D:Phenylketonuria

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Disease Term
Synonyms Atypical Phenylketonuria, ATYPICAL PHENYLKETONURIAS, Classical Phenylketonuria, Classical Phenylketonurias, Deficiency Disease Dihydropteridine Reductase, Deficiency Disease Phenylalanine Hydroxylase, DEFICIENCY DISEASE PHENYLALANINE HYDROXYLASE SEVERE, Dihydropteridine Reductase Deficiency Disease, Disease Folling, Disease Folling S, DISEASES FOLLING
Documents 60
Hot Single Events 40
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Phenylketonuria. They are ordered first by their relevance to Phenylketonuria and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT198639 S100A12 Positive_regulation of TNF 1 0.15 1.49 0.04 23.84
2 INT198646 S100A12 Positive_regulation of IL1B 1 0.01 1.49 0.04 23.84
3 INT198651 Positive_regulation of S100A12 Positive_regulation of TNF 1 0.15 1.5 0.04 23.84
4 INT198650 Positive_regulation of S100A12 Positive_regulation of IL1B 1 0.01 1.5 0.04 23.84
5 INT198653 TNF Positive_regulation of MIF 1 0.15 3.81 1.55 5.00
6 INT195668 Binding of F2 and THBD 7 0.08 5.67 0.98 5.00
7 INT198652 F2 Positive_regulation of Gene_expression of CD36 1 0.03 1.32 0.37 5.00
8 INT198647 TNF Positive_regulation of HIF1A 1 0.03 2.97 0.34 5.00
9 INT198642 GPI Positive_regulation of TNF 1 0.03 0.98 0.33 5.00
10 INT198640 TNF Positive_regulation of ISYNA1 1 0.04 1.07 0.29 5.00
11 INT198648 VCAM1 Positive_regulation of CADM1 1 0.00 1.1 0.25 5.00
12 INT198644 TNF Positive_regulation of CADM1 1 0.02 1.07 0.24 5.00
13 INT198643 CD36 Positive_regulation of CADM1 1 0.01 1.07 0.24 5.00
14 INT198649 Binding of HIF1A and MIF 1 0.01 1.53 0.18 5.00
15 INT198638 GPI Positive_regulation of Gene_expression of TNF 1 0.03 1.44 0.15 5.00
16 INT198671 HIF1A Regulation of Positive_regulation of Epo 1 0.00 1.37 0.13 5.00
17 INT272006 Binding of YWHAQ and Tsc2 1 0.27 0.39 0.1 5.00
18 INT272012 Binding of TSC1 and Lsamp 1 0.03 2.1 0.08 5.00
19 INT272003 Binding of Tsc2 and Tsc1 1 0.18 1.1 0.07 5.00
20 INT272009 Binding of YWHAQ and Tsc1 1 0.37 0.14 0.03 5.00
21 INT271990 Tsc1 Positive_regulation of Tsc2 1 0.36 0.31 0 5.00
22 INT272018 Binding of TSC1 and Tsc2 1 0.17 0.48 0 5.00
23 INT271996 Binding of Plk1 and Tsc1 1 0.09 0.32 0 5.00
24 INT271991 Tsc1 Regulation of Tsc2 1 0.23 0.15 0 5.00
25 INT272015 Pkd1 Positive_regulation of Localization of TSC1 1 0.18 0.65 0 5.00
26 INT272017 TBC1D7 Positive_regulation of Protein_catabolism of Tsc1 1 0.08 0.46 0 5.00
27 INT271982 Binding of Skp2 and Psmd9 1 0.01 0.68 0 5.00
28 INT272013 Binding of OGG1 and Tsc2 1 0.09 0.67 0 5.00
29 INT272010 Tsc2 Negative_regulation of OGG1 1 0.17 0.6 0 5.00
30 INT271966 Phosphorylation of Rasa1 Positive_regulation of Tsc2 1 0.01 0.31 0 5.00
31 INT272000 Binding of Skp2 and Hecw1 1 0.01 0.11 0 5.00
32 INT271985 Tsc1 Regulation of Cdkn1b 1 0.04 0.1 0 5.00
