D:Patent Foramen Ovale

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pChart

Disease Term
Synonyms Oval Foramen Patent, Patent Oval Foramen
Documents 372
Hot Single Events 50
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Patent Foramen Ovale. They are ordered first by their relevance to Patent Foramen Ovale and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT109887 F2 Negative_regulation of F8 1 0.00 1.32 0.16 95.92
2 INT109886 F2 Negative_regulation of Serpinc1 1 0.00 1.18 0.15 95.92
3 INT231206 Binding of KCNH2 and KCNQ1 2 0.22 1.04 0.24 5.00
4 INT231223 Binding of KCNQ1 and Nav1 1 0.03 0.59 0.11 5.00
5 INT256210 NPPB Regulation of PVR 1 0.24 1.14 0 5.00
6 INT256209 AVP Regulation of PVR 1 0.06 0.99 0 5.00
7 INT256211 NPPB Regulation of PDAP1 1 0.28 1.14 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Patent Foramen Ovale. They are ordered first by their pain relevance and then by number of times they were reported in Patent Foramen Ovale. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT54924 Gene_expression of RLS 67 0.62 83.2 14.25 100.00
2 INT83734 Negative_regulation of RLS 24 0.50 35.75 5.66 99.84
3 INT118267 Negative_regulation of ARSD 14 0.36 8.27 1.44 99.80
4 INT174987 Binding of AIRN 12 0.32 6.79 1.21 99.76
5 INT142735 Regulation of RLS 33 0.53 45.83 11.35 99.60
6 INT134667 Negative_regulation of MYH9 2 0.36 2.26 0.39 99.52
7 INT94028 Regulation of Twist1 37 0.44 22.41 5.33 98.52
8 INT356020 Binding of MKS1 1 0.02 1.36 0.2 98.50
9 INT9900 Positive_regulation of Vwf 80 0.69 51.85 18.13 97.60
10 INT88197 Binding of ZAK 9 0.46 6.23 3.54 97.32
11 INT101347 Positive_regulation of ma 2 0.10 2.62 0.37 96.76
12 INT162831 Regulation of ARSD 13 0.35 6.17 1.19 96.68
13 INT4498 Gene_expression of F2 83 0.65 57.4 10.8 95.92
14 INT71933 Positive_regulation of Gene_expression of F2 19 0.56 14.24 2.53 95.92
15 INT88667 Negative_regulation of Gene_expression of F2 11 0.41 5.53 1.62 95.92
16 INT17501 Negative_regulation of F2 70 0.58 32.23 7.51 95.92
17 INT107129 Positive_regulation of RLS 46 0.60 40.1 8.09 95.36
18 INT109880 Negative_regulation of Gene_expression of F8 3 0.12 2.12 0.54 95.08
19 INT27363 Negative_regulation of Gene_expression of Serpinc1 5 0.29 3.2 0.3 95.08
20 INT14397 Gene_expression of Serpinc1 27 0.46 14.54 3.32 95.08
21 INT61319 Positive_regulation of Gene_expression of Serpinc1 2 0.06 1.82 0.25 95.08
22 INT591 Negative_regulation of Serpinc1 44 0.57 31.73 8.82 95.08
23 INT109881 Positive_regulation of Gene_expression of F8 11 0.47 12.97 1.54 95.08
24 INT10889 Gene_expression of F8 60 0.78 41.36 5.06 95.08
25 INT2921 Positive_regulation of F8 53 0.59 41.56 8.56 94.60
26 INT20200 Positive_regulation of Serpinc1 25 0.68 17.08 4.98 94.12
27 INT185722 Positive_regulation of GATA4 2 0.50 1.09 0.39 93.40
28 INT104284 Positive_regulation of Notch3 7 0.50 5.57 0.99 93.00
29 INT62827 Positive_regulation of ICAM1 184 0.70 180.95 36.28 92.76
30 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 92.76
31 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85 92.76
32 INT63340 Positive_regulation of Gene_expression of ICAM1 109 0.70 90.82 20.61 92.76
33 INT117470 Positive_regulation of Positive_regulation of ISYNA1 7 0.51 6.87 1.94 92.76
34 INT75742 Binding of RLS 86 0.42 95.27 19.04 92.44
35 INT13406 Negative_regulation of CASP1 25 0.57 10.61 6.36 91.60
36 INT56277 Binding of MYH9 3 0.36 2.37 1.11 91.40
37 INT72947 Binding of CHM 9 0.42 5.86 0.06 89.80
38 INT45100 Gene_expression of MYH9 6 0.52 2.04 0.17 87.84
39 INT125242 Localization of RLS 15 0.64 15.87 4.99 87.08
