D:Piebaldism

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Disease Term
Synonyms ALBINISM CUTANEOUS, ALBINISM PARTIAL, Cutaneous Albinism, Partial Albinism
Documents 8
Hot Single Events 14
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Piebaldism. They are ordered first by their relevance to Piebaldism and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT311816 CD79A Positive_regulation of RAB27A 1 0.01 0.47 0 84.08
2 INT215245 Binding of Myo1f and Chd7 1 0.00 0.64 0.1 75.84
3 INT192955 Binding of KIT and VCAM1 1 0.05 0.63 0 62.08
4 INT192956 Binding of CD2 and KIT 1 0.03 0.62 0 61.44
5 INT172465 Binding of Rab27a and Rab27b 2 0.41 1.71 0.27 37.60
6 INT234831 Binding of SPTLC1 and Abo 1 0.00 1.61 0.23 5.00
7 INT311872 IGHE Positive_regulation of Localization of Mmp9 1 0.01 1.35 0.22 5.00
8 INT234801 RAB3GAP1 Regulation of RAB3A 1 0.08 1.64 0.15 5.00
9 INT311871 Cav1 Regulation of Mch 1 0.01 0.24 0.11 5.00
10 INT284552 Binding of Cd8a and Mthfd1 2 0.03 1.32 0.1 5.00
11 INT234802 Binding of AQP2 and AVPR2 2 0.15 0.84 0.07 5.00
12 INT215240 Binding of Myo1f and Racgap1 1 0.01 0.77 0.04 5.00
13 INT215244 Binding of Racgap1 and Mlph 1 0.04 0.76 0.04 5.00
14 INT311870 Positive_regulation of Binding of Cd8a and Mthfd1 1 0.00 0.32 0.03 5.00
15 INT234800 RAB27A Positive_regulation of INS 1 0.02 1.26 0 5.00
16 INT215243 Binding of Rab3a and Noc2l 1 0.00 0.26 0 5.00
17 INT215246 Binding of Rab27a and Rph3a 1 0.07 0.26 0 5.00
18 INT172464 Binding of Rab27a and Myc 1 0.13 0.69 0 5.00
19 INT215239 Binding of Rab27a and Sytl4 1 0.26 0.26 0 5.00
20 INT215241 Binding of Rab3a and Rph3a 1 0.00 0.26 0 5.00
21 INT234790 B4GALNT1 Positive_regulation of AGFG1 1 0.00 0.08 0 5.00
22 INT234793 RAB27A Positive_regulation of Localization of INS 1 0.03 1.26 0 5.00
23 INT234803 AVP Regulation of AQP2 1 0.11 1.3 0 5.00
24 INT215242 Binding of Rab27a and Noc2l 1 0.07 0.26 0 5.00
25 INT215238 Binding of Rab3a and Sytl4 1 0.01 0.26 0 5.00
26 INT234791 Binding of AVP and AVPR2 1 0.14 0.55 0 5.00
27 INT234794 Binding of GDI1 and AGFG1 1 0.01 0 0 5.00
28 INT234796 Binding of AQP2 and AVP 1 0.15 1.1 0 5.00
29 INT234797 AVP Regulation of GOPC 1 0.01 0.65 0 5.00
30 INT234795 Negative_regulation of CHM Negative_regulation of RAB27A 1 0.01 0.8 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Piebaldism. They are ordered first by their pain relevance and then by number of times they were reported in Piebaldism. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT311859 Positive_regulation of RAB27A 1 0.19 2.95 0 97.16
2 INT53212 Negative_regulation of RAB27A 4 0.57 2.46 0.26 96.96
3 INT90899 Gene_expression of Rab27a 49 0.78 26.71 0.74 93.76
4 INT215229 Gene_expression of Sytl4 1 0.31 0.44 0 93.12
5 INT192962 Positive_regulation of Transcription of KIT 1 0.46 2.74 0 91.76
6 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 91.56
7 INT192957 Transcription of KIT 5 0.69 2.19 0.23 91.56
8 INT311860 Binding of RAB27A 1 0.10 0.52 0 85.92
9 INT172463 Gene_expression of RAB27A 6 0.65 3.95 0.03 84.08
