D:Pneumococcal Meningitis

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Disease Term
Synonyms EXPERIMENTAL PNEUMOCOCCAL MENINGITIDES, Experimental Pneumococcal Meningitis, Meningitides Streptococcus Pneumoniae, Meningitis Experimental Pneumococcal, Meningitis Pneumococcal Experimental, Meningitis Pneumococcal Penicillin Resistant, Meningitis Pneumococcal Recurrent, Meningitis Streptococcus Pneumoniae, PNEUMOCOCCAL MENINGITIDES, Pneumococcal Meningitides Experimental, Pneumococcal Meningitis Experimental
Documents 55
Hot Single Events 20
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Pneumococcal Meningitis. They are ordered first by their relevance to Pneumococcal Meningitis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT325530 Positive_regulation of Gsk3b Negative_regulation of Gene_expression of Wnt2 1 0.03 0.63 0.28 81.40
2 INT269962 Bcl2 Negative_regulation of Bcl2l11 1 0.15 2.14 0.34 40.08
3 INT325529 Binding of Stat3 and Ep300 1 0.01 0.22 0.19 26.48
4 INT325531 Positive_regulation of Binding of Stat3 and Ep300 1 0.02 0.22 0.19 26.48
5 INT325532 Binding of Cx3cl1 and Cxcl10 1 0.28 0.67 0.16 25.88
6 INT314536 Positive_regulation of Ptger2 Positive_regulation of Gene_expression of Il10 1 0.02 0.83 0.04 20.56
7 INT314539 Ptger2 Positive_regulation of Gene_expression of Il10 1 0.04 0.83 0.04 20.56
8 INT314538 Il10 Negative_regulation of Gene_expression of Ptger2 1 0.02 0.65 0.04 10.24
9 INT204893 Regulation of Tlr4 Positive_regulation of gr 1 0.11 0.9 0.38 5.00
10 INT204905 Tlr4 Positive_regulation of gr 1 0.18 0.9 0.38 5.00
11 INT311872 IGHE Positive_regulation of Localization of Mmp9 1 0.01 1.35 0.22 5.00
12 INT314534 Ptger2 Regulation of Gene_expression of Itgam 1 0.02 1 0.17 5.00
13 INT220305 Binding of IL6 and IL10 1 0.00 0.51 0.14 5.00
14 INT311871 Cav1 Regulation of Mch 1 0.01 0.24 0.11 5.00
15 INT204883 gr Negative_regulation of Lcn2 1 0.07 0.15 0.11 5.00
16 INT204888 Binding of Cp and Tlr4 1 0.29 0.49 0.11 5.00
17 INT204882 gr Negative_regulation of Saa3 1 0.07 0.15 0.11 5.00
18 INT204878 Gem Positive_regulation of Tlr4 1 0.20 0.1 0.1 5.00
19 INT284552 Binding of Cd8a and Mthfd1 2 0.03 1.32 0.1 5.00
20 INT204901 Tnfsf9 Positive_regulation of Tlr4 1 0.27 0.1 0.1 5.00
21 INT204877 gr Negative_regulation of Serpina3n 1 0.23 0.15 0.1 5.00
22 INT204890 Cd83 Positive_regulation of Tlr4 1 0.25 0.1 0.1 5.00
23 INT204897 Tlr4 Positive_regulation of Il1b 1 0.21 0.09 0.09 5.00
24 INT204898 Negative_regulation of Tlr4 Negative_regulation of Ch25h 1 0.21 0.09 0.09 5.00
25 INT204886 Tlr4 Negative_regulation of Negative_regulation of C1qa 1 0.21 0.09 0.09 5.00
26 INT204894 Tlr4 Positive_regulation of Ch25h 1 0.23 0.09 0.09 5.00
27 INT204899 Tlr4 Positive_regulation of Cd44 1 0.23 0.09 0.09 5.00
28 INT204892 Tlr4 Positive_regulation of C1qa 1 0.23 0.09 0.09 5.00
29 INT204904 Tlr4 Positive_regulation of Hexb 1 0.14 0.09 0.09 5.00
30 INT204885 Tlr4 Negative_regulation of Positive_regulation of Cd44 1 0.21 0.09 0.09 5.00
31 INT204884 Tlr4 Negative_regulation of Negative_regulation of Hexb 1 0.13 0.09 0.09 5.00
32 INT204902 Negative_regulation of Tlr4 Positive_regulation of Stat1 1 0.23 0.09 0.09 5.00
33 INT204879 Tlr4 Positive_regulation of Stat1 1 0.25 0.09 0.09 5.00
34 INT204895 Tlr4 Positive_regulation of Gene_expression of Cp 1 0.38 0.47 0.09 5.00
35 INT204889 Tlr4 Negative_regulation of Cd44 1 0.10 0.09 0.09 5.00
36 INT204880 Tlr4 Positive_regulation of Cp 1 0.56 0.63 0.07 5.00