33 INT271979 Skp2 Positive_regulation of Protein_catabolism of Psmd9 1 0.01 0.35 0 5.00
34 INT272008 Tsc1 Negative_regulation of Binding of HERC1 1 0.01 0.32 0 5.00
35 INT272014 Binding of RB1CC1 and Tsc1 1 0.05 0.44 0 5.00
36 INT272016 Mtor Negative_regulation of INS 1 0.00 0.61 0 5.00
37 INT271997 Binding of Cdk1 and Plk1 1 0.03 0.3 0 5.00
38 INT271999 Binding of Fkbp1a and Positive_regulation of Negative_regulation of Mtor 1 0.00 0.18 0 5.00
39 INT271984 Binding of Tsc2 and Skp2 1 0.06 0.34 0 5.00
40 INT272011 Binding of RAB5A and Tsc2 1 0.02 0.16 0 5.00
41 INT272004 Binding of Hspa1b and Tsc2 1 0.01 0.45 0 5.00
42 INT271983 Binding of Tsc2 and Rap1a 1 0.02 0.16 0 5.00
43 INT271994 Binding of Fkbp1a and Mtor 1 0.00 0.22 0 5.00
44 INT272005 Phosphorylation of Tsc1 Regulation of Binding of Cdk1 and Plk1 1 0.02 0.3 0 5.00
45 INT271989 Binding of Tsc2 and Psmd9 1 0.02 0.47 0 5.00
46 INT272007 Binding of Tsc2 and SCPEP1 1 0.27 0.46 0 5.00
47 INT271998 Cdk1 Positive_regulation of Phosphorylation of Tsc1 1 0.17 0.3 0 5.00
48 INT271978 Positive_regulation of Racgap1 Regulation of Mtor 1 0.00 0.54 0 5.00
49 INT271987 Tsc2 Regulation of Skp2 1 0.10 0.28 0 5.00
50 INT271986 Tsc1 Regulation of Skp2 1 0.13 0.14 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Phenylketonuria. They are ordered first by their pain relevance and then by number of times they were reported in Phenylketonuria. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT127458 Positive_regulation of PAH 24 0.58 27.25 2.53 100.00
2 INT19158 Gene_expression of PAH 35 0.65 35.81 3.88 100.00
3 INT45730 Transcription of PAH 3 0.68 2.4 0.33 100.00
4 INT66193 Negative_regulation of Btd 3 0.59 3.39 0.32 99.92
5 INT38253 Localization of Trib3 35 0.63 10.28 15.42 99.40
6 INT127459 Negative_regulation of PAH 18 0.56 15.15 1.05 98.86
7 INT24080 Negative_regulation of Mtor 64 0.37 41.56 5.19 98.72
8 INT22834 Negative_regulation of CYP21A2 28 0.58 23.07 7.13 98.66
9 INT17110 Gene_expression of PSMD1 60 0.65 19.57 4.69 97.88
10 INT16772 Gene_expression of MPO 81 0.78 90.98 11.9 96.88
11 INT130001 Gene_expression of Lyz1 1 0.58 1.19 0.15 95.52
12 INT164152 Negative_regulation of PSMD2 9 0.37 3.41 1.56 95.48
13 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 93.08
14 INT142082 Positive_regulation of IDO1 17 0.60 9.46 6.33 92.96
15 INT130002 Positive_regulation of Protein_catabolism of Bglap-rs1 1 0.14 1.16 0.15 92.60
16 INT129995 Protein_catabolism of Bglap-rs1 1 0.25 1.16 0.15 92.60
17 INT129994 Positive_regulation of Protein_catabolism of Igha 1 0.11 1.16 0.15 92.60
18 INT129993 Protein_catabolism of Igha 1 0.20 1.16 0.15 92.60
19 INT130004 Positive_regulation of Protein_catabolism of FRG1 1 0.01 1.16 0.15 92.60
20 INT130003 Protein_catabolism of FRG1 1 0.03 1.16 0.15 92.60
