D:Periventricular Leukomalacia

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Disease Term
Synonyms CEREBRAL LEUKOMALACIA NEONATAL, CEREBRAL LEUKOMALACIAS NEONATAL, Cystic Periventricular Leukomalacia, CYSTIC PERIVENTRICULAR LEUKOMALACIAS, Encephalomalacia Periventricular, Encephalomalacias Periventricular, LEUCOMALACIA PERIVENTRICULAR, LEUCOMALACIAS PERIVENTRICULAR, Leukomalacia Cystic Periventricular, Leukomalacia Neonatal Cerebral, Leukomalacias Cystic Periventricular
Documents 50
Hot Single Events 11
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Periventricular Leukomalacia. They are ordered first by their relevance to Periventricular Leukomalacia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT316110 Binding of APC and SAE1 1 0.03 1.16 0.2 99.06
2 INT142286 Binding of PLG and Plat 2 0.52 0.7 0.31 93.04
3 INT316111 APC Negative_regulation of SAE1 1 0.04 1.21 0.22 80.00
4 INT180252 Negative_regulation of Gad1 Positive_regulation of CP 1 0.03 0.75 0.14 17.52
5 INT175323 Tlr4 Positive_regulation of Gene_expression of TLR2 1 0.02 0.31 0.56 5.00
6 INT175326 SERPINH1 Regulation of Pnlip 1 0.00 0.53 0.49 5.00
7 INT175319 Negative_regulation of Nos2 Negative_regulation of Positive_regulation of Pnlip 1 0.01 0.83 0.34 5.00
8 INT180246 Binding of Tbca and Uchl1 1 0.00 0.47 0.27 5.00
9 INT180245 Binding of Plp1 and Uchl1 1 0.03 0.47 0.27 5.00
10 INT175321 IL6 Positive_regulation of Localization of Oxt 1 0.01 0.7 0.25 5.00
11 INT175322 Oxt Positive_regulation of Gene_expression of PTGER2 1 0.00 0.09 0.25 5.00
12 INT175324 Hsp90b1 Positive_regulation of TLR2 1 0.00 0.65 0.23 5.00
13 INT175317 Hsp90b1 Positive_regulation of Tlr4 1 0.02 0.66 0.23 5.00
14 INT308084 Binding of HSPG2 and OXT 1 0.04 0.25 0.23 5.00
15 INT180247 Binding of Gad1 and Tbca 1 0.02 0.22 0.22 5.00
16 INT180248 Binding of Gad1 and Plp1 1 0.08 0.22 0.21 5.00
17 INT175320 Tlr4 Positive_regulation of Gene_expression of Mmp9 1 0.01 0.54 0.21 5.00
18 INT175325 Binding of TLR2 and Tlr6 1 0.00 0.39 0.09 5.00
19 INT175327 Binding of TLR2 and Tlr1 1 0.00 0.39 0.09 5.00
20 INT316112 Binding of S100B and SAE1 1 0.05 1.5 0.08 5.00
21 INT316109 TEAD1 Regulation of S100B 1 0.00 1.16 0.04 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Periventricular Leukomalacia. They are ordered first by their pain relevance and then by number of times they were reported in Periventricular Leukomalacia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT178888 Gene_expression of CHDH 41 0.65 38.66 2.51 99.78
2 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 99.52
3 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34 94.80
4 INT180238 Regulation of Gene_expression of Twist1 13 0.61 4.87 1.59 94.80
5 INT4561 Gene_expression of PLG 32 0.75 17.59 6.21 91.44
6 INT16393 Gene_expression of Serpinf2 4 0.08 3.39 1.09 91.44
7 INT142284 Gene_expression of Hrt1 2 0.13 4.77 0.34 91.44
8 INT92311 Regulation of SIL1 7 0.44 6.2 1.61 91.44
9 INT63121 Binding of APC 29 0.41 23.02 3.8 82.32
10 INT175295 Negative_regulation of Gene_expression of Phgdh 1 0.08 1.04 0.39 81.52
