D:Polio

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pChart

Disease Term
Synonyms Acute Poliomyelitis, ACUTE POLIOMYELITIS EPIDEMIC, Encephalitis Polio, EPIDEMIC ACUTE POLIOMYELITIS, Infantile Paralysis, NONPOLIOVIRUS POLIOMYELITIS, Paralysis Infantile, Polio Encephalitis, Polio Virus, Polioencephalitis, POLIOMYELITIDES PREPARALYTIC
Documents 442
Hot Single Events 40
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Polio. They are ordered first by their relevance to Polio and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT341336 Binding of Pepd and Nav1 1 0.07 0.92 1.3 5.00
2 INT74033 Binding of IGHG3 and Ighg1 2 0.08 0.87 0.06 5.00
3 INT211779 Binding of EIF4G1 and NTSR1 1 0.02 0 0 5.00
4 INT211781 Binding of NTSR1 and RDBP 1 0.00 0.42 0 5.00
5 INT319483 Binding of LCT and HSR 1 0.11 0.23 0 5.00
6 INT211777 Binding of NTSR1 and PTBP1 1 0.03 0.82 0 5.00
7 INT242015 Binding of Mdm2 and Trp53 3 0.16 5.74 0 5.00
8 INT268331 Binding of SNRNP70 and CHD7 1 0.01 1.91 0 5.00
9 INT294883 Binding of CD8A and IGHG3 1 0.03 0 0 5.00
10 INT264683 Binding of VAPB and ALS2 1 0.29 1.1 0 5.00
11 INT211780 Binding of AHSA1 and PLVAP 1 0.01 0 0 5.00
12 INT221910 Binding of SRI and COPD 1 0.01 1.27 0 5.00
13 INT211776 Binding of PTBP2 and PLVAP 1 0.05 0.43 0 5.00
14 INT264679 IGFALS Positive_regulation of CTSC 1 0.02 1.68 0 5.00
15 INT352627 Binding of IGHG3 and MAN2A1 1 0.00 1.48 0 5.00
16 INT264678 Binding of SETX and KRT20 1 0.00 2.17 0 5.00
17 INT264682 Binding of VAPB and SETX 1 0.28 1.09 0 5.00
18 INT211778 Binding of PCBP1 and PLVAP 1 0.07 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Polio. They are ordered first by their pain relevance and then by number of times they were reported in Polio. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT129762 Binding of HTN1 5 0.03 5.68 0.19 100.00
2 INT165394 Regulation of HTN1 2 0.00 2.43 0.05 100.00
3 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 100.00
4 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 100.00
5 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22 100.00
6 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 99.84
7 INT193582 Gene_expression of PVR 21 0.58 14 2.39 99.56
8 INT28929 Negative_regulation of PVR 22 0.57 16.64 1.07 99.26
9 INT46273 Gene_expression of PRNP 103 0.78 110.34 9.25 99.16
10 INT66049 Positive_regulation of Hbvi 1 0.01 0.98 0.07 99.10
11 INT94450 Gene_expression of Nav1 359 0.78 131.85 275.46 98.30
12 INT299115 Regulation of INPP5K 6 0.39 4.11 0.59 98.04
13 INT11203 Gene_expression of BCR 30 0.75 33.49 1.22 98.04
14 INT157172 Gene_expression of WWOX 2 0.65 1.99 0.18 98.04
15 INT143846 Positive_regulation of INPP5K 5 0.40 6.4 1.17 97.72
16 INT122924 Binding of ipv 27 0.42 31.81 1.99 97.26
17 INT195817 Gene_expression of ipv 28 0.58 31.04 1.86 94.72
18 INT70104 Positive_regulation of CACNA1S 6 0.47 5.92 0.68 94.44
19 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 92.80
20 INT115212 Gene_expression of PLVAP 2 0.30 1.1 0.38 92.68
21 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 92.32
22 INT216291 Negative_regulation of BTK 4 0.42 4.9 0.67 91.68
23 INT211820 Negative_regulation of PLVAP 1 0.17 0.8 0 90.12
24 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 89.88
25 INT322923 Positive_regulation of Positive_regulation of INPP5K 1 0.39 1.51 0.06 89.60
26 INT541 Positive_regulation of MBP 31 0.67 28.56 12.24 89.52
27 INT248376 Binding of MPI 1 0.40 1.4 0.82 88.64
28 INT192684 Negative_regulation of vs 15 0.19 9.18 1.75 86.68
29 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 85.36
30 INT354758 Gene_expression of D6Uwa4 1 0.04 0.17 0 85.32
