D:Pathologic Neovascularization

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Disease Term
Synonyms Angiogenesis Pathologic, Angiogenesis Pathological, Neovascularization Pathological, Pathologic Angiogenesis, Pathological Angiogenesis, Pathological Neovascularization
Documents 55
Hot Single Events 81
Hot Interactions 10

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Pathologic Neovascularization. They are ordered first by their relevance to Pathologic Neovascularization and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT271345 Negative_regulation of PIGF Negative_regulation of FLT1 1 0.02 1.17 0.13 97.84
2 INT173430 Binding of FLT4 and VEGFA 10 0.25 9.38 0.19 92.96
3 INT345157 Lpar1 Positive_regulation of Gene_expression of Gtf3a 1 0.00 0.89 0.15 91.92
4 INT329645 Galnt5 Positive_regulation of Tchh 1 0.01 1.9 0 88.64
5 INT287380 Binding of VEGFA and Kdr 12 0.18 11.97 0.34 86.28
6 INT329647 VEGFA Positive_regulation of Tchh 1 0.02 0.98 0 86.28
7 INT282859 Bpifa2 Negative_regulation of Mapk1 1 0.01 0.91 0.17 85.20
8 INT282858 Bpifa2 Negative_regulation of Akt1 1 0.05 0.91 0.17 84.32
9 INT282861 Bpifa2 Negative_regulation of Phosphorylation of Akt1 1 0.05 0.91 0.17 84.32
10 INT252357 Binding of THBS1 and Cd36 2 0.01 2.4 0.21 82.44
11 INT252177 VEGFA Regulation of Gene_expression of CPOX 1 0.03 0.56 0.14 72.56
12 INT329649 Binding of VEGFA and Rrm2 1 0.02 2.39 0 70.24
13 INT329653 Binding of VEGFA and Ear11 1 0.00 0.63 0 67.28
14 INT328435 PIK3CD Positive_regulation of Gene_expression of VEGFA 1 0.23 0.64 0.09 65.28
15 INT298684 ecs Positive_regulation of Gene_expression of KDR 1 0.01 1.2 0 65.12
16 INT329648 Flt1 Positive_regulation of Positive_regulation of VEGFA 1 0.03 0.58 0 64.36
17 INT320786 Binding of Eng and Kdr 1 0.04 1.17 0.04 53.04
18 INT282864 Bpifa2 Positive_regulation of Gene_expression of Serpinf1 1 0.15 1.16 0.2 39.08
19 INT282866 Bpifa2 Negative_regulation of Gene_expression of VEGFA 1 0.11 1.14 0.19 39.08
20 INT295871 Binding of RNPS1 and Srpk2 1 0.01 0.76 0 36.88
21 INT271355 PGF Positive_regulation of PIGF 1 0.01 0.99 0.06 35.84
22 INT282863 Bpifa2 Positive_regulation of Gene_expression of Aggf1 1 0.01 1.07 0.19 34.72
23 INT339570 Gene_expression of Positive_regulation of Gene_expression of CYP4A11 1 0.00 0.5 0.23 31.04
24 INT298637 ZDHHC2 Negative_regulation of Gene_expression of VEGFA 1 0.01 0.27 0.04 29.28
25 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1 25.96
26 INT329650 Binding of VEGFA and Gtf3a 1 0.00 0.91 0 25.60
27 INT339535 FGF2 Positive_regulation of Gene_expression of CYP4A11 1 0.00 0.55 0.22 25.36
28 INT320824 VEGFA Positive_regulation of DLL4 1 0.40 0.41 0 18.32
29 INT320825 VEGFA Positive_regulation of Gene_expression of DLL4 1 0.40 0.41 0 18.32
30 INT318787 Binding of AKT1 and VEGFA 1 0.37 0.34 0 17.84
31 INT329651 Rrm2 Regulation of Galnt5 Positive_regulation of Tchh 1 0.00 0.42 0 17.60
32 INT339532 FGF2 Positive_regulation of YWHAZ 1 0.00 1.26 0.54 9.92
33 INT298635 PPARA Negative_regulation of Localization of ZDHHC2 1 0.01 0.21 0.05 9.76
34 INT188692 Binding of Cd40 and Cd40lg 32 0.34 22.95 6.62 5.00
35 INT239037 Binding of Cd28 and Cd86 9 0.16 3.69 2.14 5.00
36 INT265213 Binding of Ctla4 and Cd86 2 0.13 1.93 1.31 5.00
37 INT197092 TNF Regulation of VEGFA 4 0.21 2.78 1.22 5.00
38 INT265210 Binding of Ctla4 and Cd28 2 0.16 1.45 0.93 5.00
39 INT282129 Il10 Positive_regulation of Icam1 1 0.56 3.12 0.82 5.00
40 INT153289 Binding of Lpar1 and Gpr87 2 0.29 1.19 0.67 5.00
41 INT255690 Binding of VEGFA and Flt1 8 0.34 3.44 0.61 5.00