11 INT108273 Gene_expression of Phgdh 7 0.65 2.29 1.48 80.68
12 INT175303 Positive_regulation of Pnlip 1 0.10 5.19 1.52 78.48
13 INT11699 Binding of HLA-E 85 0.47 52.51 13.41 77.72
14 INT180236 Binding of Etv5 2 0.36 1.09 0.18 77.40
15 INT175297 Regulation of Negative_regulation of Pnlip 1 0.07 0.81 0.07 72.48
16 INT175296 Negative_regulation of Pnlip 1 0.08 2.89 0.33 71.96
17 INT35975 Regulation of Cpox 109 0.39 57.88 49.69 70.96
18 INT107247 Regulation of Plat 10 0.44 7.21 5.14 70.40
19 INT52611 Negative_regulation of Ptgs2 142 0.59 66.31 52.71 66.72
20 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 62.60
21 INT287501 Gene_expression of Prx 1 0.02 0.3 0.08 62.08
22 INT70050 Negative_regulation of IL10 56 0.58 37.45 12.39 61.88
23 INT90792 Localization of Il10 144 0.80 87.88 30.03 56.40
24 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17 51.96
25 INT124322 Negative_regulation of PNLIP 11 0.31 6.53 1.88 51.60
26 INT58563 Negative_regulation of S100B 13 0.51 11.75 1.77 50.64
27 INT273471 Negative_regulation of PTBP1 7 0.34 9.2 1.1 49.68
28 INT201474 Regulation of Acta1 3 0.18 1.98 0 36.68
29 INT57057 Gene_expression of APC 131 0.78 122.24 8.7 33.36
30 INT11325 Gene_expression of HLA-E 209 0.76 98.05 33.72 29.28
31 INT209962 Binding of RDBP 4 0.11 2.93 1.27 27.68
32 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 24.40
33 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 23.76
34 INT42255 Negative_regulation of Gad1 7 0.56 4.83 2.54 15.76
35 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
36 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
37 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
38 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
39 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 5.00
40 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
41 INT14843 Gene_expression of Gabrg1 301 0.77 62.63 139.16 5.00
42 INT6323 Positive_regulation of Gabrg1 213 0.70 45.08 124.34 5.00
43 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 5.00
44 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
45 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 5.00
46 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
47 INT1760 Gene_expression of PTGER2 524 0.57 226.94 96.4 5.00
48 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
49 INT9516 Negative_regulation of Gabrg1 149 0.53 27.83 91.02 5.00
50 INT2893 Localization of Oxt 219 0.80 28.96 79.43 5.00
51 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
52 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6 5.00
53 INT2761 Regulation of Gabrg1 119 0.61 18.8 60.52 5.00
54 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5 5.00
55 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01 5.00
56 INT6034 Binding of Gabrg1 115 0.47 17.48 51.92 5.00
57 INT937 Positive_regulation of Oxt 195 0.70 37.82 49.3 5.00
58 INT26500 Gene_expression of MMP2 201 0.78 110.57 46.9 5.00
59 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 5.00
60 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02 5.00
