D:Patent Ductus Arteriosus

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Disease Term
Synonyms Arteriosus Patent Ductus
Documents 236
Hot Single Events 32
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Patent Ductus Arteriosus. They are ordered first by their relevance to Patent Ductus Arteriosus and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT312637 Negative_regulation of Binding of Musk and Dok7 1 0.42 1.03 0 55.60
2 INT312635 Binding of Musk and Dok7 1 0.47 3.41 0 55.60
3 INT312646 Agrn Positive_regulation of Phosphorylation of CHRNE 1 0.02 0.38 0 39.52
4 INT230723 ERVW-1 Positive_regulation of Gene_expression of EDN1 1 0.00 1.95 0 28.00
5 INT230734 Negative_regulation of Binding of EDNRA and Pah 1 0.02 3.26 0.61 5.00
6 INT230735 Binding of EDNRA and Pah 1 0.02 3.22 0.6 5.00
7 INT175323 Tlr4 Positive_regulation of Gene_expression of TLR2 1 0.02 0.31 0.56 5.00
8 INT175326 SERPINH1 Regulation of Pnlip 1 0.00 0.53 0.49 5.00
9 INT230724 EDN1 Positive_regulation of EDNRA 3 0.24 4.12 0.39 5.00
10 INT175319 Negative_regulation of Nos2 Negative_regulation of Positive_regulation of Pnlip 1 0.01 0.83 0.34 5.00
11 INT312803 F2 Positive_regulation of NPEPPS 1 0.01 1.32 0.32 5.00
12 INT312802 F2 Positive_regulation of Binding of NPEPPS 1 0.01 1.33 0.32 5.00
13 INT175321 IL6 Positive_regulation of Localization of Oxt 1 0.01 0.7 0.25 5.00
14 INT175322 Oxt Positive_regulation of Gene_expression of PTGER2 1 0.00 0.09 0.25 5.00
15 INT231206 Binding of KCNH2 and KCNQ1 2 0.22 1.04 0.24 5.00
16 INT175324 Hsp90b1 Positive_regulation of TLR2 1 0.00 0.65 0.23 5.00
17 INT175317 Hsp90b1 Positive_regulation of Tlr4 1 0.02 0.66 0.23 5.00
18 INT175320 Tlr4 Positive_regulation of Gene_expression of Mmp9 1 0.01 0.54 0.21 5.00
19 INT312631 Binding of Musk and Agrn 1 0.40 0.63 0.12 5.00
20 INT231223 Binding of KCNQ1 and Nav1 1 0.03 0.59 0.11 5.00
21 INT175325 Binding of TLR2 and Tlr6 1 0.00 0.39 0.09 5.00
22 INT175327 Binding of TLR2 and Tlr1 1 0.00 0.39 0.09 5.00
23 INT312645 Binding of DNAJA3 and Musk 1 0.08 0.96 0.07 5.00
24 INT312636 Negative_regulation of Binding of Musk and Lrp4 1 0.21 0.32 0.06 5.00
25 INT312639 Binding of Musk and Lrp4 1 0.23 0.91 0.06 5.00
26 INT312632 Binding of Agrn and Lrp4 1 0.17 0.32 0.06 5.00
27 INT312647 Binding of Agrn and SYCP3 1 0.39 0.32 0.06 5.00
28 INT312627 Negative_regulation of Binding of Musk and Agrn 1 0.46 0.32 0.06 5.00
29 INT296893 Nps Negative_regulation of Gene_expression of REN 1 0.00 1.05 0.04 5.00
30 INT283226 Binding of ACE and CC2D1A 1 0.11 2.37 0.04 5.00
31 INT311655 Shh Positive_regulation of Gene_expression of Fgf8 1 0.31 0.18 0.03 5.00
32 INT311658 Spry1 Regulation of Regulation of Slc12a3 1 0.13 0.81 0 5.00
33 INT311660 Binding of Gt(ROSA)26Sor and Spry1 1 0.03 0.91 0 5.00
34 INT312641 Binding of Dok7 and MIR605 1 0.01 0.28 0 5.00
35 INT312644 Regulation of Binding of Musk and SYCP3 1 0.29 0.28 0 5.00
36 INT312642 DNAJA3 Positive_regulation of Musk 1 0.08 0.37 0 5.00
37 INT311661 Spry1 Regulation of Slc12a3 1 0.30 1.44 0 5.00
38 INT312640 Positive_regulation of Binding of Musk and Dok7 1 0.46 0.27 0 5.00
39 INT312628 Agrn Positive_regulation of Lrp4 1 0.22 0.66 0 5.00
40 INT311656 Binding of Wnt1 and Spry1 1 0.30 0.39 0 5.00
41 INT311659 Egfr Positive_regulation of Mapk1 1 0.08 0.18 0 5.00
42 INT192618 Atrx Regulation of Gene_expression of Hba-a1 1 0.08 0.45 0 5.00