42 INT345180 Binding of Lpar4 and Gpr87 1 0.06 0.69 0.59 5.00
43 INT345192 Binding of Gpr87 and Lpar5 1 0.07 0.69 0.59 5.00
44 INT144035 IL6 Positive_regulation of STAT3 4 0.31 2.58 0.56 5.00
45 INT271344 MPO Regulation of Protein_catabolism of ACCS 1 0.02 2.42 0.51 5.00
46 INT240441 Ltb4r1 Positive_regulation of PPARA 1 0.03 1.01 0.47 5.00
47 INT240442 Binding of PPARA and Ltb4r1 1 0.02 0.94 0.46 5.00
48 INT191493 Binding of AGTR1 and NLRP3 2 0.03 2.35 0.39 5.00
49 INT153288 Binding of Lpar1 and Lpar6 2 0.31 0.78 0.36 5.00
50 INT240434 PPARA Negative_regulation of Gene_expression of CPOX 1 0.03 0.64 0.33 5.00
51 INT206704 Negative_regulation of Binding of KDR and VEGFA 4 0.39 5.18 0.3 5.00
52 INT271350 MPO Positive_regulation of TIMP1 1 0.05 1.66 0.29 5.00
53 INT182499 Binding of AGTR1 and AGTR2 3 0.20 2.79 0.28 5.00
54 INT282128 Gene_expression of Il10 Positive_regulation of Positive_regulation of Icam1 1 0.37 1.12 0.28 5.00
55 INT287699 TNF Regulation of Binding of VEGFA 1 0.02 0.46 0.27 5.00
56 INT320794 Binding of VEGFA and Flt4 4 0.08 3.04 0.27 5.00
57 INT233929 PPARA Negative_regulation of ras 1 0.02 2.39 0.22 5.00
58 INT89612 Binding of FABP3 and MB 3 0.34 1.49 0.22 5.00
59 INT345196 Lpar2 Positive_regulation of Gene_expression of VEGFA 1 0.08 2.14 0.2 5.00
60 INT345186 Lpar2 Positive_regulation of Gene_expression of Plau 1 0.05 2.2 0.2 5.00
61 INT345172 Lpar1 Positive_regulation of S1pr1 1 0.21 0.19 0.19 5.00
62 INT240435 JUN Positive_regulation of Gene_expression of CPOX 1 0.01 0.81 0.18 5.00
63 INT233904 NLRP3 Positive_regulation of AGT 1 0.06 0.81 0.17 5.00
64 INT298641 PPARA Regulation of STAT3 1 0.23 0.98 0.16 5.00
65 INT224308 INSRR Regulation of VEGFA 1 0.00 1.42 0.16 5.00
66 INT345176 Lpar1 Positive_regulation of Gene_expression of Car2 1 0.03 0.11 0.16 5.00
67 INT345175 Lpar1 Regulation of Gpbar1 1 0.05 0.22 0.15 5.00
68 INT148800 VEGFA Positive_regulation of Positive_regulation of Csk 1 0.06 0 0.14 5.00
69 INT148799 VEGFA Positive_regulation of VEGFA Positive_regulation of Csk 1 0.05 0 0.14 5.00
70 INT345171 Binding of Trip6 and Magi3 1 0.03 1.65 0.14 5.00
71 INT148802 Negative_regulation of VEGFA Positive_regulation of Csk 1 0.05 0 0.14 5.00
72 INT298639 GDE1 Negative_regulation of AKT1 1 0.00 1.14 0.14 5.00
73 INT148801 VEGFA Positive_regulation of Csk 1 0.06 0 0.14 5.00
74 INT345146 Binding of Trip6 and Siva1 1 0.02 1.6 0.14 5.00
75 INT300512 Binding of Plau and Vtn 1 0.06 2.28 0.13 5.00
76 INT345165 Lpar5 Negative_regulation of Dmbx1 1 0.05 1.24 0.13 5.00
77 INT282862 Bpifa2 Negative_regulation of Positive_regulation of Akt1 1 0.05 0.75 0.13 5.00
78 INT300511 Binding of Plaur and Vtn 1 0.10 2.28 0.13 5.00
79 INT345191 Lpar4 Negative_regulation of Dmbx1 1 0.04 1.25 0.13 5.00
80 INT300513 Binding of Serpine1 and Vtn 1 0.17 2.27 0.13 5.00
81 INT228453 Igf1 Positive_regulation of Prkca 2 0.12 1.17 0.12 5.00
82 INT345159 Binding of Cpa1 and Dmbx1 1 0.01 0 0.12 5.00
83 INT328437 PRB4 Negative_regulation of Gene_expression of VEGFA 1 0.09 0.6 0.12 5.00
84 INT287381 Cxcl2 Regulation of Gene_expression of VEGFA 1 0.42 1.1 0.1 5.00
85 INT271343 Binding of CRP and PAPPA 1 0.20 0.86 0.1 5.00
86 INT345194 Lpar1 Positive_regulation of Gene_expression of VEGFA 1 0.07 0.87 0.1 5.00
87 INT339533 VEGFA Positive_regulation of Gene_expression of CYP2C8 1 0.09 0.57 0.09 5.00
88 INT345193 VEGFA Regulation of Gene_expression of Dmbx1 1 0.01 0.82 0.09 5.00
89 INT271349 ACCS Positive_regulation of PAPPA 1 0.06 0.87 0.09 5.00
90 INT345195 VEGFA Positive_regulation of Gene_expression of Dmbx1 1 0.01 0.82 0.09 5.00
