D:Plexiform Neurofibroma

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pChart

Disease Term
Synonyms Elephantiasis Neuromatoses, ELEPHANTIASIS NEUROMATOSIS, NEUROFIBROMAS PLEXIFORM, NEUROMA PLEXIFORM, NEUROMAS PLEXIFORM, PACHYDERMATOCELE, Pachydermatoceles, Plexiform Neurofibromas, Plexiform Neuroma, Plexiform Neuromas, Tumor Royale
Documents 53
Hot Single Events 8
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Plexiform Neurofibroma. They are ordered first by their relevance to Plexiform Neurofibroma and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT103197 Nf1 Negative_regulation of ras 1 0.04 1.19 0.17 85.24
2 INT103198 NF1 Negative_regulation of ras 1 0.05 1.19 0.16 84.52
3 INT333398 CFD Negative_regulation of Gene_expression of Pdgfa 1 0.02 0.64 0.3 5.00
4 INT333394 CFD Negative_regulation of Gene_expression of Cat 1 0.03 0.79 0.22 5.00
5 INT333397 CFD Negative_regulation of Gene_expression of Nos2 1 0.04 0.8 0.22 5.00
6 INT333393 CFD Positive_regulation of Gene_expression of Timp1 1 0.07 0.82 0.16 5.00
7 INT333396 CFD Positive_regulation of Bcl2l1 1 0.05 0.98 0.13 5.00
8 INT333395 Binding of CFD and Aes 1 0.03 0.24 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Plexiform Neurofibroma. They are ordered first by their pain relevance and then by number of times they were reported in Plexiform Neurofibroma. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT64700 Binding of Nf1 14 0.45 15.24 2.29 99.10
2 INT155285 Positive_regulation of Nf1 1 0.16 0.55 0.17 98.96
3 INT18362 Positive_regulation of KIAA0101 3 0.49 2.04 1.04 92.12
4 INT103196 Negative_regulation of Gene_expression of Nf1 1 0.57 1.21 0.16 90.64
5 INT49650 Gene_expression of Nf1 4 0.76 3.38 0.67 90.32
6 INT21687 Positive_regulation of ras 143 0.58 97.34 27.31 87.84
7 INT61993 Gene_expression of NF1 29 0.78 34.47 1.23 84.88
8 INT84510 Positive_regulation of Nf1 8 0.69 9.52 1.93 83.08
9 INT61991 Negative_regulation of Gene_expression of NF1 1 0.59 1.67 0.08 75.56
10 INT61992 Positive_regulation of Gene_expression of NF1 3 0.50 4.47 0.51 73.64
11 INT68179 Gene_expression of Nf1 9 0.78 8.87 0.68 70.76
12 INT66367 Gene_expression of Gsk3b 16 0.45 9.75 3.07 67.68
13 INT61434 Regulation of Nf1 3 0.26 1.39 2.4 67.04
14 INT112334 Regulation of NF1 18 0.52 15.85 0.34 62.24
15 INT68216 Binding of NF1 40 0.48 51.24 4.59 58.88
16 INT131645 Negative_regulation of Nf1 10 0.58 8.12 1.24 51.88
17 INT28320 Negative_regulation of Abo 16 0.58 5.69 4.7 50.00
18 INT78248 Negative_regulation of Cdkn2a 17 0.59 15.15 2.8 45.68
19 INT134661 Negative_regulation of Tp53 11 0.43 10.91 1.13 45.68
20 INT25123 Negative_regulation of COL7A1 42 0.58 19.98 5.96 39.04
21 INT145302 Positive_regulation of Sox9 2 0.48 1.42 0.03 28.60
22 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 9.12
23 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
24 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
25 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
26 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
27 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
28 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 5.00