31 INT37722 Gene_expression of NCAM1 103 0.75 81.57 14.18 85.12
32 INT82846 Negative_regulation of CRX 9 0.37 5.93 3.64 83.48
33 INT8477 Negative_regulation of AFP 35 0.58 31.52 3.1 83.40
34 INT211819 Positive_regulation of PLVAP 1 0.27 0.7 0 83.28
35 INT4403 Binding of CYP2B6 113 0.48 21.17 33.83 82.32
36 INT68661 Positive_regulation of NTSR1 11 0.69 9.6 5.91 82.24
37 INT67606 Localization of POR 3 0.68 1.22 0.06 81.76
38 INT6511 Positive_regulation of AFP 76 0.70 70.15 7.28 81.44
39 INT173164 Negative_regulation of INPP5K 4 0.51 2.01 0.24 81.36
40 INT324988 Regulation of Qrfpr 1 0.05 0.31 0.04 80.52
41 INT132881 Binding of INPP5K 7 0.48 4.35 0.33 79.20
42 INT211827 Localization of PVR 3 0.61 1.33 0.13 79.04
43 INT297115 Gene_expression of TEX33 3 0.01 5.37 1.86 77.68
44 INT297113 Positive_regulation of Gene_expression of TEX33 2 0.01 3.87 1.14 77.68
45 INT147583 Gene_expression of AIS 82 0.58 48.7 7.11 75.52
46 INT1902 Gene_expression of Cck 348 0.78 70.33 241.92 75.00
47 INT1123 Positive_regulation of CD79A 74 0.70 51.96 7.14 74.92
48 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 73.44
49 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 73.44
50 INT202848 Gene_expression of Nf2 5 0.59 4.93 0.63 73.12
51 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61 68.40
52 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48 68.40
53 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 67.20
54 INT294886 Binding of EHF 1 0.21 1.36 0.1 66.20
55 INT202814 Binding of CEACAM5 1 0.17 1.14 0 65.56
56 INT61680 Positive_regulation of PVR 23 0.60 23.27 3.86 65.08
57 INT324984 Positive_regulation of Qrfpr 1 0.06 0.46 0.04 64.40
58 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 62.64
59 INT99690 Negative_regulation of Positive_regulation of VEGFA 30 0.58 14.56 4.79 62.64
60 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 62.24
61 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 61.88
62 INT211831 Binding of PLVAP 1 0.14 0.73 0 61.24
63 INT49235 Localization of DNASE1 7 0.81 1.69 1.04 59.16
64 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 58.24
65 INT248374 Binding of IKBKAP 10 0.42 10.45 1.9 58.16
66 INT248373 Gene_expression of MPI 1 0.56 3.62 3.22 57.52
67 INT89392 Negative_regulation of Positive_regulation of AKT1 23 0.50 15.69 3.02 55.52
68 INT60436 Negative_regulation of COPD 76 0.37 84.22 9.08 54.80
69 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44 54.20
70 INT33400 Regulation of CDS1 8 0.29 5.12 1.79 53.04
71 INT189809 Negative_regulation of HEXA 1 0.57 3.93 0 52.24
72 INT189811 Negative_regulation of ATXN3 1 0.35 3.09 0 51.56
73 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 50.00
74 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 50.00
75 INT767 Localization of Gnrhr 565 0.80 106.68 214.57 50.00
76 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 50.00
77 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 50.00
78 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 50.00
79 INT34777 Localization of IGF1 82 0.80 42.68 8.62 50.00
80 INT102658 Negative_regulation of Gene_expression of CSF2 42 0.50 38.63 8.32 50.00
81 INT15157 Gene_expression of INPP5K 30 0.67 15.49 2.85 50.00
82 INT144168 Gene_expression of CCL1 7 0.13 5.69 2.45 50.00
83 INT282378 Negative_regulation of CCL1 2 0.01 2.6 0.61 50.00
84 INT292918 Binding of Jsr 4 0.17 1.19 0.24 49.92
85 INT125312 Positive_regulation of COPD 134 0.59 162.55 20.27 49.84
86 INT257837 Positive_regulation of Negative_regulation of BTK 1 0.08 2.01 0.17 48.92
87 INT324987 Negative_regulation of Binding of Qrfpr 1 0.05 0.16 0 47.68
