D:Polydactyly

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Disease Term
Synonyms Accessory Digit, Hyperdactylies, Hyperdactyly, Polydactylia, POLYDACTYLIAS, Polydactylies, Polydactylism, POLYDACTYLISMS
Documents 34
Hot Single Events 9
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Polydactyly. They are ordered first by their relevance to Polydactyly and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT311658 Spry1 Regulation of Regulation of Slc12a3 1 0.13 0.81 0 72.00
2 INT311661 Spry1 Regulation of Slc12a3 1 0.30 1.44 0 71.68
3 INT311659 Egfr Positive_regulation of Mapk1 1 0.08 0.18 0 41.04
4 INT311657 Binding of Cbl and Spry2 1 0.10 0.18 0 28.08
5 INT286568 Car2 Positive_regulation of Positive_regulation of Pkd1 1 0.03 0.16 0.09 22.64
6 INT286565 Pkd2 Positive_regulation of Positive_regulation of Pkd1 1 0.21 0.11 0.09 22.64
7 INT241248 Binding of Pkd1 and Pkd2 3 0.22 1.52 0.1 5.00
8 INT286592 Binding of PKD1 and P1Ehs1 1 0.00 0.16 0.06 5.00
9 INT286563 Binding of Id2 and P1Ehs1 1 0.00 0.17 0.06 5.00
10 INT286591 Binding of PKD1 and Id2 1 0.07 0.17 0.06 5.00
11 INT311655 Shh Positive_regulation of Gene_expression of Fgf8 1 0.31 0.18 0.03 5.00
12 INT311660 Binding of Gt(ROSA)26Sor and Spry1 1 0.03 0.91 0 5.00
13 INT286566 Binding of Ctnnb1 and Cdh6 1 0.00 1 0 5.00
14 INT286562 Gene_expression of Pkd1 Positive_regulation of Ctnnb1 1 0.02 0.52 0 5.00
15 INT286571 Binding of Prkd1 and Pkd1 1 0.05 0.76 0 5.00
16 INT311656 Binding of Wnt1 and Spry1 1 0.30 0.39 0 5.00
17 INT227399 Binding of D5Mit424 and Alms1 1 0.01 0.71 0 5.00
18 INT286574 Gene_expression of Pkd1 Negative_regulation of Cdk2 1 0.10 0.09 0 5.00
19 INT286570 Pkd2 Positive_regulation of Binding of Pkd1 1 0.21 0.73 0 5.00
20 INT286501 Binding of PKD1 and LILRB1 1 0.01 1.07 0 5.00
21 INT286561 Binding of Ctnnb1 and Cdh2 1 0.00 1.06 0 5.00
22 INT286593 Binding of Pkd1 and GOPC 1 0.02 1.13 0 5.00
23 INT286589 Binding of PKHD1 and Pkd2 1 0.09 0.52 0 5.00
24 INT286567 Prkd1 Regulation of Ctnnb1 1 0.01 0.39 0 5.00
25 INT286573 Pkd2 Regulation of Pkd1 1 0.12 0.25 0 5.00
26 INT286564 Pkd1 Regulation of Mtor 1 0.00 0.51 0 5.00
27 INT286569 Binding of Pkd1 and Tsc2 1 0.06 1.01 0 5.00
28 INT286590 Binding of ID2 and Pkd2 1 0.13 0.13 0 5.00
29 INT286572 Binding of Ctnnb1 and Pkd1 1 0.02 0.96 0 5.00
30 INT227398 Binding of H2afy and Alms1 1 0.01 1.42 0 5.00
31 INT286594 Binding of LILRB1 and Pkd1 1 0.01 1.07 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Polydactyly. They are ordered first by their pain relevance and then by number of times they were reported in Polydactyly. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT282798 Binding of Prkd1 2 0.18 2.11 0.19 99.28
2 INT85462 Binding of KTWS 3 0.31 2.91 0.54 98.20
3 INT256285 Gene_expression of Efnb1 32 0.70 36.25 24.73 95.36
4 INT260037 Positive_regulation of Binding of Efnb1 1 0.24 1.04 0 92.08
5 INT86624 Binding of Efnb1 4 0.27 1.09 0.6 91.32
6 INT117096 Gene_expression of Wnt4 2 0.67 4.68 0.38 87.44
7 INT311638 Gene_expression of Spry1 1 0.72 16.38 0.86 84.24
