D:Pernicious Anemia

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Disease Term
Synonyms ADDISON ANEMIA, Addison S Anemia, Addisons Anemia, Anemia Addison, Anemia Addison S, Anemia Addisons
Documents 66
Hot Single Events 20
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Pernicious Anemia. They are ordered first by their relevance to Pernicious Anemia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01 72.48
2 INT190702 CD40 Positive_regulation of Gene_expression of F3 1 0.00 1.4 0.55 5.00
3 INT292873 Binding of Fas and Fasl 5 0.26 15.74 0.49 5.00
4 INT318994 Il17a Regulation of Il23a 1 0.00 1.38 0.22 5.00
5 INT318993 Hand1 Positive_regulation of Gene_expression of Fas 1 0.03 0.76 0.12 5.00
6 INT318995 IFN1@ Positive_regulation of Gene_expression of Fas 1 0.23 0.76 0.12 5.00
7 INT332588 Binding of RAPH1 and MND1 1 0.01 3.88 0.07 5.00
8 INT326625 Binding of ALB and Trf 1 0.01 0.64 0.04 5.00
9 INT332587 MND1 Positive_regulation of Binding of RAPH1 and MND1 1 0.00 2.21 0.03 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Pernicious Anemia. They are ordered first by their pain relevance and then by number of times they were reported in Pernicious Anemia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT693 Negative_regulation of Localization of SST 46 0.59 8.57 21.75 100.00
2 INT397 Localization of SST 232 0.81 58.05 101.19 99.92
3 INT1020 Negative_regulation of BCHE 109 0.59 44.86 16.4 99.28
4 INT19286 Negative_regulation of Cacna1c 11 0.46 5.12 2.22 99.28
5 INT2280 Negative_regulation of TNFAIP1 70 0.43 69.43 8.36 99.16
6 INT170886 Gene_expression of AIRE 2 0.49 4.63 0.19 98.16
7 INT30 Gene_expression of Gast 158 0.78 99 41.45 97.76
8 INT4075 Positive_regulation of Gene_expression of Gast 24 0.68 19.99 4.02 97.08
9 INT89 Positive_regulation of Gast 187 0.70 80.49 42.07 96.20
10 INT3911 Gene_expression of TNFAIP1 29 0.65 21.68 1.85 96.08
11 INT34058 Gene_expression of FMR1 5 0.75 5.11 0.26 94.80
12 INT812 Localization of INS 1026 0.81 515.6 145.31 92.56
13 INT230410 Negative_regulation of Gene_expression of TNFAIP1 3 0.16 3.67 0.63 92.52
14 INT332590 Negative_regulation of Gene_expression of TCN2 1 0.05 1.2 0.06 92.52
15 INT39453 Negative_regulation of TCN2 12 0.59 3.98 2.13 92.52
16 INT15580 Gene_expression of TCN2 16 0.44 7.59 1.97 91.36
17 INT2144 Localization of COL7A1 36 0.74 20.92 4.67 87.48
18 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 87.24
19 INT180359 Localization of AIRE 3 0.54 3.94 0.03 86.64
20 INT2243 Localization of GAST 67 0.81 34.54 16.19 83.76
21 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 79.24
22 INT14502 Gene_expression of BCHE 40 0.67 18.52 4.6 79.04
23 INT68589 Gene_expression of Cacna1c 14 0.58 6.36 0.69 79.04
24 INT216261 Regulation of Gene_expression of Cacna1c 3 0.25 1.12 0.15 79.04
25 INT216263 Regulation of Gene_expression of BCHE 1 0.44 0.6 0.04 79.04
26 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 78.32
27 INT72747 Localization of IgG 55 0.53 30.88 4.19 77.72
28 INT701 Localization of IGHE 87 0.80 40.5 10.62 77.20
29 INT186506 Negative_regulation of BTG3 4 0.41 3.31 0.36 73.32
30 INT8548 Gene_expression of HP 86 0.77 47.62 11.94 71.64
31 INT3530 Regulation of BCHE 18 0.60 5.47 4.12 63.04
32 INT12339 Localization of IL8 437 0.81 251.87 117.39 61.88
33 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 59.44
34 INT2365 Positive_regulation of Cck 354 0.70 87.8 277.41 56.88
