D:Peutz-jeghers Syndrome

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Disease Term
Synonyms Hamartomatous Intestinal Polyposes, Hamartomatous Intestinal Polyposis, INTESTINAL POLYPOSES HAMARTOMATOUS, INTESTINAL POLYPOSIS HAMARTOMATOUS, Lentiginoses Perioral, LENTIGINOSIS PERIORAL, Perioral Lentiginoses, Perioral Lentiginosis, Peutz Jegher S Syndrome, Peutz Jegher Syndrome, Peutz Jeghers Syndrome
Documents 1
Hot Single Events 0
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Peutz-jeghers Syndrome. They are ordered first by their relevance to Peutz-jeghers Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT304029 Binding of PTEN and TP53 1 0.35 0.62 0 5.00
2 INT304020 AR Regulation of TP53 1 0.24 1.11 0 5.00
3 INT304022 Binding of PIK3CG and TP53 1 0.10 0.72 0 5.00
4 INT304028 MDM2 Regulation of TP53 1 0.19 1.11 0 5.00
5 INT304014 Binding of MSI1 and SGCG 1 0.00 1.92 0 5.00
6 INT304012 Binding of AKT1 and PIK3CA 1 0.28 1.14 0 5.00
7 INT304018 Regulation of Binding of PIK3CG and TP53 1 0.12 0.73 0 5.00
8 INT304025 Binding of PIK3CA and TP53 1 0.30 0.67 0 5.00
9 INT304015 Binding of PIK3CA and PIK3CG 1 0.09 0.67 0 5.00
10 INT304019 Binding of AKT1 and TP53 1 0.27 0.72 0 5.00
11 INT304026 Binding of PIK3CG and PTEN 1 0.11 0.62 0 5.00
12 INT304027 Negative_regulation of PTEN Positive_regulation of Positive_regulation of AKT1 1 0.32 1.86 0 5.00
13 INT304017 Regulation of Binding of AKT1 and TP53 1 0.32 0.73 0 5.00
14 INT304023 SFRP1 Regulation of Binding of MSI1 1 0.04 1.78 0 5.00
15 INT304016 SFRP4 Regulation of Binding of MSI1 1 0.04 1.78 0 5.00
16 INT304013 Binding of SUZ12 and JAZF1 1 0.30 1.89 0 5.00
17 INT304024 Binding of AKT1 and PTEN 1 0.33 1.08 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Peutz-jeghers Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Peutz-jeghers Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 21.04
2 INT20421 Positive_regulation of MYC 19 0.67 10.43 1.9 20.92
3 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
4 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
5 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5 5.00
6 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
7 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
8 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
9 INT5206 Gene_expression of AR 316 0.78 113.83 27.29 5.00
10 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 5.00
11 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
12 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 5.00
13 INT11157 Binding of EGF 88 0.48 53.73 21.25 5.00
14 INT73593 Gene_expression of BAX 173 0.76 147.81 20.94 5.00
15 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61 5.00
16 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44 5.00
17 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79 5.00
18 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 5.00
19 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 5.00
20 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 5.00
21 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59 5.00
22 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99 5.00
23 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61 5.00
24 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
25 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 5.00
26 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 5.00
27 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 5.00
28 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57 5.00
29 INT108202 Positive_regulation of PIK3CG 47 0.67 25.83 8.25 5.00
30 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 5.00
31 INT111607 Gene_expression of CDH1 103 0.75 90.45 7.77 5.00
32 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49 5.00