40 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 86.68
41 INT9842 Binding of F2 36 0.47 22.79 4.42 85.92
42 INT152527 Negative_regulation of ME1 2 0.05 0.6 0.79 84.80
43 INT9191 Localization of EDN1 94 0.81 57.01 14.78 84.24
44 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 82.64
45 INT10145 Gene_expression of Plg 28 0.62 12.68 7.46 82.32
46 INT39640 Negative_regulation of Gene_expression of Plg 2 0.25 1.13 0.39 82.32
47 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 82.08
48 INT86717 Negative_regulation of Positive_regulation of NOS1 18 0.30 8.88 5.2 82.08
49 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 80.80
50 INT67604 Gene_expression of SERPINC1 14 0.67 11.47 1.72 80.24
51 INT76095 Positive_regulation of ISYNA1 117 0.55 79.73 25.86 78.64
52 INT11360 Localization of SERPINE1 41 0.80 33.98 5.61 77.84
53 INT2378 Negative_regulation of SERPINE1 47 0.59 34.55 9.9 77.40
54 INT166702 Negative_regulation of Ier2 2 0.20 1.62 0.61 75.64
55 INT185724 Regulation of GATA4 2 0.45 1.6 1.33 75.56
56 INT59283 Positive_regulation of Gene_expression of Plg 6 0.25 2.36 1.97 75.00
57 INT251744 Binding of GATA4 1 0.36 1.55 0.96 74.04
58 INT174986 Gene_expression of AIRN 20 0.57 6.13 0.64 67.80
59 INT86600 Gene_expression of KCNH2 37 0.78 14.88 6.14 64.88
60 INT6782 Gene_expression of SCN5A 156 0.78 33.13 17.88 63.52
61 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 60.76
62 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 60.76
63 INT356021 Gene_expression of MKS1 1 0.04 3.38 0 58.76
64 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 53.44
65 INT23598 Binding of SCN5A 32 0.40 16 5.35 51.92
66 INT86602 Binding of KCNH2 14 0.36 4.65 2.58 51.28
67 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 50.00
68 INT100861 Binding of CRP 179 0.48 175.2 26.45 50.00
69 INT152796 Protein_catabolism of RLS 4 0.59 3.64 0.33 50.00
70 INT133080 Gene_expression of GATA3 15 0.61 5.64 2.89 47.36
71 INT243481 Gene_expression of GATA2 3 0.50 3.34 0.62 47.36
72 INT251745 Gene_expression of GATA1 2 0.58 0.96 0.51 47.36
73 INT3590 Positive_regulation of AVL9 7 0.40 7.94 2.36 41.60
74 INT22429 Positive_regulation of PDAP1 34 0.61 22.58 2.91 36.28
75 INT449 Localization of PDAP1 4 0.66 2.29 0.33 33.80
76 INT6481 Binding of TNF 624 0.48 510.2 214.82 23.68
77 INT86601 Positive_regulation of KCNH2 7 0.49 1.56 0.52 22.32
78 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 20.76
79 INT14183 Negative_regulation of CPB1 5 0.41 3.53 0.53 20.76
80 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 14.72
81 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
82 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
83 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
84 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
85 INT12476 Negative_regulation of TRPV1 124 0.59 47.95 77.98 5.00
86 INT1335 Negative_regulation of Oprl1 123 0.59 18.02 77.13 5.00
87 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
88 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 5.00
89 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
90 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 5.00
91 INT3679 Gene_expression of AVP 171 0.78 72.9 35.23 5.00
92 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 5.00
93 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09 5.00
94 INT9552 Positive_regulation of TNNI3 209 0.70 128.67 19.15 5.00
95 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42 5.00
96 INT93129 Negative_regulation of KCNH2 42 0.54 9.63 10.85 5.00
97 INT10139 Positive_regulation of F13A1 64 0.56 44.75 9.69 5.00