21 INT130000 Positive_regulation of Protein_catabolism of Col1a1 1 0.49 1.15 0.15 92.60
22 INT129996 Positive_regulation of Protein_catabolism of Col1a2 1 0.49 1.15 0.15 92.60
23 INT130005 Protein_catabolism of MMP13 4 0.36 3.02 0.95 92.60
24 INT129999 Protein_catabolism of Col1a2 3 0.96 1.21 0.52 92.60
25 INT129997 Protein_catabolism of Col1a1 5 0.96 3.43 0.96 92.60
26 INT108739 Negative_regulation of Localization of Map3k12 1 0.42 0.09 0 92.32
27 INT61021 Negative_regulation of Entpd1 3 0.39 0.43 0.68 92.08
28 INT108740 Localization of Map3k12 2 0.68 0.09 1.15 91.92
29 INT152347 Binding of GCH1 8 0.37 6.13 7.36 89.68
30 INT150931 Negative_regulation of GCH1 6 0.59 1.23 1.05 88.24
31 INT65480 Gene_expression of Pts 15 0.66 7.53 6.46 88.16
32 INT129998 Positive_regulation of Lyz1 1 0.49 1.1 0.15 88.04
33 INT24895 Positive_regulation of LYZ 25 0.70 17.92 2.64 88.04
34 INT271914 Negative_regulation of Tsc1 5 0.38 3.08 0.04 86.88
35 INT271930 Gene_expression of Tsc1 1 0.69 6.88 0.04 86.08
36 INT223091 Gene_expression of ELF3 45 0.62 17.9 1.56 83.04
37 INT7180 Negative_regulation of Trib3 180 0.51 68.48 88.01 82.84
38 INT33492 Negative_regulation of Negative_regulation of Trib3 5 0.30 0.51 2.67 82.84
39 INT16131 Negative_regulation of GBE1 37 0.30 10.32 8.15 81.84
40 INT184803 Localization of TSC1 5 0.37 6.13 0.32 80.64
41 INT148564 Localization of HAL 8 0.68 2.46 0.62 79.32
42 INT101892 Gene_expression of PIM1 10 0.65 7.19 0.85 76.44
43 INT68187 Gene_expression of TNNT2 21 0.67 10.22 1.64 76.28
44 INT58564 Positive_regulation of Dpa 2 0.09 1.33 2.12 75.00
45 INT58565 Localization of Bh4p 2 0.03 0.98 0.12 75.00
46 INT85359 Negative_regulation of Map3k12 6 0.51 0.07 1.89 68.72
47 INT49706 Positive_regulation of TNNT2 22 0.69 12.65 1.56 66.88
48 INT191343 Gene_expression of IDO1 23 0.55 11.3 4.81 53.12
49 INT198666 Regulation of Gene_expression of IDO1 1 0.05 1.77 0.26 53.12
50 INT5262 Positive_regulation of AGL 14 0.40 7.51 0.65 49.92
51 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 43.76
52 INT695 Binding of POMC 304 0.48 56.66 126.85 40.88
53 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17 39.48
54 INT86867 Regulation of CREB1 15 0.46 4.95 7.28 38.08
55 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 34.20
56 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 33.80
57 INT102658 Negative_regulation of Gene_expression of CSF2 42 0.50 38.63 8.32 33.80
58 INT197446 Localization of Psmd1 10 0.56 3.78 2.79 31.84
59 INT214073 Binding of TSC1 9 0.37 22 1.34 25.04
60 INT271960 Positive_regulation of Binding of TSC1 1 0.25 0.88 0.03 25.04
61 INT18981 Gene_expression of ABAT 78 0.68 38.35 61.36 25.00
62 INT25356 Positive_regulation of S100A12 18 0.69 17.62 3.38 23.84
63 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 23.28
64 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 22.92
