D:Penetrating Head Injuries

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Disease Term
Synonyms Brain Injuries Penetrating, Brain Injury Penetrating, Cranial Trauma Penetrating, Cranial Traumas Penetrating, Craniocerebral Trauma Penetrating, Craniocerebral Traumas Penetrating, HEAD INJURIES PENETRATING MISSILE, Head Injury Penetrating, HEAD TRAUMA PENETRATING, Head Traumas Penetrating, Injuries Penetrating Head
Documents 26
Hot Single Events 38
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Penetrating Head Injuries. They are ordered first by their relevance to Penetrating Head Injuries and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT195115 Gene_expression of Gopc Positive_regulation of Positive_regulation of F2r 1 0.17 1.67 0.18 76.32
2 INT195114 Gene_expression of Il1r1 Positive_regulation of Positive_regulation of F2r 1 0.38 1.67 0.18 75.92
3 INT230499 Gene_expression of Il1rn Negative_regulation of Gene_expression of Icam1 1 0.01 0.85 0.36 38.84
4 INT319581 Binding of PIAS1 and TNFSF14 1 0.02 1.58 2.13 5.00
5 INT177457 Il1 Positive_regulation of Gene_expression of Il6 3 0.16 4.47 1.35 5.00
6 INT195117 Ptgs2 Positive_regulation of Gene_expression of Il6 1 0.10 3.26 1.16 5.00
7 INT195122 Il1 Positive_regulation of Gene_expression of Gtf3a 1 0.02 1.38 0.5 5.00
8 INT230500 Il1 Positive_regulation of Gene_expression of Tnf 1 0.07 1.83 0.4 5.00
9 INT230501 Il1 Positive_regulation of Gene_expression of S100a8 1 0.01 1.82 0.39 5.00
10 INT195120 Il1 Regulation of Gene_expression of Cp 1 0.06 0.98 0.25 5.00
11 INT195121 Gene_expression of Il1r1 Positive_regulation of Positive_regulation of Gopc 1 0.17 0.26 0.11 5.00
12 INT195119 Gene_expression of Il1r1 Positive_regulation of Positive_regulation of Gfap 1 0.38 0.26 0.11 5.00
13 INT319578 CYP3A4 Regulation of ALPPL2 1 0.00 0.56 0.05 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Penetrating Head Injuries. They are ordered first by their pain relevance and then by number of times they were reported in Penetrating Head Injuries. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT195103 Positive_regulation of Gene_expression of Slc1a2 5 0.66 3 2.09 99.98
2 INT195110 Positive_regulation of Gene_expression of Slc1a3 5 0.44 2.88 2.27 99.98
3 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1 99.92
4 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 99.78
5 INT118512 Gene_expression of F2r 33 0.63 26.56 18.26 99.76
6 INT195099 Positive_regulation of Gene_expression of F2r 7 0.57 5.31 0.78 99.76
7 INT155683 Gene_expression of Slc1a2 27 0.73 9.86 15.34 99.70
8 INT155680 Gene_expression of Slc1a3 22 0.66 6.76 7.23 99.70
9 INT36030 Gene_expression of Il1r1 16 0.68 11.42 4.87 99.16
10 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 98.40
11 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 98.40
12 INT195111 Negative_regulation of Positive_regulation of S100b 1 0.06 1.06 0.18 97.72
13 INT195101 Negative_regulation of Positive_regulation of Gfap 1 0.31 1.02 0.18 97.72
14 INT195077 Negative_regulation of Positive_regulation of Glul 1 0.19 1.06 0.18 97.72
15 INT57187 Positive_regulation of Gfap 49 0.69 27.59 11.46 97.38
16 INT195112 Positive_regulation of Positive_regulation of F2r 1 0.41 0.97 0.18 97.28
17 INT195091 Negative_regulation of Positive_regulation of F2r 1 0.48 1.69 0.25 97.00
18 INT117497 Positive_regulation of F2r 18 0.57 14.45 8.13 96.78
19 INT112986 Positive_regulation of S100b 19 0.70 17.61 6.86 96.20
20 INT10162 Positive_regulation of Gpx3 10 0.40 3.37 3.68 96.20
21 INT25607 Binding of Il1 82 0.47 64.4 23.9 95.36
