D:Pigmented Nevus

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Disease Term
Synonyms Halo Nevi, HALO NEVUS, Melanocytic Nevi, MELANOCYTIC NEVUS, Nevi Halo, Nevi Melanocytic, Nevi Pigmented, NEVUS HALO, Nevus Melanocytic, PIGMENTED NEVI
Documents 35
Hot Single Events 2
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Pigmented Nevus. They are ordered first by their relevance to Pigmented Nevus and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 5.00
2 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22 5.00
3 INT186126 Binding of CD28 and CTLA4 9 0.52 4.13 3.12 5.00
4 INT321598 Binding of MLL and TNF 1 0.05 1.07 0.49 5.00
5 INT290444 S100A4 Regulation of TIMP1 1 0.00 1.3 0.14 5.00
6 INT276228 Nrtim1 Positive_regulation of PPARG 1 0.01 2.18 0.14 5.00
7 INT290443 Gene_expression of TIMP2 Negative_regulation of MMP2 1 0.06 1.56 0.13 5.00
8 INT351032 Binding of CD80 and CD96 1 0.01 0.36 0.09 5.00
9 INT351031 Binding of CD28 and CD96 1 0.02 0.36 0.09 5.00
10 INT274715 TBL1XR1 Positive_regulation of TIMP1 1 0.00 0.26 0.04 5.00
11 INT290477 POU3F2 Negative_regulation of Gene_expression of Mitf 1 0.43 0.36 0 5.00
12 INT290474 MAPK1 Regulation of Mitf 1 0.04 0.15 0 5.00
13 INT351029 AGK Regulation of VEGFA 1 0.00 0.82 0 5.00
14 INT290482 GPR143 Regulation of Gene_expression of Mitf 1 0.36 0.64 0 5.00
15 INT290478 Mitf Positive_regulation of HIF1A 1 0.57 0.61 0 5.00
16 INT274716 TBL1XR1 Positive_regulation of Gene_expression of MMP1 1 0.02 0.45 0 5.00
17 INT290483 RAB27A Regulation of Gene_expression of Mitf 1 0.25 0.64 0 5.00
18 INT290480 MLANA Regulation of Gene_expression of Mitf 1 0.27 0.64 0 5.00
19 INT351030 AGK Regulation of ARAF 1 0.00 0.82 0 5.00
20 INT290479 Binding of HIF1A and Mitf 1 0.30 1.29 0 5.00
21 INT290476 Mitf Regulation of Gene_expression of CD200 1 0.34 0.2 0 5.00
22 INT290475 POU3F2 Negative_regulation of Mitf 1 0.43 1.14 0 5.00
23 INT290481 MLANA Regulation of Mitf 1 0.16 0.2 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Pigmented Nevus. They are ordered first by their pain relevance and then by number of times they were reported in Pigmented Nevus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT73625 Gene_expression of PPARG 108 0.78 104.85 21.42 88.12
2 INT276227 Gene_expression of UBL4A 9 0.20 7.12 0.64 80.48
3 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 75.76
4 INT8629 Positive_regulation of COL7A1 72 0.69 40.66 12.09 50.00
5 INT67613 Positive_regulation of PPARG 94 0.70 69.15 34.38 42.16
6 INT4756 Positive_regulation of Nrtim1 37 0.33 14.6 24.12 42.16
7 INT100275 Gene_expression of TBL1XR1 19 0.25 6.99 1.33 39.92
8 INT165841 Gene_expression of BPIFA4P 17 0.65 6.48 2.38 22.36
9 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 20.88
10 INT276224 Binding of Nrtim1 1 0.01 1.3 0.23 10.00
11 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
12 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 5.00
13 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
14 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
15 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 5.00
16 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 5.00
17 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 5.00