91 INT298634 Binding of IL6 and STAT3 1 0.04 1.41 0.08 5.00
92 INT233907 Positive_regulation of Binding of AGTR2 and NLRP3 1 0.01 1.09 0.08 5.00
93 INT320789 NRP2 Positive_regulation of Binding of Flt1 and Kdr 1 0.00 0.68 0.08 5.00
94 INT271347 Negative_regulation of Binding of TNNT2 and ACCS 1 0.01 0.67 0.08 5.00
95 INT271354 MPO Regulation of Gene_expression of CRP 1 0.16 1.74 0.08 5.00
96 INT271346 Binding of TNNT2 and ACCS 1 0.01 0.67 0.08 5.00
97 INT233906 Binding of AGTR2 and NLRP3 1 0.01 1.09 0.08 5.00
98 INT345169 Lpar1 Negative_regulation of Dmbx1 1 0.08 2.26 0.08 5.00
99 INT320785 Binding of Flt1 and Kdr 1 0.15 0.67 0.08 5.00
100 INT320788 VEGFA Positive_regulation of Binding of Flt1 and Kdr 1 0.15 0.68 0.08 5.00
101 INT328425 PRB4 Regulation of Localization of VEGFA 1 0.05 0.27 0.08 5.00
102 INT339534 VEGFA Positive_regulation of CYP2C18 1 0.04 0.57 0.08 5.00
103 INT271351 MPO Positive_regulation of CRP 1 0.07 1.69 0.08 5.00
104 INT268325 Lep Positive_regulation of Ptgs2 1 0.09 0.39 0.08 5.00
105 INT279286 Binding of TXK and VEGFA 3 0.05 2.35 0.07 5.00
106 INT345178 S1pr1 Positive_regulation of Lpar1 1 0.14 0.09 0.07 5.00
107 INT301402 Enpp2 Positive_regulation of Lpar1 2 0.33 0.55 0.07 5.00
108 INT345160 S1pr1 Positive_regulation of P2ry10 1 0.11 0.09 0.07 5.00
109 INT345198 S1pr1 Positive_regulation of Binding of Lpar1 and P2ry10 1 0.08 0.09 0.07 5.00
110 INT345179 Binding of Lpar1 and Gpbar1 1 0.05 0.15 0.07 5.00
111 INT345164 Binding of Lpar1 and P2ry10 1 0.14 0.09 0.07 5.00
112 INT345173 Binding of Siva1 and Lpar2 1 0.05 0.75 0.06 5.00
113 INT320795 Flt1 Negative_regulation of VEGFA 1 0.29 0.29 0.06 5.00
114 INT328433 PRB4 Negative_regulation of VEGFA 1 0.09 0.29 0.05 5.00
115 INT298638 IL6 Positive_regulation of IL6R 1 0.00 0.9 0.05 5.00
116 INT345197 Gpr87 Regulation of Gpr87 Regulation of Trp53 1 0.00 0.42 0.05 5.00
117 INT328426 PRB4 Positive_regulation of GOPC 1 0.03 0.55 0.05 5.00
118 INT302632 Rac1 Positive_regulation of Gene_expression of Rhog 1 0.37 0.21 0.05 5.00
119 INT295866 Dss1 Positive_regulation of PSS 1 0.01 0.07 0.05 5.00
120 INT268326 Ins1 Regulation of Gene_expression of VEGFA 1 0.01 0.32 0.05 5.00
121 INT328429 PRB4 Negative_regulation of Gene_expression of AKT1 1 0.03 0.52 0.05 5.00
122 INT282860 Bpifa2 Regulation of Mapk1 1 0.01 0.65 0.05 5.00
123 INT328438 PRB4 Negative_regulation of PIK3CD 1 0.06 0.29 0.05 5.00
124 INT224310 EPAS1 Positive_regulation of CXCL12 1 0.02 0.63 0.05 5.00
125 INT106823 Binding of MBP and PAPPA 2 0.17 3.89 0.05 5.00
126 INT345181 Gpr87 Regulation of Trp53 1 0.01 0.42 0.05 5.00
127 INT328434 PRB4 Negative_regulation of AKT1 1 0.02 0.29 0.05 5.00
128 INT279284 TXK Regulation of KDR 3 0.05 2.22 0.04 5.00
129 INT298683 ecs Positive_regulation of Gene_expression of VEGFA 1 0.02 1.41 0.04 5.00
130 INT345190 Lpar1 Regulation of Localization of Il6 1 0.05 1.19 0.04 5.00
131 INT339569 VEGFA Positive_regulation of Litaf 1 0.18 0.6 0.04 5.00
132 INT345170 Pla2g6 Positive_regulation of Gene_expression of Lpar1 1 0.07 0 0.04 5.00
133 INT178503 Binding of Cd36 and ecs 1 0.01 0.34 0.04 5.00
134 INT295854 Srpk2 Regulation of Localization of Srsf1 1 0.21 0 0.04 5.00
135 INT345182 Binding of Lpar1 and Gsn 1 0.04 0 0.04 5.00
136 INT178501 Angpt1 Positive_regulation of Tek 1 0.06 0.78 0.04 5.00
137 INT345147 Binding of S1pr1 and Gpbar1 1 0.03 0.07 0.03 5.00
138 INT224304 KDR Positive_regulation of Binding of VEGFA 1 0.24 0.36 0.03 5.00
139 INT345167 Binding of S1pr1 and Lpar1 1 0.13 0.07 0.03 5.00