43 INT312634 Dok7 Positive_regulation of Musk 1 0.68 0.37 0 5.00
44 INT312643 Binding of Musk and SYCP3 1 0.39 0.28 0 5.00
45 INT311657 Binding of Cbl and Spry2 1 0.10 0.18 0 5.00
46 INT312629 Agrn Positive_regulation of Musk 1 0.76 1.03 0 5.00
47 INT312630 Agrn Positive_regulation of Ldlr 1 0.14 0.66 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Patent Ductus Arteriosus. They are ordered first by their pain relevance and then by number of times they were reported in Patent Ductus Arteriosus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT115908 Localization of TCO 3 0.48 1.76 1.39 100.00
2 INT45342 Binding of AVSD1 6 0.31 7.23 0.27 100.00
3 INT228158 Positive_regulation of PDIA2 7 0.44 2.33 0.28 100.00
4 INT84811 Gene_expression of Ado 6 0.51 2.65 2.74 99.98
5 INT63779 Localization of Ado 6 0.64 4.8 3.81 99.90
6 INT182514 Binding of AGTR1 18 0.47 13.35 1.48 99.76
7 INT81224 Negative_regulation of Ado 3 0.29 1.28 1.46 99.08
8 INT175305 Localization of Pnlip 1 0.11 1.01 0.14 98.68
9 INT57922 Gene_expression of CYP2C9 65 0.78 22.24 7.53 98.64
10 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 97.52
11 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 96.80
12 INT480 Negative_regulation of Localization of Avp 151 0.59 27.64 63.72 96.60
13 INT477 Localization of Avp 813 0.81 131.58 300.4 96.60
14 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 93.84
15 INT1158 Regulation of Agt 106 0.61 29.4 30.29 91.44
16 INT20672 Gene_expression of CDS1 19 0.76 8.19 4.08 91.12
17 INT320041 Negative_regulation of Gene_expression of CDS1 1 0.03 0.44 0.35 91.12
18 INT385 Gene_expression of Agt 182 0.78 63.62 37.91 89.48
19 INT37103 Gene_expression of CHRNE 5 0.67 4.32 0.12 87.44
20 INT175296 Negative_regulation of Pnlip 1 0.08 2.89 0.33 87.40
21 INT129703 Negative_regulation of ptd 3 0.37 2.63 1.87 87.40
22 INT286713 Gene_expression of Musk 3 0.66 2.56 0.1 87.08
23 INT138844 Positive_regulation of CC2D1A 25 0.41 41.36 1.92 85.84
24 INT3403 Positive_regulation of BCAR1 18 0.63 18.95 3.23 85.80
25 INT311638 Gene_expression of Spry1 1 0.72 16.38 0.86 85.52
26 INT208643 Gene_expression of Gt(ROSA)26Sor 11 0.65 4.85 0.37 85.52
27 INT183820 Regulation of BCAR1 4 0.39 3.27 1.06 84.68
28 INT339055 Binding of Tgfbr2 1 0.07 0.92 0 83.36
29 INT70615 Binding of TXNRD1 25 0.36 12.15 1.27 83.16
30 INT5194 Positive_regulation of Lpo 63 0.70 26.44 8.37 82.80
31 INT228404 Gene_expression of Slc12a3 6 0.35 7.18 1 82.32
32 INT263073 Gene_expression of TAPVR1 6 0.58 4.66 2.61 82.24
33 INT390 Positive_regulation of Agt 170 0.70 61.47 36.08 79.84
34 INT183818 Positive_regulation of MKKS 1 0.01 1.82 0.05 78.28
35 INT131788 Positive_regulation of NPPB 87 0.67 86.1 8.81 77.68
36 INT3597 Positive_regulation of Pla2g1b 37 0.63 17.94 11.41 76.88
37 INT77020 Negative_regulation of Positive_regulation of Pla2g1b 1 0.06 0.32 0.24 76.88
38 INT2067 Localization of Ptger1 14 0.47 1.87 4.57 76.48
39 INT28028 Positive_regulation of Localization of Ptger1 1 0.03 0.81 0.12 76.48
40 INT339058 Binding of Fbn1 1 0.48 3.13 0.03 76.40
41 INT3467 Positive_regulation of Ptger1 28 0.54 10.59 8.93 76.16
42 INT138843 Binding of CC2D1A 19 0.33 33.06 1.25 74.56
43 INT621 Positive_regulation of SERPINH1 19 0.57 21.52 8.44 71.44
44 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19 70.96