61 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65 5.00
62 INT29496 Gene_expression of MMP3 136 0.75 49.49 41.78 5.00
63 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94 5.00
64 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46 5.00
65 INT133028 Gene_expression of TLR2 209 0.73 131.92 36.17 5.00
66 INT927 Gene_expression of Oxt 184 0.78 44.71 35.79 5.00
67 INT104392 Gene_expression of Cxcl10 113 0.75 106.86 34.12 5.00
68 INT81289 Positive_regulation of Gene_expression of Tlr4 192 0.69 104.5 33.89 5.00
69 INT9694 Positive_regulation of Csf2 102 0.68 70.09 33.07 5.00
70 INT9658 Negative_regulation of Gene_expression of Il6 110 0.59 66.29 32.58 5.00
71 INT56809 Binding of Tlr4 184 0.48 106.02 31.18 5.00
72 INT11650 Negative_regulation of Gpt 122 0.59 69.15 30.36 5.00
73 INT32165 Binding of CALM1 92 0.48 24.19 29.57 5.00
74 INT651 Positive_regulation of PTGS1 93 0.69 37.27 29.18 5.00
75 INT55737 Positive_regulation of MMP2 101 0.68 59.11 27.71 5.00
76 INT1765 Positive_regulation of Gene_expression of PTGER2 140 0.51 68.68 27 5.00
77 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 5.00
78 INT1761 Positive_regulation of PTGER2 135 0.49 90.17 26.26 5.00
79 INT50490 Regulation of PTGS2 80 0.48 39.51 25.85 5.00
80 INT2040 Positive_regulation of CYP2B6 95 0.69 34.3 25.6 5.00
81 INT10836 Negative_regulation of IL8 95 0.59 52.59 24.71 5.00
82 INT34488 Negative_regulation of MMP2 85 0.59 41.98 21.72 5.00
83 INT7535 Negative_regulation of Tlr4 111 0.56 56.84 21.37 5.00
84 INT10565 Gene_expression of MRXS5 94 0.53 37.35 19.08 5.00
85 INT37835 Negative_regulation of CPP 61 0.51 31.34 18.57 5.00
86 INT15470 Regulation of CPP 42 0.48 26.1 18.25 5.00
87 INT168263 Gene_expression of IL23A 57 0.58 47.1 17.67 5.00
88 INT10834 Binding of IL8 65 0.48 41.66 16.53 5.00
89 INT26314 Positive_regulation of MMP3 48 0.67 22.14 16.17 5.00
90 INT22143 Gene_expression of Gad1 35 0.76 14.4 15.4 5.00
91 INT113606 Positive_regulation of Gene_expression of Mmp9 46 0.64 44 15.07 5.00
92 INT180497 Binding of MRI1 45 0.42 28.35 14.77 5.00
93 INT28314 Negative_regulation of Gene_expression of Gabrg1 29 0.44 12.56 13.8 5.00
94 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 5.00
95 INT39587 Gene_expression of CP 42 0.65 31.48 11.87 5.00
96 INT133030 Positive_regulation of Gene_expression of TLR2 53 0.65 38.15 10.65 5.00
97 INT150540 Binding of TLR2 50 0.45 35.86 10.43 5.00
98 INT71768 Regulation of Gene_expression of Il10 27 0.62 19.17 10.4 5.00
99 INT96637 Gene_expression of Gad2 21 0.76 8.15 9.53 5.00
100 INT26502 Negative_regulation of Gene_expression of MMP2 39 0.58 21.45 9.42 5.00
101 INT37896 Positive_regulation of Gene_expression of PTGS1 37 0.67 17.28 9.27 5.00
102 INT43820 Positive_regulation of Twist1 75 0.59 42.15 8.47 5.00
103 INT621 Positive_regulation of SERPINH1 19 0.57 21.52 8.44 5.00
104 INT25392 Positive_regulation of Gene_expression of Csf2 41 0.49 34.28 8.36 5.00
105 INT57922 Gene_expression of CYP2C9 65 0.78 22.24 7.53 5.00
106 INT67822 Binding of SERPINH1 17 0.36 19.05 7.24 5.00
107 INT28315 Regulation of Gene_expression of Gabrg1 20 0.60 4.78 7 5.00