18 INT48232 Gene_expression of MMP1 245 0.78 96.31 57.72 5.00
19 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 5.00
20 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
21 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 5.00
22 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 5.00
23 INT103094 Binding of PPARA 308 0.47 177.26 34.75 5.00
24 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 5.00
25 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 5.00
26 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 5.00
27 INT17331 Positive_regulation of JUN 132 0.69 60.4 27.03 5.00
28 INT101517 Negative_regulation of PPARA 168 0.57 112.24 21.41 5.00
29 INT51055 Positive_regulation of TIMP1 103 0.69 50.07 19.86 5.00
30 INT93663 Positive_regulation of MMP1 72 0.67 33.38 19.86 5.00
31 INT11508 Positive_regulation of TGFBI 24 0.70 19.81 15.78 5.00
32 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66 5.00
33 INT103096 Regulation of PPARA 113 0.60 62.47 14.57 5.00
34 INT92823 Positive_regulation of Gene_expression of MMP1 65 0.68 25.69 14.31 5.00
35 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11 5.00
36 INT1758 Positive_regulation of Gene_expression of TIMP1 62 0.69 31.72 13.98 5.00
37 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
38 INT61624 Positive_regulation of Gene_expression of IL12A 50 0.56 33.07 13.07 5.00
39 INT148207 Gene_expression of CTLA4 53 0.77 29.13 12.07 5.00
40 INT100379 Positive_regulation of HIF1A 69 0.69 57.31 10.4 5.00
41 INT173159 Localization of PPARA 96 0.74 64.55 10.26 5.00
42 INT13010 Gene_expression of TYR 38 0.65 14.81 8.84 5.00
43 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31 5.00
44 INT36798 Gene_expression of Mki67 178 0.77 132 8.24 5.00
45 INT93664 Gene_expression of TIMP2 33 0.67 36.67 7.14 5.00
46 INT75497 Regulation of JUN 28 0.61 11.04 7.09 5.00
47 INT181194 Regulation of Gene_expression of PPARA 31 0.44 21.27 5.96 5.00
48 INT119523 Gene_expression of EDNRB 32 0.75 26.47 5.75 5.00
49 INT73262 Negative_regulation of BCL2 67 0.57 61.01 5.07 5.00
50 INT94433 Negative_regulation of TIMP2 16 0.55 9.38 4.78 5.00
51 INT15474 Gene_expression of PLAUR 36 0.75 22.32 4.63 5.00
52 INT73626 Positive_regulation of Gene_expression of PPARG 22 0.70 18.82 4.4 5.00
53 INT79692 Negative_regulation of PPARG 24 0.59 16 4.31 5.00
54 INT88414 Negative_regulation of CDK2 30 0.57 18.4 3.96 5.00
55 INT106318 Gene_expression of S100A4 21 0.75 12.13 3.23 5.00
56 INT112365 Regulation of HIF1A 27 0.60 21.24 3.05 5.00
57 INT99187 Negative_regulation of Positive_regulation of PPARG 5 0.42 5.07 2.99 5.00
58 INT222961 Negative_regulation of Binding of PPARA 22 0.41 10.76 2.72 5.00
59 INT219180 Gene_expression of TLR7 13 0.68 9.51 2.21 5.00
60 INT35058 Positive_regulation of PLAUR 11 0.61 7.21 2.16 5.00
61 INT101912 Regulation of TIMP2 8 0.44 5.55 2 5.00
62 INT110925 Positive_regulation of Positive_regulation of JUN 14 0.49 6.22 1.98 5.00
63 INT71644 Gene_expression of MLANA 16 0.75 11.55 1.82 5.00
64 INT79691 Regulation of Gene_expression of PPARG 10 0.50 10.44 1.62 5.00
65 INT79690 Negative_regulation of Gene_expression of PPARG 10 0.59 10.48 1.55 5.00
66 INT119048 Negative_regulation of Gene_expression of HIF1A 10 0.57 9.23 1.5 5.00
