D:Philadelphia Chromosome

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pChart

Disease Term
Synonyms 1 Chromosome Ph, 1 Chromosomes Ph, Chromosome Ph 1, Chromosome Ph1, Chromosome Philadelphia, Chromosomes Ph 1, Chromosomes Ph1, Ph 1 Chromosome, PH 1 CHROMOSOMES, Ph1 Chromosome, Ph1 Chromosomes
Documents 72
Hot Single Events 66
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Philadelphia Chromosome. They are ordered first by their relevance to Philadelphia Chromosome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT292680 Negative_regulation of TXK Negative_regulation of ABL1 1 0.00 0.26 0 98.84
2 INT7204 Binding of IFNA1 and IFNG 1 0.01 1.34 0.11 90.80
3 INT249117 Binding of Abl1 and Bcr 4 0.36 2.22 0.09 41.32
4 INT347226 Hck Regulation of Gene_expression of Lyn 1 0.10 0.08 0 32.60
5 INT347224 Lyn Regulation of Positive_regulation of Bcr 1 0.14 0.07 0 31.52
6 INT347225 Hck Regulation of Positive_regulation of Bcr 1 0.15 0.07 0 31.32
7 INT183269 Binding of CEBPB and CPOX 1 0.07 1.61 0.89 5.00
8 INT200808 Binding of Akt1 and Insrr 2 0.00 0.98 0.61 5.00
9 INT200811 Epo Positive_regulation of Akt1 2 0.30 1.77 0.09 5.00
10 INT200807 Jak2 Positive_regulation of Mvd 1 0.18 3.46 0.06 5.00
11 INT241536 Binding of Abcb1b and Abcg2 1 0.10 0.17 0.04 5.00
12 INT200821 Binding of Jak2 and Mvd 1 0.14 0.68 0.04 5.00
13 INT200813 Jak2 Positive_regulation of Akt1 1 0.26 1.46 0.03 5.00
14 INT200816 Jak2 Positive_regulation of Binding of Mvd 1 0.19 1.51 0.03 5.00
15 INT200809 Binding of Akt1 and Epo 1 0.23 0.98 0.03 5.00
16 INT277765 Binding of BCR and Abl1 1 0.18 1.55 0.03 5.00
17 INT200810 Jak2 Positive_regulation of Src 1 0.29 1.46 0.03 5.00
18 INT200823 Akt1 Negative_regulation of Binding of Akt1 and Insrr 1 0.00 0.98 0.03 5.00
19 INT200814 Epo Positive_regulation of Lyn 1 0.36 1.42 0.03 5.00
20 INT200815 Binding of Epo and Jak2 1 0.36 0.98 0.03 5.00
21 INT200820 Epo Positive_regulation of Src 1 0.25 1.41 0.03 5.00
22 INT200822 Akt1 Regulation of Jak2 1 0.25 1.48 0.03 5.00
23 INT292679 GOPC Positive_regulation of HSP90AA1 1 0.01 0.1 0 5.00
24 INT350523 ABL1 Negative_regulation of Pmf1 1 0.01 2.19 0 5.00
25 INT200812 Akt1 Positive_regulation of Negative_regulation of Hck 1 0.25 1.02 0 5.00
26 INT241500 Binding of Kit and Kitl 1 0.08 0.92 0 5.00
27 INT200819 Epo Positive_regulation of Gene_expression of Jak2 1 0.49 0.91 0 5.00
28 INT292727 GSK Positive_regulation of Negative_regulation of Hsf1 1 0.21 0 0 5.00
29 INT292723 Akt1 Positive_regulation of Localization of Hsf1 1 0.05 0.36 0 5.00
30 INT292722 Akt1 Regulation of Localization of Hsf1 1 0.06 0 0 5.00
31 INT292721 Mapk1 Negative_regulation of Phosphorylation of Hsf1 1 0.02 0.06 0 5.00
32 INT350503 Binding of HSP90AA1 and JAK2 1 0.06 1.39 0 5.00
33 INT200817 Akt1 Positive_regulation of Negative_regulation of Fgr 1 0.25 1.02 0 5.00
34 INT292725 GOPC Positive_regulation of Protein_catabolism of Akt1 1 0.01 0.1 0 5.00
35 INT241535 Abl1 Regulation of Positive_regulation of Jak2 1 0.10 0.53 0 5.00
36 INT241537 Negative_regulation of Binding of Abl1 and Src 1 0.04 0.14 0 5.00
37 INT241539 Binding of Abl1 and Lyn 1 0.09 0.14 0 5.00
38 INT350505 Negative_regulation of Binding of HSP90AA1 and JAK2 1 0.07 1.5 0 5.00
39 INT241534 Binding of Abl1 and Src 1 0.04 0.14 0 5.00
40 INT284184 Binding of Akt1 and Pdgfrb 1 0.00 0.14 0 5.00
41 INT200818 Akt1 Positive_regulation of Negative_regulation of Lyn 1 0.25 1.02 0 5.00