108 INT168600 Binding of Mmp9 14 0.44 12.79 6.92 5.00
109 INT19302 Localization of OXT 31 0.79 3.39 6.92 5.00
110 INT3309 Binding of CP 25 0.47 17.87 6.62 5.00
111 INT96218 Positive_regulation of Pgr 17 0.68 5.23 6.57 5.00
112 INT168383 Positive_regulation of Mmp13 27 0.67 17.9 6.27 5.00
113 INT103760 Regulation of Gene_expression of Tlr4 35 0.59 16.26 5.95 5.00
114 INT25394 Negative_regulation of Gene_expression of Csf2 22 0.52 13.18 5.84 5.00
115 INT26919 Gene_expression of ITPR3 47 0.42 5.86 5.79 5.00
116 INT23401 Gene_expression of HLA-DOA 91 0.30 38.21 5.52 5.00
117 INT10916 Positive_regulation of BDNF-AS 39 0.49 25.88 5.28 5.00
118 INT26334 Localization of ITPR3 39 0.49 2.53 5.07 5.00
119 INT175312 Positive_regulation of Gene_expression of IL23A 17 0.45 14.8 5.05 5.00
120 INT17742 Localization of S100B 44 0.80 17.14 4.65 5.00
121 INT50595 Positive_regulation of HRASLS 16 0.49 9.65 4.24 5.00
122 INT19300 Positive_regulation of OXT 34 0.43 4.43 4.07 5.00
123 INT92653 Gene_expression of IL12B 21 0.75 17.28 3.89 5.00
124 INT158596 Binding of Tlr3 24 0.47 11.66 3.69 5.00
125 INT78284 Positive_regulation of PTPRC 40 0.49 27.17 3.45 5.00
126 INT42251 Regulation of Gad1 10 0.44 5.25 3.45 5.00
127 INT57252 Negative_regulation of PGR 22 0.43 12.95 3.33 5.00
128 INT180250 Positive_regulation of GLUL 23 0.29 7.57 3.23 5.00
129 INT17749 Positive_regulation of Gene_expression of MRXS5 15 0.23 8.02 3.15 5.00
130 INT70596 Regulation of Uchl1 5 0.39 3.87 3.11 5.00
131 INT157572 Gene_expression of Ccl12 10 0.70 10.52 3.09 5.00
132 INT132760 Gene_expression of Pgr 47 0.66 28.17 2.85 5.00
133 INT116540 Binding of Twist1 35 0.48 16.32 2.85 5.00
134 INT131929 Positive_regulation of Gene_expression of S100B 25 0.67 12.61 2.83 5.00
135 INT173336 Gene_expression of GLUL 16 0.27 6.74 2.78 5.00
136 INT21533 Positive_regulation of Il1f5 7 0.25 4.78 2.77 5.00
137 INT165514 Regulation of Gad2 7 0.45 3.15 2.76 5.00
138 INT23775 Regulation of S100B 24 0.62 16.75 2.57 5.00
139 INT3308 Localization of PTGER1 9 0.73 5.32 2.55 5.00
140 INT8466 Binding of Plp1 5 0.48 5.07 2.29 5.00
141 INT159645 Negative_regulation of Uchl1 8 0.31 6.84 2.14 5.00
142 INT197681 Binding of CHDH 40 0.48 33.72 2.13 5.00
143 INT42256 Positive_regulation of Gad1 4 0.66 1.1 2.09 5.00
144 INT8766 Positive_regulation of Positive_regulation of CYP2B6 5 0.49 3.41 1.97 5.00
145 INT129703 Negative_regulation of ptd 3 0.37 2.63 1.87 5.00
146 INT175298 Gene_expression of Meta 7 0.75 2.37 1.85 5.00
147 INT112648 Positive_regulation of Fn1 19 0.49 13.73 1.66 5.00
148 INT36188 Positive_regulation of PNLIP 7 0.68 5.99 1.6 5.00
149 INT96642 Transcription of Gad2 4 0.59 0.88 1.59 5.00
150 INT175307 Regulation of Gene_expression of TLR2 9 0.56 7.08 1.58 5.00
151 INT174230 Positive_regulation of Gene_expression of IL12B 6 0.49 3.2 1.56 5.00
152 INT180249 Negative_regulation of GLUL 5 0.15 0.69 1.46 5.00
153 INT90567 Negative_regulation of Gene_expression of Gad1 4 0.41 2.88 1.36 5.00
154 INT36947 Gene_expression of PNLIP 13 0.45 11.04 1.23 5.00
