D:Pick Disease Of The Brain

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Disease Term
Synonyms ATROPHIES LOBAR BRAIN, Atrophy Lobar Brain, Brain Atrophy Circumscribed Lobar, Circumscribed Lobar Atrophy Of The Brain, Disease Pick, Disease Pick S, Lobar Atrophies Brain, Lobar Atrophy Brain, Pick Disease, Pick S Disease, Picks Disease
Documents 21
Hot Single Events 21
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Pick Disease Of The Brain. They are ordered first by their relevance to Pick Disease Of The Brain and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT191923 Binding of EXOSC10 and Tlr4 1 0.21 0.48 0.04 96.68
2 INT77646 Binding of Ngf and Ntrk1 23 0.40 7.85 9.26 70.04
3 INT106559 Binding of Bdnf and Ntrk2 23 0.43 11.09 7.33 68.52
4 INT308650 Binding of nt and Ntrk2 1 0.01 0.41 0.21 68.52
5 INT308654 Binding of Ngfr and Nts 1 0.06 0.39 0.21 63.36
6 INT320848 Binding of Npc1 and Npc2 1 0.39 0 0 50.00
7 INT296867 Binding of B4galnt2 and Mtor 1 0.00 0.51 0 38.16
8 INT88279 Ngf Positive_regulation of Ntrk1 5 0.76 3.06 5.23 5.00
9 INT165583 Binding of Bdnf and Ngf 3 0.33 0.81 0.69 5.00
10 INT308668 Akt1 Positive_regulation of Nos3 3 0.05 4.61 0.65 5.00
11 INT308656 Pik3r1 Positive_regulation of Nos3 1 0.02 1.8 0.5 5.00
12 INT197496 Binding of Apoe and Lrp1 4 0.22 2.32 0.46 5.00
13 INT230437 Binding of PDX1 and HRCT1 1 0.04 2.45 0.43 5.00
14 INT308653 Proc Regulation of Gene_expression of Mapk8 1 0.00 1.48 0.36 5.00
15 INT230438 Binding of PDX1 and HAUS7 1 0.02 2.29 0.35 5.00
16 INT308667 Binding of Chrm1 and Positive_regulation of Binding of App 1 0.04 1.14 0.32 5.00
17 INT255740 Pik3r1 Positive_regulation of Akt1 5 0.24 2.42 0.31 5.00
18 INT308661 Akt1 Positive_regulation of Chuk 1 0.02 0.6 0.25 5.00
19 INT308670 Positive_regulation of CYBB Positive_regulation of Gene_expression of Ros1 1 0.00 0.68 0.23 5.00
20 INT238802 Binding of Ager and Renbp 6 0.02 6.46 0.22 5.00
21 INT308645 Binding of Esr1 and Itpr3 1 0.00 0 0.2 5.00
22 INT308646 Car2 Regulation of Gene_expression of Ins1 1 0.00 0 0.19 5.00
23 INT308669 CREB1 Regulation of Gene_expression of Ins1 1 0.01 0 0.19 5.00
24 INT308657 Creb1 Regulation of Gene_expression of Ins1 1 0.01 0 0.19 5.00
25 INT331628 Binding of HLA-DQA2 and Pain1 1 0.01 2.13 0.14 5.00
26 INT331627 Binding of HLA-DRB3 and Pain1 1 0.00 2.15 0.14 5.00
27 INT308659 Binding of Ager and ecs 1 0.01 1.14 0.12 5.00
28 INT331612 ETV4 Positive_regulation of Gene_expression of TGFB1 1 0.00 1.32 0.12 5.00
29 INT308647 Ager Positive_regulation of Gene_expression of Bace1 1 0.09 1.01 0.12 5.00
30 INT308660 Binding of Ager and App 1 0.08 1.22 0.12 5.00
31 INT308651 Binding of Igf1 and Ins1 1 0.02 0.22 0.11 5.00
32 INT308662 Binding of Esr1 and Fdft1 1 0.00 0.05 0.09 5.00
33 INT308666 Binding of Lrp1 and Chol1 1 0.10 0.69 0.09 5.00
34 INT308652 Binding of Renbp and Nps 1 0.01 1.38 0.09 5.00
35 INT331626 Edn1 Positive_regulation of Itk 1 0.00 0.57 0.07 5.00
36 INT308655 Binding of Lrp1 and Gopc 1 0.01 0.49 0.07 5.00
37 INT331629 Binding of TGFB1 and Positive_regulation of Gene_expression of Itk 1 0.00 0.84 0.07 5.00
38 INT308665 Binding of Apoe and Gopc 1 0.02 0.49 0.07 5.00
39 INT308663 Apoe Regulation of Car2 1 0.02 0.44 0.07 5.00
40 INT308649 Binding of Ppp1r13b and Iars 1 0.01 0.29 0.04 5.00
41 INT296868 Binding of B4galnt2 and Map1lc3a 1 0.04 0.69 0.03 5.00
42 INT308658 Binding of Apoa2 and Apoe 1 0.17 0.15 0.03 5.00