42 INT292726 ABL1 Positive_regulation of Mapk1 1 0.01 0.15 0 5.00
43 INT241538 Negative_regulation of Binding of Abl1 and Lyn 1 0.11 0.14 0 5.00
44 INT350504 ABL1 Negative_regulation of JAK2 1 0.20 2.18 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Philadelphia Chromosome. They are ordered first by their pain relevance and then by number of times they were reported in Philadelphia Chromosome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT91754 Gene_expression of Cp 42 0.77 21.97 5.38 100.00
2 INT199553 Gene_expression of Bcr 25 0.76 13.83 0.48 99.84
3 INT199557 Positive_regulation of Gene_expression of Bcr 6 0.68 4.21 0.3 99.52
4 INT119519 Positive_regulation of Gene_expression of TXK 3 0.09 2.92 1.02 99.52
5 INT190023 Negative_regulation of Mrc1 15 0.25 12.36 0.16 99.34
6 INT117662 Gene_expression of ABL1 21 0.69 18.76 0.39 99.22
7 INT11203 Gene_expression of BCR 30 0.75 33.49 1.22 99.22
8 INT119520 Gene_expression of TXK 19 0.19 17.54 1.45 99.04
9 INT113659 Gene_expression of ABR 19 0.65 8.49 1.45 98.92
10 INT70134 Negative_regulation of TXK 124 0.23 81.96 9.59 98.84
11 INT163461 Regulation of ABL1 8 0.32 5.98 0.14 98.80
12 INT123877 Negative_regulation of ABL1 40 0.57 27.94 1.17 98.52
13 INT199573 Gene_expression of Abl1 33 0.65 20.79 0.75 98.04
14 INT199563 Negative_regulation of Abl1 38 0.46 21.5 0.87 98.00
15 INT98456 Negative_regulation of Src 17 0.42 8.3 0.42 98.00
16 INT323078 Negative_regulation of Phosphorylation of SERPINA5 1 0.23 1.05 0 97.76
17 INT323079 Phosphorylation of SERPINA5 1 0.44 1.04 0 97.76
18 INT273550 Positive_regulation of Bcr 14 0.68 6.71 0.49 97.68
19 INT136181 Negative_regulation of BCR 5 0.42 2.94 0 96.84
20 INT273560 Negative_regulation of Crkl 2 0.22 2.5 0.14 96.20
21 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42 96.04
22 INT36921 Regulation of Mdk 14 0.26 6.49 5.8 96.04
23 INT105336 Regulation of AKT1 52 0.56 32.53 4.89 96.04
24 INT347214 Positive_regulation of Negative_regulation of Bcr 1 0.38 1.43 0.17 95.40
25 INT31281 Binding of Dbp 4 0.19 1.28 0.88 94.84
26 INT273544 Negative_regulation of Transcription of Bcr 1 0.42 0.3 0 94.80
27 INT273546 Negative_regulation of Transcription of Abl1 1 0.46 0.3 0 94.80
28 INT199561 Positive_regulation of Gene_expression of Abl1 8 0.36 4.77 0.16 94.56
29 INT273555 Negative_regulation of Bcr 17 0.57 9.65 0.44 94.48
30 INT18379 Transcription of Cp 2 0.11 1.23 0.18 94.40
31 INT23148 Gene_expression of RUNX1 10 0.10 6.58 1.71 94.36
32 INT215980 Positive_regulation of Gene_expression of RUNX1 1 0.08 0.89 0 94.36
33 INT273557 Transcription of Bcr 1 0.70 0.3 0 94.28
34 INT273558 Transcription of Abl1 1 0.57 0.3 0 94.12
35 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58 94.00
36 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59 94.00
37 INT20066 Gene_expression of Mdk 38 0.76 21.41 13.4 94.00
38 INT189833 Negative_regulation of Phosphorylation of Stat1 4 0.51 1.1 0.3 93.32
39 INT273556 Phosphorylation of Crkl 9 0.37 8.43 0.33 92.84
40 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 92.84
41 INT200803 Phosphorylation of Stat5a 2 0.59 1.23 0 92.84
42 INT163756 Phosphorylation of Stat1 45 0.82 14.51 6.11 92.84
43 INT241499 Binding of Abl1 23 0.47 8.86 0.75 92.44
44 INT59790 Binding of BCR 16 0.36 15.34 1.75 92.44
45 INT249114 Gene_expression of Cd48 2 0.10 5.06 0.68 91.00
