D:Pericardial Effusion

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Disease Term
Synonyms CHYLOPERICARDIUM, CHYLOPERICARDIUMS, Effusion Pericardial, EFFUSIONS PERICARDIAL, HEMOPERICARDIUM, Pericardial Effusions
Documents 120
Hot Single Events 13
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Pericardial Effusion. They are ordered first by their relevance to Pericardial Effusion and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT102130 Il6 Positive_regulation of Gene_expression of Crp 4 0.05 7.39 1.91 5.00
2 INT151849 IL10 Negative_regulation of Gene_expression of IL8 4 0.14 3.26 1.54 5.00
3 INT222691 Negative_regulation of Binding of FLNA and TNF 1 0.14 1.92 0.54 5.00
4 INT222692 Binding of FLNA and TNF 1 0.12 1.92 0.53 5.00
5 INT352972 IL4 Negative_regulation of Gene_expression of IL8 1 0.07 1.01 0.43 5.00
6 INT352986 IL10 Negative_regulation of Gene_expression of Il6 1 0.01 1 0.43 5.00
7 INT352985 IL4 Negative_regulation of Gene_expression of Il6 1 0.01 1 0.43 5.00
8 INT352970 IL4 Negative_regulation of Positive_regulation of TH1L 1 0.01 0.91 0.4 5.00
9 INT222690 TNF Positive_regulation of Gene_expression of NPEPPS 1 0.01 1.03 0.3 5.00
10 INT354544 Avp Positive_regulation of ADCY1 1 0.24 2.23 0.22 5.00
11 INT126944 Binding of PKD2 and Pkd1 2 0.08 2.09 0.19 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Pericardial Effusion. They are ordered first by their pain relevance and then by number of times they were reported in Pericardial Effusion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT1190 Positive_regulation of F2 53 0.70 46.41 11.64 99.90
2 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 98.76
3 INT355488 Positive_regulation of Binding of ADC 1 0.09 2.28 0.18 98.44
4 INT78329 Binding of ADC 7 0.31 7.57 0.73 98.44
5 INT4173 Binding of Cys1 3 0.37 2.8 0.15 97.20
6 INT1934 Positive_regulation of Cys1 68 0.68 60.56 10.47 96.56
7 INT118267 Negative_regulation of ARSD 14 0.36 8.27 1.44 92.00
8 INT174875 Gene_expression of Myl3 3 0.43 2.56 0.1 91.64
9 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 88.48
10 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 86.00
11 INT57252 Negative_regulation of PGR 22 0.43 12.95 3.33 85.72
12 INT241245 Negative_regulation of PKD2 2 0.42 2.35 0 80.92
13 INT271915 Negative_regulation of Pkd1 8 0.36 6.44 0 80.92
14 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39 76.64
15 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 74.96
16 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 74.96
17 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 74.40
18 INT154553 Positive_regulation of RHOH 3 0.45 2.76 0.29 73.76
19 INT65054 Positive_regulation of Nfkb1 285 0.70 149.33 126.73 73.76
20 INT86673 Positive_regulation of Bcl2 77 0.70 57.74 17.37 73.76
21 INT121388 Positive_regulation of BCL6 2 0.28 2.71 0.32 73.76
22 INT154549 Positive_regulation of Pim1 1 0.02 1.3 0.13 73.76
23 INT154550 Positive_regulation of Mal 1 0.00 1.32 0.13 73.76
24 INT81530 Gene_expression of Nfkb1 93 0.78 48.58 32.58 72.88
25 INT154554 Gene_expression of RHOH 3 0.75 3.26 0.24 69.60
26 INT154548 Gene_expression of Pim1 1 0.02 1.26 0.12 68.24
27 INT126457 Gene_expression of BCL6 34 0.66 22.45 1.75 67.68
28 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03 64.48
29 INT151289 Gene_expression of Mal 4 0.51 2.17 0.12 64.48
30 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 56.88
31 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 55.40