43 INT308648 Binding of sps and Gopc 1 0.01 2.71 0 5.00
44 INT308643 Binding of Proc and Renbp 1 0.00 1.61 0 5.00
45 INT331611 NKX2-1 Regulation of Transcription of SFTPB 1 0.01 0.49 0 5.00
46 INT308664 Akt1 Positive_regulation of Phosphorylation of Insr 1 0.02 0.43 0 5.00
47 INT296869 Mtor Positive_regulation of Gene_expression of B4galnt2 1 0.01 1.56 0 5.00
48 INT121225 Positive_regulation of Ngf Positive_regulation of Ntrk1 2 0.49 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Pick Disease Of The Brain. They are ordered first by their pain relevance and then by number of times they were reported in Pick Disease Of The Brain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT97859 Localization of Npc1 12 0.75 6.66 0.35 100.00
2 INT84638 Regulation of Smpd1 3 0.37 2.36 0.22 100.00
3 INT320845 Regulation of Localization of Npc1 1 0.39 0.71 0 100.00
4 INT84430 Negative_regulation of Smpd1 22 0.59 10.33 3.95 99.72
5 INT215117 Gene_expression of Ctsa 14 0.33 8.66 1.18 97.96
6 INT240423 Regulation of Ctsa 5 0.25 5.27 0.89 97.96
7 INT296846 Regulation of Gene_expression of Ctsa 1 0.18 1.35 0 97.96
8 INT315310 Gene_expression of CHIA 1 0.12 4.45 0.33 97.76
9 INT296845 Regulation of B4galnt2 1 0.05 4.76 0.08 95.28
10 INT38039 Positive_regulation of LIPA 2 0.37 1.36 0.22 89.84
11 INT296862 Positive_regulation of Gene_expression of Ctsa 1 0.20 1.35 0 87.84
12 INT20233 Negative_regulation of SMPD1 8 0.51 4.19 1.4 87.04
13 INT20232 Negative_regulation of Negative_regulation of SMPD1 1 0.37 0.55 0.1 87.04
14 INT296864 Negative_regulation of cma 1 0.20 1.22 0 85.76
15 INT15505 Regulation of nt 6 0.24 1.5 1.88 84.48
16 INT151774 Positive_regulation of Mtor 38 0.45 20.15 1.01 82.44
17 INT296849 Positive_regulation of Positive_regulation of Mtor 1 0.05 1.24 0 82.44
18 INT191919 Binding of PRRC2A 1 0.36 0.3 0.03 81.80
19 INT191915 Binding of Blai1 1 0.36 0.3 0.03 81.80
20 INT39417 Gene_expression of Fcer2a 65 0.76 32.1 7.37 81.16
21 INT254881 Negative_regulation of Atg7 9 0.34 5.69 0.32 81.08
22 INT320843 Negative_regulation of Gene_expression of Npc1 2 0.59 5.82 0.07 75.32
23 INT32515 Negative_regulation of B4GALNT1 82 0.43 28.1 17.46 75.00
24 INT128609 Gene_expression of C1S 18 0.75 17.36 0.98 75.00
25 INT79941 Negative_regulation of Npc1 9 0.59 3.97 0.82 75.00
26 INT97860 Gene_expression of CTSA 8 0.43 2.22 0.54 75.00
27 INT97861 Negative_regulation of Gene_expression of CTSA 3 0.13 1.11 0.09 75.00
28 INT170346 Gene_expression of Npc1 18 0.78 7.69 0.48 74.96
29 INT63042 Binding of Apoe 59 0.48 31.23 5.88 74.72
30 INT138438 Gene_expression of Smpd1 7 0.67 2.67 0.21 74.64
31 INT320839 Regulation of Gene_expression of Smpd1 1 0.37 0.61 0 74.64
32 INT282985 Negative_regulation of Becn1 11 0.20 7.72 0.04 74.48
33 INT288078 Gene_expression of Npc2 2 0.64 1.01 0 72.52
34 INT97453 Negative_regulation of MOCS1 25 0.04 13.4 2.4 64.04
35 INT36293 Gene_expression of Mtor 24 0.25 14.5 2.04 60.48
36 INT161248 Positive_regulation of Gene_expression of Mtor 2 0.06 6.47 0.51 60.48
37 INT23542 Negative_regulation of B4galnt2 3 0.22 1.67 0.6 58.68
38 INT160115 Regulation of Fcer2a 5 0.11 3.24 0.37 55.12
39 INT72890 Positive_regulation of Gene_expression of Fcer2a 12 0.17 6.81 2.25 54.96
40 INT42410 Positive_regulation of Cyb5d2 13 0.31 6.75 0.54 51.92
41 INT288083 Positive_regulation of Gene_expression of Cyb5d2 1 0.10 0.75 0 51.92