46 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53 87.08
47 INT124185 Negative_regulation of Kit 57 0.59 35.43 3.61 87.08
48 INT144019 Negative_regulation of Pdgfrb 21 0.58 14.93 1.26 87.08
49 INT142184 Regulation of TXK 10 0.11 8.25 0.59 86.44
50 INT292711 Regulation of Gene_expression of ABL1 1 0.06 1.02 0 86.44
51 INT141231 Negative_regulation of Cntnap1 2 0.32 1.18 0.58 85.92
52 INT141230 Negative_regulation of Evpl 2 0.23 2.6 0.11 85.92
53 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 85.76
54 INT119102 Gene_expression of PDGFRA 13 0.75 11.99 0.81 85.76
55 INT292713 Phosphorylation of ABL1 2 0.44 1.04 0 85.56
56 INT174979 Phosphorylation of GOPC 45 0.51 10.11 2.28 85.40
57 INT136180 Binding of MTOR 9 0.35 5.01 0.38 85.36
58 INT10923 Positive_regulation of Lipg 30 0.50 22.87 4.26 85.12
59 INT126683 Localization of Lipg 7 0.70 3.87 0.46 85.12
60 INT266627 Positive_regulation of Ugt1a2 3 0.04 5.54 0.56 82.64
61 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 81.08
62 INT136182 Negative_regulation of PDGFRA 3 0.43 2.43 0.08 80.88
63 INT129783 Positive_regulation of Gene_expression of KIT 16 0.50 18.12 0.58 80.60
64 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 80.24
65 INT234461 Negative_regulation of Gene_expression of HDAC9 5 0.24 2.74 0.24 80.24
66 INT350500 Negative_regulation of Prss27 1 0.01 0.85 0 80.24
67 INT95116 Negative_regulation of PDGFA 24 0.57 19.56 1.29 79.44
68 INT192225 Gene_expression of HDAC9 35 0.58 32.82 6.36 79.36
69 INT312302 Gene_expression of Prss27 2 0.02 3.95 0.19 78.64
70 INT241510 Negative_regulation of Phosphorylation of Kit 3 0.31 2.06 0.03 76.88
71 INT241515 Negative_regulation of Phosphorylation of Abl1 3 0.30 1.36 0.09 76.88
72 INT213789 Phosphorylation of Kit 7 0.69 5.32 0.43 76.56
73 INT241512 Phosphorylation of Abl1 4 0.59 2.68 0.09 76.56
74 INT109327 Negative_regulation of KIT 42 0.57 43.2 2.15 76.24
75 INT347219 Positive_regulation of Dleu2 1 0.67 1.59 0.14 75.60
76 INT11235 Positive_regulation of IFNA2 27 0.69 15.32 2.57 75.00
77 INT150165 Gene_expression of MTTP 21 0.75 10.1 0.73 75.00
78 INT101068 Negative_regulation of CDCP1 27 0.03 17.67 3.45 73.92
79 INT117002 Negative_regulation of Sfpi1 16 0.58 9.72 1 73.44
80 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 70.24
81 INT292705 Regulation of Binding of Hsf1 1 0.10 0.89 0 69.12
82 INT60957 Negative_regulation of Abcb1b 18 0.57 6 4.73 69.04
83 INT103925 Negative_regulation of Positive_regulation of Akt1 32 0.58 15.19 7.39 68.48
84 INT113160 Negative_regulation of Jak2 26 0.58 20.3 2.57 67.72
85 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 66.96
86 INT75137 Regulation of Akt1 74 0.48 37.89 9.7 66.92
87 INT91890 Positive_regulation of Kit 36 0.50 25.44 3.06 66.92
88 INT144020 Positive_regulation of Pdgfrb 30 0.69 24.8 1.92 66.92
89 INT140175 Regulation of Kit 23 0.62 8.59 1.79 66.92
90 INT241498 Regulation of Abl1 8 0.32 6.46 0.22 66.92
91 INT223082 Regulation of Pdgfrb 3 0.25 2.14 0.08 66.92
92 INT241507 Positive_regulation of Abl1 5 0.40 2.69 0.05 66.92
93 INT62199 Binding of Hsf1 12 0.45 10.77 0.6 66.20
94 INT277761 Gene_expression of DPM1 1 0.03 9.23 0.27 64.88
95 INT197173 Positive_regulation of Cyp4a10 29 0.62 15.68 1.61 64.76
96 INT42391 Positive_regulation of BCR 7 0.49 4.93 1.44 63.44
97 INT109594 Positive_regulation of ABL1 10 0.49 7.19 0.05 63.44
