D:Pneumoconiosis

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Disease Term
Synonyms Bagassosis, Black Lung Disease, Coal Workers Pneumoconioses, COAL WORKERS PNEUMOCONIOSIS, PNEUMOCONIOSES, Pneumoconioses Coal Workers, Pneumoconiosis Coal Workers
Documents 41
Hot Single Events 5
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Pneumoconiosis. They are ordered first by their relevance to Pneumoconiosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT230437 Binding of PDX1 and HRCT1 1 0.04 2.45 0.43 77.56
2 INT302421 IFNA1 Positive_regulation of Cxcl10 1 0.02 1.8 0.45 5.00
3 INT302422 IFNA1 Positive_regulation of Cxcl9 1 0.03 1.81 0.45 5.00
4 INT302423 Etohi5 Positive_regulation of IFNA1 1 0.00 1.77 0.44 5.00
5 INT230438 Binding of PDX1 and HAUS7 1 0.02 2.29 0.35 5.00
6 INT333398 CFD Negative_regulation of Gene_expression of Pdgfa 1 0.02 0.64 0.3 5.00
7 INT202422 IL8 Positive_regulation of Localization of ELANE 1 0.02 0.91 0.24 5.00
8 INT333394 CFD Negative_regulation of Gene_expression of Cat 1 0.03 0.79 0.22 5.00
9 INT333397 CFD Negative_regulation of Gene_expression of Nos2 1 0.04 0.8 0.22 5.00
10 INT269994 Binding of Nfkb2 and Tpx2 1 0.04 0.51 0.21 5.00
11 INT269995 Positive_regulation of Binding of Nfkb2 and Tpx2 1 0.05 0.51 0.21 5.00
12 INT333393 CFD Positive_regulation of Gene_expression of Timp1 1 0.07 0.82 0.16 5.00
13 INT333396 CFD Positive_regulation of Bcl2l1 1 0.05 0.98 0.13 5.00
14 INT310727 Binding of DKC1 and TERT 1 0.23 0.91 0.05 5.00
15 INT227072 Binding of LTF and PTPRC 1 0.00 0.51 0.04 5.00
16 INT311144 CAT Positive_regulation of APRT 1 0.01 0 0.03 5.00
17 INT311145 CAT Positive_regulation of Protein_catabolism of APRT 1 0.01 0 0 5.00
18 INT333395 Binding of CFD and Aes 1 0.03 0.24 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Pneumoconiosis. They are ordered first by their pain relevance and then by number of times they were reported in Pneumoconiosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT72060 Positive_regulation of Gene_expression of Ros1 127 0.41 76.76 20.91 90.56
2 INT55344 Gene_expression of Ros1 396 0.54 217.64 59.98 90.16
3 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 88.12
4 INT147607 Binding of TERT 16 0.48 12.36 1.31 83.00
5 INT171060 Gene_expression of PDX1 72 0.75 72.57 17.97 82.48
6 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71 79.72
7 INT69436 Negative_regulation of Gene_expression of ROS1 81 0.38 46.58 12.22 79.72
8 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 79.12
9 INT311146 Protein_catabolism of APRT 1 0.01 0.39 0.2 78.08
10 INT311147 Positive_regulation of Protein_catabolism of APRT 1 0.01 0.07 0 73.36
11 INT249469 Gene_expression of BMF 1 0.54 1.53 0 70.24
12 INT170854 Gene_expression of CFD 26 0.68 39.77 4.74 59.24
13 INT249471 Binding of BMF 1 0.30 1.3 0 58.00
14 INT15801 Positive_regulation of TFRC 11 0.33 6.35 3.3 57.12
15 INT83332 Regulation of Gene_expression of TFRC 5 0.22 3.03 1.99 51.56
16 INT303885 Negative_regulation of Serpinh1 5 0.05 1.68 0.7 51.28
17 INT15805 Gene_expression of TFRC 35 0.75 17.44 8.52 51.20
18 INT29393 Positive_regulation of APRT 18 0.67 5.28 2.13 50.40
19 INT15798 Positive_regulation of Gene_expression of TFRC 9 0.46 4.99 1.42 45.40
20 INT200072 Gene_expression of APRT 8 0.65 1 0.54 42.32
21 INT92941 Binding of ASAP1 24 0.39 12.38 1.25 35.80
22 INT60974 Gene_expression of Scgb1a1 34 0.71 7.48 0.9 24.08
23 INT187045 Regulation of Scgb1a1 6 0.46 1.42 0.3 16.04
24 INT96778 Positive_regulation of Pdgfa 22 0.46 12.7 5.31 14.44
25 INT44529 Positive_regulation of Pdgfb 11 0.43 7.98 1.36 13.16
26 INT269969 Binding of Scgb1a1 1 0.28 0.4 0.08 12.68
27 INT20856 Binding of APRT 2 0.36 0 0.34 8.84
28 INT6852 Localization of TNF 883 0.81 705.95 270.84 6.80