140 INT328436 PRB4 Negative_regulation of Gene_expression of PIK3CD 1 0.07 0.24 0.03 5.00
141 INT345187 Positive_regulation of Binding of Alb and Lpar1 1 0.04 0.92 0.03 5.00
142 INT328439 PRB4 Negative_regulation of Localization of VEGFA 1 0.09 0.66 0.03 5.00
143 INT328430 PRB4 Regulation of Positive_regulation of PIK3CD 1 0.06 0.4 0.03 5.00
144 INT298633 STAT3 Regulation of MCL1 1 0.04 0.85 0.03 5.00
145 INT328432 PRB4 Regulation of Gene_expression of VEGFA 1 0.09 0.47 0.03 5.00
146 INT178502 Col18a1 Negative_regulation of ecs 1 0.01 0.52 0.03 5.00
147 INT345183 Binding of Lhx3 and Trip6 1 0.03 0.66 0.03 5.00
148 INT328428 PRB4 Regulation of Positive_regulation of AKT1 1 0.04 0.4 0.03 5.00
149 INT295867 Srsf1 Regulation of VEGFA 1 0.10 0 0.03 5.00
150 INT345155 Lpar1 Positive_regulation of Lpar3 1 0.23 0.07 0.03 5.00
151 INT345161 Lpar1 Positive_regulation of Lpar2 1 0.36 0.07 0.03 5.00
152 INT271328 FABP3 Positive_regulation of Binding of FABP3 and MB 1 0.00 0.81 0.03 5.00
153 INT224309 Binding of VEGFA and NUDT6 1 0.05 0.39 0.03 5.00
154 INT224306 KDR Positive_regulation of VEGFA 1 0.24 0.36 0.03 5.00
155 INT298640 IL6R Positive_regulation of STAT3 1 0.01 0.73 0.03 5.00
156 INT345188 Binding of Lhx3 and Lpar2 1 0.06 0.66 0.03 5.00
157 INT224305 Positive_regulation of Binding of KDR and VEGFA 2 0.45 0.36 0.03 5.00
158 INT328440 PRB4 Negative_regulation of Phosphorylation of AKT1 1 0.04 0.24 0.03 5.00
159 INT345156 Binding of Alb and Lpar1 1 0.04 0.92 0.03 5.00
160 INT329641 Rrm2 Regulation of Ear11 1 0.01 0.49 0 5.00
161 INT295858 Prkca Positive_regulation of Gtf3a 1 0.00 0 0 5.00
162 INT233905 PPARA Positive_regulation of Localization of NCOR2 1 0.01 0.19 0 5.00
163 INT302640 Rac1 Regulation of Gene_expression of VEGFA 1 0.03 0 0 5.00
164 INT329642 Rrm2 Regulation of Eefsec 1 0.04 0.42 0 5.00
165 INT295868 Igf1 Positive_regulation of VEGFA 1 0.16 0.19 0 5.00
166 INT233930 Binding of PPARA and Ncoa1 1 0.12 0.19 0 5.00
167 INT329646 Binding of VEGFA and Vegfa 1 0.05 0.97 0 5.00
168 INT345163 Lpar1 Positive_regulation of Gtf3a 1 0.00 0.77 0 5.00
169 INT345168 Binding of Lpar1 and Ppard 1 0.03 0.21 0 5.00
170 INT268316 Cdk1 Positive_regulation of Mcm3 1 0.28 0.25 0 5.00
171 INT345149 Enpp2 Regulation of Gene_expression of Lpar1 1 0.01 0.41 0 5.00
172 INT328431 PIK3CD Negative_regulation of Gene_expression of VEGFA 1 0.22 0.29 0 5.00
173 INT268321 Cdc20 Positive_regulation of Mcm5 1 0.09 0.25 0 5.00
174 INT301410 Binding of Lpar1 and Lpar2 2 0.20 0.65 0 5.00
175 INT345158 Lpar1 Positive_regulation of Gene_expression of Sele 1 0.02 0.21 0 5.00
176 INT295857 Igf1 Regulation of Localization of Srsf1 1 0.50 0 0 5.00
177 INT302641 Rac1 Regulation of TIE1 1 0.25 0.47 0 5.00
178 INT345162 Dmbx1 Regulation of Gene_expression of Lpar1 1 0.03 0.41 0 5.00
179 INT345174 Spib Regulation of P2ry10 1 0.05 0.26 0 5.00
180 INT233928 PPARA Positive_regulation of Localization of Ncoa1 1 0.18 0.19 0 5.00
181 INT268318 Cdk1 Positive_regulation of Orc2 1 0.29 0.25 0 5.00
182 INT345152 Binding of Lpar1 and Siva1 1 0.03 0.66 0 5.00
183 INT144032 STAT3 Regulation of BCL2 2 0.07 0.86 0 5.00
184 INT295869 Binding of VEGFA and Srsf1 1 0.17 0 0 5.00
185 INT271348 Binding of CHKB and MB 1 0.01 1.01 0 5.00
186 INT345154 Lpar1 Positive_regulation of Phosphorylation of Gsn 1 0.05 0 0 5.00
187 INT345148 Lpar1 Positive_regulation of Gene_expression of Vcam1 1 0.07 0.21 0 5.00
188 INT295870 Gene_expression of Srpk1 Negative_regulation of VEGFA 1 0.11 0 0 5.00
189 INT268320 Cdc20 Positive_regulation of Orc2 1 0.08 0.25 0 5.00
190 INT233927 PPARA Positive_regulation of Ncoa1 1 0.08 0.19 0 5.00