98 INT16321 Gene_expression of Cd3e 111 0.72 49.9 14.21 63.36
99 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 62.48
100 INT119396 Regulation of Positive_regulation of Mapk1 22 0.61 7.88 12.25 62.48
101 INT292703 Regulation of Hsf1 5 0.26 1.78 0 62.12
102 INT180382 Gene_expression of Fcgr3 9 0.34 7.94 1.1 62.00
103 INT95790 Regulation of Mapk1 55 0.61 21.17 16.31 61.60
104 INT80983 Regulation of Abcb1b 16 0.60 1.95 4.32 60.08
105 INT250466 Regulation of Gene_expression of Sfpi1 1 0.39 0.98 0 57.68
106 INT117004 Gene_expression of Sfpi1 21 0.75 15.95 5.29 57.16
107 INT350517 Negative_regulation of Gene_expression of ABL1 1 0.23 0.53 0 56.68
108 INT153294 Binding of FIP1L1 1 0.36 0.7 0.08 51.80
109 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46 51.36
110 INT92437 Positive_regulation of Phosphorylation of Mapk1 113 0.70 32.19 40.29 51.36
111 INT239412 Binding of ABL1 8 0.28 5.39 0.18 50.00
112 INT129679 Negative_regulation of Hsf1 9 0.43 3.22 0.22 48.20
113 INT110020 Gene_expression of Mapk14 142 0.77 72.33 30.08 47.48
114 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68 46.72
115 INT193674 Binding of Bcr 10 0.47 4.3 0.36 46.52
116 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81 45.76
117 INT173796 Gene_expression of Stat5a 5 0.56 1.41 0 45.32
118 INT106483 Negative_regulation of Gene_expression of Mpl 6 0.43 5.87 0.27 43.88
119 INT106484 Gene_expression of Mpl 7 0.78 20.2 16.48 43.48
120 INT86446 Protein_catabolism of Lipg 9 0.50 3.52 1.25 42.40
121 INT320147 Phosphorylation of Bcr 2 0.67 0.64 0.11 41.84
122 INT200797 Positive_regulation of Ptprv 4 0.14 3.19 0.58 40.72
123 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 39.52
124 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 38.48
125 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 38.48
126 INT350519 Positive_regulation of STK19 1 0.01 0.59 0 37.72
127 INT204367 Positive_regulation of SIRT1 13 0.68 4.17 0 37.28
128 INT112993 Binding of Mrc1 7 0.21 6.55 0.12 36.36
129 INT273554 Positive_regulation of Binding of Abl1 2 0.40 2.05 0.05 36.24
130 INT273551 Positive_regulation of Binding of Bcr 1 0.49 1.03 0 36.24
131 INT285208 Gene_expression of Slc22a1 2 0.65 0.08 0 33.92
132 INT146946 Gene_expression of Lyn 16 0.76 8.9 3.75 32.80
133 INT144038 Transcription of STAT3 4 0.56 0.99 0.25 32.64
134 INT145932 Gene_expression of Hck 5 0.77 2.69 0.73 32.60
135 INT207276 Transcription of BCL6 3 0.45 0.64 0.03 31.60
136 INT350515 Transcription of SMAD7 1 0.07 0.38 0.03 31.12
137 INT73476 Transcription of MYC 18 0.69 12.14 2.13 30.56
138 INT55952 Transcription of TP53 16 0.61 12.14 2.36 30.00
139 INT217802 Regulation of Transcription of TP53 2 0.37 0.81 0.03 30.00
140 INT62196 Positive_regulation of Positive_regulation of Hsf1 3 0.47 2.72 0.25 25.96
141 INT129680 Transcription of Hsf1 2 0.53 1.68 0.17 25.08
142 INT62195 Positive_regulation of Hsf1 17 0.70 11.51 0.95 24.72
143 INT125320 Negative_regulation of HSP90AA1 20 0.45 23.93 1.42 22.96
144 INT200796 Negative_regulation of Epo 7 0.43 3.22 0.18 19.96
145 INT350521 Negative_regulation of Negative_regulation of ABL1 1 0.23 0.55 0 16.92
146 INT273552 Negative_regulation of Phosphorylation of Crkl 5 0.19 5.86 0.33 16.24
147 INT200247 Negative_regulation of Dbp 5 0.15 0.8 0.5 16.20
148 INT7776 Gene_expression of Abcb1b 63 0.75 21.35 14.92 14.72
149 INT54617 Positive_regulation of Gene_expression of Abcb1b 22 0.67 9.8 5.34 14.72