29 INT6481 Binding of TNF 624 0.48 510.2 214.82 6.80
30 INT53577 Negative_regulation of Localization of TNF 110 0.59 59.28 35.23 6.80
31 INT6478 Negative_regulation of Binding of TNF 36 0.58 30.42 13.31 6.80
32 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
33 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
34 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
35 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
36 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
37 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
38 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
39 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
40 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 5.00
41 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 5.00
42 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
43 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
44 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 5.00
45 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
46 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
47 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
48 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 5.00
49 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
50 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
51 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
52 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
53 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
54 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
55 INT6489 Positive_regulation of Gene_expression of Tnf 140 0.70 92.31 67.85 5.00
56 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05 5.00
57 INT1425 Gene_expression of Rbm39 143 0.58 51.32 65.44 5.00
58 INT11937 Localization of Il6 228 0.81 139.83 64.39 5.00
59 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 5.00
60 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 5.00
61 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
62 INT5770 Binding of Rbm39 88 0.41 13.23 55.5 5.00
63 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 5.00
64 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05 5.00
65 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 5.00
66 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2 5.00
67 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
68 INT2609 Localization of ELANE 111 0.81 50.22 26.63 5.00
69 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 5.00
70 INT72370 Gene_expression of Timp1 82 0.65 57.52 24.16 5.00
71 INT10835 Regulation of IL8 79 0.49 53.04 24.14 5.00
72 INT147792 Gene_expression of COPD 230 0.70 287.13 24.1 5.00
73 INT66758 Binding of Nfkb1 97 0.48 50.65 23.65 5.00
74 INT4465 Gene_expression of CEL 116 0.77 98.35 23.58 5.00
75 INT48081 Localization of Il1b 46 0.80 21.59 22.4 5.00
76 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23 5.00
77 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03 5.00
78 INT84732 Positive_regulation of Hand2 81 0.69 62.07 22 5.00
79 INT74682 Positive_regulation of Mmp2 72 0.69 40.46 21.73 5.00
80 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 5.00
81 INT14701 Negative_regulation of IFNA1 118 0.54 84.19 20.08 5.00
82 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 5.00
83 INT19509 Localization of Ifng 55 0.78 28.25 18.67 5.00
84 INT65260 Positive_regulation of Col7a1 95 0.69 61.73 18.42 5.00
85 INT19929 Negative_regulation of Positive_regulation of TNF 52 0.59 38.16 16.51 5.00
86 INT12950 Gene_expression of Cat 85 0.75 35.94 15.76 5.00
87 INT96775 Gene_expression of Pdgfa 42 0.54 29.78 15.46 5.00
88 INT55740 Gene_expression of Timp1 53 0.75 28.63 13.85 5.00