32 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 53.76
33 INT28802 Binding of F2 15 0.47 8.8 3.47 50.00
34 INT271793 Regulation of Binding of F2 1 0.03 0.46 0.05 50.00
35 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3 49.76
36 INT8775 Binding of IGHE 167 0.48 102.61 23.54 49.64
37 INT66423 Binding of ELOVL1 52 0.40 61.63 5.16 38.56
38 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 36.56
39 INT145001 Gene_expression of IFNB1 6 0.68 4.36 1.77 36.56
40 INT258990 Localization of Emb 1 0.21 0.98 0.21 35.92
41 INT258989 Binding of Emb 1 0.10 0.98 0.21 34.44
42 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 33.08
43 INT167052 Gene_expression of Cr2 43 0.56 25.7 7.76 33.08
44 INT60700 Gene_expression of Itgax 93 0.71 51.89 6.57 33.08
45 INT66852 Gene_expression of Fcer2 15 0.14 9.74 1.27 33.08
46 INT62031 Gene_expression of Cd19 27 0.65 10.39 0.93 33.08
47 INT117661 Gene_expression of Cd22 7 0.30 5.69 0.62 33.08
48 INT327716 Gene_expression of Cd52 1 0.10 0.36 0.04 33.08
49 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 32.40
50 INT16359 Positive_regulation of Gene_expression of AGT 30 0.49 28.27 6.14 25.16
51 INT58765 Positive_regulation of Gene_expression of ANGPT2 11 0.38 8.2 0.81 25.16
52 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 24.20
53 INT58766 Gene_expression of ANGPT2 41 0.67 21.65 4.82 23.56
54 INT54886 Negative_regulation of ANGPT2 25 0.42 9.33 3.79 21.92
55 INT258991 Gene_expression of Emb 2 0.43 2.55 0.23 12.36
56 INT277802 Gene_expression of Rit1 3 0.35 4.59 0.21 6.16
57 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
58 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
59 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
60 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
61 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
62 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
63 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
64 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
65 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
66 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
67 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
68 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
69 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
70 INT118381 Gene_expression of Il17a 405 0.76 306.97 112.06 5.00
71 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 5.00
72 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
73 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
74 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
75 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 5.00
76 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
77 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
78 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9 5.00
79 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 5.00
80 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
81 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
82 INT19775 Localization of Il1 183 0.78 145.5 50.91 5.00
83 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 5.00
84 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24 5.00
85 INT97596 Localization of S100a8 94 0.78 90.69 40.41 5.00
86 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 5.00
87 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
88 INT72651 Gene_expression of TH1L 114 0.75 80.15 35.15 5.00
89 INT65698 Localization of CCL2 118 0.81 77.54 32.69 5.00
90 INT660 Negative_regulation of REN 194 0.59 82.06 29.46 5.00