67 INT68652 Regulation of Positive_regulation of JUN 4 0.54 4.95 1.26 5.00
68 INT153757 Positive_regulation of Mitf 10 0.46 8.38 1.22 5.00
69 INT79689 Regulation of PPARG 10 0.62 8.04 1.07 5.00
70 INT107714 Localization of PPARG 4 0.73 0.88 0.91 5.00
71 INT114017 Gene_expression of CD200 10 0.75 2.38 0.88 5.00
72 INT109133 Gene_expression of VCAN 52 0.75 53.11 0.84 5.00
73 INT105330 Gene_expression of CDK2 31 0.63 13.7 0.67 5.00
74 INT274725 Regulation of TBL1XR1 5 0.11 2.08 0.64 5.00
75 INT44478 Negative_regulation of PTEN 32 0.57 27.45 0.63 5.00
76 INT106004 Positive_regulation of Gene_expression of PLAUR 9 0.67 5.96 0.56 5.00
77 INT114018 Binding of CD200 5 0.47 2.12 0.52 5.00
78 INT245223 Negative_regulation of Gene_expression of TLR7 3 0.37 2.81 0.5 5.00
79 INT210 Positive_regulation of Sln 10 0.43 4.06 0.49 5.00
80 INT97446 Localization of Mki67 9 0.46 3.74 0.46 5.00
81 INT197765 Gene_expression of Sln 26 0.58 12.11 0.45 5.00
82 INT274724 Positive_regulation of TBL1XR1 5 0.12 2.74 0.45 5.00
83 INT113564 Regulation of PLAUR 3 0.48 5.15 0.41 5.00
84 INT97450 Gene_expression of Mitf 36 0.75 17.22 0.39 5.00
85 INT143442 Positive_regulation of NRP1 11 0.57 2.62 0.3 5.00
86 INT197766 Binding of Sln 5 0.32 1.6 0.25 5.00
87 INT124944 Regulation of KIT 15 0.60 11.84 0.24 5.00
88 INT131612 Negative_regulation of Mitf 3 0.56 3.91 0.23 5.00
89 INT186628 Gene_expression of DCT 5 0.46 3.79 0.21 5.00
90 INT173956 Negative_regulation of Gene_expression of CTLA4 3 0.37 0.91 0.2 5.00
91 INT242851 Transcription of TGFBI 2 0.43 1.67 0.18 5.00
92 INT180885 Positive_regulation of Gene_expression of VCAN 10 0.35 12.52 0.18 5.00
93 INT97451 Negative_regulation of Gene_expression of Mitf 3 0.41 0.88 0.17 5.00
94 INT290471 Positive_regulation of Transcription of ECM1 1 0.04 1.56 0.12 5.00
95 INT290472 Positive_regulation of Transcription of TGFBI 1 0.12 1.56 0.12 5.00
96 INT290469 Transcription of ECM1 1 0.04 1.55 0.12 5.00
97 INT213771 Positive_regulation of Gene_expression of Mitf 4 0.48 2.01 0.12 5.00
98 INT213766 Regulation of Mitf 6 0.44 3.18 0.1 5.00
99 INT97449 Transcription of Mitf 4 0.69 4.28 0.09 5.00
100 INT168708 Negative_regulation of MLANA 2 0.41 1.42 0.08 5.00
101 INT223605 Negative_regulation of ARAF 5 0.05 3.87 0.05 5.00
102 INT290459 Regulation of Transcription of Mitf 1 0.44 0.2 0 5.00
103 INT290467 Gene_expression of GPR143 1 0.21 0.32 0 5.00
104 INT290465 Regulation of GPR143 1 0.19 0.58 0 5.00
105 INT290473 Positive_regulation of Regulation of PLAUR 1 0.24 1.71 0 5.00
106 INT290461 Regulation of Gene_expression of Mitf 3 0.59 3.13 0 5.00
107 INT351033 Regulation of SNRPE 1 0.12 0.81 0 5.00
108 INT290466 Regulation of Transcription of MLANA 1 0.24 0.2 0 5.00
109 INT290463 Regulation of MLANA 1 0.15 0.58 0 5.00
110 INT290464 Transcription of POU3F2 1 0.64 1.08 0 5.00
111 INT224345 Gene_expression of NUDT1 4 0.17 4.46 0 5.00
112 INT290460 Protein_catabolism of Mitf 1 0.63 0.39 0 5.00
113 INT290470 Gene_expression of POU3F2 1 0.69 0.4 0 5.00
114 INT290075 Regulation of RAB27A 2 0.44 1.31 0 5.00
115 INT290468 Transcription of MLANA 1 0.37 0.2 0 5.00
116 INT278055 Negative_regulation of AGK 2 0.01 2.1 0 5.00
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