37 INT204896 Tlr4 Negative_regulation of Ch25h 1 0.21 0.09 0.07 5.00
38 INT204891 Tlr4 Negative_regulation of Stat1 1 0.10 0.09 0.07 5.00
39 INT204903 Gopc Positive_regulation of Gene_expression of Cp 1 0.16 0.26 0.05 5.00
40 INT204906 Tlr4 Negative_regulation of Hexb 1 0.13 0.09 0.04 5.00
41 INT204900 Tlr4 Negative_regulation of Il1b 1 0.19 0.09 0.04 5.00
42 INT204887 Tlr4 Negative_regulation of C1qa 1 0.21 0.09 0.04 5.00
43 INT311870 Positive_regulation of Binding of Cd8a and Mthfd1 1 0.00 0.32 0.03 5.00
44 INT314537 Il10 Positive_regulation of Gene_expression of Itgam 1 0.21 1.23 0 5.00
45 INT314535 Il10 Negative_regulation of Gene_expression of Gopc 1 0.05 0.23 0 5.00
46 INT311816 CD79A Positive_regulation of RAB27A 1 0.01 0.47 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Pneumococcal Meningitis. They are ordered first by their pain relevance and then by number of times they were reported in Pneumococcal Meningitis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT122301 Positive_regulation of Map2 5 0.44 1.38 0.92 98.70
2 INT325496 Positive_regulation of Dpysl3 1 0.02 0.39 0.04 98.70
3 INT25608 Regulation of Gene_expression of Il1 37 0.44 27.76 10.1 97.84
4 INT11439 Positive_regulation of Csf2 105 0.69 62.63 37.77 97.36
5 INT71764 Positive_regulation of Mri1 24 0.44 12.31 5.67 97.36
6 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 97.04
7 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 96.70
8 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 95.52
9 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 95.52
10 INT124375 Gene_expression of Wnt2 67 0.56 38.03 4.67 94.12
11 INT124373 Positive_regulation of Gene_expression of Wnt2 14 0.42 8.28 0.6 94.12
12 INT188047 Positive_regulation of Wnt2 51 0.58 31.41 2.94 93.08
13 INT76884 Positive_regulation of Cp 22 0.69 12.84 4.6 92.20
14 INT205511 Gene_expression of ST5 2 0.65 1.4 0.09 87.72
15 INT6150 Positive_regulation of Negative_regulation of Calca 20 0.68 4.06 16.26 84.88
16 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38 84.52
17 INT99391 Localization of Ctnnb1 7 0.80 5.84 1.61 83.04
18 INT325506 Positive_regulation of Localization of Ctnnb1 1 0.05 0.28 0.17 83.04
19 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 82.32
20 INT66366 Positive_regulation of Gsk3b 15 0.68 6.56 4.27 80.36
21 INT97596 Localization of S100a8 94 0.78 90.69 40.41 78.72
22 INT70145 Gene_expression of Trav6-3 136 0.76 69.6 18.05 78.40
23 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 69.96
24 INT123990 Positive_regulation of Ctnnb1 8 0.43 2.85 1.63 69.04
25 INT99390 Regulation of Ctnnb1 4 0.62 3.12 0.64 69.04
26 INT325497 Negative_regulation of Gene_expression of Id1 1 0.19 0.48 0 65.12
27 INT311844 Negative_regulation of Irak4 1 0.29 2.88 0.72 64.72
28 INT77310 Gene_expression of Aif1 89 0.78 50.49 33.68 64.48
29 INT268392 Regulation of Positive_regulation of Wnt2 2 0.09 0.87 0.18 63.68
30 INT135749 Gene_expression of Id1 3 0.58 0.57 0.49 62.48
31 INT9695 Negative_regulation of Csf2 41 0.57 31.65 6.28 61.44
32 INT22939 Gene_expression of Csf2 164 0.78 85.1 32.22 59.52
33 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 50.00
34 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92 50.00
35 INT58852 Positive_regulation of Enc1 20 0.49 7.51 13.25 50.00
36 INT174844 Binding of Fig4 81 0.41 18.03 12.87 50.00
37 INT9945 Negative_regulation of Csf2 35 0.51 17.85 11.22 50.00