35 INT7205 Positive_regulation of HBG1 65 0.69 40.35 6.37 53.28
36 INT10835 Regulation of IL8 79 0.49 53.04 24.14 50.00
37 INT46087 Regulation of F3 4 0.45 3.49 0.68 50.00
38 INT170138 Positive_regulation of Regulation of IL8 2 0.22 0.89 0.04 50.00
39 INT3179 Positive_regulation of SCT 15 0.50 4.79 1.98 49.84
40 INT257457 Positive_regulation of Positive_regulation of SCT 1 0.20 1.66 0.07 49.84
41 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 47.20
42 INT36449 Negative_regulation of G6PD 74 0.59 54.15 8.85 45.32
43 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 43.20
44 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 29.84
45 INT240281 Positive_regulation of IGFALS 11 0.31 10.44 0.56 27.52
46 INT354026 Positive_regulation of ICOS 1 0.17 2.32 0 23.52
47 INT2132 Localization of SCT 29 0.81 8.39 5.43 23.36
48 INT2131 Positive_regulation of Localization of SCT 6 0.47 2.01 0.88 23.36
49 INT25022 Binding of PAEP 66 0.42 22.83 6.59 18.08
50 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 14.40
51 INT8773 Gene_expression of HBG1 58 0.76 37.6 4.59 11.00
52 INT216262 Gene_expression of CYGB 2 0.43 2.18 0.03 10.56
53 INT75841 Binding of Trav6-3 66 0.47 29.14 7.63 5.68
54 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
55 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 5.00
56 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
57 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
58 INT1893 Localization of Gh 1041 0.79 340.23 256.58 5.00
59 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
60 INT90 Localization of Gast 400 0.81 137.67 113 5.00
61 INT118381 Gene_expression of Il17a 405 0.76 306.97 112.06 5.00
62 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
63 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
64 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
65 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
66 INT11937 Localization of Il6 228 0.81 139.83 64.39 5.00
67 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
68 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 5.00
69 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
70 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 5.00
71 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01 5.00
72 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
73 INT1894 Negative_regulation of Localization of Gh 168 0.58 64.12 43.56 5.00
74 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 5.00
75 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
76 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 5.00
77 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
78 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
79 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 5.00
80 INT2278 Regulation of Localization of Gast 81 0.62 16.93 30.64 5.00
81 INT34729 Positive_regulation of IFN1@ 233 0.67 128.04 30.38 5.00
82 INT90792 Localization of Il10 144 0.80 87.88 30.03 5.00
83 INT7832 Localization of Cck 39 0.81 6.81 26.54 5.00
84 INT15458 Gene_expression of NPY 50 0.76 22.67 23.03 5.00
85 INT74423 Localization of IL10 91 0.80 61.6 22.95 5.00
86 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52 5.00
87 INT150022 Positive_regulation of Il17a 69 0.64 70.04 21.87 5.00
88 INT11161 Gene_expression of HLA-DRB1 121 0.78 75.33 20.96 5.00
89 INT160564 Gene_expression of Il22 64 0.55 59.29 20.9 5.00
90 INT20379 Localization of Il4 85 0.73 51.22 20.55 5.00