10 INT215223 Regulation of Localization of Rab27a 1 0.45 0.73 0 83.80
11 INT172459 Localization of Rab27a 2 0.75 1.57 0 83.80
12 INT172460 Positive_regulation of Rab27b 2 0.46 1.55 0.04 80.64
13 INT9884 Localization of CD79A 41 0.78 21.75 3.06 80.56
14 INT126941 Binding of OCA2 2 0.42 1.31 0.07 80.56
15 INT85085 Positive_regulation of KIT 36 0.53 30.08 2.17 76.72
16 INT172458 Regulation of Gopc 155 0.53 62.57 24.86 75.72
17 INT129783 Positive_regulation of Gene_expression of KIT 16 0.50 18.12 0.58 75.64
18 INT172455 Protein_catabolism of Rab27a 1 1.00 2.11 0 68.72
19 INT192960 Regulation of Gene_expression of KIT 3 0.45 4.16 0 67.40
20 INT83531 Gene_expression of KITLG 54 0.65 26 7.07 66.80
21 INT215233 Positive_regulation of Gene_expression of Rab3d 1 0.45 0.38 0 65.04
22 INT215231 Gene_expression of Rab3d 1 0.50 0.38 0 65.04
23 INT90897 Regulation of Rab27a 6 0.45 3.28 0.5 60.72
24 INT172438 Gene_expression of Rab27b 8 0.77 10.95 0.27 60.60
25 INT215235 Localization of Rab3d 1 0.52 0.38 0 60.32
26 INT215225 Regulation of Localization of Rab3d 1 0.29 0.38 0 60.32
27 INT109327 Negative_regulation of KIT 42 0.57 43.2 2.15 39.68
28 INT172452 Gene_expression of Myc 121 0.78 69.56 1.36 38.64
29 INT172442 Binding of Rab27a 3 0.37 1.5 0.21 30.80
30 INT128376 Binding of KIT 26 0.48 14.24 0.47 29.28
31 INT186998 Negative_regulation of Gene_expression of KIT 20 0.43 16.77 0.46 23.96
32 INT172441 Negative_regulation of Rab27b 2 0.43 1.06 0.03 17.20
33 INT172461 Positive_regulation of Negative_regulation of Rab27b 1 0.33 0.54 0 17.20
34 INT199771 Localization of Ahr 8 0.70 4.86 0.2 15.32
35 INT701 Localization of IGHE 87 0.80 40.5 10.62 14.00
36 INT9223 Localization of Ighg1 22 0.78 11.03 3.67 14.00
37 INT172456 Negative_regulation of Rpe 2 0.32 1.18 0.03 8.00
38 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
39 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
40 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
41 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
42 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
43 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
44 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
45 INT6585 Positive_regulation of Insrr 110 0.52 40.67 89.9 5.00
46 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
47 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
48 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
49 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02 5.00
50 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 5.00
51 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2 5.00
52 INT20380 Gene_expression of Il5 172 0.78 104.75 34.78 5.00
53 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 5.00
54 INT77652 Negative_regulation of Gene_expression of IL8 99 0.59 67.57 30.21 5.00
55 INT5206 Gene_expression of AR 316 0.78 113.83 27.29 5.00
56 INT21900 Gene_expression of Mthfd1 150 0.75 69.47 27.03 5.00
57 INT4809 Gene_expression of PTGDS 103 0.76 52.94 24.01 5.00
58 INT8775 Binding of IGHE 167 0.48 102.61 23.54 5.00