89 INT99780 Positive_regulation of Cxcl10 43 0.69 39.67 13.27 5.00
90 INT61624 Positive_regulation of Gene_expression of IL12A 50 0.56 33.07 13.07 5.00
91 INT36263 Positive_regulation of CEL 53 0.69 34.88 12.87 5.00
92 INT92686 Gene_expression of Ctgf 51 0.77 34.4 11.93 5.00
93 INT36287 Binding of CD4 96 0.47 58.93 11.88 5.00
94 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57 5.00
95 INT48956 Negative_regulation of Positive_regulation of Nos2 34 0.46 13.15 11.15 5.00
96 INT48203 Positive_regulation of Tgfb1 67 0.70 41.31 11.07 5.00
97 INT13240 Gene_expression of TF 94 0.76 57.81 10.99 5.00
98 INT94465 Positive_regulation of Gene_expression of Hand1 43 0.38 29.76 10.88 5.00
99 INT94784 Binding of ROS1 113 0.40 71.57 10.26 5.00
100 INT167964 Gene_expression of Aes 30 0.58 25.41 10.16 5.00
101 INT95565 Positive_regulation of IL12A 47 0.56 33.96 10.16 5.00
102 INT32344 Localization of LTF 30 0.80 15.28 10.09 5.00
103 INT57876 Positive_regulation of Egr1 46 0.70 25.6 9.41 5.00
104 INT140224 Localization of Ccl2 32 0.72 26.91 9.39 5.00
105 INT149138 Binding of PDX1 27 0.37 32.62 9.33 5.00
106 INT101105 Positive_regulation of FUT1 62 0.30 55.96 9.28 5.00
107 INT25381 Localization of Csf2 62 0.76 47.48 9.03 5.00
108 INT96068 Positive_regulation of Timp1 30 0.58 23.94 8.17 5.00
109 INT72337 Positive_regulation of Positive_regulation of Nos2 37 0.65 17.02 8.11 5.00
110 INT126478 Gene_expression of Cxcl12 78 0.77 58.69 8.01 5.00
111 INT104387 Positive_regulation of Cxcl9 24 0.67 22.26 7.87 5.00
112 INT121496 Gene_expression of TERT 107 0.78 45.6 7.42 5.00
113 INT58365 Gene_expression of LTF 51 0.78 44.14 7.25 5.00
114 INT138922 Positive_regulation of Stat1 57 0.69 28.35 7.2 5.00
115 INT76120 Gene_expression of Ptprc 102 0.59 30.42 7.02 5.00
116 INT17049 Localization of CD4 57 0.75 35.33 6.89 5.00
117 INT52180 Binding of Aes 38 0.42 23.16 6.7 5.00
118 INT65265 Positive_regulation of Gene_expression of Col7a1 48 0.69 23.81 6.16 5.00
119 INT126481 Gene_expression of Cxcr4 69 0.77 34.99 6 5.00
120 INT15132 Gene_expression of TNFRSF1A 33 0.75 20.09 5.93 5.00
121 INT52904 Positive_regulation of LTF 21 0.67 15.58 5.78 5.00
122 INT35536 Negative_regulation of CAT 26 0.57 14.39 5.38 5.00
123 INT6476 Gene_expression of TNFRSF1B 21 0.67 18.22 5.25 5.00
124 INT22597 Positive_regulation of TF 43 0.68 27.27 5.17 5.00
125 INT143234 Gene_expression of Nfkbia 10 0.62 5.2 5.02 5.00
126 INT161220 Binding of Ccl2 17 0.46 17.63 4.94 5.00
127 INT23245 Positive_regulation of Gene_expression of CEL 19 0.69 14.81 4.92 5.00
128 INT69215 Gene_expression of Col1a1 38 0.68 17.39 4.77 5.00
129 INT26069 Positive_regulation of Positive_regulation of IFNA1 26 0.50 16.61 4.76 5.00
130 INT153269 Binding of Ccl3 10 0.48 8.87 4.69 5.00
131 INT101594 Positive_regulation of Cd40 36 0.69 16.14 4.56 5.00
132 INT18995 Binding of CEL 23 0.47 14.46 4.5 5.00
133 INT55741 Negative_regulation of Timp1 15 0.51 8.12 4.09 5.00
134 INT156137 Gene_expression of Col1a2 28 0.73 13.3 3.99 5.00
135 INT138916 Transcription of Cxcl9 13 0.68 9.88 3.96 5.00
136 INT15724 Negative_regulation of Fn1 15 0.53 5.61 3.87 5.00
137 INT160409 Transcription of Cxcl10 9 0.65 7.95 3.53 5.00
138 INT28528 Gene_expression of MSMB 25 0.65 7.66 3.49 5.00
139 INT92681 Positive_regulation of Ctgf 13 0.69 9.78 3.47 5.00
140 INT133214 Regulation of PDX1 9 0.34 10.26 3.36 5.00
141 INT55002 Gene_expression of ASAP1 46 0.64 22.8 3.2 5.00
142 INT70885 Gene_expression of Pdgfb 48 0.67 42.27 3.19 5.00
143 INT132149 Positive_regulation of Gene_expression of LTF 10 0.70 11.5 3.14 5.00
144 INT66367 Gene_expression of Gsk3b 16 0.45 9.75 3.07 5.00
145 INT130603 Binding of Timp1 9 0.35 8.52 3.04 5.00
146 INT138141 Transcription of Mmp2 10 0.64 6.52 2.99 5.00