191 INT268319 Cdk1 Positive_regulation of Cdc20 1 0.32 0.25 0 5.00
192 INT345189 Dmbx1 Positive_regulation of Lpar1 1 0.06 0.23 0 5.00
193 INT302634 Rac1 Regulation of Gene_expression of Kdr 1 0.36 0 0 5.00
194 INT345150 Lpar1 Regulation of Gene_expression of Cd1 1 0.11 0.15 0 5.00
195 INT295856 Binding of Prkca and Srsf1 1 0.10 0 0 5.00
196 INT345153 Dmbx1 Regulation of Enpp2 1 0.00 0.41 0 5.00
197 INT295855 Prkca Positive_regulation of Akt1 1 0.02 0 0 5.00
198 INT183462 Agt Positive_regulation of Ros1 1 0.02 0.11 0 5.00
199 INT268317 Cdk1 Positive_regulation of Mcm7 1 0.33 0.25 0 5.00
200 INT328427 PIK3CD Negative_regulation of Phosphorylation of AKT1 1 0.09 0.29 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Pathologic Neovascularization. They are ordered first by their pain relevance and then by number of times they were reported in Pathologic Neovascularization. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 99.92
2 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 99.92
3 INT65263 Positive_regulation of Gene_expression of Igf1 61 0.69 25.69 14.49 99.92
4 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 99.80
5 INT49146 Negative_regulation of Hgf 6 0.57 2.46 1.95 99.64
6 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 99.60
7 INT200855 Positive_regulation of Kdr 14 0.45 11.14 0.77 99.60
8 INT59870 Gene_expression of F3 51 0.65 51.83 14.01 99.36
9 INT84527 Positive_regulation of Gene_expression of F3 16 0.49 15.83 2.85 99.36
10 INT165490 Regulation of Lpar1 8 0.45 15.31 5.05 99.28
11 INT228103 Positive_regulation of Rac1 25 0.67 18.92 0.57 99.10
12 INT17324 Negative_regulation of Plg 26 0.38 13.5 4.05 98.92
13 INT103096 Regulation of PPARA 113 0.60 62.47 14.57 98.88
14 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 98.56
15 INT10171 Binding of Gtf3a 33 0.36 19.84 5.1 98.56
16 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 98.24
17 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 98.24
18 INT271369 Negative_regulation of PIGF 1 0.12 1.11 0.13 97.84
19 INT217104 Negative_regulation of Rrm2 2 0.28 1.46 0.03 96.88
20 INT329639 Negative_regulation of Ear11 1 0.05 1.4 0 96.88
21 INT329628 Positive_regulation of Negative_regulation of Rrm2 1 0.24 0.54 0 96.88
22 INT329640 Positive_regulation of Negative_regulation of Ear11 1 0.04 0.54 0 96.88
23 INT109535 Gene_expression of Vegfa 116 0.75 84.61 14.89 96.72
24 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 96.48
25 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14 95.52
26 INT228801 Positive_regulation of Eefsec 2 0.09 0.54 0 95.40
27 INT233921 Binding of PDR 6 0.14 7.03 0.75 95.32
28 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 95.00
29 INT181194 Regulation of Gene_expression of PPARA 31 0.44 21.27 5.96 94.80
30 INT86521 Gene_expression of Lpar1 167 0.78 154.61 80.35 94.72
31 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 94.56
32 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04 94.56
33 INT15941 Negative_regulation of Serpine1 42 0.58 21.07 4.95 94.52
34 INT16263 Regulation of Serpine1 13 0.45 5.24 3.6 94.52
35 INT45481 Negative_regulation of 4930519F16Rik 5 0.09 1.61 2.58 92.96
36 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67 92.48
37 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 92.40
38 INT86111 Positive_regulation of Positive_regulation of VEGFA 38 0.69 33.81 5.78 92.36
39 INT15540 Positive_regulation of PDGFA 24 0.47 19.01 2.5 92.18
40 INT65033 Negative_regulation of Fgf2 21 0.59 12.36 2.94 92.00