22 INT54331 Positive_regulation of Glul 8 0.67 3.55 2.74 95.06
23 INT36028 Positive_regulation of Gene_expression of Il1r1 4 0.40 1.82 0.81 94.72
24 INT195089 Positive_regulation of Slc1a2 3 0.66 1.57 0.61 93.44
25 INT190619 Positive_regulation of F2rl2 3 0.14 2.41 0.42 87.16
26 INT195090 Positive_regulation of Gene_expression of F2rl2 2 0.15 2.09 0.34 87.16
27 INT195088 Negative_regulation of Positive_regulation of F2rl2 1 0.13 0.91 0.18 87.16
28 INT195105 Negative_regulation of Gene_expression of F2r 3 0.37 1.41 0.91 86.84
29 INT160256 Gene_expression of F2rl2 3 0.30 3.16 0.34 86.84
30 INT195096 Negative_regulation of Gene_expression of F2rl2 1 0.13 0.91 0.17 86.84
31 INT195086 Negative_regulation of F2rl2 1 0.06 0.9 0.17 86.28
32 INT82652 Negative_regulation of F2r 4 0.37 3.5 2.19 85.12
33 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 84.28
34 INT195087 Protein_catabolism of Pars2 1 0.12 0.83 0.09 84.00
35 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 81.68
36 INT195092 Protein_catabolism of F2 4 0.26 2.75 0.47 81.16
37 INT191831 Positive_regulation of Slc1a3 6 0.49 3.66 0.87 80.72
38 INT195104 Positive_regulation of Il1r1 4 0.40 2.18 0.68 80.72
39 INT63506 Localization of F2 21 0.77 7.53 3.41 79.92
40 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 76.32
41 INT25610 Positive_regulation of Gene_expression of Il1 136 0.67 104.43 43.86 72.40
42 INT15511 Gene_expression of Tnfrsf1a 84 0.76 63.3 24.03 72.28
43 INT195080 Positive_regulation of Tnc 4 0.45 26.67 2.34 71.16
44 INT36029 Negative_regulation of Il1r1 9 0.41 4.64 2.3 70.32
45 INT352045 Binding of Cd48 1 0.05 2.8 0.25 69.40
46 INT1120 Gene_expression of C3 33 0.67 22.86 7.56 68.88
47 INT195107 Localization of S100b 3 0.51 2.63 0.73 68.60
48 INT66200 Gene_expression of Gfap 215 0.78 88.04 28.25 62.32
49 INT101474 Positive_regulation of Gene_expression of Gfap 61 0.70 38.3 10.35 62.32
50 INT17886 Negative_regulation of Il1 95 0.57 70.91 31.25 59.44
51 INT195095 Positive_regulation of Gene_expression of S100b 4 0.36 5.37 0.61 59.28
52 INT195085 Gene_expression of S100b 12 0.56 12.26 2.33 58.80
53 INT12010 Gene_expression of Cp 38 0.65 20.55 7.84 57.24
54 INT91754 Gene_expression of Cp 42 0.77 21.97 5.38 57.24
55 INT175298 Gene_expression of Meta 7 0.75 2.37 1.85 56.88
56 INT230492 Positive_regulation of Gene_expression of Meta 3 0.45 0.92 0.72 56.88
57 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54 56.32
58 INT52801 Regulation of Gene_expression of Tnf 55 0.62 48.74 26.59 55.36
59 INT230491 Regulation of Il1r1 1 0.01 0.76 0.25 54.84
60 INT76884 Positive_regulation of Cp 22 0.69 12.84 4.6 54.60
61 INT25608 Regulation of Gene_expression of Il1 37 0.44 27.76 10.1 50.64
62 INT195082 Regulation of Gene_expression of F2r 1 0.37 0.67 0.07 50.64
63 INT66198 Negative_regulation of Gene_expression of Gfap 13 0.59 10.33 3.41 50.40
64 INT113602 Positive_regulation of Gene_expression of Ccl2 48 0.70 48.71 17.85 49.48
65 INT102546 Gene_expression of Ccl2 197 0.78 192.8 67.41 49.12
66 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 48.08
67 INT21793 Positive_regulation of Ngf 154 0.70 94.78 85.27 44.80
68 INT2432 Positive_regulation of Cp 41 0.67 31.1 16.68 44.80
69 INT64539 Gene_expression of Gpx3 14 0.58 9.42 3.64 42.40
70 INT134967 Gene_expression of Ecm1 66 0.29 38.4 7.16 42.04
71 INT78190 Gene_expression of Tnc 10 0.75 21.23 2.91 39.32
72 INT33542 Gene_expression of Il1rn 41 0.76 32.47 18.08 38.84
73 INT126395 Positive_regulation of Gene_expression of Il1rn 11 0.41 7.66 6.25 38.84