33 INT38671 Positive_regulation of KRT20 62 0.53 40.17 5.6 5.00
34 INT15376 Positive_regulation of Gene_expression of ERBB2 215 0.70 168.54 5.23 5.00
35 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93 5.00
36 INT105336 Regulation of AKT1 52 0.56 32.53 4.89 5.00
37 INT10115 Gene_expression of INSR 31 0.75 11.98 4.86 5.00
38 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62 5.00
39 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45 5.00
40 INT109450 Positive_regulation of Phosphorylation of AKT1 62 0.64 25.18 4.21 5.00
41 INT64766 Gene_expression of TWIST1 41 0.76 37.89 3.4 5.00
42 INT51607 Positive_regulation of DES 33 0.67 32.24 3.29 5.00
43 INT94164 Phosphorylation of RB1 83 0.80 48.84 3.21 5.00
44 INT192676 Binding of PTEN 14 0.46 10.58 3.06 5.00
45 INT89392 Negative_regulation of Positive_regulation of AKT1 23 0.50 15.69 3.02 5.00
46 INT200670 Gene_expression of AKT2 25 0.75 16.25 3 5.00
47 INT89397 Positive_regulation of PIK3CA 33 0.67 16.98 2.78 5.00
48 INT74293 Positive_regulation of BAK1 13 0.60 14.13 2.73 5.00
49 INT119838 Positive_regulation of PTEN 25 0.67 21.71 2.5 5.00
50 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48 5.00
51 INT25208 Gene_expression of IGF2 43 0.74 30.64 2.31 5.00
52 INT179885 Regulation of PTEN 8 0.26 11.88 2.18 5.00
53 INT38674 Regulation of KRT20 32 0.44 19 2.15 5.00
54 INT107987 Gene_expression of MRC1 27 0.75 36.94 1.99 5.00
55 INT125080 Positive_regulation of Positive_regulation of TP53 21 0.58 16.16 1.98 5.00
56 INT81641 Gene_expression of Ctnnb1 23 0.72 14.93 1.97 5.00
57 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87 5.00
58 INT48792 Regulation of ERBB2 48 0.57 36.56 1.8 5.00
59 INT86909 Negative_regulation of MSH2 9 0.41 12.65 1.7 5.00
60 INT94169 Negative_regulation of Phosphorylation of RB1 16 0.41 8.87 1.57 5.00
61 INT65684 Gene_expression of MDM2 30 0.62 24.94 1.55 5.00
62 INT162462 Protein_catabolism of TP53 8 0.86 7.89 1.41 5.00
63 INT304045 Transcription of PTEN 2 0.51 4.12 1.4 5.00
64 INT92383 Gene_expression of KRAS 38 0.65 32.94 1.32 5.00
65 INT137382 Negative_regulation of Gene_expression of KRT20 22 0.58 12.29 1.29 5.00
66 INT139237 Negative_regulation of Gene_expression of CDH1 23 0.57 24.31 1.28 5.00
67 INT210399 Gene_expression of IGF2R 22 0.65 17.1 1.23 5.00
68 INT10117 Positive_regulation of INSR 10 0.43 4.71 1.22 5.00
69 INT119832 Positive_regulation of Gene_expression of PTEN 12 0.49 7.12 1.19 5.00
70 INT135556 Localization of AKT1 38 0.69 12.78 1.17 5.00
71 INT220206 Gene_expression of CCNB2 4 0.67 3.75 1.16 5.00
72 INT146546 Gene_expression of MSI1 22 0.48 22.91 1.15 5.00
73 INT111605 Positive_regulation of CDH1 12 0.50 7.95 1.15 5.00
74 INT157765 Negative_regulation of CDH1 32 0.53 35.72 1.15 5.00
75 INT86908 Negative_regulation of MLH1 7 0.43 6.98 1.12 5.00
76 INT92139 Binding of MLH1 12 0.42 15.62 1 5.00
77 INT163280 Negative_regulation of Phosphorylation of CCND1 6 0.19 3.92 0.87 5.00
78 INT163289 Phosphorylation of CCND1 7 0.36 4.81 0.81 5.00
79 INT275575 Gene_expression of FOLR1 12 0.66 2.81 0.8 5.00
80 INT108204 Regulation of PIK3CG 9 0.12 4.16 0.75 5.00
81 INT102813 Regulation of Gene_expression of TP53 25 0.59 25.95 0.75 5.00
82 INT86370 Regulation of CDH1 10 0.54 13.89 0.7 5.00
83 INT206139 Phosphorylation of KRT20 8 0.48 9.1 0.66 5.00
84 INT304060 Positive_regulation of AGR2 2 0.70 13 0.63 5.00
85 INT47038 Gene_expression of SFRP1 14 0.67 9.6 0.63 5.00
86 INT44478 Negative_regulation of PTEN 32 0.57 27.45 0.63 5.00
87 INT161322 Localization of PTEN 9 0.73 5.65 0.57 5.00
88 INT201846 Positive_regulation of SFRP4 4 0.37 2.74 0.54 5.00
89 INT201858 Gene_expression of SFRP4 3 0.48 4.91 0.51 5.00
90 INT81645 Positive_regulation of Gene_expression of Ctnnb1 6 0.63 3.78 0.47 5.00