38 INT83817 Regulation of Enc1 5 0.14 2.37 2.04 50.00
39 INT142780 Negative_regulation of Positive_regulation of Csf2 3 0.35 1.48 0.6 50.00
40 INT225131 Negative_regulation of Binding of Fig4 5 0.19 1.43 0.08 50.00
41 INT14838 Regulation of Cnp 2 0.27 1.39 0.76 49.04
42 INT325502 Regulation of Transcription of Cnp 1 0.08 0.33 0.17 49.04
43 INT325504 Transcription of Cnp 1 0.13 0.33 0.17 47.84
44 INT235742 Regulation of Smad4 1 0.04 1.66 0.06 45.04
45 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 44.16
46 INT25610 Positive_regulation of Gene_expression of Il1 136 0.67 104.43 43.86 44.16
47 INT188050 Regulation of Gene_expression of Wnt2 9 0.37 3.13 0.44 41.60
48 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 41.32
49 INT75684 Regulation of Aif1 32 0.47 8.03 7.89 38.28
50 INT62002 Regulation of Cd68 6 0.35 7.89 0.86 38.28
51 INT205721 Regulation of Regulation of Mmp3 2 0.27 0.66 0.66 38.28
52 INT325495 Regulation of Regulation of Cxcl10 1 0.23 0.66 0.16 38.28
53 INT325511 Regulation of Meta 1 0.44 0.47 0.12 38.28
54 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 37.20
55 INT111718 Localization of Cd68 6 0.70 2.84 0.64 36.20
56 INT77311 Localization of Aif1 10 0.75 4.21 1.5 35.84
57 INT546 Binding of ALB 311 0.48 85.98 60.14 35.44
58 INT172689 Localization of Mmp3 15 0.68 5.52 3.32 35.36
59 INT185487 Localization of Cxcl10 6 0.61 3.21 3.21 35.36
60 INT278927 Localization of Meta 3 0.78 1.66 0.71 35.36
61 INT228130 Positive_regulation of Bcl2l11 14 0.49 10 0.9 34.48
62 INT138157 Regulation of Mmp3 12 0.54 6.12 5.36 33.36
63 INT222225 Regulation of Cxcl10 4 0.23 2.59 2.19 32.92
64 INT77306 Negative_regulation of Gene_expression of Bcl2 46 0.58 38.05 7.71 31.36
65 INT121161 Localization of Cx3cl1 14 0.75 10.07 10.61 29.12
66 INT325490 Positive_regulation of Ep300 1 0.03 0.22 0.19 26.48
67 INT185482 Binding of Cxcl10 5 0.30 3.76 3.13 25.88
68 INT179341 Binding of Stat3 3 0.23 0.95 0.27 24.40
69 INT204293 Protein_catabolism of Bid 9 0.65 6.07 0.45 22.08
70 INT325491 Positive_regulation of Localization of Mmp3 1 0.12 0.67 0.16 21.04
71 INT93718 Protein_catabolism of Mmp3 9 0.73 4.32 2.11 20.60
72 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 20.56
73 INT325499 Binding of Smad1 1 0.15 0.55 0.46 18.96
74 INT278734 Phosphorylation of Smad1 5 0.34 1.48 0.3 17.92
75 INT47075 Positive_regulation of Ptger2 142 0.70 78.55 25.47 16.24
76 INT95427 Positive_regulation of Mmp3 39 0.70 15.28 13.36 14.20
77 INT108780 Positive_regulation of Gene_expression of Ptger2 94 0.49 59.71 16.22 10.88
78 INT39565 Gene_expression of Ptger2 424 0.75 229.28 72.68 10.24
79 INT325492 Regulation of Ep300 1 0.04 0.29 0.24 9.44
80 INT97394 Regulation of Stat3 6 0.41 2.52 1.34 8.72
81 INT311862 Negative_regulation of Protein_catabolism of MCS 1 0.05 0.27 0.36 8.20
82 INT70619 Regulation of Bmp2 6 0.60 3.1 1.29 8.16
83 INT230879 Protein_catabolism of MCS 2 0.44 0.94 0.47 7.80
84 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
85 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 5.00
86 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 5.00
87 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
88 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
89 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
90 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
91 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
92 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