29 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 5.00
30 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
31 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 5.00
32 INT55344 Gene_expression of Ros1 396 0.54 217.64 59.98 5.00
33 INT53577 Negative_regulation of Localization of TNF 110 0.59 59.28 35.23 5.00
34 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03 5.00
35 INT74682 Positive_regulation of Mmp2 72 0.69 40.46 21.73 5.00
36 INT72060 Positive_regulation of Gene_expression of Ros1 127 0.41 76.76 20.91 5.00
37 INT19929 Negative_regulation of Positive_regulation of TNF 52 0.59 38.16 16.51 5.00
38 INT12950 Gene_expression of Cat 85 0.75 35.94 15.76 5.00
39 INT96775 Gene_expression of Pdgfa 42 0.54 29.78 15.46 5.00
40 INT55740 Gene_expression of Timp1 53 0.75 28.63 13.85 5.00
41 INT6478 Negative_regulation of Binding of TNF 36 0.58 30.42 13.31 5.00
42 INT48956 Negative_regulation of Positive_regulation of Nos2 34 0.46 13.15 11.15 5.00
43 INT167964 Gene_expression of Aes 30 0.58 25.41 10.16 5.00
44 INT101105 Positive_regulation of FUT1 62 0.30 55.96 9.28 5.00
45 INT72337 Positive_regulation of Positive_regulation of Nos2 37 0.65 17.02 8.11 5.00
46 INT52180 Binding of Aes 38 0.42 23.16 6.7 5.00
47 INT96778 Positive_regulation of Pdgfa 22 0.46 12.7 5.31 5.00
48 INT69215 Gene_expression of Col1a1 38 0.68 17.39 4.77 5.00
49 INT170854 Gene_expression of CFD 26 0.68 39.77 4.74 5.00
50 INT88278 Binding of Kit 33 0.37 24.45 4.13 5.00
51 INT55741 Negative_regulation of Timp1 15 0.51 8.12 4.09 5.00
52 INT15724 Negative_regulation of Fn1 15 0.53 5.61 3.87 5.00
53 INT37590 Regulation of COL7A1 15 0.54 9.4 3.12 5.00
54 INT146793 Positive_regulation of Tp53 30 0.70 32.93 1.94 5.00
55 INT153201 Negative_regulation of Gene_expression of Col1a1 7 0.38 6.37 1.52 5.00
56 INT120004 Transcription of Tp53 8 0.72 4.92 1.48 5.00
57 INT147788 Regulation of FUT1 11 0.12 7.72 1.44 5.00
58 INT170853 Positive_regulation of Gene_expression of CFD 7 0.23 9.89 1.41 5.00
59 INT125980 Binding of CFD 8 0.42 10.96 1.39 5.00
60 INT159775 Negative_regulation of Gene_expression of Timp1 9 0.37 4.36 1.08 5.00
61 INT127459 Negative_regulation of PAH 18 0.56 15.15 1.05 5.00
62 INT126030 Regulation of CFD 4 0.21 3.92 0.83 5.00
63 INT248227 Protein_catabolism of CFD 4 0.46 2.48 0.77 5.00
64 INT303885 Negative_regulation of Serpinh1 5 0.05 1.68 0.7 5.00
65 INT302664 Positive_regulation of SMAD2 2 0.49 0.85 0.64 5.00
66 INT224442 Negative_regulation of Gene_expression of Pdgfa 2 0.30 2.48 0.5 5.00
67 INT279571 Regulation of Gene_expression of CFD 2 0.21 2.86 0.31 5.00
68 INT6702 Binding of GLUL 3 0.21 2.04 0.28 5.00
69 INT333364 Negative_regulation of Positive_regulation of Pdgfa 1 0.03 0.99 0.22 5.00
70 INT185412 Negative_regulation of CFD 5 0.27 3.49 0.2 5.00
71 INT333390 Positive_regulation of Col4a1 1 0.04 1.19 0.17 5.00
72 INT279586 Negative_regulation of Gene_expression of CFD 3 0.20 3.99 0.16 5.00
73 INT258190 Negative_regulation of Binding of Aes 2 0.37 0.47 0.14 5.00
74 INT333385 Negative_regulation of Binding of CFD 1 0.20 0.26 0 5.00
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