65 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
66 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
67 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
68 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
69 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
70 INT738 Regulation of POMC 459 0.62 111.19 243.74 5.00
71 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
72 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
73 INT6354 Localization of Gabrg1 321 0.74 41.41 186.74 5.00
74 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
75 INT14843 Gene_expression of Gabrg1 301 0.77 62.63 139.16 5.00
76 INT6323 Positive_regulation of Gabrg1 213 0.70 45.08 124.34 5.00
77 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
78 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
79 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 5.00
80 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 5.00
81 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
82 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85 5.00
83 INT1536 Negative_regulation of NA 244 0.55 52.67 59.79 5.00
84 INT5016 Negative_regulation of Crh 129 0.59 36.74 59.28 5.00
85 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
86 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 5.00
87 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
88 INT6357 Positive_regulation of Localization of Gabrg1 53 0.41 7.03 39.21 5.00
89 INT62827 Positive_regulation of ICAM1 184 0.70 180.95 36.28 5.00
90 INT59466 Gene_expression of ISYNA1 204 0.77 112.57 35.48 5.00
91 INT6943 Positive_regulation of Gabrd 71 0.70 17.36 35.25 5.00
92 INT84825 Gene_expression of CD36 121 0.78 43.73 33.23 5.00
93 INT34729 Positive_regulation of IFN1@ 233 0.67 128.04 30.38 5.00
94 INT66381 Regulation of Prkaca 40 0.62 13.38 27.96 5.00
95 INT69036 Gene_expression of IL18 99 0.77 77.92 25.95 5.00
96 INT76095 Positive_regulation of ISYNA1 117 0.55 79.73 25.86 5.00
97 INT61116 Positive_regulation of Ppara 119 0.69 58.62 21.6 5.00
98 INT1756 Negative_regulation of DNAH8 105 0.59 42.73 20.24 5.00
99 INT12725 Positive_regulation of Racgap1 66 0.68 32.74 19.29 5.00
100 INT33327 Positive_regulation of Gene_expression of Gabrg1 39 0.69 9.68 18.82 5.00
101 INT170754 Localization of IFN1@ 121 0.78 66.78 15.6 5.00
102 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42 5.00
103 INT6947 Negative_regulation of Gene_expression of POMC 37 0.59 10.32 14.14 5.00
104 INT52714 Regulation of PRKCA 28 0.61 7.73 13.66 5.00
105 INT59665 Positive_regulation of Ugt1a6 24 0.69 7.24 13.25 5.00
106 INT116528 Gene_expression of HMOX1 106 0.78 86.13 12.8 5.00
107 INT2385 Gene_expression of MIF 57 0.68 40.74 12.78 5.00
108 INT2129 Positive_regulation of F2 83 0.70 58.95 12.63 5.00
109 INT11288 Negative_regulation of CRH 44 0.00 16.69 12.37 5.00