74 INT79227 Negative_regulation of Gene_expression of Icam1 45 0.59 41.65 14.97 36.56
75 INT62543 Gene_expression of Icam1 231 0.78 187.58 52.71 36.24
76 INT66199 Negative_regulation of Gfap 14 0.46 6.88 2.57 22.16
77 INT97596 Localization of S100a8 94 0.78 90.69 40.41 20.56
78 INT11325 Gene_expression of HLA-E 209 0.76 98.05 33.72 13.60
79 INT28671 Positive_regulation of Gene_expression of HLA-E 43 0.67 22.85 8.39 13.60
80 INT195100 Positive_regulation of Cspg4 2 0.62 0.92 0.19 6.80
81 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 5.00
82 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71 5.00
83 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 5.00
84 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 5.00
85 INT65500 Gene_expression of App 605 0.78 429.94 98.31 5.00
86 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 5.00
87 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
88 INT96914 Phosphorylation of Mapk14 168 0.82 108.46 53.32 5.00
89 INT52611 Negative_regulation of Ptgs2 142 0.59 66.31 52.71 5.00
90 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 5.00
91 INT19775 Localization of Il1 183 0.78 145.5 50.91 5.00
92 INT53083 Gene_expression of Ptgs2 153 0.78 90.04 50.39 5.00
93 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24 5.00
94 INT81289 Positive_regulation of Gene_expression of Tlr4 192 0.69 104.5 33.89 5.00
95 INT56809 Binding of Tlr4 184 0.48 106.02 31.18 5.00
96 INT47712 Positive_regulation of App 135 0.69 101.38 28.94 5.00
97 INT48853 Positive_regulation of BDNF 82 0.69 43.92 27.99 5.00
98 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6 5.00
99 INT73670 Gene_expression of Vcam1 128 0.78 123.79 24.96 5.00
100 INT58301 Positive_regulation of Mpo 87 0.70 80.19 23.99 5.00
101 INT9079 Gene_expression of PPBP 52 0.75 31.2 21.52 5.00
102 INT69877 Positive_regulation of Positive_regulation of Nfkb1 53 0.68 31.44 20.7 5.00
103 INT20129 Regulation of Il1 53 0.53 44.14 19.89 5.00
104 INT16794 Binding of App 103 0.48 64.87 19.79 5.00
105 INT6993 Negative_regulation of Mpo 72 0.59 61.83 19.51 5.00
106 INT65502 Regulation of App 77 0.62 52.05 19.44 5.00
107 INT170051 Positive_regulation of Gene_expression of Gopc 150 0.43 56.75 16.93 5.00
108 INT24225 Gene_expression of Alms1 93 0.62 52.75 16.93 5.00
109 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83 5.00
110 INT43906 Regulation of Tlr4 71 0.53 35.18 15.49 5.00
111 INT87823 Positive_regulation of Cxcl2 51 0.66 35.47 14.79 5.00
112 INT67641 Negative_regulation of Gene_expression of Tlr4 90 0.58 46 14.6 5.00
113 INT25076 Negative_regulation of Gene_expression of Il1 41 0.52 30.58 13.85 5.00
114 INT36177 Binding of Alms1 70 0.31 35.47 13.81 5.00
115 INT69878 Positive_regulation of Gene_expression of Gtf3a 48 0.29 36.78 13.57 5.00
116 INT65501 Regulation of Gene_expression of App 56 0.62 32.51 11.48 5.00
117 INT53081 Negative_regulation of Gene_expression of Ptgs2 29 0.59 15.83 10.39 5.00
118 INT108931 Negative_regulation of BDNF 38 0.59 19.61 8.84 5.00
119 INT22481 Gene_expression of CADM1 28 0.65 30.26 8.5 5.00
120 INT91772 Gene_expression of PSEN1 115 0.75 38.12 8.48 5.00
121 INT127378 Localization of Mpo 21 0.78 26.36 8.28 5.00
122 INT54662 Positive_regulation of Positive_regulation of Il1 21 0.43 19.33 7.14 5.00
123 INT53572 Negative_regulation of Localization of Il1 18 0.40 12.78 6.7 5.00
124 INT127023 Negative_regulation of Gene_expression of Vcam1 24 0.59 20.39 6.28 5.00
125 INT57256 Gene_expression of HLA-DQA2 52 0.55 23.87 6.27 5.00
126 INT90077 Gene_expression of Casp1 29 0.76 20.79 6.26 5.00