155 INT16427 Negative_regulation of Positive_regulation of Csf2 2 0.43 1.5 1.2 5.00
156 INT170767 Binding of UGCG 4 0.18 5.33 1.17 5.00
157 INT51591 Regulation of GLUL 3 0.11 2.62 1.15 5.00
158 INT134743 Positive_regulation of TEAD1 6 0.36 5.33 1.14 5.00
159 INT105149 Gene_expression of PTBP1 10 0.75 12.27 1.09 5.00
160 INT78353 Positive_regulation of Positive_regulation of PTGS1 4 0.27 0.95 1.06 5.00
161 INT161706 Negative_regulation of Gene_expression of S100B 8 0.43 2.69 1.06 5.00
162 INT37241 Negative_regulation of Localization of ITPR3 7 0.13 1.22 1.05 5.00
163 INT48687 Gene_expression of Plp1 7 0.54 3.51 1.03 5.00
164 INT129878 Positive_regulation of CTSS 6 0.70 7.86 0.97 5.00
165 INT90568 Regulation of Gene_expression of Gad1 3 0.27 0.46 0.89 5.00
166 INT180240 Binding of Gad1 7 0.47 2.99 0.86 5.00
167 INT39586 Transcription of CP 5 0.67 1.7 0.83 5.00
168 INT129877 Gene_expression of CTSS 4 0.75 4.65 0.81 5.00
169 INT84979 Regulation of CHDH 22 0.38 22.34 0.78 5.00
170 INT95699 Binding of Gad2 5 0.40 1.14 0.73 5.00
171 INT204180 Positive_regulation of TPPP 4 0.16 3.54 0.71 5.00
172 INT129879 Positive_regulation of Gene_expression of CTSS 3 0.47 3.25 0.7 5.00
173 INT4109 Localization of PGF 15 0.81 5.57 0.69 5.00
174 INT105443 Negative_regulation of Localization of PTGER1 3 0.04 1.37 0.66 5.00
175 INT132759 Positive_regulation of Gene_expression of Pgr 9 0.38 5.12 0.64 5.00
176 INT180244 Positive_regulation of Gad2 4 0.49 1.07 0.61 5.00
177 INT144080 Gene_expression of LDB3 17 0.04 1.33 0.58 5.00
178 INT175294 Binding of Phgdh 2 0.06 1.37 0.57 5.00
179 INT180239 Negative_regulation of Gene_expression of Gad2 2 0.42 1.59 0.55 5.00
180 INT117436 Binding of IKBKB 2 0.26 1.44 0.47 5.00
181 INT162843 Negative_regulation of Gene_expression of CP 2 0.11 2.79 0.45 5.00
182 INT175299 Positive_regulation of Binding of Mmp9 2 0.28 1.17 0.42 5.00
183 INT180234 Negative_regulation of Gene_expression of Plp1 1 0.08 1.54 0.42 5.00
184 INT175306 Regulation of Pnlip 1 0.04 1.1 0.41 5.00
185 INT202189 Transcription of PGR 5 0.51 0.8 0.4 5.00
186 INT182790 Positive_regulation of SAE1 3 0.49 3.18 0.39 5.00
187 INT17555 Regulation of SLC10A4 2 0.08 0.07 0.37 5.00
188 INT191243 Binding of SAE1 4 0.35 2.88 0.29 5.00
189 INT228158 Positive_regulation of PDIA2 7 0.44 2.33 0.28 5.00
190 INT222685 Binding of TEAD1 4 0.27 2.63 0.26 5.00
191 INT262274 Gene_expression of UGCG 8 0.27 1.62 0.22 5.00
192 INT287496 Regulation of lla 2 0.03 0.46 0.21 5.00
193 INT39714 Negative_regulation of Localization of PGF 4 0.59 0.47 0.2 5.00
194 INT316115 Negative_regulation of Binding of TEAD1 1 0.00 1.55 0.18 5.00
195 INT180242 Positive_regulation of Binding of Gad1 1 0.49 0.86 0.17 5.00
196 INT51065 Transcription of S100B 3 0.60 0.83 0.17 5.00
197 INT174520 Negative_regulation of Gene_expression of HLA-DOA 10 0.14 2.62 0.17 5.00
198 INT247099 Positive_regulation of PTBP1 7 0.50 9.21 0.16 5.00
199 INT180237 Binding of Tbca 2 0.03 1.08 0.15 5.00
200 INT180233 Negative_regulation of Negative_regulation of Uchl1 1 0.14 0.6 0.14 5.00
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