42 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 50.00
43 INT173693 Localization of Gopc 249 0.65 70.49 38.81 50.00
44 INT9055 Positive_regulation of Cog1 22 0.68 14.08 2.95 50.00
45 INT231266 Gene_expression of Prh1 13 0.08 3.95 1.02 50.00
46 INT209387 Negative_regulation of Ugcg 9 0.25 7.61 0.9 50.00
47 INT3477 Regulation of Npc1 6 0.45 1.87 0.47 50.00
48 INT32509 Positive_regulation of Npc1 6 0.50 2.24 0.33 50.00
49 INT4133 Binding of Npc1 14 0.47 8.24 0.33 50.00
50 INT9054 Negative_regulation of Positive_regulation of Cog1 3 0.08 1.38 0.28 50.00
51 INT240424 Binding of Ctsa 4 0.20 3.94 0.16 50.00
52 INT288084 Gene_expression of Rab9 2 0.27 1.05 0.13 50.00
53 INT320841 Positive_regulation of Chit1 1 0.02 0.82 0.07 50.00
54 INT288082 Positive_regulation of Npc2 2 0.48 0.67 0.04 50.00
55 INT198787 Localization of Cyb5d2 3 0.73 0.56 0.03 50.00
56 INT319022 Positive_regulation of Binding of Npc1 2 0.50 0.24 0.03 50.00
57 INT320842 Localization of Npc2 1 0.76 1.01 0.03 50.00
58 INT320844 Regulation of Npc2 1 0.43 0 0 50.00
59 INT320840 Binding of Npc2 1 0.46 1.81 0 50.00
60 INT87332 Gene_expression of Cyb5d2 8 0.65 2.85 0.15 49.00
61 INT48240 Binding of Ngf 46 0.46 23.51 24.42 48.36
62 INT95651 Positive_regulation of Binding of Ngf 3 0.50 0.48 0.25 48.36
63 INT24080 Negative_regulation of Mtor 64 0.37 41.56 5.19 46.48
64 INT296851 Localization of Atg7 1 0.60 0.82 0.14 40.64
65 INT277345 Localization of Mtor 3 0.08 1.89 0.09 40.64
66 INT282977 Regulation of Becn1 4 0.25 2.29 0.04 40.40
67 INT50971 Gene_expression of Ntrk1 180 0.75 73.52 62.28 37.92
68 INT68244 Positive_regulation of Ighg1 60 0.61 48.86 5.01 26.92
69 INT296857 Gene_expression of B4galnt2 1 0.07 9.46 0.55 20.00
70 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 16.48
71 INT60695 Positive_regulation of Gene_expression of Il10 154 0.70 120.28 43.07 14.96
72 INT234494 Positive_regulation of Syp 12 0.65 2.47 0.69 14.88
73 INT20380 Gene_expression of Il5 172 0.78 104.75 34.78 6.96
74 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
75 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 5.00
76 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
77 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
78 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
79 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 5.00
80 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
81 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71 5.00
82 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
83 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91 5.00
84 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 5.00
85 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
86 INT92669 Gene_expression of Bdnf 309 0.78 178.26 116.68 5.00
87 INT49171 Gene_expression of Nos1 241 0.78 140.7 104.76 5.00
88 INT4742 Gene_expression of Tac1 177 0.78 69.99 102.66 5.00
89 INT65500 Gene_expression of App 605 0.78 429.94 98.31 5.00
90 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 5.00
91 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
92 INT21793 Positive_regulation of Ngf 154 0.70 94.78 85.27 5.00
93 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 5.00
94 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 5.00
95 INT3214 Localization of Ins1 527 0.80 196.9 79.26 5.00
96 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 5.00
97 INT87686 Positive_regulation of Gene_expression of Trpv1 101 0.70 72.41 69.15 5.00