127 INT103760 Regulation of Gene_expression of Tlr4 35 0.59 16.26 5.95 5.00
128 INT28088 Binding of Alb 34 0.47 11.06 5.48 5.00
129 INT3275 Negative_regulation of Slco1c1 28 0.37 10.93 5.15 5.00
130 INT114183 Positive_regulation of Il1rn 17 0.55 11.31 4.83 5.00
131 INT174277 Positive_regulation of Positive_regulation of Gopc 23 0.33 8.08 3.73 5.00
132 INT15002 Regulation of Gfap 17 0.37 5.34 3.61 5.00
133 INT84320 Negative_regulation of Positive_regulation of Mpo 11 0.46 8 3.09 5.00
134 INT133744 Gene_expression of Vcan 27 0.74 10.64 2.85 5.00
135 INT155216 Negative_regulation of Gene_expression of CYP3A4 9 0.56 3.81 2.71 5.00
136 INT59321 Transcription of Il1 13 0.50 9.73 2.68 5.00
137 INT163544 Binding of Psen1 40 0.36 15.28 2.42 5.00
138 INT56084 Negative_regulation of SLC43A3 11 0.39 5.39 2.27 5.00
139 INT49631 Gene_expression of Slc43a3 14 0.59 4.15 2.15 5.00
140 INT44851 Gene_expression of RT1-DMb 3 0.52 2.2 2.1 5.00
141 INT43900 Gene_expression of RASA1 13 0.58 12 2.03 5.00
142 INT135616 Negative_regulation of Gene_expression of PPBP 6 0.26 2.58 1.91 5.00
143 INT30168 Gene_expression of Dnahc8 20 0.65 4.17 1.73 5.00
144 INT161371 Gene_expression of Glul 7 0.61 2.44 1.58 5.00
145 INT205681 Regulation of Positive_regulation of Il1 4 0.23 4.96 1.29 5.00
146 INT39834 Positive_regulation of Gene_expression of Cp 6 0.49 3.14 1.18 5.00
147 INT209915 Protein_catabolism of Il1 6 0.57 3.97 1.17 5.00
148 INT98489 Binding of Il1r1 3 0.36 1.46 1.06 5.00
149 INT184435 Negative_regulation of Binding of Il1 4 0.41 2.64 1 5.00
150 INT150879 Gene_expression of PTCRA 12 0.77 2.1 0.94 5.00
151 INT173514 Negative_regulation of Gene_expression of Alms1 3 0.06 3.49 0.91 5.00
152 INT230497 Positive_regulation of Transcription of Il1 2 0.40 2.77 0.77 5.00
153 INT230493 Regulation of Binding of Alms1 3 0.12 1.89 0.76 5.00
154 INT146505 Positive_regulation of Regulation of Gfap 4 0.44 1.98 0.7 5.00
155 INT249114 Gene_expression of Cd48 2 0.10 5.06 0.68 5.00
156 INT35048 Localization of TNFSF14 5 0.68 3.12 0.66 5.00
157 INT230495 Regulation of Gene_expression of Alms1 4 0.04 4.53 0.53 5.00
158 INT195094 Binding of S100b 2 0.35 3.49 0.51 5.00
159 INT195106 Positive_regulation of Gene_expression of Cp 5 0.50 2.96 0.49 5.00
160 INT195097 Positive_regulation of Gene_expression of Gpx3 4 0.45 1.09 0.47 5.00
161 INT7248 Localization of RASA1 4 0.61 2.52 0.47 5.00
162 INT183682 Positive_regulation of Positive_regulation of Cxcl2 3 0.40 0.86 0.45 5.00
163 INT195093 Positive_regulation of Vcan 2 0.58 2.66 0.44 5.00
164 INT195102 Gene_expression of Cspg4 3 0.60 1.56 0.42 5.00
165 INT230494 Regulation of Binding of Tlr4 3 0.45 2.97 0.31 5.00
166 INT195084 Positive_regulation of Gene_expression of Cspg4 2 0.49 0.87 0.25 5.00
167 INT195079 Binding of Slc1a2 2 0.35 0 0.2 5.00
168 INT335032 Binding of THEG 1 0.04 2.4 0.2 5.00
169 INT195076 Transcription of Cspg4 1 0.62 0.63 0.17 5.00
170 INT195078 Binding of F2rl2 1 0.11 0 0.15 5.00
171 INT249112 Positive_regulation of Cd48 2 0.07 1.1 0.11 5.00
172 INT352046 Regulation of Positive_regulation of Cd48 1 0.05 0.64 0.09 5.00
173 INT352044 Positive_regulation of Gene_expression of Slc43a3 1 0.03 0.27 0.04 5.00
174 INT195083 Localization of Cspg4 2 0.67 0.28 0.04 5.00
175 INT195081 Gene_expression of Cspg5 1 0.07 0.88 0 5.00
176 INT195098 Transcription of Vcan 1 0.30 0.87 0 5.00
177 INT335031 Positive_regulation of Gene_expression of RASA1 1 0.09 1.49 0 5.00
178 INT195108 Positive_regulation of Transcription of Vcan 1 0.26 0.87 0 5.00
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