91 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 5.00
92 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 5.00
93 INT19330 Binding of HLA-A 99 0.48 76.26 22.85 5.00
94 INT83797 Gene_expression of Bcl2l1 124 0.77 94.55 22.39 5.00
95 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 5.00
96 INT150022 Positive_regulation of Il17a 69 0.64 70.04 21.87 5.00
97 INT11161 Gene_expression of HLA-DRB1 121 0.78 75.33 20.96 5.00
98 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 5.00
99 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 5.00
100 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92 5.00
101 INT110767 Localization of Mcpt1 43 0.68 24.3 16.74 5.00
102 INT5333 Gene_expression of NPEPPS 45 0.65 26.34 15.25 5.00
103 INT75540 Positive_regulation of TH1L 62 0.67 43.45 15.02 5.00
104 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 5.00
105 INT18773 Localization of ALB 117 0.80 69.18 13.8 5.00
106 INT56651 Binding of HLA-DRB1 58 0.48 52.25 13.68 5.00
107 INT27268 Localization of Gtf3a 71 0.21 56.93 12.51 5.00
108 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63 5.00
109 INT37541 Gene_expression of SPP1 113 0.77 68.54 11.35 5.00
110 INT23402 Binding of HLA-DOA 74 0.48 52.01 10.89 5.00
111 INT15054 Gene_expression of Mme 48 0.77 42.52 10.63 5.00
112 INT27651 Gene_expression of S100A12 45 0.76 52.25 10.51 5.00
113 INT95565 Positive_regulation of IL12A 47 0.56 33.96 10.16 5.00
114 INT68373 Negative_regulation of FLNA 59 0.57 60.46 9.55 5.00
115 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 5.00
116 INT9548 Gene_expression of CHKB 99 0.65 50.86 9.03 5.00
117 INT10879 Positive_regulation of Avp 39 0.65 14.01 8.76 5.00
118 INT20205 Binding of IgG 108 0.46 66.68 8.57 5.00
119 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86 5.00
120 INT165036 Gene_expression of S100a9 38 0.77 38.33 7.84 5.00
121 INT39417 Gene_expression of Fcer2a 65 0.76 32.1 7.37 5.00
122 INT48626 Positive_regulation of Csf3 33 0.66 29.79 7.34 5.00
123 INT102572 Gene_expression of Ccnd1 79 0.69 56.37 7.34 5.00
124 INT60527 Transcription of IL10 16 0.56 13.57 6.42 5.00
125 INT25123 Negative_regulation of COL7A1 42 0.58 19.98 5.96 5.00
126 INT56299 Transcription of IL4 15 0.64 10.2 5.44 5.00
127 INT63957 Positive_regulation of Tnnt2 33 0.69 18.56 5.41 5.00
128 INT77146 Binding of IL4 23 0.36 13.69 5.39 5.00
129 INT24080 Negative_regulation of Mtor 64 0.37 41.56 5.19 5.00
130 INT116150 Positive_regulation of Ddit3 26 0.67 22.58 5.01 5.00
131 INT113948 Gene_expression of FLNA 32 0.73 36.06 4.81 5.00
132 INT4679 Negative_regulation of RAPGEF5 55 0.57 47.51 4.55 5.00
133 INT83794 Positive_regulation of Gene_expression of Bcl2l1 26 0.69 16.89 4.28 5.00
134 INT83798 Negative_regulation of Gene_expression of Bcl2l1 28 0.58 20.26 4.21 5.00
135 INT47949 Positive_regulation of ELOVL1 19 0.42 29.78 3.3 5.00
136 INT51607 Positive_regulation of DES 33 0.67 32.24 3.29 5.00
137 INT20419 Negative_regulation of Gene_expression of MYC 19 0.57 9.7 3.29 5.00
138 INT181018 Binding of S100a8 20 0.45 22.14 3.18 5.00
139 INT35910 Binding of Mme 8 0.37 4.79 3.16 5.00
140 INT15584 Binding of S100A12 14 0.48 15.14 3 5.00
141 INT146758 Gene_expression of LCN2 45 0.78 38.29 2.97 5.00
142 INT12887 Positive_regulation of Mme 9 0.60 15.41 2.93 5.00
143 INT50765 Positive_regulation of Fcer2a 23 0.68 10.22 2.92 5.00
144 INT152861 Binding of S100a9 11 0.37 12.19 2.91 5.00
145 INT154334 Localization of S100A12 9 0.80 9.32 2.89 5.00