110 INT10009 Positive_regulation of TRH 31 0.67 8.94 11.03 5.00
111 INT111223 Positive_regulation of HMOX1 47 0.70 39.14 10.92 5.00
112 INT4498 Gene_expression of F2 83 0.65 57.4 10.8 5.00
113 INT100379 Positive_regulation of HIF1A 69 0.69 57.31 10.4 5.00
114 INT170333 Binding of IFN1@ 68 0.47 49.01 9.72 5.00
115 INT36449 Negative_regulation of G6PD 74 0.59 54.15 8.85 5.00
116 INT85651 Positive_regulation of ACACA 17 0.67 4.73 8.63 5.00
117 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 5.00
118 INT25585 Positive_regulation of DNAH8 39 0.70 17.96 7.85 5.00
119 INT157932 Positive_regulation of ADHD1 46 0.48 52.18 6.13 5.00
120 INT121370 Positive_regulation of MIF 22 0.70 17.79 6.08 5.00
121 INT62525 Positive_regulation of SELE 38 0.70 46 5.25 5.00
122 INT83442 Negative_regulation of MIF 18 0.57 9.51 5.12 5.00
123 INT170927 Negative_regulation of Ppara 27 0.54 13.58 5.12 5.00
124 INT17312 Binding of HSPG2 30 0.41 33.01 4.88 5.00
125 INT9842 Binding of F2 36 0.47 22.79 4.42 5.00
126 INT167284 Phosphorylation of Gsk3b 88 0.82 36.03 4.21 5.00
127 INT105975 Gene_expression of ACACA 16 0.75 5.73 3.86 5.00
128 INT184288 Localization of HMGB1 20 0.61 14.5 3.84 5.00
129 INT123411 Gene_expression of Sp1 15 0.69 4.2 3.79 5.00
130 INT2936 Gene_expression of AGL 36 0.49 9.55 3.63 5.00
131 INT66960 Negative_regulation of ACACA 4 0.57 1.21 3.59 5.00
132 INT224234 Gene_expression of GPR17 33 0.65 4.25 3.45 5.00
133 INT163290 Binding of MIF 9 0.31 7.57 2.8 5.00
134 INT41874 Positive_regulation of GPI 9 0.49 9.97 2.79 5.00
135 INT71933 Positive_regulation of Gene_expression of F2 19 0.56 14.24 2.53 5.00
136 INT39560 Positive_regulation of F10 25 0.67 10.67 2.5 5.00
137 INT266841 Gene_expression of Cdh13 9 0.69 2.44 2.49 5.00
138 INT198662 Positive_regulation of CD36 14 0.68 7.73 2.36 5.00
139 INT108710 Gene_expression of HAL 36 0.58 14.75 2.16 5.00
140 INT103095 Binding of ISYNA1 10 0.28 6.17 2.03 5.00
141 INT130775 Regulation of FASLG 4 0.30 5.8 1.82 5.00
142 INT98580 Positive_regulation of CADM1 11 0.49 10.16 1.78 5.00
143 INT59790 Binding of BCR 16 0.36 15.34 1.75 5.00
144 INT30039 Negative_regulation of HAL 7 0.42 4.32 1.61 5.00
145 INT108913 Positive_regulation of HAL 10 0.28 5.71 1.59 5.00
146 INT198663 Positive_regulation of HMGB1 14 0.52 11.41 1.58 5.00
147 INT180249 Negative_regulation of GLUL 5 0.15 0.69 1.46 5.00
148 INT50010 Negative_regulation of CHR 5 0.42 3.64 1.41 5.00
149 INT11203 Gene_expression of BCR 30 0.75 33.49 1.22 5.00
150 INT167283 Negative_regulation of Phosphorylation of Gsk3b 12 0.59 7.94 1.16 5.00
151 INT36451 Gene_expression of G6PD 26 0.75 7.2 1.09 5.00
152 INT102249 Binding of HIF1A 39 0.36 30.47 1.04 5.00
153 INT151774 Positive_regulation of Mtor 38 0.45 20.15 1.01 5.00
154 INT178026 Positive_regulation of Epo 12 0.70 8.14 0.95 5.00