8 INT311645 Gene_expression of Spry2 1 0.70 1.81 0 82.56
9 INT286547 Negative_regulation of Kif3a 1 0.15 0.48 0.05 81.00
10 INT311654 Regulation of Spry2 1 0.21 0.75 0 79.68
11 INT311633 Localization of Spry2 1 0.68 0.26 0 77.52
12 INT121954 Binding of Mthfr 17 0.44 13.47 4.66 77.28
13 INT68216 Binding of NF1 40 0.48 51.24 4.59 75.00
14 INT259848 Regulation of Slc12a3 2 0.12 2.1 0.3 71.32
15 INT311644 Positive_regulation of Gene_expression of Spry1 1 0.46 2.54 0.13 69.80
16 INT210430 Gene_expression of Arl3 1 0.55 1.85 0.12 64.72
17 INT202628 Gene_expression of Wnt1 20 0.67 9.2 0.82 62.52
18 INT260038 Localization of Efnb1 3 0.57 1.14 0.3 56.56
19 INT72703 Gene_expression of Ide 79 0.70 45.04 4.47 51.44
20 INT4360 Gene_expression of Hypism 29 0.22 38.1 4.07 51.12
21 INT6511 Positive_regulation of AFP 76 0.70 70.15 7.28 50.00
22 INT260048 Binding of PCDH19 1 0.37 4.77 0 42.92
23 INT228404 Gene_expression of Slc12a3 6 0.35 7.18 1 42.64
24 INT169355 Localization of Egfr 6 0.75 3.24 0.43 39.60
25 INT215844 Gene_expression of Ex 12 0.65 9.24 0.54 34.44
26 INT260049 Negative_regulation of PCDH19 1 0.58 4.41 0.04 30.32
27 INT81796 Binding of AGRP 62 0.36 37.19 5.3 28.80
28 INT167084 Binding of Cbl 3 0.10 1.34 0.39 28.08
29 INT150826 Positive_regulation of Pkd1 9 0.37 3.65 0.35 22.64
30 INT241238 Positive_regulation of Pkd2 5 0.46 1.44 0.24 22.64
31 INT286548 Positive_regulation of Prkd1 7 0.36 4.35 0.15 16.24
32 INT286588 Positive_regulation of Localization of PKHD1 1 0.16 0.79 0 15.92
33 INT286552 Positive_regulation of Localization of Nek8 1 0.38 0.73 0 15.92
34 INT286585 Positive_regulation of Localization of ALMS1 1 0.15 0.75 0 15.92
35 INT286586 Positive_regulation of Localization of OFD1 1 0.12 0.74 0 15.92
36 INT286539 Localization of Nek8 1 0.57 0.73 0 14.88
37 INT286582 Localization of BBS1 1 0.02 0.74 0 14.16
38 INT258949 Localization of OFD1 2 0.41 3.87 0 14.16
39 INT286578 Localization of ALMS1 1 0.22 0.75 0 14.16
40 INT286579 Localization of PKHD1 1 0.24 0.79 0 14.16
41 INT17561 Localization of Car2 303 0.79 60.95 44.52 9.28
42 INT311647 Negative_regulation of Gene_expression of Spry1 1 0.39 0.18 0.04 8.20
43 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
44 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
45 INT397 Localization of SST 232 0.81 58.05 101.19 5.00
46 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 5.00
47 INT30170 Gene_expression of Car2 330 0.66 77.26 46.76 5.00
48 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
49 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 5.00
50 INT70437 Negative_regulation of Mdk 115 0.57 41.03 35.72 5.00
51 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
52 INT24225 Gene_expression of Alms1 93 0.62 52.75 16.93 5.00
53 INT85639 Positive_regulation of Tg(CAG-EGFP)D4Nagy 95 0.43 24.83 15.69 5.00
54 INT98647 Positive_regulation of Mdk 65 0.59 32.93 15.67 5.00
55 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 5.00
56 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
57 INT67653 Gene_expression of Om 46 0.36 15.28 13.32 5.00