93 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
94 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
95 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 5.00
96 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
97 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
98 INT47243 Gene_expression of Prkcg 195 0.78 58.05 108.44 5.00
99 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
100 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
101 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
102 INT10166 Localization of Tnf 237 0.81 153.95 88.64 5.00
103 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35 5.00
104 INT48244 Gene_expression of Il4 172 0.76 132.38 73.42 5.00
105 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54 5.00
106 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
107 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
108 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 5.00
109 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
110 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
111 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
112 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
113 INT5770 Binding of Rbm39 88 0.41 13.23 55.5 5.00
114 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 5.00
115 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
116 INT12345 Gene_expression of Il2 142 0.78 59.17 51.21 5.00
117 INT19775 Localization of Il1 183 0.78 145.5 50.91 5.00
118 INT20345 Gene_expression of Dbi 136 0.78 56.41 46.2 5.00
119 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 5.00
120 INT60695 Positive_regulation of Gene_expression of Il10 154 0.70 120.28 43.07 5.00
121 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02 5.00
122 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 5.00
123 INT48075 Positive_regulation of Il1b 71 0.67 48.63 40.48 5.00
124 INT173693 Localization of Gopc 249 0.65 70.49 38.81 5.00
125 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
126 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2 5.00
127 INT20380 Gene_expression of Il5 172 0.78 104.75 34.78 5.00
128 INT81289 Positive_regulation of Gene_expression of Tlr4 192 0.69 104.5 33.89 5.00
129 INT51698 Positive_regulation of Gene_expression of Prkcg 44 0.68 14.02 32.9 5.00
130 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 5.00
131 INT56809 Binding of Tlr4 184 0.48 106.02 31.18 5.00
132 INT77652 Negative_regulation of Gene_expression of IL8 99 0.59 67.57 30.21 5.00
133 INT90792 Localization of Il10 144 0.80 87.88 30.03 5.00
134 INT15174 Gene_expression of Itgam 238 0.73 104.92 29.26 5.00
135 INT2532 Negative_regulation of Cebpz 98 0.00 53.06 28.57 5.00
136 INT66200 Gene_expression of Gfap 215 0.78 88.04 28.25 5.00
137 INT5206 Gene_expression of AR 316 0.78 113.83 27.29 5.00
138 INT21900 Gene_expression of Mthfd1 150 0.75 69.47 27.03 5.00
139 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 5.00
140 INT13995 Gene_expression of gr 96 0.74 48.21 26.54 5.00
141 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53 5.00
142 INT172458 Regulation of Gopc 155 0.53 62.57 24.86 5.00
143 INT49141 Gene_expression of Selp 157 0.78 85.22 24.78 5.00
144 INT55583 Localization of IFNA1 135 0.78 85.07 24.13 5.00
145 INT5988 Localization of Dbi 74 0.81 17.52 24.09 5.00
146 INT4809 Gene_expression of PTGDS 103 0.76 52.94 24.01 5.00
147 INT8775 Binding of IGHE 167 0.48 102.61 23.54 5.00