155 INT30041 Binding of HAL 8 0.35 2.36 0.95 5.00
156 INT126523 Phosphorylation of Mapkapk2 19 0.79 7.76 0.82 5.00
157 INT74019 Regulation of TSC1 27 0.35 23.61 0.79 5.00
158 INT271917 Phosphorylation of Mtor 11 0.13 6.76 0.78 5.00
159 INT198669 Binding of THBD 5 0.10 4.45 0.75 5.00
160 INT129174 Gene_expression of PKD1 24 0.67 14.91 0.74 5.00
161 INT184694 Gene_expression of Usf1 10 0.55 4.27 0.72 5.00
162 INT27077 Binding of CD36 4 0.37 2.14 0.72 5.00
163 INT168000 Protein_catabolism of F2 6 0.63 2.19 0.63 5.00
164 INT71497 Binding of Hspa1b 3 0.08 1.43 0.58 5.00
165 INT182435 Localization of OGG1 36 0.76 1.66 0.58 5.00
166 INT271939 Regulation of Tsc1 2 0.41 1.16 0.47 5.00
167 INT175423 Positive_regulation of TSC1 25 0.36 21.81 0.45 5.00
168 INT247798 Negative_regulation of Rasa1 3 0.09 1.05 0.44 5.00
169 INT128793 Gene_expression of HBB 16 0.78 10.69 0.42 5.00
170 INT230653 Phosphorylation of Rasa1 3 0.55 0.6 0.42 5.00
171 INT271922 Phosphorylation of Cdk1 2 0.44 0.37 0.39 5.00
172 INT49302 Localization of TNNT2 6 0.78 3.1 0.34 5.00
173 INT80664 Phosphorylation of G6PD 3 0.08 0.58 0.3 5.00
174 INT105976 Protein_catabolism of ACACA 2 0.64 0.37 0.28 5.00
175 INT126522 Positive_regulation of Phosphorylation of Mapkapk2 7 0.59 3.8 0.28 5.00
176 INT190676 Binding of Fkbp1a 15 0.36 3.11 0.28 5.00
177 INT70144 Gene_expression of Sry 4 0.63 1.15 0.28 5.00
178 INT241240 Gene_expression of Pkd1 18 0.54 12.2 0.27 5.00
179 INT246762 Phosphorylation of Tsc2 60 0.67 15.71 0.25 5.00
180 INT198659 Protein_catabolism of F10 1 0.01 0.51 0.22 5.00
181 INT182413 Binding of OGG1 17 0.46 2.44 0.22 5.00
182 INT271929 Protein_catabolism of Psmd9 4 0.11 1.69 0.21 5.00
183 INT179044 Regulation of Cdkn1b 4 0.22 2.64 0.18 5.00
184 INT224232 Protein_catabolism of GPR17 1 0.86 0 0.16 5.00
185 INT224229 Negative_regulation of TNFRSF1B 1 0.01 0.83 0.13 5.00
186 INT271943 Phosphorylation of Tsc2 9 0.52 3.35 0.13 5.00
187 INT271573 Binding of SCPEP1 3 0.35 1.21 0.13 5.00
188 INT246749 Negative_regulation of Phosphorylation of Tsc2 11 0.35 3.4 0.12 5.00
189 INT246776 Negative_regulation of Tsc2 18 0.48 6.82 0.12 5.00
190 INT271941 Binding of Tsc2 12 0.24 2.96 0.11 5.00
191 INT125096 Gene_expression of NEU2 2 0.03 0.14 0.1 5.00
192 INT107777 Phosphorylation of AGL 3 0.54 2.45 0.09 5.00
193 INT224230 Gene_expression of MDH1 1 0.19 0 0.09 5.00
194 INT245785 Negative_regulation of NDUFS4 1 0.06 1.16 0.09 5.00
195 INT200595 Regulation of Gene_expression of TNNT2 1 0.24 0.95 0.08 5.00
196 INT271938 Binding of Tsc1 1 0.43 3.18 0.07 5.00
197 INT211006 Binding of PKD1 6 0.22 2.69 0.05 5.00
198 INT197280 Regulation of Psmd9 2 0.07 0.1 0.05 5.00
199 INT198670 Negative_regulation of Pdk4 1 0.00 1.49 0.04 5.00
200 INT271916 Positive_regulation of Phosphorylation of Tsc2 4 0.32 0.52 0.04 5.00
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