59 INT74423 Localization of IL10 91 0.80 61.6 22.95 5.00
60 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 5.00
61 INT20379 Localization of Il4 85 0.73 51.22 20.55 5.00
62 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 5.00
63 INT12725 Positive_regulation of Racgap1 66 0.68 32.74 19.29 5.00
64 INT73252 Positive_regulation of Mthfd1 124 0.59 59.48 18.35 5.00
65 INT70145 Gene_expression of Trav6-3 136 0.76 69.6 18.05 5.00
66 INT132997 Localization of Mmp9 59 0.80 45.9 17.61 5.00
67 INT32515 Negative_regulation of B4GALNT1 82 0.43 28.1 17.46 5.00
68 INT110767 Localization of Mcpt1 43 0.68 24.3 16.74 5.00
69 INT9220 Gene_expression of Ighg1 125 0.77 85.74 15.92 5.00
70 INT9783 Gene_expression of INSRR 81 0.50 32.99 15.52 5.00
71 INT104674 Positive_regulation of F2rl1 35 0.65 27.76 14.16 5.00
72 INT14572 Binding of INS 205 0.48 175.43 13.38 5.00
73 INT80756 Gene_expression of CD86 77 0.77 46.68 11.36 5.00
74 INT35366 Binding of AR 87 0.47 30.52 8.9 5.00
75 INT70017 Positive_regulation of BCL2 87 0.67 66.62 8.68 5.00
76 INT20205 Binding of IgG 108 0.46 66.68 8.57 5.00
77 INT15529 Gene_expression of GCG 51 0.75 18.55 8.35 5.00
78 INT65959 Positive_regulation of Gene_expression of BCL2 75 0.70 77.3 8.27 5.00
79 INT18185 Gene_expression of Tyr 32 0.76 12.52 8.17 5.00
80 INT93914 Gene_expression of CD80 70 0.75 36.35 7.74 5.00
81 INT5381 Gene_expression of FYN 18 0.75 7.65 7.35 5.00
82 INT14637 Negative_regulation of MBP 19 0.43 7.06 7.18 5.00
83 INT10917 Positive_regulation of ITGAM 31 0.67 16.39 6.69 5.00
84 INT84685 Regulation of BCL2 67 0.60 72.96 6.65 5.00
85 INT50387 Negative_regulation of AR 67 0.45 26.31 6.61 5.00
86 INT62509 Gene_expression of MCS 58 0.67 21.46 6.57 5.00
87 INT181525 Localization of Il13 24 0.66 21.51 6.55 5.00
88 INT85923 Positive_regulation of CREM 25 0.67 7.03 6.53 5.00
89 INT234813 Gene_expression of RAB5A 58 0.66 3.67 6.48 5.00
90 INT60527 Transcription of IL10 16 0.56 13.57 6.42 5.00
91 INT83119 Negative_regulation of Gene_expression of IL12A 24 0.42 17.52 5.69 5.00
92 INT87420 Gene_expression of BCL2L1 56 0.75 48.84 5.32 5.00
93 INT70613 Negative_regulation of Gene_expression of BCL2 48 0.59 38.91 5.22 5.00
94 INT20372 Localization of Il5 26 0.41 18.33 4.27 5.00
95 INT4528 Negative_regulation of Sell 12 0.58 4.76 4.22 5.00
96 INT110343 Negative_regulation of PIK3CD 22 0.40 5.84 4.2 5.00
97 INT160915 Regulation of Mmp9 16 0.35 10.25 4.07 5.00
98 INT75688 Binding of KITLG 24 0.30 11.73 4.06 5.00
99 INT132994 Positive_regulation of Localization of Mmp9 12 0.42 9.4 3.75 5.00
100 INT109403 Regulation of Gene_expression of BCL2 31 0.60 31.22 3.4 5.00
101 INT147572 Gene_expression of Ahr 73 0.75 38.99 3.15 5.00
102 INT234825 Positive_regulation of Gene_expression of RAB5A 16 0.59 1.15 2.71 5.00
103 INT133029 Regulation of TLR2 18 0.56 11.31 2.62 5.00
104 INT120551 Negative_regulation of Rock2 8 0.52 2.73 2.53 5.00
105 INT91836 Negative_regulation of Gene_expression of BCL2L1 9 0.49 8.59 2.25 5.00
106 INT35866 Transcription of IGHE 9 0.60 12.83 2.19 5.00