148 INT74423 Localization of IL10 91 0.80 61.6 22.95 5.00
149 INT48081 Localization of Il1b 46 0.80 21.59 22.4 5.00
150 INT142594 Gene_expression of Tlr2 165 0.78 139.73 22.26 5.00
151 INT78057 Localization of Tlr4 140 0.77 67.75 21.72 5.00
152 INT14700 Regulation of IFNA1 111 0.45 66.16 21.52 5.00
153 INT7535 Negative_regulation of Tlr4 111 0.56 56.84 21.37 5.00
154 INT89805 Gene_expression of Prkaca 45 0.77 11.03 20.77 5.00
155 INT109650 Gene_expression of Aqp4 87 0.78 51.52 20.72 5.00
156 INT20379 Localization of Il4 85 0.73 51.22 20.55 5.00
157 INT7561 Positive_regulation of gr 70 0.57 31.92 20.22 5.00
158 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 5.00
159 INT12725 Positive_regulation of Racgap1 66 0.68 32.74 19.29 5.00
160 INT73252 Positive_regulation of Mthfd1 124 0.59 59.48 18.35 5.00
161 INT132997 Localization of Mmp9 59 0.80 45.9 17.61 5.00
162 INT134298 Gene_expression of Ptges2 96 0.54 56.52 17.19 5.00
163 INT110767 Localization of Mcpt1 43 0.68 24.3 16.74 5.00
164 INT9220 Gene_expression of Ighg1 125 0.77 85.74 15.92 5.00
165 INT68913 Gene_expression of Cd14 55 0.76 38.99 15.67 5.00
166 INT43906 Regulation of Tlr4 71 0.53 35.18 15.49 5.00
167 INT85964 Gene_expression of Pecam1 109 0.78 69.73 15.21 5.00
168 INT67641 Negative_regulation of Gene_expression of Tlr4 90 0.58 46 14.6 5.00
169 INT11762 Regulation of Dbi 40 0.62 7.83 14.48 5.00
170 INT70265 Regulation of MRI1 42 0.39 30.95 14.18 5.00
171 INT104674 Positive_regulation of F2rl1 35 0.65 27.76 14.16 5.00
172 INT142593 Positive_regulation of Tlr2 85 0.70 75.9 13.62 5.00
173 INT18720 Localization of Csf2 72 0.67 13.65 13.41 5.00
174 INT144646 Positive_regulation of Rela 53 0.67 27.78 13.2 5.00
175 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 5.00
176 INT137614 Gene_expression of Lgals3 70 0.77 66.13 12.53 5.00
177 INT14510 Gene_expression of SOD1 208 0.76 88.56 12.4 5.00
178 INT49509 Negative_regulation of Ptger2 53 0.42 24.87 11.66 5.00
179 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63 5.00
180 INT80756 Gene_expression of CD86 77 0.77 46.68 11.36 5.00
181 INT79835 Regulation of Il10 28 0.61 21.22 11.29 5.00
182 INT53201 Negative_regulation of gr 35 0.50 17.76 10.62 5.00
183 INT701 Localization of IGHE 87 0.80 40.5 10.62 5.00
184 INT71769 Negative_regulation of Gene_expression of Il10 40 0.57 22.53 10.37 5.00
185 INT58449 Binding of Mthfd1 47 0.47 22.02 10.29 5.00
186 INT96319 Negative_regulation of Gene_expression of gr 16 0.56 12.82 9.4 5.00
187 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 5.00
188 INT5512 Negative_regulation of Dbi 32 0.36 7.33 9.1 5.00
189 INT35366 Binding of AR 87 0.47 30.52 8.9 5.00
190 INT20205 Binding of IgG 108 0.46 66.68 8.57 5.00
191 INT148703 Gene_expression of NOVA2 73 0.65 18.05 8.3 5.00
192 INT77249 Positive_regulation of Gene_expression of gr 24 0.67 16.09 8.17 5.00
193 INT25387 Binding of Ptger2 42 0.47 16 7.98 5.00
194 INT93914 Gene_expression of CD80 70 0.75 36.35 7.74 5.00
195 INT64816 Transcription of Jun 31 0.69 16.01 7.64 5.00
196 INT18524 Regulation of Gene_expression of IFNA1 37 0.44 18.79 7.62 5.00
197 INT52937 Gene_expression of Cd68 37 0.67 31.33 7.54 5.00
198 INT1952 Negative_regulation of Positive_regulation of Tlr4 33 0.51 15.8 7.41 5.00
199 INT138922 Positive_regulation of Stat1 57 0.69 28.35 7.2 5.00
200 INT14637 Negative_regulation of MBP 19 0.43 7.06 7.18 5.00
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