D:Polycystic Kidney Disease

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Disease Term
Synonyms ADPKD, ARPKD, Autosomal Dominant Polycystic Renal Disease, Autosomal Recessive Polycystic Renal Disease, Disease Polycystic Kidney, Disease Polycystic Renal, Diseases Polycystic Kidney, Diseases Polycystic Renal, KIDNEY DISEASE POLYCYSTIC, Kidney Diseases Polycystic, Kidney Polycystic
Documents 348
Hot Single Events 150
Hot Interactions 19

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Polycystic Kidney Disease. They are ordered first by their relevance to Polycystic Kidney Disease and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT214919 Pkd1 Positive_regulation of CDKN1A 1 0.51 2.6 0 100.00
2 INT214917 Pkd1 Positive_regulation of Negative_regulation of CDKN1A 1 0.37 1.46 0 100.00
3 INT286561 Binding of Ctnnb1 and Cdh2 1 0.00 1.06 0 100.00
4 INT286566 Binding of Ctnnb1 and Cdh6 1 0.00 1 0 100.00
5 INT286594 Binding of LILRB1 and Pkd1 1 0.01 1.07 0 99.36
6 INT214918 Gtf3a Positive_regulation of CDKN1A 1 0.01 0.66 0 99.28
7 INT214891 HGF Positive_regulation of CDKN1A 1 0.25 1.15 0 99.12
8 INT286501 Binding of PKD1 and LILRB1 1 0.01 1.07 0 98.80
9 INT286572 Binding of Ctnnb1 and Pkd1 1 0.02 0.96 0 98.02
10 INT199667 Cep290 Regulation of Atf4 1 0.04 1.96 0.09 97.68
11 INT199666 Cntln Regulation of Atf4 1 0.00 1.95 0.09 97.68
12 INT286593 Binding of Pkd1 and GOPC 1 0.02 1.13 0 96.88
13 INT241772 AVP Positive_regulation of ADCY1 1 0.09 1.08 0.15 96.00
14 INT214902 Binding of Pcna and Trib3 1 0.00 1.51 0 93.92
15 INT272011 Binding of RAB5A and Tsc2 1 0.02 0.16 0 88.56
16 INT271983 Binding of Tsc2 and Rap1a 1 0.02 0.16 0 87.84
17 INT241777 Negative_regulation of Binding of AVP and TRGV9 1 0.10 0.75 0.13 81.28
18 INT241780 Binding of AVP and TRGV9 1 0.12 2.41 0.35 80.96
19 INT286564 Pkd1 Regulation of Mtor 1 0.00 0.51 0 80.32
20 INT241247 Binding of Pkd2 and Trpv4 1 0.54 1.22 0.52 79.28
21 INT286569 Binding of Pkd1 and Tsc2 1 0.06 1.01 0 77.60
22 INT271990 Tsc1 Positive_regulation of Tsc2 1 0.36 0.31 0 76.80
23 INT272008 Tsc1 Negative_regulation of Binding of HERC1 1 0.01 0.32 0 76.80
24 INT286589 Binding of PKHD1 and Pkd2 1 0.09 0.52 0 70.92
25 INT286562 Gene_expression of Pkd1 Positive_regulation of Ctnnb1 1 0.02 0.52 0 70.72
26 INT210990 Binding of KCNMA1 and PKDREJ 1 0.00 0.6 0.19 67.56
27 INT286570 Pkd2 Positive_regulation of Binding of Pkd1 1 0.21 0.73 0 66.88
28 INT241248 Binding of Pkd1 and Pkd2 3 0.22 1.52 0.1 66.40
29 INT272014 Binding of RB1CC1 and Tsc1 1 0.05 0.44 0 64.04
30 INT126944 Binding of PKD2 and Pkd1 2 0.08 2.09 0.19 63.92
31 INT286590 Binding of ID2 and Pkd2 1 0.13 0.13 0 62.88
32 INT218784 Binding of TCEB2 and VHL 1 0.04 3.81 0.1 62.68
33 INT286571 Binding of Prkd1 and Pkd1 1 0.05 0.76 0 58.88
34 INT210993 Binding of SEA and PKDREJ 1 0.05 0.17 0.1 56.88