88 INT324986 Regulation of Binding of Qrfpr 1 0.05 0.16 0 46.00
89 INT146793 Positive_regulation of Tp53 30 0.70 32.93 1.94 43.68
90 INT144341 Binding of Qrfpr 4 0.36 0.89 1.4 42.88
91 INT56149 Localization of CD8A 56 0.74 30.41 5.75 40.16
92 INT154772 Positive_regulation of Localization of CD8A 7 0.24 3.58 0.63 40.16
93 INT85767 Gene_expression of Scn9a 11 0.76 9.27 2.74 39.04
94 INT79425 Gene_expression of SMN1 42 0.65 36.37 6.1 38.60
95 INT226826 Gene_expression of Scn1b 5 0.57 0.52 0.22 33.12
96 INT341335 Gene_expression of Scn2b 1 0.41 0 0.22 33.12
97 INT3315 Negative_regulation of Positive_regulation of INS 31 0.57 14.73 2.27 32.80
98 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 31.44
99 INT120466 Gene_expression of LCT 21 0.78 6 1.75 31.12
100 INT8959 Binding of Gnb5 17 0.40 31.38 5.1 29.60
101 INT19430 Positive_regulation of IGHA1 10 0.67 6.42 2.58 29.16
102 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 28.60
103 INT352629 Binding of MAN2A1 1 0.05 4.16 0.23 25.88
104 INT15610 Localization of GOPC 223 0.65 68.26 28.7 25.68
105 INT211809 Localization of NTSR1 1 0.10 0.63 0.07 23.44
106 INT211822 Transcription of PLVAP 1 0.21 0 0 23.12
107 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 21.36
108 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81 21.36
109 INT104396 Positive_regulation of Positive_regulation of Akt1 44 0.55 14.78 8.69 21.36
110 INT114882 Positive_regulation of Gene_expression of Akt1 45 0.69 21.29 6.06 21.36
111 INT49209 Positive_regulation of GAD1 17 0.70 15.39 5.59 21.08
112 INT119446 Positive_regulation of Gnb5 6 0.58 6.47 3.72 18.68
113 INT12039 Localization of TFPI 22 0.68 9.88 5.35 14.24
114 INT34729 Positive_regulation of IFN1@ 233 0.67 128.04 30.38 13.36
115 INT192409 Positive_regulation of Gene_expression of IFN1@ 102 0.67 64.66 18.8 13.36
116 INT236371 Negative_regulation of Acta1 4 0.25 1.12 0.07 9.44
117 INT324983 Negative_regulation of Qrfpr 1 0.05 0.29 0 9.44
118 INT59792 Gene_expression of STH 14 0.75 15.2 0.61 5.60
119 INT228360 Positive_regulation of Gene_expression of STH 1 0.10 0.52 0 5.60
120 INT443 Localization of POMC 1020 0.81 284.52 443.17 5.00
121 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
122 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 5.00
123 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 5.00
124 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
125 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
126 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 5.00
127 INT6354 Localization of Gabrg1 321 0.74 41.41 186.74 5.00
128 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
129 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
130 INT14843 Gene_expression of Gabrg1 301 0.77 62.63 139.16 5.00
131 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64 5.00
132 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 5.00
133 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
134 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
135 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
136 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
137 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
138 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 5.00
139 INT148 Positive_regulation of Gnrhr 182 0.70 47.44 79.64 5.00
140 INT62374 Gene_expression of NGF 158 0.78 77.87 76.45 5.00
141 INT48244 Gene_expression of Il4 172 0.76 132.38 73.42 5.00
142 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
143 INT5969 Gene_expression of Il1a 221 0.75 96.31 71.38 5.00
144 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
145 INT6849 Localization of IL1B 229 0.81 112.56 69.63 5.00