41 INT43415 Gene_expression of CYP4A11 11 0.56 7.65 5.94 91.76
42 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 91.52
43 INT71768 Regulation of Gene_expression of Il10 27 0.62 19.17 10.4 90.84
44 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 90.84
45 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 90.84
46 INT120722 Gene_expression of TYMP 35 0.75 19.26 1.31 90.84
47 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 90.36
48 INT20102 Gene_expression of Serpine1 102 0.78 65.99 12.61 90.24
49 INT233908 Protein_catabolism of amd 1 0.08 1.73 0.04 90.04
50 INT108477 Gene_expression of Ear11 3 0.44 0.86 0.93 89.92
51 INT282127 Regulation of Regulation of Best1 1 0.15 1.67 0.18 89.88
52 INT211972 Regulation of Best1 18 0.33 12.04 0.67 89.48
53 INT99613 Gene_expression of alphaVbeta3 5 0.66 2.53 0.91 88.64
54 INT26974 Negative_regulation of Adipoq 27 0.52 26.01 2.59 88.60
55 INT103094 Binding of PPARA 308 0.47 177.26 34.75 88.56
56 INT107121 Positive_regulation of Tchh 4 0.60 5.88 0.5 88.24
57 INT243003 Positive_regulation of Angpt2 7 0.65 6.31 0.26 87.52
58 INT211968 Localization of Best1 11 0.40 9.33 0.38 86.64
59 INT16013 Gene_expression of Rac1 52 0.75 23.79 1.21 86.16
60 INT199567 Binding of Kdr 18 0.47 13.81 1.34 86.08
61 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46 85.20
62 INT114751 Gene_expression of Mapk1 137 0.76 60.14 39.98 85.20
63 INT145821 Negative_regulation of Gene_expression of Mapk1 16 0.41 8.05 2.77 85.20
64 INT240711 Gene_expression of Srsf1 3 0.67 1.99 0.03 84.60
65 INT295845 Positive_regulation of Gene_expression of Srsf1 1 0.60 0.97 0.05 84.60
66 INT100139 Positive_regulation of Gene_expression of PPARA 160 0.63 97.78 14.53 84.32
67 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 84.32
68 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81 84.32
69 INT122569 Negative_regulation of Gene_expression of Akt1 34 0.54 17.15 4.44 84.32
70 INT139863 Binding of amd 27 0.41 41.3 0.91 83.68
71 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 83.36
72 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 83.28
73 INT156097 Negative_regulation of Localization of VEGFA 70 0.58 34.96 4.17 83.28
74 INT247569 Positive_regulation of Regulation of VEGFA 6 0.48 4.15 0.07 83.12
75 INT157378 Gene_expression of PDR 14 0.53 11.46 0.64 81.44
76 INT217083 Gene_expression of Rrm2 10 0.47 4.16 0.47 80.56
77 INT278278 Positive_regulation of Gene_expression of Rrm2 3 0.33 1.9 0 80.56
78 INT139862 Negative_regulation of amd 8 0.35 10.15 0.6 80.52
79 INT265327 Negative_regulation of Binding of ecs 3 0.13 2.59 0.23 80.36
80 INT101481 Positive_regulation of Lep 81 0.69 62.59 9.95 80.24
81 INT15684 Positive_regulation of Serpine1 65 0.70 43.51 13.67 80.20
82 INT1149 Binding of ecs 19 0.37 13.67 3.9 79.84
83 INT59901 Localization of Ear11 3 0.59 0.72 1.57 79.80
84 INT329626 Localization of Rrm2 1 0.39 0.72 0 79.80
85 INT178485 Binding of Cd36 11 0.22 6.65 0.8 78.32
86 INT199084 Gene_expression of Cd36 31 0.53 16.94 1.94 77.64
87 INT16428 Positive_regulation of Gtf3a 135 0.20 106.44 26.67 76.96
88 INT227759 Gene_expression of Best1 26 0.42 20.36 1.73 74.32
89 INT134625 Gene_expression of Kdr 116 0.71 53.13 10.09 73.32
90 INT89294 Gene_expression of Ccr3 53 0.68 43.9 12.62 73.28
91 INT12632 Negative_regulation of Binding of INSRR 13 0.38 6.54 6.39 72.48
92 INT90792 Localization of Il10 144 0.80 87.88 30.03 72.28
93 INT9781 Binding of INSRR 64 0.31 19.1 25.2 72.12
94 INT178511 Gene_expression of EML2 1 0.01 1.35 0.19 71.28
95 INT69878 Positive_regulation of Gene_expression of Gtf3a 48 0.29 36.78 13.57 70.96