146 INT129358 Gene_expression of ELOVL1 23 0.66 29.39 2.83 5.00
147 INT155889 Binding of Nps 22 0.42 9.79 2.6 5.00
148 INT16964 Binding of IFNG 27 0.48 14.31 2.45 5.00
149 INT147349 Localization of Bcl2 13 0.65 7.83 2.31 5.00
150 INT72890 Positive_regulation of Gene_expression of Fcer2a 12 0.17 6.81 2.25 5.00
151 INT101641 Gene_expression of Mcl1 25 0.54 20.3 2.23 5.00
152 INT181061 Localization of S100a9 9 0.74 4.98 2.19 5.00
153 INT14 Regulation of LDHA 22 0.57 15.26 2.14 5.00
154 INT48444 Localization of Csf3 28 0.72 14.85 2.11 5.00
155 INT55470 Regulation of Mtor 16 0.24 12.51 2.07 5.00
156 INT71870 Positive_regulation of Gene_expression of Mme 6 0.48 4.27 2 5.00
157 INT221431 Negative_regulation of FOXP3 8 0.40 9.92 1.98 5.00
158 INT18007 Positive_regulation of C6orf25 23 0.66 14.98 1.95 5.00
159 INT172961 Localization of Egf 26 0.71 16.74 1.81 5.00
160 INT48141 Binding of Csf3 18 0.39 9.93 1.71 5.00
161 INT216932 Positive_regulation of Negative_regulation of Il6 3 0.38 4.88 1.55 5.00
162 INT37485 Regulation of RAPGEF5 10 0.44 6.64 1.51 5.00
163 INT9784 Binding of B2M 9 0.47 6.18 1.44 5.00
164 INT20633 Positive_regulation of Gene_expression of LDHA 15 0.49 15.94 1.42 5.00
165 INT47734 Positive_regulation of RAPGEF5 19 0.56 13.16 1.41 5.00
166 INT47434 Gene_expression of Tnnt2 14 0.60 10.4 1.37 5.00
167 INT199681 Gene_expression of SERPINA5 13 0.36 15.42 1.25 5.00
168 INT20397 Positive_regulation of Itgax 12 0.46 6.48 1.19 5.00
169 INT34141 Positive_regulation of IMPA1 8 0.50 2.38 1.12 5.00
170 INT146759 Positive_regulation of LCN2 18 0.69 18.44 1.08 5.00
171 INT181973 Positive_regulation of MAS1 8 0.49 7.64 1.07 5.00
172 INT224722 Binding of Mcpt1 6 0.10 4.82 1.03 5.00
173 INT131488 Binding of MAS1 9 0.36 8.49 1.01 5.00
174 INT87329 Positive_regulation of Gene_expression of Itgax 15 0.64 10.85 0.93 5.00
175 INT20627 Regulation of Gene_expression of LDHA 5 0.42 4.07 0.92 5.00
176 INT70027 Positive_regulation of Gene_expression of C6orf25 10 0.62 7.21 0.83 5.00
177 INT2108 Localization of Mif 5 0.77 2.7 0.73 5.00
178 INT63958 Regulation of Tnnt2 7 0.45 5.36 0.7 5.00
179 INT61910 Binding of Slc3a2 6 0.01 3 0.7 5.00
180 INT137850 Gene_expression of PKD2 9 0.65 6.68 0.63 5.00
181 INT164595 Binding of LCN2 8 0.37 6.03 0.6 5.00
182 INT236711 Gene_expression of Bcl6 15 0.30 12.98 0.58 5.00
183 INT34143 Regulation of IMPA1 14 0.44 4.83 0.58 5.00
184 INT158329 Positive_regulation of Gene_expression of Mcl1 9 0.32 7.53 0.54 5.00
185 INT241243 Gene_expression of Pkd2 30 0.77 9.05 0.53 5.00
186 INT136074 Regulation of ELOVL1 5 0.23 3.6 0.49 5.00
187 INT11118 Gene_expression of RAPGEF5 13 0.65 9.35 0.43 5.00
188 INT182339 Gene_expression of Ms4a1 18 0.68 16.6 0.42 5.00
189 INT352983 Protein_catabolism of IL10 1 0.13 1.04 0.41 5.00
190 INT241236 Negative_regulation of Pkd2 11 0.43 1.82 0.39 5.00
191 INT150826 Positive_regulation of Pkd1 9 0.37 3.65 0.35 5.00
192 INT209602 Positive_regulation of Gene_expression of Cd22 4 0.19 3.25 0.33 5.00
193 INT202485 Positive_regulation of Cd22 4 0.19 2.28 0.3 5.00
194 INT236270 Binding of Hhex 2 0.07 1.55 0.29 5.00
195 INT241240 Gene_expression of Pkd1 18 0.54 12.2 0.27 5.00
196 INT181738 Positive_regulation of Localization of Gtf3a 4 0.02 2.46 0.25 5.00
197 INT222695 Binding of CLEC2B 1 0.03 0.89 0.23 5.00
198 INT241498 Regulation of Abl1 8 0.32 6.46 0.22 5.00
199 INT132459 Binding of FABP3 4 0.35 2.19 0.2 5.00
200 INT208476 Binding of Pkd1 13 0.39 7.23 0.17 5.00
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