107 INT211979 Positive_regulation of Localization of Mcpt1 5 0.09 2.68 2.16 5.00
108 INT47780 Gene_expression of CREM 17 0.74 5.37 2.13 5.00
109 INT80191 Gene_expression of PTGDR2 9 0.74 4.15 2.11 5.00
110 INT173851 Localization of FN1 20 0.76 13.95 1.97 5.00
111 INT273335 Negative_regulation of Localization of Mcpt1 5 0.32 2.66 1.83 5.00
112 INT234827 Positive_regulation of RAB5A 3 0.59 0.54 1.69 5.00
113 INT135955 Positive_regulation of Cav1 17 0.48 7.73 1.61 5.00
114 INT91739 Positive_regulation of MYLK 9 0.54 2.89 1.58 5.00
115 INT167085 Negative_regulation of ERBB2 67 0.57 44.6 1.48 5.00
116 INT123877 Negative_regulation of ABL1 40 0.57 27.94 1.17 5.00
117 INT90670 Positive_regulation of KRT1 10 0.44 6.25 1.16 5.00
118 INT183046 Transcription of INS 25 0.70 11.14 1.13 5.00
119 INT311848 Localization of Smr3a 1 0.14 5.85 1.04 5.00
120 INT90898 Negative_regulation of Rab27a 5 0.43 1.99 1.04 5.00
121 INT45079 Binding of Ahr 21 0.44 10.07 1 5.00
122 INT38036 Gene_expression of Rac2 4 0.57 3.74 0.95 5.00
123 INT311843 Gene_expression of Smr3a 1 0.13 4.85 0.93 5.00
124 INT201261 Regulation of AGFG1 4 0.09 2.72 0.9 5.00
125 INT51704 Phosphorylation of AVP 2 0.79 0.33 0.86 5.00
126 INT219358 Gene_expression of CDK5 9 0.58 5.65 0.81 5.00
127 INT157492 Transcription of Foxp3 4 0.61 1.69 0.81 5.00
128 INT70019 Binding of BCL2 25 0.47 17.55 0.79 5.00
129 INT234820 Localization of AGFG1 3 0.14 0.86 0.74 5.00
130 INT229789 Regulation of RAB7A 4 0.42 7.09 0.72 5.00
131 INT311844 Negative_regulation of Irak4 1 0.29 2.88 0.72 5.00
132 INT92838 Positive_regulation of Col4a1 8 0.36 3.48 0.6 5.00
133 INT52347 Negative_regulation of CHM 17 0.58 13.03 0.59 5.00
134 INT228103 Positive_regulation of Rac1 25 0.67 18.92 0.57 5.00
135 INT311835 Regulation of Gene_expression of Smr3a 1 0.05 2.56 0.53 5.00
136 INT311846 Regulation of Localization of Smr3a 1 0.05 2.56 0.53 5.00
137 INT57163 Gene_expression of AGFG1 11 0.75 2.45 0.48 5.00
138 INT230879 Protein_catabolism of MCS 2 0.44 0.94 0.47 5.00
139 INT64965 Binding of AGFG1 8 0.10 3.53 0.45 5.00
140 INT196517 Negative_regulation of Gene_expression of MCS 2 0.05 1.2 0.43 5.00
141 INT108650 Positive_regulation of Gene_expression of KITLG 2 0.33 2.57 0.41 5.00
142 INT56815 Gene_expression of ckrtgr 6 0.01 1.7 0.4 5.00
143 INT171111 Regulation of Spg7 1 0.09 0.94 0.4 5.00
144 INT234828 Gene_expression of RAB3A 2 0.30 2.05 0.37 5.00
145 INT53262 Gene_expression of TSS 6 0.52 1.35 0.37 5.00
146 INT158764 Binding of SPINK5 7 0.35 8.84 0.37 5.00
147 INT221973 Negative_regulation of CDK5 4 0.57 2.26 0.36 5.00
148 INT311862 Negative_regulation of Protein_catabolism of MCS 1 0.05 0.27 0.36 5.00
149 INT163489 Binding of CDH1 13 0.19 8.63 0.35 5.00
150 INT225110 Regulation of Localization of FN1 2 0.21 0.93 0.27 5.00
151 INT177520 Localization of EPX 3 0.47 3.3 0.26 5.00
152 INT172445 Positive_regulation of Gene_expression of Myc 58 0.70 39.62 0.25 5.00
153 INT311830 Regulation of Smr3a 1 0.05 1.18 0.25 5.00
154 INT234817 Gene_expression of GDI1 4 0.17 2.99 0.25 5.00