96 INT62543 Gene_expression of Icam1 231 0.78 187.58 52.71 70.32
97 INT300510 Gene_expression of Wibg 1 0.01 0.88 0.09 70.20
98 INT300509 Regulation of Gene_expression of Wibg 1 0.01 0.89 0.09 70.20
99 INT302624 Negative_regulation of Gene_expression of Rac1 1 0.56 3.67 0.06 69.48
100 INT302611 Regulation of Gene_expression of Rac1 1 0.43 4.5 0.03 69.48
101 INT228870 Negative_regulation of Lpar1 17 0.51 20.97 8.77 68.12
102 INT89240 Gene_expression of VEGFC 23 0.75 15.94 2.03 68.04
103 INT300514 Positive_regulation of Gene_expression of VEGFC 5 0.67 3.85 0.34 68.04
104 INT75137 Regulation of Akt1 74 0.48 37.89 9.7 67.92
105 INT109967 Gene_expression of Mmv7 21 0.35 15.66 1.7 67.76
106 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 67.32
107 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 67.32
108 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 66.68
109 INT298644 Positive_regulation of Positive_regulation of Meta 1 0.67 1.4 0.23 66.20
110 INT258548 Positive_regulation of Meta 10 0.67 5.05 1.42 65.84
111 INT103155 Gene_expression of KDR 78 0.66 50.53 4.38 65.12
112 INT329635 Positive_regulation of Binding of Eefsec 1 0.09 0.52 0 63.76
113 INT329629 Positive_regulation of Cdc42se1 1 0.03 0.47 0 63.76
114 INT103298 Binding of CALCR 5 0.47 6.03 2.15 63.64
115 INT86025 Positive_regulation of Positive_regulation of PPARA 34 0.52 22.89 5.74 63.36
116 INT112963 Regulation of Positive_regulation of PPARA 8 0.44 5.29 1.43 63.00
117 INT222848 Binding of Eefsec 9 0.06 1.65 0.11 63.00
118 INT320829 Negative_regulation of DLL4 1 0.45 2.26 0 62.88
119 INT1150 Gene_expression of ecs 42 0.59 29.38 7.73 62.00
120 INT158016 Positive_regulation of VEGFC 7 0.49 6.58 2.18 61.20
121 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 61.12
122 INT67174 Negative_regulation of Rac1 22 0.56 10.72 0.99 60.96
123 INT302610 Positive_regulation of Gene_expression of Kitl 4 0.33 0.63 0.09 60.68
124 INT271365 Gene_expression of PIGF 1 0.21 3.98 0.32 60.24
125 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55 60.04
126 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 58.88
127 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 58.88
128 INT77498 Positive_regulation of ZBP1 2 0.40 1.59 0.09 58.88
129 INT101517 Negative_regulation of PPARA 168 0.57 112.24 21.41 58.72
130 INT1664 Gene_expression of Kitl 30 0.65 13.63 7.47 58.72
131 INT271362 Positive_regulation of PIGF 1 0.19 4.16 0.54 56.60
132 INT295839 Binding of Srpk1 1 0.22 1.2 0 56.52
133 INT130358 Gene_expression of Tsp2 8 0.65 4.84 0.67 55.48
134 INT196142 Gene_expression of Olfr435 3 0.02 4.1 0.24 55.00
135 INT8270 Positive_regulation of Ear11 8 0.60 1.74 3.42 54.48
136 INT90940 Binding of Eng 5 0.35 1.92 0.13 53.88
137 INT217514 Gene_expression of Dss1 12 0.47 7.6 1.35 53.68
138 INT169561 Negative_regulation of Dss1 8 0.28 4.92 1.01 53.68
139 INT11937 Localization of Il6 228 0.81 139.83 64.39 53.04
140 INT86805 Localization of HGF 49 0.71 28.48 6.35 53.04
141 INT7723 Localization of Hgf 10 0.46 6.28 0.68 53.04
142 INT295851 Gene_expression of Srpk1 1 0.46 1.72 0.05 51.68
143 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 51.24
144 INT173180 Positive_regulation of Binding of PPARA 14 0.49 3.66 1.88 49.44
145 INT68681 Transcription of VEGFA 132 0.71 80.47 17.03 49.24
146 INT52695 Regulation of Ptgs2 20 0.42 8.72 5.71 49.16
147 INT209935 Regulation of Regulation of PPARA 4 0.44 1.56 0.69 49.12
148 INT85653 Regulation of Gene_expression of Cpox 24 0.24 20.55 5.22 48.44
149 INT174873 Regulation of Transcription of VEGFA 8 0.43 3.71 0.55 48.24