98 INT131788 Positive_regulation of NPPB 87 0.67 86.1 8.81 5.00
99 INT96619 Negative_regulation of CSAD 7 0.36 8.96 7.47 5.00
100 INT34767 Gene_expression of PTGIR 36 0.42 14.79 6.69 5.00
101 INT62950 Gene_expression of NPPB 73 0.75 65.91 6.54 5.00
102 INT60776 Regulation of EDNRA 20 0.51 16.62 5.36 5.00
103 INT98613 Gene_expression of CSAD 7 0.53 7.86 4.8 5.00
104 INT7298 Gene_expression of NPPA 35 0.70 18.23 4.76 5.00
105 INT61680 Positive_regulation of PVR 23 0.60 23.27 3.86 5.00
106 INT21406 Negative_regulation of Gene_expression of IgG 20 0.41 9.36 3.58 5.00
107 INT67468 Regulation of SCN5A 27 0.44 4.4 3.47 5.00
108 INT4003 Positive_regulation of Gene_expression of IGHG3 31 0.46 20.38 3.16 5.00
109 INT136266 Gene_expression of KCNQ1 23 0.64 8.34 3.11 5.00
110 INT14872 Gene_expression of TGFB3 15 0.55 12.45 2.96 5.00
111 INT108501 Binding of ARSD 14 0.32 11.5 2.93 5.00
112 INT17688 Positive_regulation of IKZF1 5 0.50 0.48 2.11 5.00
113 INT127777 Positive_regulation of Mthfr 4 0.38 3.8 2.09 5.00
114 INT103095 Binding of ISYNA1 10 0.28 6.17 2.03 5.00
115 INT10976 Negative_regulation of ENPP3 13 0.42 5.11 1.92 5.00
116 INT211224 Positive_regulation of Serpind1 8 0.59 12.15 1.8 5.00
117 INT119346 Positive_regulation of PTGIR 9 0.58 6.2 1.61 5.00
118 INT35132 Gene_expression of PDAP1 18 0.52 9.05 1.5 5.00
119 INT48269 Negative_regulation of FANCB 16 0.56 5.34 1.38 5.00
120 INT234493 Gene_expression of sch 5 0.67 3.87 1.22 5.00
121 INT15896 Gene_expression of FANCB 18 0.65 6.44 1.18 5.00
122 INT79598 Regulation of PDE5A 16 0.60 8.68 1.17 5.00
123 INT15746 Negative_regulation of PDAP1 13 0.52 6.45 1.12 5.00
124 INT28929 Negative_regulation of PVR 22 0.57 16.64 1.07 5.00
125 INT129971 Regulation of PVR 5 0.60 3.96 0.97 5.00
126 INT210571 Gene_expression of KCNE2 7 0.61 2.7 0.97 5.00
127 INT137276 Binding of Acads 3 0.32 1.82 0.84 5.00
128 INT132662 Binding of Hcm 11 0.31 14.41 0.73 5.00
129 INT52590 Transcription of SCN5A 4 0.55 0.91 0.65 5.00
130 INT256204 Negative_regulation of ERAS 4 0.31 1.71 0.57 5.00
131 INT120591 Positive_regulation of Acads 2 0.40 1.25 0.56 5.00
132 INT200401 Gene_expression of KCNE1 14 0.57 6.42 0.45 5.00
133 INT192006 Gene_expression of RYR2 5 0.23 7.69 0.44 5.00
134 INT79599 Protein_catabolism of PDE5A 7 1.00 3.16 0.39 5.00
135 INT179214 Binding of AMIGO2 4 0.32 3.9 0.35 5.00
136 INT136267 Binding of KCNQ1 3 0.36 3.28 0.28 5.00
137 INT303483 Positive_regulation of PDE5A 2 0.39 1.5 0.23 5.00
138 INT341756 Negative_regulation of Gene_expression of FANCB 1 0.03 0.06 0.21 5.00
139 INT230722 Regulation of Hcm 4 0.37 3 0.21 5.00
140 INT231220 Localization of ANK2 1 0.40 0.91 0.17 5.00
141 INT286439 Regulation of Myl3 3 0.26 1.43 0.16 5.00
142 INT242346 Negative_regulation of Positive_regulation of PDAP1 2 0.45 2.43 0.15 5.00
143 INT231217 Positive_regulation of ANK2 1 0.26 0.67 0.12 5.00
144 INT193632 Positive_regulation of ARVD4 2 0.01 2.73 0.11 5.00
145 INT303482 Positive_regulation of Protein_catabolism of PDE5A 1 0.20 1.27 0.1 5.00
146 INT192016 Localization of RYR2 5 0.25 4.18 0.05 5.00
147 INT168933 Positive_regulation of Car5b 2 0.15 0.64 0.05 5.00
148 INT201155 Regulation of Jph2 2 0.37 1.13 0.05 5.00
149 INT221865 Positive_regulation of Localization of RYR2 2 0.15 4.56 0.05 5.00
150 INT231205 Negative_regulation of Binding of Hcm 1 0.03 0.87 0.04 5.00
151 INT205998 Binding of PDAP1 3 0.33 2.66 0.03 5.00
152 INT231221 Gene_expression of Prkag2 1 0.07 0.94 0.03 5.00
153 INT231222 Gene_expression of Lamp2 1 0.07 0.93 0.03 5.00
154 INT211830 Binding of PVR 3 0.32 2.26 0.03 5.00
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