58 INT36287 Binding of CD4 96 0.47 58.93 11.88 5.00
59 INT170601 Positive_regulation of Gene_expression of GOPC 122 0.43 42.79 11.68 5.00
60 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63 5.00
61 INT111607 Gene_expression of CDH1 103 0.75 90.45 7.77 5.00
62 INT186142 Gene_expression of Ghrh 45 0.66 34.04 6.94 5.00
63 INT11258 Gene_expression of Gnas 58 0.58 21.6 6.33 5.00
64 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22 5.00
65 INT24080 Negative_regulation of Mtor 64 0.37 41.56 5.19 5.00
66 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93 5.00
67 INT3817 Negative_regulation of Apc 29 0.58 22.12 3.91 5.00
68 INT108761 Localization of Alms1 24 0.70 13.92 3.74 5.00
69 INT31757 Negative_regulation of Egf 18 0.41 9.7 2.94 5.00
70 INT104182 Gene_expression of ABCC2 19 0.76 5.92 2.88 5.00
71 INT4686 Gene_expression of Cys1 32 0.66 36.24 2.49 5.00
72 INT32920 Gene_expression of Msx1 19 0.71 4.24 2.42 5.00
73 INT174979 Phosphorylation of GOPC 45 0.51 10.11 2.28 5.00
74 INT81641 Gene_expression of Ctnnb1 23 0.72 14.93 1.97 5.00
75 INT173512 Positive_regulation of Gene_expression of Alms1 12 0.44 8.66 1.95 5.00
76 INT65545 Localization of EGFR 35 0.79 20.8 1.88 5.00
77 INT153599 Gene_expression of SCN1A 8 0.75 7.01 1.47 5.00
78 INT207521 Gene_expression of Tfap2a 7 0.48 1.89 1.45 5.00
79 INT110434 Positive_regulation of Gene_expression of Apc 20 0.50 11.37 1.3 5.00
80 INT139237 Negative_regulation of Gene_expression of CDH1 23 0.57 24.31 1.28 5.00
81 INT188396 Positive_regulation of Positive_regulation of GOPC 13 0.42 1.78 1.21 5.00
82 INT157765 Negative_regulation of CDH1 32 0.53 35.72 1.15 5.00
83 INT147909 Gene_expression of Lpl 21 0.58 9.35 1.14 5.00
84 INT151774 Positive_regulation of Mtor 38 0.45 20.15 1.01 5.00
85 INT81795 Negative_regulation of AGRP 23 0.41 10.93 0.87 5.00
86 INT124850 Gene_expression of Tpt1 42 0.77 14.51 0.79 5.00
87 INT134207 Gene_expression of Ptk2 56 0.73 31.97 0.78 5.00
88 INT114880 Negative_regulation of Cdk2 7 0.35 3.89 0.77 5.00
89 INT129174 Gene_expression of PKD1 24 0.67 14.91 0.74 5.00
90 INT95617 Regulation of Msx1 2 0.56 1.05 0.73 5.00
91 INT1939 Localization of Cys1 6 0.73 5.9 0.64 5.00
92 INT137850 Gene_expression of PKD2 9 0.65 6.68 0.63 5.00
93 INT241235 Binding of Pkd2 11 0.48 2.43 0.55 5.00
94 INT241243 Gene_expression of Pkd2 30 0.77 9.05 0.53 5.00
95 INT134208 Negative_regulation of Ptk2 19 0.58 23.59 0.52 5.00
96 INT163993 Gene_expression of Hnf1a 2 0.65 1.38 0.49 5.00
97 INT81645 Positive_regulation of Gene_expression of Ctnnb1 6 0.63 3.78 0.47 5.00
98 INT268007 Gene_expression of Fgf8 8 0.72 1.38 0.47 5.00
99 INT259832 Positive_regulation of Slc12a3 3 0.23 2.07 0.46 5.00
100 INT286550 Negative_regulation of Prkd1 4 0.42 3.68 0.45 5.00
101 INT277465 Regulation of Gene_expression of Fgf8 2 0.25 0.43 0.43 5.00
102 INT76958 Positive_regulation of Ctnnb1 14 0.64 5.48 0.41 5.00
103 INT185370 Gene_expression of ANC 28 0.65 13.28 0.4 5.00
104 INT208643 Gene_expression of Gt(ROSA)26Sor 11 0.65 4.85 0.37 5.00