45 INT83006 Gene_expression of AGTR1 59 0.75 54.46 7.27 70.96
46 INT3962 Regulation of AGT 50 0.62 20.96 13.01 69.52
47 INT50849 Negative_regulation of Regulation of AGT 2 0.42 1.26 0.08 69.52
48 INT90792 Localization of Il10 144 0.80 87.88 30.03 66.96
49 INT86600 Gene_expression of KCNH2 37 0.78 14.88 6.14 66.96
50 INT6782 Gene_expression of SCN5A 156 0.78 33.13 17.88 65.60
51 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 63.28
52 INT17399 Positive_regulation of Positive_regulation of REN 13 0.69 7.05 1.9 63.28
53 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 60.40
54 INT47010 Negative_regulation of Gusb 6 0.43 4.16 1.2 58.08
55 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 56.60
56 INT175303 Positive_regulation of Pnlip 1 0.10 5.19 1.52 55.44
57 INT23598 Binding of SCN5A 32 0.40 16 5.35 54.00
58 INT86602 Binding of KCNH2 14 0.36 4.65 2.58 53.36
59 INT7535 Negative_regulation of Tlr4 111 0.56 56.84 21.37 53.04
60 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 52.72
61 INT180525 Regulation of LCN2 4 0.54 4.37 0.18 51.04
62 INT146758 Gene_expression of LCN2 45 0.78 38.29 2.97 50.60
63 INT133567 Regulation of IL18 11 0.50 9.54 2.31 46.96
64 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 43.76
65 INT312617 Phosphorylation of CHRNE 1 0.02 0.7 0 39.52
66 INT312615 Negative_regulation of Phosphorylation of CHRNE 1 0.02 0.77 0 39.52
67 INT312624 Phosphorylation of Agrn 1 0.61 0.9 0 38.80
68 INT312605 Phosphorylation of Musk 1 0.80 3.12 0 38.80
69 INT301733 Positive_regulation of Musk 2 0.68 1.76 0.09 35.04
70 INT286721 Negative_regulation of Gene_expression of Musk 2 0.42 0.53 0 35.04
71 INT312598 Negative_regulation of Positive_regulation of Musk 1 0.42 0.38 0 35.04
72 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 34.00
73 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59 31.68
74 INT67822 Binding of SERPINH1 17 0.36 19.05 7.24 30.40
75 INT86023 Transcription of PPARA 60 0.66 25.8 5.7 28.88
76 INT294897 Negative_regulation of Slc12a3 2 0.20 1.77 0.2 28.72
77 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 28.00
78 INT175295 Negative_regulation of Gene_expression of Phgdh 1 0.08 1.04 0.39 24.64
79 INT339056 Negative_regulation of Gene_expression of Fbn1 1 0.42 1.17 0 24.52
80 INT86601 Positive_regulation of KCNH2 7 0.49 1.56 0.52 24.40
81 INT101487 Gene_expression of Fbn1 3 0.77 3.54 0 24.08
82 INT108273 Gene_expression of Phgdh 7 0.65 2.29 1.48 23.80
83 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 22.24
84 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 22.24
85 INT32783 Gene_expression of Pah 33 0.60 30.55 6.86 21.52
86 INT230730 Negative_regulation of Gene_expression of Pah 2 0.28 1.54 0.12 21.52
87 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 20.88
88 INT64175 Negative_regulation of Gene_expression of CPOX 66 0.38 39.64 23.07 20.88
89 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 20.32
90 INT192619 Regulation of SMARCA2 1 0.06 0.3 0 19.96
91 INT192620 Regulation of BTAF1 1 0.06 0.3 0 19.96
92 INT78210 Gene_expression of MCC 7 0.65 1.8 0.98 17.64
93 INT175297 Regulation of Negative_regulation of Pnlip 1 0.07 0.81 0.07 15.60
94 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 11.76
95 INT133028 Gene_expression of TLR2 209 0.73 131.92 36.17 11.76
96 INT103760 Regulation of Gene_expression of Tlr4 35 0.59 16.26 5.95 11.76