91 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22 5.00
92 INT49103 Positive_regulation of Vcam1 71 0.69 59.52 19.85 5.00
93 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 5.00
94 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01 5.00
95 INT56301 Positive_regulation of IL4 68 0.56 54.51 18.65 5.00
96 INT9656 Regulation of Gene_expression of Il6 57 0.62 33.3 17.71 5.00
97 INT8571 Gene_expression of B3GAT1 54 0.75 36.85 15.98 5.00
98 INT2064 Positive_regulation of BTG3 29 0.49 25.58 15.37 5.00
99 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 5.00
100 INT59870 Gene_expression of F3 51 0.65 51.83 14.01 5.00
101 INT161515 Positive_regulation of Gene_expression of Il17a 50 0.64 41.52 13.82 5.00
102 INT173505 Localization of Hand2 63 0.57 45.32 13.66 5.00
103 INT14572 Binding of INS 205 0.48 175.43 13.38 5.00
104 INT20378 Localization of Hand1 53 0.71 41.96 13.31 5.00
105 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 5.00
106 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 5.00
107 INT148207 Gene_expression of CTLA4 53 0.77 29.13 12.07 5.00
108 INT87239 Localization of Il12a 51 0.75 31.95 12.05 5.00
109 INT69158 Localization of IL4 48 0.71 31.3 11.98 5.00
110 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57 5.00
111 INT24816 Binding of CD40LG 68 0.47 45.48 11.56 5.00
112 INT126743 Positive_regulation of Gene_expression of LEP 61 0.66 50.02 11.17 5.00
113 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75 5.00
114 INT16449 Binding of IGHG3 67 0.48 39.55 10.59 5.00
115 INT160563 Localization of Il17a 34 0.74 26.53 10.24 5.00
116 INT25608 Regulation of Gene_expression of Il1 37 0.44 27.76 10.1 5.00
117 INT35164 Negative_regulation of IGHE 96 0.58 76.3 9.74 5.00
118 INT860 Regulation of ALB 48 0.60 25.11 8.95 5.00
119 INT75907 Binding of LEP 53 0.46 46.65 8.44 5.00
120 INT86705 Gene_expression of BTG3 41 0.65 37.29 8.29 5.00
121 INT81399 Regulation of Vcam1 24 0.46 23.53 7.68 5.00
122 INT8669 Positive_regulation of Afp 66 0.70 58.21 7.67 5.00
123 INT95133 Gene_expression of FASLG 38 0.75 44.09 7.51 5.00
124 INT132822 Localization of IL13 26 0.67 22.85 6.66 5.00
125 INT138833 Binding of MTHFR 12 0.46 16.08 6.4 5.00
126 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33 5.00
127 INT8683 Positive_regulation of F3 31 0.67 42.89 6.21 5.00
128 INT17551 Positive_regulation of Gene_expression of HLA-DRA 31 0.70 15.39 6 5.00
129 INT53196 Binding of Cd4 44 0.47 27.28 5.85 5.00
130 INT11360 Localization of SERPINE1 41 0.80 33.98 5.61 5.00
131 INT69156 Localization of IL5 21 0.68 14.95 5.37 5.00
132 INT45753 Localization of CD40LG 45 0.79 32.31 5.28 5.00
133 INT85415 Positive_regulation of IL9 10 0.28 6.93 4.71 5.00
134 INT151230 Positive_regulation of IL7 14 0.37 11.89 4.56 5.00
135 INT14714 Negative_regulation of NPY 10 0.58 4.41 4.52 5.00
136 INT745 Gene_expression of Afp 65 0.78 52.89 4.24 5.00
137 INT63977 Positive_regulation of Sele 28 0.68 18.49 4.17 5.00
138 INT115889 Binding of Fas 27 0.36 28.87 4.08 5.00
139 INT151736 Binding of Hand1 15 0.26 9.77 4.04 5.00
140 INT156131 Binding of Hand2 14 0.25 10.35 3.99 5.00
141 INT54701 Localization of Ptafr 19 0.49 18.68 3.82 5.00
142 INT63979 Regulation of Sele 13 0.54 10.64 3.7 5.00
143 INT285489 Positive_regulation of Gene_expression of Il22 9 0.32 10.97 3.63 5.00
144 INT2886 Gene_expression of SCT 13 0.78 4.55 3.57 5.00
145 INT188406 Binding of Fasl 19 0.44 24.67 3.17 5.00