105 INT283683 Binding of Id2 5 0.35 0.8 0.35 5.00
106 INT226835 Gene_expression of Cdh2 14 0.22 8.04 0.31 5.00
107 INT294806 Gene_expression of Dlx5 6 0.71 2.07 0.3 5.00
108 INT241240 Gene_expression of Pkd1 18 0.54 12.2 0.27 5.00
109 INT214128 Negative_regulation of Gene_expression of Msx1 3 0.53 1.25 0.26 5.00
110 INT286538 Gene_expression of Prkd1 7 0.56 3.97 0.24 5.00
111 INT259867 Binding of SCN1A 2 0.36 4.7 0.21 5.00
112 INT294897 Negative_regulation of Slc12a3 2 0.20 1.77 0.2 5.00
113 INT208539 Positive_regulation of Gene_expression of Gnas 4 0.08 2.76 0.18 5.00
114 INT208476 Binding of Pkd1 13 0.39 7.23 0.17 5.00
115 INT286532 Localization of Prkd1 3 0.58 3.02 0.16 5.00
116 INT217569 Binding of Wnt1 2 0.36 1.07 0.15 5.00
117 INT230524 Binding of LILRB1 2 0.35 2.14 0.15 5.00
118 INT193777 Negative_regulation of Fgf1 6 0.13 4.26 0.12 5.00
119 INT271941 Binding of Tsc2 12 0.24 2.96 0.11 5.00
120 INT283708 Localization of Id2 2 0.71 0.72 0.11 5.00
121 INT125391 Gene_expression of Rim5 2 0.01 1.94 0.11 5.00
122 INT283560 Negative_regulation of Gene_expression of Ptk2 6 0.40 4.84 0.09 5.00
123 INT260050 Gene_expression of PCDH19 1 0.77 12.52 0.09 5.00
124 INT228403 Binding of Slc12a3 2 0.16 0.52 0.07 5.00
125 INT286583 Localization of PKD2 1 0.35 0.17 0.06 5.00
126 INT311643 Negative_regulation of Spry1 1 0.40 0.95 0.05 5.00
127 INT235057 Positive_regulation of Negative_regulation of Apc 2 0.30 0.66 0.05 5.00
128 INT211006 Binding of PKD1 6 0.22 2.69 0.05 5.00
129 INT286535 Regulation of Prkd1 3 0.33 2.24 0.04 5.00
130 INT247803 Positive_regulation of Cdh2 2 0.11 2.03 0.04 5.00
131 INT311641 Regulation of Gene_expression of Spry1 1 0.57 0.5 0.04 5.00
132 INT205607 Regulation of Fgf1 4 0.24 3.34 0.04 5.00
133 INT311648 Regulation of Gene_expression of Wnt1 1 0.39 0.09 0.04 5.00
134 INT286543 Localization of Pkd1 5 0.52 3.74 0.04 5.00
135 INT238180 Binding of Ptk2 5 0.35 2.99 0.04 5.00
136 INT303538 Positive_regulation of Fgfr1 3 0.65 0.92 0.03 5.00
137 INT185372 Negative_regulation of ANC 6 0.26 1.52 0.03 5.00
138 INT286581 Gene_expression of PKHD1 1 0.24 0.19 0.03 5.00
139 INT286533 Negative_regulation of Gene_expression of Cdh2 1 0.11 1.4 0.03 5.00
140 INT282568 Positive_regulation of Cdk2 6 0.34 2.95 0.03 5.00
141 INT241241 Positive_regulation of Gene_expression of Pkd2 3 0.50 1.3 0.03 5.00
142 INT286580 Positive_regulation of Gene_expression of PKHD1 1 0.16 0.1 0.03 5.00
143 INT311635 Negative_regulation of Gene_expression of Dlx6 1 0.39 0.23 0 5.00
144 INT286551 Binding of Pxn 1 0.08 0.94 0 5.00
145 INT286556 Binding of Neat1 1 0.05 0.94 0 5.00
146 INT311629 Negative_regulation of Gene_expression of Dlx5 1 0.39 0.42 0 5.00
147 INT239065 Localization of ANC 3 0.46 0.77 0 5.00
148 INT311653 Binding of Spry1 1 0.34 0.98 0 5.00
149 INT260046 Gene_expression of PCDH11Y 1 0.48 0.62 0 5.00
150 INT311636 Positive_regulation of Gene_expression of Slc12a3 1 0.23 0.62 0 5.00
151 INT286577 Binding of ID2 1 0.19 0.12 0 5.00
152 INT311627 Regulation of Barx1 1 0.56 0.88 0 5.00
153 INT286555 Binding of Ift88 1 0.30 0.08 0 5.00