150 INT69993 Positive_regulation of Gene_expression of Cpox 93 0.55 69.4 22.05 47.92
151 INT103153 Positive_regulation of Transcription of VEGFA 34 0.69 22.16 4.22 47.84
152 INT49439 Gene_expression of Cpox 508 0.73 326.97 130.17 47.52
153 INT153913 Positive_regulation of Lpar1 31 0.70 33.5 16.14 47.52
154 INT281823 Gene_expression of PRB4 2 0.15 2.37 0.39 47.44
155 INT228771 Localization of C3ar1 2 0.03 2.71 0.38 47.44
156 INT247568 Negative_regulation of Negative_regulation of VEGFA 5 0.41 5.35 0.43 47.20
157 INT39256 Localization of PTGS1 17 0.74 6.62 5.1 47.12
158 INT339564 Regulation of Localization of CYP2J2 1 0.30 0.47 0.12 47.12
159 INT339554 Localization of CYP2J2 1 0.49 0.47 0.12 47.12
160 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32 46.48
161 INT18583 Positive_regulation of Gene_expression of Ins1 67 0.50 49.72 8.26 46.48
162 INT329624 Localization of Tchh 1 0.21 0.56 0 46.40
163 INT101483 Gene_expression of Lep 159 0.78 104.77 25.12 46.12
164 INT174054 Positive_regulation of Gene_expression of Lep 25 0.69 21.3 3.72 46.12
165 INT2512 Negative_regulation of Cp 27 0.51 10.15 8.37 46.08
166 INT178498 Negative_regulation of Fgf2 11 0.42 4.21 0.84 45.96
167 INT26975 Gene_expression of Adipoq 113 0.75 106.71 14.46 45.68
168 INT146043 Positive_regulation of Gene_expression of Adipoq 39 0.67 29.93 6.12 45.68
169 INT217091 Positive_regulation of Rrm2 5 0.33 4.12 0.6 45.32
170 INT329627 Positive_regulation of Positive_regulation of Rrm2 1 0.24 0.57 0 45.32
171 INT49441 Negative_regulation of Cpox 494 0.59 303.22 177.46 44.92
172 INT106522 Negative_regulation of Phosphorylation of Akt1 65 0.58 34.44 7.83 43.32
173 INT151774 Positive_regulation of Mtor 38 0.45 20.15 1.01 41.28
174 INT178510 Localization of EML2 1 0.02 1.24 0.1 40.56
175 INT79816 Localization of Pla2g2a 13 0.74 8.08 2.06 40.32
176 INT168257 Binding of MLL 4 0.02 4.25 0.53 38.84
177 INT205218 Localization of Ocln 3 0.46 1.71 0.32 38.64
178 INT291085 Localization of Col4a5 1 0.12 0.91 0.3 38.64
179 INT291084 Localization of Cldn5 1 0.31 0.84 0.29 38.64
180 INT10131 Gene_expression of Serpinf1 53 0.76 35.57 6.42 38.44
181 INT130560 Negative_regulation of Gene_expression of Serpinf1 17 0.58 13.39 1.94 38.44
182 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01 38.32
183 INT86295 Gene_expression of Mmp2 114 0.76 73.68 24.25 38.32
184 INT53386 Negative_regulation of Cyp4a10 7 0.32 4.13 0.7 38.08
185 INT60695 Positive_regulation of Gene_expression of Il10 154 0.70 120.28 43.07 37.84
186 INT166115 Positive_regulation of Gene_expression of Lpar1 42 0.61 31 20.71 37.68
187 INT142984 Positive_regulation of S1pr1 13 0.70 7.9 3.84 37.68
188 INT116164 Positive_regulation of Gene_expression of S1pr1 5 0.66 4.72 2.42 37.68
189 INT116163 Gene_expression of S1pr1 29 0.78 14.11 7.27 37.00
190 INT295821 Binding of Srpk2 1 0.22 0.75 0 36.88
191 INT295861 Binding of RNPS1 1 0.01 0.76 0 36.20
192 INT39050 Positive_regulation of PGF 14 0.49 8.05 1.43 35.84
193 INT295864 Phosphorylation of RNPS1 1 0.02 0.81 0.04 35.84
194 INT271358 Regulation of Gene_expression of PIGF 1 0.12 1.08 0.23 35.20
195 INT271366 Regulation of PIGF 1 0.07 1.07 0.23 35.20
196 INT37394 Localization of ecs 9 0.34 6.41 2.11 34.08
197 INT94144 Localization of ZDHHC2 2 0.13 0.59 0.26 33.84
198 INT298660 Negative_regulation of Localization of ZDHHC2 1 0.02 0.22 0.04 33.84
199 INT12010 Gene_expression of Cp 38 0.65 20.55 7.84 33.68
200 INT318795 Positive_regulation of ISPD 1 0.01 0.44 0 33.68
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