97 INT175307 Regulation of Gene_expression of TLR2 9 0.56 7.08 1.58 11.76
98 INT29651 Regulation of Pah 11 0.37 9.95 2.79 10.56
99 INT192614 Gene_expression of Atrx 1 0.77 1.75 0 8.08
100 INT6957 Positive_regulation of OXTR 38 0.70 6.55 7.81 7.80
101 INT126374 Gene_expression of Gli3 6 0.77 3.67 2.02 7.28
102 INT256033 Negative_regulation of Musk 2 0.42 0.92 0.44 6.80
103 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
104 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 5.00
105 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
106 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
107 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
108 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
109 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
110 INT1760 Gene_expression of PTGER2 524 0.57 226.94 96.4 5.00
111 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
112 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
113 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 5.00
114 INT1635 Gene_expression of Vip 245 0.78 53.36 88.13 5.00
115 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
116 INT2893 Localization of Oxt 219 0.80 28.96 79.43 5.00
117 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
118 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
119 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 5.00
120 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5 5.00
121 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
122 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01 5.00
123 INT35975 Regulation of Cpox 109 0.39 57.88 49.69 5.00
124 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 5.00
125 INT26500 Gene_expression of MMP2 201 0.78 110.57 46.9 5.00
126 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02 5.00
127 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65 5.00
128 INT29496 Gene_expression of MMP3 136 0.75 49.49 41.78 5.00
129 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94 5.00
130 INT103094 Binding of PPARA 308 0.47 177.26 34.75 5.00
131 INT104392 Gene_expression of Cxcl10 113 0.75 106.86 34.12 5.00
132 INT81289 Positive_regulation of Gene_expression of Tlr4 192 0.69 104.5 33.89 5.00
133 INT81530 Gene_expression of Nfkb1 93 0.78 48.58 32.58 5.00
134 INT56809 Binding of Tlr4 184 0.48 106.02 31.18 5.00
135 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
136 INT11650 Negative_regulation of Gpt 122 0.59 69.15 30.36 5.00
137 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27 5.00
138 INT55737 Positive_regulation of MMP2 101 0.68 59.11 27.71 5.00
139 INT1765 Positive_regulation of Gene_expression of PTGER2 140 0.51 68.68 27 5.00
140 INT1761 Positive_regulation of PTGER2 135 0.49 90.17 26.26 5.00
141 INT2040 Positive_regulation of CYP2B6 95 0.69 34.3 25.6 5.00
142 INT172458 Regulation of Gopc 155 0.53 62.57 24.86 5.00
143 INT10836 Negative_regulation of IL8 95 0.59 52.59 24.71 5.00
144 INT23937 Gene_expression of EDNRA 103 0.65 55.63 24.67 5.00
145 INT79061 Positive_regulation of NOS2 92 0.65 58.89 23.96 5.00
146 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 5.00
147 INT34488 Negative_regulation of MMP2 85 0.59 41.98 21.72 5.00
148 INT73625 Gene_expression of PPARG 108 0.78 104.85 21.42 5.00
149 INT101517 Negative_regulation of PPARA 168 0.57 112.24 21.41 5.00
150 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 5.00