98 INT7344 Gene_expression of TAC1 132 0.75 35.48 68.26 5.00
99 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
100 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 5.00
101 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 5.00
102 INT79093 Positive_regulation of Nos1 101 0.70 46.89 59.61 5.00
103 INT64159 Gene_expression of Prkca 90 0.78 34.65 55.97 5.00
104 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32 5.00
105 INT27954 Positive_regulation of Gene_expression of Ngf 87 0.70 57.91 51.96 5.00
106 INT64110 Positive_regulation of Gene_expression of Nos1 68 0.70 58.11 51.64 5.00
107 INT19775 Localization of Il1 183 0.78 145.5 50.91 5.00
108 INT4985 Positive_regulation of Tac1 81 0.69 35.79 50.67 5.00
109 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 5.00
110 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 5.00
111 INT25610 Positive_regulation of Gene_expression of Il1 136 0.67 104.43 43.86 5.00
112 INT100939 Gene_expression of Il13 176 0.73 125.1 43.38 5.00
113 INT52531 Gene_expression of Nfkb1 153 0.75 82.84 42.9 5.00
114 INT57442 Phosphorylation of Prkca 98 0.70 31.58 41.04 5.00
115 INT97596 Localization of S100a8 94 0.78 90.69 40.41 5.00
116 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
117 INT20210 Localization of Ngf 69 0.79 46.22 38.57 5.00
118 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2 5.00
119 INT104551 Gene_expression of Il18 156 0.76 115.51 36.95 5.00
120 INT8747 Positive_regulation of Ins1 221 0.69 154.28 35.15 5.00
121 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 5.00
122 INT33768 Positive_regulation of Cysltr1 87 0.46 54.66 33.52 5.00
123 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2 5.00
124 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81 5.00
125 INT124860 Gene_expression of Bace1 330 0.78 157.11 31.65 5.00
126 INT29743 Negative_regulation of App 91 0.59 65.56 31.26 5.00
127 INT56809 Binding of Tlr4 184 0.48 106.02 31.18 5.00
128 INT64164 Regulation of Prkca 34 0.62 10.44 30.99 5.00
129 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 5.00
130 INT47712 Positive_regulation of App 135 0.69 101.38 28.94 5.00
131 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43 5.00
132 INT133876 Positive_regulation of Gene_expression of Ros1 141 0.32 75.55 27.45 5.00
133 INT37296 Binding of Esr1 117 0.43 62.51 27.33 5.00
134 INT3217 Regulation of Ins1 154 0.62 87.11 27.29 5.00
135 INT116861 Gene_expression of Apoe 182 0.78 100.41 27.26 5.00
136 INT14690 Localization of CSF2 124 0.80 85.17 27.26 5.00
137 INT145426 Positive_regulation of Ros1 185 0.56 106.76 27.21 5.00
138 INT86062 Positive_regulation of Tnfrsf1a 51 0.69 40.69 26.2 5.00
139 INT63769 Regulation of Ngf 44 0.62 21.82 25.84 5.00
140 INT89662 Positive_regulation of Gene_expression of App 169 0.70 133.36 25.62 5.00
141 INT93738 Gene_expression of Tnfrsf1a 63 0.74 57.66 23.09 5.00
142 INT113925 Localization of Bdnf 59 0.79 24.03 22.76 5.00
143 INT17962 Regulation of Car2 124 0.41 33.98 22.71 5.00
144 INT18322 Negative_regulation of Ins1 132 0.58 88.49 22.59 5.00
145 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23 5.00
146 INT14733 Positive_regulation of Gene_expression of TGFB1 71 0.69 49.89 22.2 5.00
147 INT1558 Positive_regulation of Dnahc8 30 0.69 5.78 22.19 5.00
148 INT45437 Localization of Acot1 84 0.79 17.37 22.18 5.00
149 INT84732 Positive_regulation of Hand2 81 0.69 62.07 22 5.00