91 INT47030 Negative_regulation of ARMC9 22 0.38 13.08 0.47 5.00
92 INT148882 Regulation of LTF 9 0.12 4.8 0.44 5.00
93 INT12089 Positive_regulation of MSX2 4 0.46 3.92 0.39 5.00
94 INT81644 Regulation of Ctnnb1 5 0.41 3.38 0.37 5.00
95 INT185886 Gene_expression of JUP 20 0.75 15.41 0.32 5.00
96 INT107983 Gene_expression of MSH6 6 0.51 5.57 0.27 5.00
97 INT181920 Gene_expression of MSH3 2 0.50 2.54 0.18 5.00
98 INT206869 Gene_expression of ALDH1A2 3 0.38 2.51 0.16 5.00
99 INT292659 Positive_regulation of Gene_expression of FOLR1 2 0.47 1.59 0.14 5.00
100 INT200671 Gene_expression of AKT3 4 0.69 1.88 0.13 5.00
101 INT165516 Regulation of MSX2 8 0.23 3.41 0.09 5.00
102 INT184985 Regulation of TFF3 2 0.26 1.43 0.07 5.00
103 INT182302 Negative_regulation of Localization of AKT1 5 0.39 3.52 0.06 5.00
104 INT206866 Positive_regulation of SFRP1 7 0.51 3.97 0.05 5.00
105 INT105948 Gene_expression of AURKA 5 0.65 4.26 0.03 5.00
106 INT207233 Transcription of KRAS 3 0.48 1.56 0.03 5.00
107 INT176154 Gene_expression of PIK3CA 6 0.55 10.43 0.03 5.00
108 INT105949 Positive_regulation of Gene_expression of AURKA 3 0.49 1.91 0.03 5.00
109 INT219360 Regulation of MMP11 2 0.54 1.71 0.03 5.00
110 INT172329 Binding of MRC1 8 0.36 3.88 0.03 5.00
111 INT282953 Regulation of MSI1 2 0.03 1.63 0.03 5.00
112 INT304047 Positive_regulation of Transcription of TWIST1 1 0.10 0.57 0 5.00
113 INT304067 Positive_regulation of Transcription of GEMIN2 1 0.09 0.57 0 5.00
114 INT304078 Regulation of Phosphorylation of KRT20 1 0.00 1 0 5.00
115 INT304046 Positive_regulation of Transcription of SNAI2 1 0.49 0.57 0 5.00
116 INT304062 Regulation of Localization of PTEN 1 0.43 1.29 0 5.00
117 INT304074 Binding of MSH5 1 0.14 1.11 0 5.00
118 INT236621 Regulation of KRAS 7 0.53 6.16 0 5.00
119 INT304066 Gene_expression of BUB1 1 0.07 1.41 0 5.00
120 INT304063 Positive_regulation of ALDH1A2 1 0.29 0.97 0 5.00
121 INT304075 Regulation of AURKA 1 0.15 1.38 0 5.00
122 INT304059 Gene_expression of GEMIN2 1 0.12 0.66 0 5.00
123 INT304058 Positive_regulation of MSI1 1 0.07 2.74 0 5.00
124 INT198037 Regulation of PIK3CA 2 0.28 2.63 0 5.00
125 INT291934 Regulation of FOXA2 2 0.26 2.15 0 5.00
126 INT304050 Gene_expression of SUZ12 1 0.54 6.53 0 5.00
127 INT190053 Gene_expression of CASP5 3 0.45 2.46 0 5.00
128 INT304076 Regulation of Localization of KRAS 2 0.36 2.39 0 5.00
129 INT304049 Transcription of SNAI2 1 0.67 0.56 0 5.00
130 INT304052 Binding of MSI1 8 0.05 12.19 0 5.00
131 INT268686 Gene_expression of JAZF1 2 0.68 9.33 0 5.00
132 INT304051 Regulation of SCGB2A1 1 0.17 1.19 0 5.00
133 INT304065 Transcription of GEMIN2 1 0.12 0.57 0 5.00
134 INT180396 Localization of KRAS 3 0.69 2.89 0 5.00
135 INT304053 Gene_expression of KIAA1324 1 0.18 0.98 0 5.00
136 INT304064 Positive_regulation of KIAA1324 1 0.14 0.98 0 5.00
137 INT185004 Positive_regulation of TFF3 4 0.47 3.77 0 5.00
138 INT304073 Regulation of CCNB2 1 0.10 1.39 0 5.00
139 INT304048 Negative_regulation of Gene_expression of SFRP4 1 0.34 0.97 0 5.00
140 INT304057 Regulation of JAZF1 1 0.24 1 0 5.00
141 INT304079 Regulation of AGR2 2 0.27 1.2 0 5.00
142 INT304070 Regulation of SUZ12 1 0.22 1 0 5.00
143 INT304068 Regulation of VPS11 1 0.12 1.24 0 5.00
144 INT107991 Positive_regulation of Gene_expression of MSH6 3 0.38 1.35 0 5.00
145 INT304071 Binding of MSH6 1 0.28 1.11 0 5.00
146 INT304061 Regulation of BUB1 1 0.07 1.39 0 5.00
147 INT304072 Positive_regulation of FOXA2 1 0.15 1.29 0 5.00
148 INT291365 Positive_regulation of Gene_expression of PIK3CA 2 0.41 5.76 0 5.00
149 INT304055 Transcription of TWIST1 1 0.14 0.57 0 5.00
150 INT304056 Gene_expression of SNAI2 1 0.65 0.66 0 5.00
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