35 INT210988 Binding of SP3 and PKDREJ 1 0.01 0.17 0.1 56.88
36 INT210991 Binding of FSCN1 and PKDREJ 1 0.00 0.17 0.1 56.88
37 INT210992 Binding of KCNMA1 and SP3 1 0.00 0.17 0.1 56.52
38 INT210989 Binding of FSCN1 and SP3 1 0.00 0.17 0.1 56.52
39 INT210994 Binding of SEA and SP3 1 0.00 0.17 0.1 56.52
40 INT286563 Binding of Id2 and P1Ehs1 1 0.00 0.17 0.06 56.24
41 INT286591 Binding of PKD1 and Id2 1 0.07 0.17 0.06 56.24
42 INT272017 TBC1D7 Positive_regulation of Protein_catabolism of Tsc1 1 0.08 0.46 0 55.68
43 INT286567 Prkd1 Regulation of Ctnnb1 1 0.01 0.39 0 55.04
44 INT286592 Binding of PKD1 and P1Ehs1 1 0.00 0.16 0.06 54.80
45 INT354544 Avp Positive_regulation of ADCY1 1 0.24 2.23 0.22 52.52
46 INT272007 Binding of Tsc2 and SCPEP1 1 0.27 0.46 0 51.44
47 INT272004 Binding of Hspa1b and Tsc2 1 0.01 0.45 0 50.96
48 INT286568 Car2 Positive_regulation of Positive_regulation of Pkd1 1 0.03 0.16 0.09 50.56
49 INT315868 Vhl Positive_regulation of Transcription of PDGFA 1 0.00 1.39 0 50.20
50 INT315867 Vhl Positive_regulation of Transcription of VEGFA 1 0.01 1.39 0 50.20
51 INT286565 Pkd2 Positive_regulation of Positive_regulation of Pkd1 1 0.21 0.11 0.09 50.00
52 INT214892 Positive_regulation of HGF Positive_regulation of CDKN1A 1 0.17 0.31 0 50.00
53 INT214890 GOPC Positive_regulation of CDKN1A 1 0.06 0.57 0 50.00
54 INT286574 Gene_expression of Pkd1 Negative_regulation of Cdk2 1 0.10 0.09 0 50.00
55 INT286573 Pkd2 Regulation of Pkd1 1 0.12 0.25 0 50.00
56 INT13014 Avp Positive_regulation of Adcy5 1 0.00 0.07 0.13 49.44
57 INT272003 Binding of Tsc2 and Tsc1 1 0.18 1.1 0.07 42.60
58 INT256632 Binding of PTCH1 and Jkamp 1 0.00 2.32 0 39.72
59 INT190632 Binding of Srf and Yy1 1 0.20 0.14 0 35.28
60 INT271996 Binding of Plk1 and Tsc1 1 0.09 0.32 0 31.12
61 INT271997 Binding of Cdk1 and Plk1 1 0.03 0.3 0 27.60
62 INT272005 Phosphorylation of Tsc1 Regulation of Binding of Cdk1 and Plk1 1 0.02 0.3 0 27.60
63 INT271998 Cdk1 Positive_regulation of Phosphorylation of Tsc1 1 0.17 0.3 0 27.60
64 INT315856 FLT3 Positive_regulation of Gene_expression of PDGFA 1 0.01 1.15 0 23.96
65 INT295552 Binding of Ghrl and Ghsr 7 0.40 1.64 0.88 23.84
66 INT295540 Binding of Gh and Ghrl 2 0.10 0.13 0.12 23.84
67 INT241252 Binding of Pkd1 and Tbpl1 1 0.02 0.79 0.1 20.56
68 INT261883 PKD2 Positive_regulation of Localization of Ca2 1 0.02 0.67 0 20.28
69 INT331405 Binding of Gh and Ghsr 1 0.08 0.13 0 18.76
70 INT295546 Ghrl Positive_regulation of Ghsr 3 0.39 0.09 0.77 5.00
71 INT241776 Binding of AVP and Positive_regulation of ADCY1 1 0.06 0.54 0.32 5.00
72 INT237641 Binding of Cntnap1 and Nfasc 2 0.36 0.1 0.29 5.00
73 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19 5.00
74 INT190628 Negative_regulation of Binding of Rab7 and Sirt1 1 0.33 0.62 0.17 5.00