150 INT1561 Negative_regulation of Dnahc8 59 0.59 18.12 20.99 5.00
151 INT112029 Positive_regulation of Pik3r1 90 0.67 38.76 20.95 5.00
152 INT11625 Localization of App 98 0.78 55.46 20.86 5.00
153 INT116282 Gene_expression of Mmp13 83 0.75 45.4 20.18 5.00
154 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14 5.00
155 INT46016 Gene_expression of Ngfr 69 0.77 41.22 19.8 5.00
156 INT16794 Binding of App 103 0.48 64.87 19.79 5.00
157 INT65502 Regulation of App 77 0.62 52.05 19.44 5.00
158 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 5.00
159 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 5.00
160 INT171060 Gene_expression of PDX1 72 0.75 72.57 17.97 5.00
161 INT12081 Localization of TGFB1 64 0.81 35.4 17.47 5.00
162 INT24225 Gene_expression of Alms1 93 0.62 52.75 16.93 5.00
163 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 5.00
164 INT8742 Regulation of Localization of Ins1 65 0.61 14.98 16.43 5.00
165 INT112027 Gene_expression of Pik3r1 58 0.75 30.9 15.95 5.00
166 INT97871 Gene_expression of Ntf3 47 0.78 25.9 15.94 5.00
167 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 5.00
168 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74 5.00
169 INT36177 Binding of Alms1 70 0.31 35.47 13.81 5.00
170 INT10016 Negative_regulation of CD8A 81 0.42 56.68 13.15 5.00
171 INT114420 Negative_regulation of Pik3r1 67 0.54 34.86 12.82 5.00
172 INT107916 Protein_catabolism of App 114 1.00 66.71 12.38 5.00
173 INT100821 Localization of Ros1 59 0.60 45.26 11.92 5.00
174 INT66038 Positive_regulation of Ngfr 32 0.69 26.07 11.75 5.00
175 INT109315 Gene_expression of Mapk8 70 0.78 45.46 11.65 5.00
176 INT119400 Phosphorylation of Car2 19 0.52 8.47 11.63 5.00
177 INT73431 Positive_regulation of Nos3 82 0.65 53.22 11.61 5.00
178 INT65501 Regulation of Gene_expression of App 56 0.62 32.51 11.48 5.00
179 INT4723 Transcription of Tac1 26 0.71 8.33 11.18 5.00
180 INT62576 Transcription of Creb1 34 0.69 16.97 10.6 5.00
181 INT3982 Gene_expression of Acot1 53 0.56 7.61 10.46 5.00
182 INT25613 Gene_expression of Il1f5 32 0.77 13.29 10.44 5.00
183 INT27955 Negative_regulation of Gene_expression of Ngf 16 0.59 10.43 10.17 5.00
184 INT35284 Positive_regulation of Chrm1 14 0.67 5.64 10.11 5.00
185 INT102865 Positive_regulation of Positive_regulation of Prkca 25 0.69 8.34 9.9 5.00
186 INT6361 Localization of Edn1 30 0.81 19.09 9.7 5.00
187 INT75137 Regulation of Akt1 74 0.48 37.89 9.7 5.00
188 INT57162 Positive_regulation of Gene_expression of CDKN1A 64 0.68 35.3 9.69 5.00
189 INT81264 Positive_regulation of Localization of Ngf 13 0.58 9.82 9.53 5.00
190 INT149138 Binding of PDX1 27 0.37 32.62 9.33 5.00
191 INT132586 Negative_regulation of Hand2 40 0.30 26.58 9.28 5.00
192 INT108384 Binding of Ntrk1 28 0.39 10.73 9.09 5.00
193 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86 5.00
194 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79 5.00
195 INT104396 Positive_regulation of Positive_regulation of Akt1 44 0.55 14.78 8.69 5.00
196 INT19185 Negative_regulation of Cd4 80 0.51 61.32 8.51 5.00
197 INT109005 Gene_expression of Proc 61 0.75 37.86 8.49 5.00
198 INT224366 Gene_expression of Ager 111 0.77 125.37 8.49 5.00
199 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31 5.00
200 INT18583 Positive_regulation of Gene_expression of Ins1 67 0.50 49.72 8.26 5.00
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