146 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
147 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85 5.00
148 INT2761 Regulation of Gabrg1 119 0.61 18.8 60.52 5.00
149 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 5.00
150 INT49993 Positive_regulation of Gene_expression of Il6 149 0.70 88.07 53.78 5.00
151 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 5.00
152 INT12345 Gene_expression of Il2 142 0.78 59.17 51.21 5.00
153 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 5.00
154 INT111051 Negative_regulation of Nav1 64 0.59 25.51 47.27 5.00
155 INT5025 Positive_regulation of Gene_expression of Cck 63 0.70 10.96 47.11 5.00
156 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92 5.00
157 INT26500 Gene_expression of MMP2 201 0.78 110.57 46.9 5.00
158 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17 5.00
159 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 5.00
160 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 5.00
161 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
162 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
163 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
164 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
165 INT103261 Positive_regulation of Nav1 68 0.70 24.25 39.27 5.00
166 INT1931 Positive_regulation of Gene_expression of POMC 116 0.70 37.26 38.67 5.00
167 INT116321 Regulation of Nav1 38 0.62 26.62 37.97 5.00
168 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2 5.00
169 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
170 INT111052 Positive_regulation of Gene_expression of Nav1 44 0.70 18.98 35.28 5.00
171 INT103262 Localization of Nav1 53 0.81 19.23 34.44 5.00
172 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
173 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
174 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 5.00
175 INT23435 Positive_regulation of NGF 54 0.70 32.41 30.11 5.00
176 INT50230 Positive_regulation of Localization of IL6 105 0.70 69.21 29.52 5.00
177 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
178 INT1196 Positive_regulation of Positive_regulation of POMC 51 0.70 15.99 28.58 5.00
179 INT66200 Gene_expression of Gfap 215 0.78 88.04 28.25 5.00
180 INT52722 Localization of RETNLB 54 0.38 48.63 27.98 5.00
181 INT55737 Positive_regulation of MMP2 101 0.68 59.11 27.71 5.00
182 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 5.00
183 INT62710 Gene_expression of HGF 160 0.78 88.27 26.14 5.00
184 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
185 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58 5.00
186 INT5199 Gene_expression of Fosl1 44 0.78 8.66 24.8 5.00
187 INT110427 Gene_expression of Spp1 199 0.78 176.11 23.31 5.00
188 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 5.00
189 INT11659 Gene_expression of COL2A1 164 0.78 78.49 22.58 5.00
190 INT48312 Gene_expression of NTRK1 72 0.78 38.21 22.24 5.00
191 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 5.00
192 INT73593 Gene_expression of BAX 173 0.76 147.81 20.94 5.00
193 INT78901 Localization of CCL5 67 0.78 40.79 20.59 5.00
194 INT96269 Positive_regulation of Mcpt1 71 0.61 52.38 20.4 5.00
195 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
196 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 5.00
197 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 5.00
198 INT70970 Binding of COPD 144 0.42 180.34 18.29 5.00
199 INT3364 Binding of SGCG 87 0.47 31.93 17.24 5.00
200 INT111050 Negative_regulation of Gene_expression of Nav1 23 0.58 5.97 17.06 5.00
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