D:Polyglandular Deficiency Syndrome

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pChart

Disease Term
Synonyms Autoimmune Polyendocrinopathies, Autoimmune Polyendocrinopathy, Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophies, AUTOIMMUNE POLYENDOCRINOPATHY CANDIDIASIS ECTODERMAL DYSTROPHY, Autoimmune Polyglandular Syndrome, Autoimmune Polyglandular Syndrome Type I, AUTOIMMUNE POLYGLANDULAR SYNDROME TYPE II, Autoimmune Polyglandular Syndromes, Autoimmune Syndrome Type I Polyglandular, AUTOIMMUNE SYNDROME TYPE II POLYGLANDULAR, POLYENDOCRINE DEFICIENCY SYNDROMES
Documents 11
Hot Single Events 2
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Polyglandular Deficiency Syndrome. They are ordered first by their relevance to Polyglandular Deficiency Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT180350 Binding of HLA-DMA and ENAM 1 0.00 1.85 0 48.84
2 INT180351 Binding of TNFRSF25 and ENAM 1 0.01 1.85 0 48.84
3 INT180346 Binding of PRTN3 and SMN1 1 0.00 3.22 0 25.00
4 INT180347 Binding of PRTN3 and BTG3 1 0.00 1.9 0 25.00
5 INT180345 Binding of HLA-DMA and HLA-DRB4 1 0.00 1.51 0.12 5.00
6 INT180344 CYP2A6 Regulation of AMELX 1 0.01 2.01 0.05 5.00
7 INT180348 CYP2A6 Regulation of AIRE 1 0.01 2.01 0.05 5.00
8 INT180372 CYP2A6 Regulation of Cyp1a2 1 0.03 2.02 0.05 5.00
9 INT180373 CYP2A6 Regulation of Cyp2d4 1 0.05 2.01 0.05 5.00
10 INT180349 Binding of AMELX and BTG3 1 0.00 0.56 0 5.00
11 INT186502 Binding of AMELX and HLA-A 1 0.00 0.71 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Polyglandular Deficiency Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Polyglandular Deficiency Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT10721 Gene_expression of BDNF-AS 119 0.76 72.8 16.29 99.92
2 INT180370 Phosphorylation of AMELX 1 0.06 3.05 0 97.24
3 INT86705 Gene_expression of BTG3 41 0.65 37.29 8.29 78.00
4 INT79425 Gene_expression of SMN1 42 0.65 36.37 6.1 77.80
5 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57 77.52
6 INT180332 Gene_expression of Sla 6 0.17 9.77 0.16 76.84
7 INT180360 Gene_expression of ENAM 2 0.45 3.58 0 71.12
8 INT180341 Regulation of Ftcd 1 0.01 2.06 0 64.00
9 INT34058 Gene_expression of FMR1 5 0.75 5.11 0.26 62.76
10 INT170886 Gene_expression of AIRE 2 0.49 4.63 0.19 62.16
11 INT180325 Regulation of Secp43 1 0.01 1.6 0 58.48
12 INT180359 Localization of AIRE 3 0.54 3.94 0.03 54.60
13 INT180331 Regulation of Sla 1 0.06 1.44 0 50.64
14 INT113219 Binding of TNFRSF25 12 0.35 9.77 0.46 48.84
15 INT180369 Binding of ENAM 6 0.24 8.53 0.08 48.84
16 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 46.28
17 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 46.28
18 INT23952 Gene_expression of Cyp2d4 18 0.78 4.76 5.31 25.00
19 INT180367 Positive_regulation of ENAM 1 0.07 1.67 0 25.00
20 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 5.00
21 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
22 INT6230 Localization of Ddc 40 0.79 13.11 20.88 5.00
23 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 5.00
24 INT68347 Negative_regulation of Cyp2d4 34 0.58 7.62 18.35 5.00
25 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 5.00