147 INT136388 Gene_expression of Cxcl5 13 0.75 21.45 2.98 5.00
148 INT41545 Negative_regulation of APRT 8 0.57 2.99 2.88 5.00
149 INT171058 Negative_regulation of PDX1 5 0.32 9.31 2.72 5.00
150 INT175685 Positive_regulation of Gene_expression of Timp1 11 0.57 8.18 2.58 5.00
151 INT133194 Negative_regulation of TERT 23 0.48 4.01 2.45 5.00
152 INT183468 Localization of TBK1 6 0.32 4.35 2.36 5.00
153 INT38118 Negative_regulation of Positive_regulation of IFNA1 8 0.43 3.95 2.04 5.00
154 INT46332 Binding of Mmp2 10 0.34 5.63 2 5.00
155 INT142461 Positive_regulation of Positive_regulation of Stat1 7 0.54 5.06 1.94 5.00
156 INT146793 Positive_regulation of Tp53 30 0.70 32.93 1.94 5.00
157 INT171059 Localization of PDX1 8 0.56 6.7 1.9 5.00
158 INT133269 Positive_regulation of PDX1 10 0.54 9.77 1.9 5.00
159 INT152155 Positive_regulation of Col1a2 7 0.56 10.18 1.89 5.00
160 INT45167 Positive_regulation of ASAP1 32 0.60 17.09 1.84 5.00
161 INT57875 Positive_regulation of Positive_regulation of Egr1 6 0.49 2.74 1.75 5.00
162 INT37978 Localization of Ripk2 4 0.78 0.57 1.73 5.00
163 INT64378 Gene_expression of DMRT1 9 0.54 1.72 1.71 5.00
164 INT166131 Positive_regulation of Positive_regulation of Col7a1 8 0.46 6.4 1.65 5.00
165 INT120071 Negative_regulation of Positive_regulation of Tgfb1 4 0.16 4.06 1.55 5.00
166 INT139317 Negative_regulation of Col1a2 8 0.41 7.17 1.54 5.00
167 INT153201 Negative_regulation of Gene_expression of Col1a1 7 0.38 6.37 1.52 5.00
168 INT120004 Transcription of Tp53 8 0.72 4.92 1.48 5.00
169 INT147788 Regulation of FUT1 11 0.12 7.72 1.44 5.00
170 INT54593 Positive_regulation of Gene_expression of TF 16 0.68 9.05 1.43 5.00
171 INT170853 Positive_regulation of Gene_expression of CFD 7 0.23 9.89 1.41 5.00
172 INT125980 Binding of CFD 8 0.42 10.96 1.39 5.00
173 INT183065 Positive_regulation of Gene_expression of PDX1 7 0.54 6.58 1.29 5.00
174 INT22403 Regulation of MSMB 10 0.39 2.5 1.28 5.00
175 INT17805 Regulation of Localization of ELANE 7 0.59 1.88 1.08 5.00
176 INT159775 Negative_regulation of Gene_expression of Timp1 9 0.37 4.36 1.08 5.00
177 INT127459 Negative_regulation of PAH 18 0.56 15.15 1.05 5.00
178 INT224722 Binding of Mcpt1 6 0.10 4.82 1.03 5.00
179 INT230440 Gene_expression of HAUS7 1 0.04 4.13 1.02 5.00
180 INT226691 Positive_regulation of Gene_expression of Cxcr4 14 0.57 7.9 0.9 5.00
181 INT143714 Phosphorylation of Nfkbia 4 0.64 2.94 0.87 5.00
182 INT126030 Regulation of CFD 4 0.21 3.92 0.83 5.00
183 INT143720 Negative_regulation of Phosphorylation of Nfkbia 3 0.33 2.68 0.83 5.00
184 INT78706 Positive_regulation of Ksr1 2 0.08 1 0.78 5.00
185 INT248227 Protein_catabolism of CFD 4 0.46 2.48 0.77 5.00
186 INT174553 Localization of Stat1 17 0.80 6.62 0.73 5.00
187 INT5211 Localization of Cd40 6 0.78 1.75 0.71 5.00
188 INT158295 Transcription of CD8A 11 0.53 4.02 0.7 5.00
189 INT76127 Transcription of CEL 5 0.71 2.02 0.7 5.00
190 INT160799 Regulation of IGFALS 11 0.29 9.09 0.7 5.00
191 INT202428 Positive_regulation of Binding of CD4 4 0.37 2.11 0.68 5.00
192 INT302664 Positive_regulation of SMAD2 2 0.49 0.85 0.64 5.00
193 INT108328 Negative_regulation of Gene_expression of CEL 6 0.57 2.56 0.63 5.00
194 INT269997 Regulation of Gene_expression of TNFRSF1B 3 0.44 3.33 0.6 5.00
195 INT269970 Positive_regulation of Positive_regulation of Cd40 2 0.50 1.79 0.57 5.00
196 INT202427 Negative_regulation of Localization of CD4 2 0.32 3.1 0.56 5.00
197 INT28238 Positive_regulation of Hrct1 5 0.38 3.66 0.5 5.00
198 INT224442 Negative_regulation of Gene_expression of Pdgfa 2 0.30 2.48 0.5 5.00
199 INT202426 Transcription of CD4 6 0.69 3.96 0.49 5.00
200 INT168801 Localization of Egr1 4 0.78 0.7 0.48 5.00
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