155 INT180599 Gene_expression of EEC1 5 0.63 2.73 0.23 5.00
156 INT311832 Positive_regulation of Localization of Smr3a 1 0.09 1.25 0.21 5.00
157 INT192958 Negative_regulation of IGF1R 8 0.30 6.35 0.21 5.00
158 INT195576 Binding of Myo1f 6 0.06 2.79 0.21 5.00
159 INT311837 Positive_regulation of Rac2 1 0.15 1.91 0.2 5.00
160 INT129672 Positive_regulation of Rab27a 2 0.69 2.72 0.19 5.00
161 INT219375 Localization of CDK5 4 0.52 2.8 0.19 5.00
162 INT299419 Transcription of Ctla4 2 0.43 0.71 0.17 5.00
163 INT234810 Regulation of RAB5A 3 0.38 1.64 0.16 5.00
164 INT111549 Phosphorylation of KITLG 2 0.37 1.13 0.15 5.00
165 INT215234 Binding of Rab27b 1 0.37 0.54 0.14 5.00
166 INT119145 Binding of RAC2 2 0.13 0.47 0.14 5.00
167 INT311833 Localization of Ctla4 1 0.17 0.26 0.14 5.00
168 INT311842 Transcription of Lag3 1 0.15 0.36 0.14 5.00
169 INT311841 Localization of Lag3 1 0.19 0.26 0.14 5.00
170 INT125711 Negative_regulation of TSS 6 0.51 3.64 0.12 5.00
171 INT311866 Gene_expression of CDK5R2 1 0.06 1.06 0.11 5.00
172 INT192906 Negative_regulation of Col4a1 4 0.31 1.79 0.11 5.00
173 INT311839 Negative_regulation of Positive_regulation of Col4a1 1 0.03 0.22 0.1 5.00
174 INT311849 Localization of Rac2 1 0.23 0.72 0.08 5.00
175 INT172453 Binding of Myc 6 0.48 2.36 0.08 5.00
176 INT234814 Positive_regulation of AGFG1 6 0.10 2.33 0.07 5.00
177 INT162271 Negative_regulation of Gene_expression of KITLG 4 0.28 2.31 0.07 5.00
178 INT228295 Negative_regulation of Transcription of INS 2 0.43 1.1 0.07 5.00
179 INT192961 Positive_regulation of Negative_regulation of ERBB2 2 0.64 3.53 0.06 5.00
180 INT311863 Regulation of FBP1 3 0.15 0.77 0.06 5.00
181 INT219355 Binding of CDK5 3 0.35 2.02 0.06 5.00
182 INT191284 Gene_expression of LSS 3 0.35 1.16 0.05 5.00
183 INT311854 Regulation of ALDOC 1 0.01 0.44 0.04 5.00
184 INT215224 Regulation of Rab27b 1 0.27 0.65 0.03 5.00
185 INT311861 Regulation of Regulation of FBP1 1 0.03 0.31 0.03 5.00
186 INT172449 Positive_regulation of Gene_expression of Rab27a 4 0.50 2.37 0.03 5.00
187 INT215228 Positive_regulation of Gene_expression of Rab27b 1 0.69 1.36 0.03 5.00
188 INT311864 Negative_regulation of Positive_regulation of FBP1 1 0.04 0.24 0.03 5.00
189 INT145071 Positive_regulation of FBP1 2 0.49 0.29 0.03 5.00
190 INT234821 Positive_regulation of Gene_expression of AGFG1 1 0.10 0.07 0 5.00
191 INT311867 Regulation of Positive_regulation of FBP1 1 0.05 0.16 0 5.00
192 INT234809 Phosphorylation of MYO5A 1 0.61 0.23 0 5.00
193 INT234812 Binding of AVPR2 1 0.17 0.55 0 5.00
194 INT215230 Gene_expression of Rab3a 1 0.02 0.39 0 5.00
195 INT101179 Positive_regulation of MYH11 2 0.41 0.25 0 5.00
196 INT215227 Positive_regulation of Gene_expression of Rab3a 1 0.02 0.39 0 5.00
197 INT234815 Phosphorylation of RAB27A 1 0.37 0.77 0 5.00
198 INT311836 Negative_regulation of Scc9 1 0.02 0.49 0 5.00
199 INT311855 Regulation of Negative_regulation of PIK3CD 1 0.04 0.28 0 5.00
200 INT234829 Phosphorylation of AVPR2 1 0.29 0.24 0 5.00
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