26 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 5.00
27 INT17565 Regulation of Gpt 85 0.60 43.64 13.68 5.00
28 INT47811 Positive_regulation of Localization of Ddc 11 0.69 4 7.6 5.00
29 INT13520 Binding of HLA-DRB4 30 0.42 32.65 6.74 5.00
30 INT16068 Gene_expression of SERPINB1 27 0.60 20.51 6.56 5.00
31 INT16997 Binding of PRTN3 34 0.48 33.44 6.45 5.00
32 INT2144 Localization of COL7A1 36 0.74 20.92 4.67 5.00
33 INT65514 Gene_expression of Cyp1a2 25 0.77 6.12 4.6 5.00
34 INT180338 Binding of Cyp2d4 12 0.47 6.87 4.09 5.00
35 INT112340 Gene_expression of Cyp11a1 11 0.77 5.19 3.7 5.00
36 INT79477 Binding of HLA-DMA 19 0.26 13.78 3.47 5.00
37 INT96542 Negative_regulation of SMN1 14 0.51 10.72 3.11 5.00
38 INT180343 Negative_regulation of Negative_regulation of Cyp2d4 2 0.36 0.49 2.38 5.00
39 INT70878 Gene_expression of CYP2A6 17 0.75 4.25 2.02 5.00
40 INT10576 Gene_expression of Cyp21a1 7 0.44 1.62 1.32 5.00
41 INT13674 Gene_expression of Cyp1a1 13 0.65 2.22 1.25 5.00
42 INT130671 Regulation of Gene_expression of Cyp1a2 2 0.43 1.27 0.87 5.00
43 INT180361 Positive_regulation of AMELX 7 0.12 6.03 0.76 5.00
44 INT180353 Binding of AMELX 10 0.04 15.34 0.4 5.00
45 INT42338 Gene_expression of Amhr2 3 0.65 1.02 0.39 5.00
46 INT186506 Negative_regulation of BTG3 4 0.41 3.31 0.36 5.00
47 INT144885 Gene_expression of AMELX 4 0.11 2.89 0.29 5.00
48 INT180362 Negative_regulation of AMELX 2 0.11 1.51 0.27 5.00
49 INT52177 Binding of Cyp2d1 2 0.36 0.57 0.26 5.00
50 INT180352 Regulation of AMELX 1 0.03 4.02 0.21 5.00
51 INT180336 Regulation of Asgr2 1 0.05 1.41 0.08 5.00
52 INT180333 Positive_regulation of Asgr2 1 0.08 0.82 0.07 5.00
53 INT180339 Localization of Sla 1 0.16 1.34 0.07 5.00
54 INT180328 Binding of Uggt1 1 0.12 2.03 0.05 5.00
55 INT180329 Positive_regulation of Binding of Cyp2d4 1 0.33 1.97 0.05 5.00
56 INT180335 Positive_regulation of Binding of Uggt1 1 0.17 2.04 0.05 5.00
57 INT180342 Gene_expression of Asgr2 1 0.09 1.46 0.05 5.00
58 INT180355 Binding of AIRE 1 0.06 7.13 0.05 5.00
59 INT180357 Positive_regulation of Binding of AIRE 1 0.08 1.96 0.05 5.00
60 INT180371 Positive_regulation of Binding of ENAM 1 0.08 1.97 0.05 5.00
61 INT176561 Gene_expression of Cyp17a1 3 0.25 1.38 0.04 5.00
62 INT180368 Localization of AMELX 1 0.06 1.9 0.03 5.00
63 INT180326 Regulation of Gene_expression of Cyp2d4 1 0.18 0.77 0 5.00
64 INT180327 Gene_expression of Bcar3 1 0.01 0.66 0 5.00
65 INT180330 Positive_regulation of Amhr2 1 0.01 0.57 0 5.00
66 INT180334 Gene_expression of Asf1a 1 0.01 1.29 0 5.00
67 INT180337 Gene_expression of Cyp2b3 1 0.27 0.32 0 5.00
68 INT180340 Binding of Asf1a 1 0.01 0.36 0 5.00
69 INT180354 Negative_regulation of ENAM 1 0.06 1.64 0 5.00
70 INT180356 Binding of SEPSECS 1 0.02 0.71 0 5.00
71 INT180358 Positive_regulation of Localization of AIRE 1 0.07 1.17 0 5.00
72 INT180363 Positive_regulation of AIRE 1 0.10 1.18 0 5.00
73 INT180364 Gene_expression of TRNP 1 0.03 1.1 0 5.00
74 INT180365 Negative_regulation of Negative_regulation of ENAM 1 0.06 1.67 0 5.00
75 INT186505 Negative_regulation of Gene_expression of BTG3 1 0.03 1.46 0 5.00
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