150 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3 11.36
151 INT320148 Negative_regulation of Negative_regulation of Bcr 1 0.35 0.2 0 10.96
152 INT133898 Binding of HSP90AA1 17 0.30 8.83 1.12 9.80
153 INT106522 Negative_regulation of Phosphorylation of Akt1 65 0.58 34.44 7.83 9.00
154 INT144024 Negative_regulation of Phosphorylation of Pdgfrb 6 0.42 3.48 0.51 8.08
155 INT137908 Phosphorylation of Pdgfrb 14 0.81 8.44 2.45 7.52
156 INT241501 Regulation of BCRP1 1 0.26 0.64 0.07 7.36
157 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
158 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
159 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 5.00
160 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
161 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
162 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
163 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
164 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 5.00
165 INT16654 Gene_expression of Insrr 138 0.46 58.96 75.68 5.00
166 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 5.00
167 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91 5.00
168 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
169 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
170 INT50672 Positive_regulation of CPOX 205 0.44 125.93 60.06 5.00
171 INT31186 Negative_regulation of Insrr 81 0.37 24.91 55.94 5.00
172 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42 5.00
173 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 5.00
174 INT62426 Gene_expression of Mc1r 127 0.78 42.99 48.01 5.00
175 INT1726 Positive_regulation of Kitl 65 0.70 38.81 44.85 5.00
176 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
177 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
178 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 5.00
179 INT102611 Negative_regulation of Positive_regulation of Mapk1 74 0.58 35.57 39.37 5.00
180 INT70437 Negative_regulation of Mdk 115 0.57 41.03 35.72 5.00
181 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 5.00
182 INT14823 Gene_expression of MET 103 0.75 51.92 32.48 5.00
183 INT88318 Gene_expression of CXCR4 208 0.77 189.67 31.72 5.00
184 INT117112 Negative_regulation of Mapk1 87 0.56 40.34 31.18 5.00
185 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 5.00
186 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27 5.00
187 INT16428 Positive_regulation of Gtf3a 135 0.20 106.44 26.67 5.00
188 INT95788 Positive_regulation of Positive_regulation of Mapk1 83 0.69 24.75 25.84 5.00
189 INT79979 Gene_expression of Ret 94 0.75 19.21 25.51 5.00
190 INT64175 Negative_regulation of Gene_expression of CPOX 66 0.38 39.64 23.07 5.00
191 INT19330 Binding of HLA-A 99 0.48 76.26 22.85 5.00
192 INT83797 Gene_expression of Bcl2l1 124 0.77 94.55 22.39 5.00
193 INT112029 Positive_regulation of Pik3r1 90 0.67 38.76 20.95 5.00
194 INT73593 Gene_expression of BAX 173 0.76 147.81 20.94 5.00
195 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
196 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61 5.00
197 INT81194 Binding of CPOX 40 0.29 23.7 18.95 5.00
198 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 5.00
199 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 5.00
200 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 5.00
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