151 INT125312 Positive_regulation of COPD 134 0.59 162.55 20.27 5.00
152 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14 5.00
153 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09 5.00
154 INT37835 Negative_regulation of CPP 61 0.51 31.34 18.57 5.00
155 INT15470 Regulation of CPP 42 0.48 26.1 18.25 5.00
156 INT168263 Gene_expression of IL23A 57 0.58 47.1 17.67 5.00
157 INT10834 Binding of IL8 65 0.48 41.66 16.53 5.00
158 INT26314 Positive_regulation of MMP3 48 0.67 22.14 16.17 5.00
159 INT85639 Positive_regulation of Tg(CAG-EGFP)D4Nagy 95 0.43 24.83 15.69 5.00
160 INT113606 Positive_regulation of Gene_expression of Mmp9 46 0.64 44 15.07 5.00
161 INT100139 Positive_regulation of Gene_expression of PPARA 160 0.63 97.78 14.53 5.00
162 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71 5.00
163 INT67653 Gene_expression of Om 46 0.36 15.28 13.32 5.00
164 INT2129 Positive_regulation of F2 83 0.70 58.95 12.63 5.00
165 INT112003 Localization of ROS1 94 0.73 66.32 12.16 5.00
166 INT159127 Gene_expression of Nps 49 0.75 16.91 12.06 5.00
167 INT661 Gene_expression of REN 100 0.78 48.21 11.36 5.00
168 INT93129 Negative_regulation of KCNH2 42 0.54 9.63 10.85 5.00
169 INT133030 Positive_regulation of Gene_expression of TLR2 53 0.65 38.15 10.65 5.00
170 INT150540 Binding of TLR2 50 0.45 35.86 10.43 5.00
171 INT94784 Binding of ROS1 113 0.40 71.57 10.26 5.00
172 INT10184 Regulation of EDN1 44 0.62 23.78 10.06 5.00
173 INT122584 Negative_regulation of Gene_expression of PPARA 56 0.58 37.61 9.76 5.00
174 INT26502 Negative_regulation of Gene_expression of MMP2 39 0.58 21.45 9.42 5.00
175 INT37896 Positive_regulation of Gene_expression of PTGS1 37 0.67 17.28 9.27 5.00
176 INT14301 Binding of CSF2 82 0.48 67.95 8.98 5.00
177 INT22965 Positive_regulation of Pah 42 0.61 41.41 8.84 5.00
178 INT591 Negative_regulation of Serpinc1 44 0.57 31.73 8.82 5.00
179 INT18025 Binding of Pah 32 0.45 30.72 7.93 5.00
180 INT143996 Positive_regulation of CISH 28 0.49 17.31 7.17 5.00
181 INT32709 Negative_regulation of Hbb 30 0.54 18.27 6.97 5.00
182 INT168600 Binding of Mmp9 14 0.44 12.79 6.92 5.00
183 INT62950 Gene_expression of NPPB 73 0.75 65.91 6.54 5.00
184 INT3041 Positive_regulation of MIA3 34 0.56 21.11 6.49 5.00
185 INT49468 Negative_regulation of Pah 28 0.55 24.95 6.29 5.00
186 INT168383 Positive_regulation of Mmp13 27 0.67 17.9 6.27 5.00
187 INT8683 Positive_regulation of F3 31 0.67 42.89 6.21 5.00
188 INT16359 Positive_regulation of Gene_expression of AGT 30 0.49 28.27 6.14 5.00
189 INT19916 Gene_expression of GPHA2 18 0.48 9.78 6.04 5.00
190 INT86111 Positive_regulation of Positive_regulation of VEGFA 38 0.69 33.81 5.78 5.00
191 INT103260 Positive_regulation of Nps 35 0.48 23.8 5.67 5.00
192 INT60776 Regulation of EDNRA 20 0.51 16.62 5.36 5.00
193 INT175312 Positive_regulation of Gene_expression of IL23A 17 0.45 14.8 5.05 5.00
194 INT30031 Gene_expression of Hba-a1 7 0.60 7.46 4.41 5.00
195 INT92653 Gene_expression of IL12B 21 0.75 17.28 3.89 5.00
196 INT158596 Binding of Tlr3 24 0.47 11.66 3.69 5.00
197 INT159472 Localization of NPPB 32 0.79 33.67 3.59 5.00
198 INT131877 Negative_regulation of Nps 12 0.39 8.19 3.56 5.00
199 INT67468 Regulation of SCN5A 27 0.44 4.4 3.47 5.00
200 INT136266 Gene_expression of KCNQ1 23 0.64 8.34 3.11 5.00
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