75 INT241250 Binding of Pkd2 and Trpc1 1 0.23 0.3 0.17 5.00
76 INT190637 Negative_regulation of Binding of Rab7 and Rnf115 1 0.25 0.68 0.17 5.00
77 INT190638 Binding of Rab7 and Sirt1 1 0.29 0.62 0.17 5.00
78 INT190630 Binding of Rab7 and Rnf115 1 0.22 0.68 0.17 5.00
79 INT190635 Binding of Lmo2 and Nr1h2 1 0.09 0.59 0.16 5.00
80 INT190629 Binding of Lmo2 and Usf1 1 0.11 0.6 0.16 5.00
81 INT190634 Binding of Lmo2 and Maz 1 0.14 0.59 0.16 5.00
82 INT190633 Binding of Lmo2 and Deaf1 1 0.18 0.59 0.16 5.00
83 INT254488 Dtx1 Regulation of Sorbs1 1 0.01 0 0.12 5.00
84 INT254490 Dtx1 Regulation of Gopc 1 0.04 0 0.12 5.00
85 INT190631 Gusb Positive_regulation of Tlr4 1 0.08 0.44 0.11 5.00
86 INT272006 Binding of YWHAQ and Tsc2 1 0.27 0.39 0.1 5.00
87 INT186539 Crh Regulation of Hpse 1 0.09 0.52 0.1 5.00
88 INT254492 Dtx1 Regulation of Cldn11 1 0.03 0 0.09 5.00
89 INT241249 Pkd2 Regulation of Trpc1 1 0.21 0.14 0.09 5.00
90 INT241774 Binding of AVPR1A and TRGV9 1 0.02 0.48 0.09 5.00
91 INT186540 Binding of Cort and Hpse 1 0.05 0.92 0.08 5.00
92 INT254491 Positive_regulation of Binding of Cntnap1 and Nfasc 1 0.02 0.1 0.08 5.00
93 INT190529 IFNA1 Positive_regulation of Transcription of TRIM63 1 0.00 0.39 0.08 5.00
94 INT272012 Binding of TSC1 and Lsamp 1 0.03 2.1 0.08 5.00
95 INT190636 Nr1h2 Positive_regulation of Rnf115 1 0.20 0.71 0.08 5.00
96 INT241246 Pkd2 Negative_regulation of Gene_expression of Trpv4 1 0.48 0.47 0.07 5.00
97 INT200212 Binding of EPAS1 and VHL 3 0.06 4.1 0.05 5.00
98 INT241253 Gene_expression of Trpv4 Positive_regulation of Gene_expression of Pkd2 1 0.52 0.29 0.03 5.00
99 INT341043 Avp Regulation of Camp 1 0.10 0.47 0.03 5.00
100 INT272009 Binding of YWHAQ and Tsc1 1 0.37 0.14 0.03 5.00
101 INT241251 Pkd2 Negative_regulation of Gene_expression of Gopc 1 0.12 0.24 0.03 5.00
102 INT199665 Binding of Fxn and Lamtor3 1 0.00 0.16 0.03 5.00
103 INT241775 AVP Positive_regulation of Gene_expression of AQP2 1 0.08 0.17 0 5.00
104 INT272018 Binding of TSC1 and Tsc2 1 0.17 0.48 0 5.00
105 INT241779 AVP Positive_regulation of TRGV9 1 0.17 0.48 0 5.00
106 INT241769 AVP Regulation of Binding of AVPR1A 1 0.11 0.49 0 5.00
107 INT241771 Binding of AVP and AVPR1B 1 0.04 0.49 0 5.00
108 INT271991 Tsc1 Regulation of Tsc2 1 0.23 0.15 0 5.00
109 INT272015 Pkd1 Positive_regulation of Localization of TSC1 1 0.18 0.65 0 5.00
110 INT271982 Binding of Skp2 and Psmd9 1 0.01 0.68 0 5.00
111 INT272013 Binding of OGG1 and Tsc2 1 0.09 0.67 0 5.00
112 INT272010 Tsc2 Negative_regulation of OGG1 1 0.17 0.6 0 5.00
113 INT271966 Phosphorylation of Rasa1 Positive_regulation of Tsc2 1 0.01 0.31 0 5.00
114 INT272000 Binding of Skp2 and Hecw1 1 0.01 0.11 0 5.00
115 INT241778 AVP Positive_regulation of AVPR1A 1 0.10 1.32 0 5.00
116 INT271985 Tsc1 Regulation of Cdkn1b 1 0.04 0.1 0 5.00
117 INT271979 Skp2 Positive_regulation of Protein_catabolism of Psmd9 1 0.01 0.35 0 5.00
118 INT272016 Mtor Negative_regulation of INS 1 0.00 0.61 0 5.00
119 INT271999 Binding of Fkbp1a and Positive_regulation of Negative_regulation of Mtor 1 0.00 0.18 0 5.00
120 INT271984 Binding of Tsc2 and Skp2 1 0.06 0.34 0 5.00
121 INT241768 Binding of AVP and AVPR1A 1 0.08 0.49 0 5.00
122 INT192618 Atrx Regulation of Gene_expression of Hba-a1 1 0.08 0.45 0 5.00
123 INT271994 Binding of Fkbp1a and Mtor 1 0.00 0.22 0 5.00
124 INT241770 AVP Regulation of Binding of TRGV9 1 0.11 0.49 0 5.00
125 INT271989 Binding of Tsc2 and Psmd9 1 0.02 0.47 0 5.00
126 INT241773 AVP Regulation of Binding of AVPR1B 1 0.05 0.49 0 5.00
127 INT218785 Binding of FN1 and VHL 1 0.06 1.12 0 5.00
128 INT271978 Positive_regulation of Racgap1 Regulation of Mtor 1 0.00 0.54 0 5.00
129 INT271987 Tsc2 Regulation of Skp2 1 0.10 0.28 0 5.00
130 INT271986 Tsc1 Regulation of Skp2 1 0.13 0.14 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Polycystic Kidney Disease. They are ordered first by their pain relevance and then by number of times they were reported in Polycystic Kidney Disease. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT109061 Gene_expression of PRKD1 5 0.58 1.8 3.04 100.00
2 INT286584 Positive_regulation of PKHD1 1 0.13 1.01 0 100.00
3 INT283147 Gene_expression of SCNN1B 1 0.09 0.26 0.3 100.00
4 INT53449 Gene_expression of PPL 8 0.75 3.8 1.69 100.00
5 INT111189 Binding of PPL 3 0.36 1.33 0.64 100.00
6 INT237382 Localization of VUR 11 0.72 14.58 0.11 100.00
7 INT81088 Gene_expression of ASIC1 26 0.77 17.8 15.07 99.92
8 INT104330 Negative_regulation of CDKN1A 57 0.58 39.93 5.88 99.84
9 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 99.84
10 INT226835 Gene_expression of Cdh2 14 0.22 8.04 0.31 99.84
11 INT286559 Positive_regulation of Gene_expression of Cdh2 1 0.04 1.04 0 99.84
12 INT286537 Gene_expression of Cdh6 1 0.04 0.98 0 99.84
13 INT104182 Gene_expression of ABCC2 19 0.76 5.92 2.88 99.84
14 INT241236 Negative_regulation of Pkd2 11 0.43 1.82 0.39 99.84
15 INT247803 Positive_regulation of Cdh2 2 0.11 2.03 0.04 99.82
16 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74 99.68
17 INT151774 Positive_regulation of Mtor 38 0.45 20.15 1.01 99.68
18 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 99.44
19 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93 99.44
20 INT208476 Binding of Pkd1 13 0.39 7.23 0.17 99.36
21 INT69801 Positive_regulation of DPEP1 3 0.49 0.89 0.23 99.36
22 INT98647 Positive_regulation of Mdk 65 0.59 32.93 15.67 99.18
23 INT150826 Positive_regulation of Pkd1 9 0.37 3.65 0.35 99.14
24 INT241238 Positive_regulation of Pkd2 5 0.46 1.44 0.24 99.14
25 INT190603 Negative_regulation of Nr5a1 1 0.13 0.29 0 99.04
26 INT190554 Gene_expression of Ptma 1 0.16 0.58 0 99.00
27 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 98.92
28 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 98.90
29 INT134208 Negative_regulation of Ptk2 19 0.58 23.59 0.52 98.90
30 INT211006 Binding of PKD1 6 0.22 2.69 0.05 98.80
31 INT286581 Gene_expression of PKHD1 1 0.24 0.19 0.03 98.76
32 INT134207 Gene_expression of Ptk2 56 0.73 31.97 0.78 98.72
33 INT55470 Regulation of Mtor 16 0.24 12.51 2.07 98.68
34 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 98.64
35 INT241240 Gene_expression of Pkd1 18 0.54 12.2 0.27 98.60
36 INT148326 Gene_expression of Pkd1 7 0.76 5.38 1.85 98.56
37 INT137354 Gene_expression of Nr5a1 7 0.24 2.04 0.37 98.48
38 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 98.36
39 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63 98.36
40 INT190611 Gene_expression of Cnn1 13 0.56 5.87 0.75 98.28
41 INT104331 Negative_regulation of Gene_expression of CDKN1A 24 0.57 13.68 1.63 98.02
42 INT11551 Localization of VHL 12 0.65 22.76 0.68 97.88
43 INT286535 Regulation of Prkd1 3 0.33 2.24 0.04 97.68
44 INT286580 Positive_regulation of Gene_expression of PKHD1 1 0.16 0.1 0.03 97.52
45 INT111607 Gene_expression of CDH1 103 0.75 90.45 7.77 97.40
46 INT77306 Negative_regulation of Gene_expression of Bcl2 46 0.58 38.05 7.71 97.40
47 INT286543 Localization of Pkd1 5 0.52 3.74 0.04 97.24
48 INT24080 Negative_regulation of Mtor 64 0.37 41.56 5.19 97.04
49 INT70437 Negative_regulation of Mdk 115 0.57 41.03 35.72 96.54
50 INT231266 Gene_expression of Prh1 13 0.08 3.95 1.02 96.00
51 INT286533 Negative_regulation of Gene_expression of Cdh2 1 0.11 1.4 0.03 95.96
52 INT286541 Negative_regulation of Cdh2 1 0.03 1.09 0 95.96
53 INT101568 Negative_regulation of Pcna 1 0.41 5.24 0.42 95.64
54 INT7180 Negative_regulation of Trib3 180 0.51 68.48 88.01 95.64
55 INT286588 Positive_regulation of Localization of PKHD1 1 0.16 0.79 0 95.56
56 INT286579 Localization of PKHD1 1 0.24 0.79 0 95.56
57 INT250337 Binding of MCOLN1 1 0.04 0.43 0.14 95.48
58 INT72878 Positive_regulation of crf 5 0.26 6.47 0.63 95.40
59 INT286554 Negative_regulation of Gene_expression of Pkd1 1 0.35 1.77 0 95.36
60 INT4679 Negative_regulation of RAPGEF5 55 0.57 47.51 4.55 95.14
61 INT37485 Regulation of RAPGEF5 10 0.44 6.64 1.51 95.14
62 INT120527 Localization of ABCC2 3 0.78 1.03 0 95.08
63 INT286545 Positive_regulation of Gene_expression of Pkd1 1 0.42 1.55 0 95.04
64 INT477 Localization of Avp 813 0.81 131.58 300.4 94.76
65 INT4207 Regulation of Avp 267 0.62 63.72 115.33 94.56
66 INT129174 Gene_expression of PKD1 24 0.67 14.91 0.74 94.36
67 INT152404 Regulation of PKD1 2 0.45 2.02 1.04 94.36
68 INT286548 Positive_regulation of Prkd1 7 0.36 4.35 0.15 93.84
69 INT286536 Positive_regulation of Positive_regulation of Prkd1 1 0.08 1.28 0 93.84
70 INT11919 Regulation of KRT1 9 0.10 4.97 0.77 93.72
71 INT286550 Negative_regulation of Prkd1 4 0.42 3.68 0.45 93.64
72 INT286534 Negative_regulation of Gene_expression of Prkd1 2 0.31 0.89 0 93.64
73 INT238180 Binding of Ptk2 5 0.35 2.99 0.04 93.60
74 INT286556 Binding of Neat1 1 0.05 0.94 0 93.60
75 INT286542 Binding of Vcl 1 0.04 0.94 0 93.60
76 INT286551 Binding of Pxn 1 0.08 0.94 0 93.60
77 INT81641 Gene_expression of Ctnnb1 23 0.72 14.93 1.97 93.56
78 INT139237 Negative_regulation of Gene_expression of CDH1 23 0.57 24.31 1.28 93.36
79 INT283560 Negative_regulation of Gene_expression of Ptk2 6 0.40 4.84 0.09 93.36
80 INT179038 Positive_regulation of Regulation of Bcl2 1 0.39 3.49 0.12 93.12
81 INT286538 Gene_expression of Prkd1 7 0.56 3.97 0.24 93.08
82 INT64234 Regulation of Bcl2 41 0.54 31.88 3.16 92.76
83 INT73223 Gene_expression of UPF1 78 0.41 31.44 9.94 92.72
84 INT163993 Gene_expression of Hnf1a 2 0.65 1.38 0.49 92.48
85 INT205576 Positive_regulation of Hnf1a 2 0.49 1.1 0 92.48
86 INT205577 Positive_regulation of Gene_expression of Hnf1a 1 0.49 1.1 0 92.48
87 INT109821 Negative_regulation of Trpv4 19 0.55 6.86 3.98 91.96
88 INT205579 Positive_regulation of Gene_expression of Hnf1b 1 0.44 2.1 0 91.92
89 INT205583 Gene_expression of Hnf1b 1 0.59 2.09 0 91.92
90 INT205582 Positive_regulation of Hnf1b 1 0.44 1.05 0 91.92
91 INT228895 Binding of Tsc2 5 0.30 2.41 0 91.76
92 INT241243 Gene_expression of Pkd2 30 0.77 9.05 0.53 91.60
93 INT286578 Localization of ALMS1 1 0.22 0.75 0 91.44
94 INT286585 Positive_regulation of Localization of ALMS1 1 0.15 0.75 0 91.44
95 INT283566 Localization of Ptk2 5 0.75 0.93 0 91.24
96 INT5118 Regulation of SST 97 0.62 34.35 51.74 91.24
97 INT258949 Localization of OFD1 2 0.41 3.87 0 91.16
98 INT286586 Positive_regulation of Localization of OFD1 1 0.12 0.74 0 91.16
99 INT137850 Gene_expression of PKD2 9 0.65 6.68 0.63 91.04
100 INT157765 Negative_regulation of CDH1 32 0.53 35.72 1.15 91.04
101 INT286553 Transcription of Prkd1 1 0.12 0.7 0 91.04
102 INT286582 Localization of BBS1 1 0.02 0.74 0 90.92
103 INT286558 Transcription of Nek8 1 0.46 0.7 0 90.48
104 INT286539 Localization of Nek8 1 0.57 0.73 0 90.28
105 INT286552 Positive_regulation of Localization of Nek8 1 0.38 0.73 0 90.28
106 INT82796 Regulation of CDKN1A 22 0.53 9.83 3.33 90.20
107 INT103888 Gene_expression of Atf2 7 0.58 1.69 0.59 90.16
108 INT190552 Gene_expression of Sacm1l 1 0.50 0.38 0 89.64
109 INT44972 Negative_regulation of Gfra1 16 0.58 10.17 0.93 89.20
110 INT397 Localization of SST 232 0.81 58.05 101.19 89.12
111 INT934 Regulation of Gtf3a 25 0.35 11.35 6.34 88.96
112 INT31757 Negative_regulation of Egf 18 0.41 9.7 2.94 88.84
113 INT73263 Negative_regulation of MYC 20 0.57 12.86 2.95 88.68
114 INT10976 Negative_regulation of ENPP3 13 0.42 5.11 1.92 88.64
115 INT212307 Regulation of Gene_expression of Trpv4 8 0.44 2.85 0.39 88.32
116 INT170296 Regulation of Gene_expression of Gopc 33 0.38 12.49 6 88.32
117 INT660 Negative_regulation of REN 194 0.59 82.06 29.46 88.08
118 INT286532 Localization of Prkd1 3 0.58 3.02 0.16 87.52
119 INT1939 Localization of Cys1 6 0.73 5.9 0.64 87.52
120 INT286540 Localization of Btk 1 0.28 1.26 0 87.52
121 INT286544 Localization of Ift88 1 0.52 1.26 0 87.52
122 INT119168 Negative_regulation of Cd34 8 0.37 4.91 0.96 87.00
123 INT166312 Negative_regulation of Vim 7 0.22 5.9 0.46 87.00
124 INT30170 Gene_expression of Car2 330 0.66 77.26 46.76 86.88
125 INT286587 Negative_regulation of LAMA3 1 0.01 1.01 0 86.72
126 INT49325 Gene_expression of Cd34 102 0.78 82.75 8.97 86.48
127 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 86.24
128 INT241241 Positive_regulation of Gene_expression of Pkd2 3 0.50 1.3 0.03 85.52
129 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03 84.96
130 INT48219 Gene_expression of SLC4A1 34 0.75 33.18 2.84 84.96
131 INT143850 Gene_expression of S100a1 19 0.73 9.52 1.54 84.96
132 INT178222 Gene_expression of Yy1 5 0.57 2.06 0.56 84.64
133 INT190571 Gene_expression of Eef2 9 0.35 1.64 0.43 84.64
134 INT173086 Negative_regulation of VHL 14 0.59 12.54 0.29 84.28
135 INT214913 Positive_regulation of Positive_regulation of Tp53 2 0.08 2.47 0 84.16
136 INT271938 Binding of Tsc1 1 0.43 3.18 0.07 83.76
137 INT109820 Gene_expression of Trpv4 121 0.78 39.69 33.11 83.68
138 INT146793 Positive_regulation of Tp53 30 0.70 32.93 1.94 83.60
139 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 83.60
140 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 83.60
141 INT170601 Positive_regulation of Gene_expression of GOPC 122 0.43 42.79 11.68 83.60
142 INT188396 Positive_regulation of Positive_regulation of GOPC 13 0.42 1.78 1.21 83.60
143 INT41721 Negative_regulation of MTOR 40 0.58 32.49 2.83 82.76
144 INT271941 Binding of Tsc2 12 0.24 2.96 0.11 82.68
145 INT2451 Positive_regulation of Avp 355 0.70 102.66 147.69 82.52
146 INT60279 Gene_expression of VHL 70 0.78 75.21 2.21 81.76
147 INT17561 Localization of Car2 303 0.79 60.95 44.52 81.64
148 INT177594 Binding of TRGV9 7 0.14 3.28 0.33 80.80
149 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 80.48
150 INT282568 Positive_regulation of Cdk2 6 0.34 2.95 0.03 80.32
151 INT65545 Localization of EGFR 35 0.79 20.8 1.88 79.56
152 INT175900 Regulation of ENPP1 1 0.00 1.96 0.16 79.28
153 INT62266 Phosphorylation of Rb1 4 0.71 2.68 0.54 79.24
154 INT179036 Gene_expression of Fez1 1 0.70 13.28 0.11 78.84
155 INT82795 Binding of MYC 16 0.47 6.1 0.9 78.60
156 INT11823 Positive_regulation of GGT1 53 0.67 45.84 7.55 78.52
157 INT114880 Negative_regulation of Cdk2 7 0.35 3.89 0.77 78.40
158 INT156296 Regulation of Trpv4 20 0.45 7.84 4.86 78.00
159 INT241235 Binding of Pkd2 11 0.48 2.43 0.55 77.92
160 INT124850 Gene_expression of Tpt1 42 0.77 14.51 0.79 77.76
161 INT169921 Negative_regulation of Gene_expression of Tpt1 3 0.25 1.38 0 77.76
162 INT41125 Positive_regulation of Localization of Rb1 2 0.38 0.78 0.39 77.52
163 INT241790 Negative_regulation of AVPR1A 6 0.57 4.62 0.35 77.36
164 INT935 Localization of Gtf3a 124 0.70 35.72 43.3 77.20
165 INT41126 Localization of Rb1 2 0.61 0.78 0.39 77.20
166 INT109450 Positive_regulation of Phosphorylation of AKT1 62 0.64 25.18 4.21 76.92
167 INT176262 Positive_regulation of Phosphorylation of CDKN1A 3 0.49 2.12 0.06 76.92
168 INT123529 Phosphorylation of CDKN1A 8 0.80 5.69 0.29 76.72
169 INT160055 Localization of CDKN1A 15 0.78 12.56 4.83 76.72
170 INT74017 Regulation of VHL 4 0.43 7.59 0.16 76.08
171 INT5940 Negative_regulation of Avp 236 0.59 67.86 101.2 75.40
172 INT117096 Gene_expression of Wnt4 2 0.67 4.68 0.38 75.20
173 INT205578 Negative_regulation of Wnt4 1 0.43 1.69 0 75.20
174 INT211011 Gene_expression of PKDREJ 1 0.46 1.95 0.21 75.00
175 INT271964 Binding of HERC1 1 0.01 0.31 0 74.96
176 INT4686 Gene_expression of Cys1 32 0.66 36.24 2.49 74.80
177 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61 74.64
178 INT286546 Negative_regulation of Gene_expression of Pkd2 2 0.27 0.57 0 74.64
179 INT241292 Transcription of TRGV9 2 0.16 1.13 0.12 74.08
180 INT135556 Localization of AKT1 38 0.69 12.78 1.17 74.04
181 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 73.28
182 INT18515 Gene_expression of Lipg 18 0.66 9.3 3.72 73.04
183 INT212876 Negative_regulation of Gene_expression of Lipg 1 0.06 0.37 0.1 73.04
184 INT271905 Positive_regulation of Protein_catabolism of Tsc2 1 0.35 1.46 0 72.52
185 INT271915 Negative_regulation of Pkd1 8 0.36 6.44 0 72.48
186 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 72.48
187 INT17562 Negative_regulation of Lipg 32 0.51 16.91 3.17 72.48
188 INT211005 Gene_expression of SP3 1 0.03 0.58 0.09 72.24
189 INT271940 Protein_catabolism of Tsc2 1 0.50 0.7 0 72.16
190 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 71.64
191 INT283708 Localization of Id2 2 0.71 0.72 0.11 70.88
192 INT84598 Regulation of Aqp2 13 0.45 4.28 0.86 70.68
193 INT286576 Binding of PKHD1 1 0.12 0.63 0 69.20
194 INT175895 Negative_regulation of KRT1 5 0.37 3.23 0.05 66.96
195 INT175901 Negative_regulation of POLR2B 1 0.00 0.34 0 66.96
196 INT175887 Negative_regulation of IGHVIII-67-3 1 0.00 0.34 0 66.96
197 INT175899 Negative_regulation of LRFN2 1 0.00 0.34 0 66.96
198 INT163828 Localization of Cdkn1b 4 0.66 5.2 0.48 66.64
199 INT175894 Regulation of IGHVIII-67-3 2 0.05 1.05 0.15 65.44
200 INT175893 Regulation of POLR2B 2 0.08 1.34 0 65.44
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