154 INT227397 Localization of Rim5 1 0.02 0.49 0 5.00
155 INT205576 Positive_regulation of Hnf1a 2 0.49 1.1 0 5.00
156 INT283691 Binding of Aatf 2 0.03 0.19 0 5.00
157 INT205587 Negative_regulation of Cyp17a1 1 0.28 0.24 0 5.00
158 INT286541 Negative_regulation of Cdh2 1 0.03 1.09 0 5.00
159 INT311639 Positive_regulation of Spry1 1 0.64 0.19 0 5.00
160 INT286545 Positive_regulation of Gene_expression of Pkd1 1 0.42 1.55 0 5.00
161 INT311640 Regulation of Binding of Spry1 1 0.42 0.77 0 5.00
162 INT286576 Binding of PKHD1 1 0.12 0.63 0 5.00
163 INT311637 Positive_regulation of Gene_expression of Ex 1 0.49 0.18 0 5.00
164 INT286558 Transcription of Nek8 1 0.46 0.7 0 5.00
165 INT206909 Negative_regulation of Gene_expression of Msx2 2 0.53 0.29 0 5.00
166 INT205583 Gene_expression of Hnf1b 1 0.59 2.09 0 5.00
167 INT286549 Regulation of Tsc2 1 0.11 0.42 0 5.00
168 INT271919 Gene_expression of Tsc2 6 0.39 2.23 0 5.00
169 INT286557 Regulation of Binding of Aatf 1 0.02 0 0 5.00
170 INT120527 Localization of ABCC2 3 0.78 1.03 0 5.00
171 INT260051 Positive_regulation of PCDH19 1 0.69 1.69 0 5.00
172 INT205579 Positive_regulation of Gene_expression of Hnf1b 1 0.44 2.1 0 5.00
173 INT311634 Positive_regulation of Spry2 1 0.45 0.4 0 5.00
174 INT206911 Gene_expression of Msx2 4 0.71 1.26 0 5.00
175 INT202633 Positive_regulation of Gene_expression of Wnt1 3 0.43 0.85 0 5.00
176 INT175050 Regulation of Etv5 2 0.60 0.87 0 5.00
177 INT205582 Positive_regulation of Hnf1b 1 0.44 1.05 0 5.00
178 INT311628 Negative_regulation of Gene_expression of Spry2 1 0.39 0.43 0 5.00
179 INT286542 Binding of Vcl 1 0.04 0.94 0 5.00
180 INT286544 Localization of Ift88 1 0.52 1.26 0 5.00
181 INT286537 Gene_expression of Cdh6 1 0.04 0.98 0 5.00
182 INT205585 Regulation of Wnt4 1 0.45 0.7 0 5.00
183 INT311651 Positive_regulation of Fgf8 1 0.46 0.26 0 5.00
184 INT150827 Regulation of Pkd1 4 0.32 2.18 0 5.00
185 INT311632 Positive_regulation of Wnt1 1 0.43 0.19 0 5.00
186 INT286554 Negative_regulation of Gene_expression of Pkd1 1 0.35 1.77 0 5.00
187 INT286534 Negative_regulation of Gene_expression of Prkd1 2 0.31 0.89 0 5.00
188 INT286540 Localization of Btk 1 0.28 1.26 0 5.00
189 INT205578 Negative_regulation of Wnt4 1 0.43 1.69 0 5.00
190 INT286587 Negative_regulation of LAMA3 1 0.01 1.01 0 5.00
191 INT311652 Negative_regulation of Regulation of Fgf1 1 0.13 0.32 0 5.00
192 INT286559 Positive_regulation of Gene_expression of Cdh2 1 0.04 1.04 0 5.00
193 INT286584 Positive_regulation of PKHD1 1 0.13 1.01 0 5.00
194 INT286536 Positive_regulation of Positive_regulation of Prkd1 1 0.08 1.28 0 5.00
195 INT244080 Positive_regulation of Gene_expression of Gt(ROSA)26Sor 2 0.36 0.7 0 5.00
196 INT311649 Regulation of Dlx6 1 0.41 0.22 0 5.00
197 INT311642 Binding of Gt(ROSA)26Sor 1 0.03 0.21 0 5.00
198 INT271915 Negative_regulation of Pkd1 8 0.36 6.44 0 5.00
199 INT205581 Regulation of Negative_regulation of Wnt4 1 0.27 0.7 0 5.00
200 INT283566 Localization of Ptk2 5 0.75 0.93 0 5.00
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