146 INT43907 Binding of CD79A 28 0.48 28.11 3.04 5.00
147 INT84527 Positive_regulation of Gene_expression of F3 16 0.49 15.83 2.85 5.00
148 INT90094 Gene_expression of Cytl1 14 0.75 12.75 2.81 5.00
149 INT16964 Binding of IFNG 27 0.48 14.31 2.45 5.00
150 INT46088 Localization of F3 15 0.37 13.7 2.23 5.00
151 INT1153 Negative_regulation of FUT3 17 0.38 8.61 2.21 5.00
152 INT21965 Regulation of Positive_regulation of Gast 6 0.62 0.26 2.11 5.00
153 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87 5.00
154 INT650 Gene_expression of Afp 13 0.78 7.44 1.47 5.00
155 INT107985 Gene_expression of MLH1 29 0.67 31.31 1.46 5.00
156 INT93001 Localization of CD40 4 0.78 1.97 1.45 5.00
157 INT83891 Gene_expression of FUT3 20 0.61 10.49 1.41 5.00
158 INT105569 Binding of IGFALS 13 0.25 17.31 1.36 5.00
159 INT87029 Positive_regulation of Positive_regulation of IL2 8 0.50 8.17 1.36 5.00
160 INT87988 Gene_expression of ASAH1 9 0.77 9.75 1.18 5.00
161 INT7207 Regulation of HBG1 27 0.60 22.1 1.12 5.00
162 INT188398 Positive_regulation of IL15 8 0.19 4.64 1.06 5.00
163 INT240280 Gene_expression of IGFALS 14 0.42 20.38 0.95 5.00
164 INT57596 Regulation of Gene_expression of ALB 9 0.44 5.44 0.91 5.00
165 INT160799 Regulation of IGFALS 11 0.29 9.09 0.7 5.00
166 INT28118 Binding of Atm 13 0.38 12.24 0.68 5.00
167 INT649 Positive_regulation of Afp 10 0.55 6.5 0.62 5.00
168 INT165066 Gene_expression of GAGE4 3 0.09 2.82 0.57 5.00
169 INT15046 Positive_regulation of Gene_expression of Afp 6 0.46 5.95 0.52 5.00
170 INT73731 Binding of RAPH1 9 0.33 14.58 0.5 5.00
171 INT185621 Positive_regulation of Gene_expression of SCT 4 0.14 2.14 0.49 5.00
172 INT190487 Negative_regulation of SCLY 3 0.08 2.12 0.46 5.00
173 INT326623 Binding of Ttr 2 0.35 4.76 0.46 5.00
174 INT264689 Negative_regulation of IGFALS 10 0.33 12.58 0.45 5.00
175 INT266786 Binding of ASAH1 2 0.11 3.87 0.44 5.00
176 INT215031 Localization of Ppy 2 0.23 1.73 0.37 5.00
177 INT190695 Localization of Abnormal 1 0.01 2.03 0.37 5.00
178 INT240278 Localization of IGFALS 11 0.53 9.44 0.29 5.00
179 INT112837 Regulation of GPX1 3 0.17 1.81 0.25 5.00
180 INT318992 Localization of NOD1 1 0.11 1.1 0.23 5.00
181 INT101742 Regulation of Cacna1c 3 0.22 1.35 0.23 5.00
182 INT76177 Binding of YOD1 2 0.15 1.29 0.21 5.00
183 INT36479 Binding of NR0B2 2 0.36 3.5 0.21 5.00
184 INT64224 Localization of FUT3 3 0.06 3.16 0.2 5.00
185 INT45098 Negative_regulation of CBWD1 1 0.02 0 0.17 5.00
186 INT214692 Negative_regulation of Gene_expression of FUT3 3 0.24 2.2 0.17 5.00
187 INT332592 Binding of MND1 1 0.08 9.21 0.16 5.00
188 INT229301 Gene_expression of NR0B2 3 0.18 3.49 0.16 5.00
189 INT181968 Negative_regulation of Prf1 3 0.16 4.27 0.15 5.00
190 INT345973 Binding of EVL 1 0.07 1.4 0.14 5.00
191 INT175556 Regulation of Positive_regulation of PTH 3 0.39 2.34 0.12 5.00
192 INT240786 Binding of Bcl2a1c 10 0.18 9.47 0.12 5.00
193 INT345972 Binding of HGD 1 0.02 1.95 0.08 5.00
194 INT283245 Gene_expression of MND1 2 0.11 1.94 0.07 5.00
195 INT190703 Regulation of Negative_regulation of TSC1 3 0.06 3.08 0.07 5.00
196 INT240787 Positive_regulation of Bcl2a1c 12 0.22 9.79 0.06 5.00
197 INT190696 Gene_expression of Prame 1 0.75 2.4 0.03 5.00
198 INT190486 Regulation of BTG3 1 0.04 0 0 5.00
199 INT332589 Localization of MND1 1 0.12 2.01 0 5.00
200 INT332591 Positive_regulation of MND1 1 0.11 1.56 0 5.00
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