INT70437 Negative_regulation of Mdk 115 0.57 41.03 35.72 5.00
175 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 5.00
176 INT5862 Positive_regulation of Egr1 82 0.70 30.4 33.96 5.00
177 INT81289 Positive_regulation of Gene_expression of Tlr4 192 0.69 104.5 33.89 5.00
178 INT67039 Positive_regulation of Cpox 144 0.65 98.4 33.77 5.00
179 INT666 Gene_expression of Jun 124 0.78 54.61 33.67 5.00
180 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 5.00
181 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2 5.00
182 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81 5.00
183 INT17886 Negative_regulation of Il1 95 0.57 70.91 31.25 5.00
184 INT50230 Positive_regulation of Localization of IL6 105 0.70 69.21 29.52 5.00
185 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
186 INT66200 Gene_expression of Gfap 215 0.78 88.04 28.25 5.00
187 INT133876 Positive_regulation of Gene_expression of Ros1 141 0.32 75.55 27.45 5.00
188 INT73314 Gene_expression of Arc 133 0.78 67.78 27.44 5.00
189 INT80470 Negative_regulation of Gene_expression of Grin1 33 0.59 10.22 27.15 5.00
190 INT32826 Positive_regulation of Gene_expression of Ltp 52 0.45 10.34 26.8 5.00
191 INT63444 Regulation of Gene_expression of Abat 26 0.51 14.65 26.29 5.00
192 INT276 Regulation of Ache 83 0.62 16.75 25.99 5.00
193 INT47075 Positive_regulation of Ptger2 142 0.70 78.55 25.47 5.00
194 INT9886 Gene_expression of Ptgs1 92 0.77 40.66 25.31 5.00
195 INT55583 Localization of IFNA1 135 0.78 85.07 24.13 5.00
196 INT25607 Binding of Il1 82 0.47 64.4 23.9 5.00
197 INT6866 Regulation of Gfap 51 0.61 19.6 23.56 5.00
198 INT110427 Gene_expression of Spp1 199 0.78 176.11 23.31 5.00
199 INT69993 Positive_regulation of Gene_expression of Cpox 93 0.55 69.4 22.05 5.00
200 INT78057 Localization of Tlr4 140 0.77 67.75 21.72 5.00
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox