D:Polymyalgia Rheumatica

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Disease Term
Synonyms FORESTIER CERTONCINY SYNDROME, MYALGIC SYNDROME OF THE AGED, Peri Extra Articular Rheumatism, Pmr Polymyalgia Rheumatica, Polymyalgia Arteritica, Polymyalgia Rheumatica Disorder, POLYMYALGIA RHEUMATICA SYNDROME, Pseudopolyarthritides Rhizomelic, Pseudopolyarthritis Rhizomelic, Rheumatism Peri Extra Articular, Rhizomelic Pseudopolyarthritides
Documents 311
Hot Single Events 78
Hot Interactions 6

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Polymyalgia Rheumatica. They are ordered first by their relevance to Polymyalgia Rheumatica and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT171940 Binding of TNF and ATP2C1 1 0.08 7.32 0.39 100.00
2 INT171938 Binding of HLA-DOA and ATP2C1 1 0.01 3.88 0.2 100.00
3 INT171942 Binding of HLA-DRB1 and ATP2C1 1 0.04 2.18 0.12 100.00
4 INT171945 PECAM1 Positive_regulation of Gene_expression of ICAM1 1 0.06 1.66 0.16 99.92
5 INT171944 ICAM1 Positive_regulation of Gene_expression of PECAM1 1 0.06 1.66 0.16 99.92
6 INT171939 Binding of HLA-DOA and TNF 1 0.05 6.8 0.26 99.40
7 INT299725 AFP Positive_regulation of Positive_regulation of ACPP 1 0.00 0.78 0.17 46.72
8 INT316748 IL18 Positive_regulation of Regulation of Hand2 1 0.14 1.11 0.18 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Polymyalgia Rheumatica. They are ordered first by their pain relevance and then by number of times they were reported in Polymyalgia Rheumatica. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT152763 Binding of ATP2C1 2 0.32 4.11 0.61 100.00
2 INT171955 Localization of ATP2C1 1 0.12 4.02 0.22 100.00
3 INT15687 Regulation of ESR1 91 0.60 40.42 7.95 100.00
4 INT86128 Negative_regulation of ATP2C1 1 0.09 1.65 0.31 100.00
5 INT171953 Regulation of ATP2C1 1 0.07 2.21 0.38 100.00
6 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 99.96
7 INT63339 Transcription of ICAM1 6 0.69 3.92 1.37 99.96
8 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 99.92
9 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 99.92
10 INT73902 Regulation of Gene_expression of IL1RN 6 0.61 4.59 6.14 99.88
11 INT1635 Gene_expression of Vip 245 0.78 53.36 88.13 99.84
12 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 99.84
13 INT92354 Localization of ESR1 77 0.75 33.04 15.51 99.84
14 INT26314 Positive_regulation of MMP3 48 0.67 22.14 16.17 99.84
15 INT56448 Regulation of ICAM1 52 0.60 55.1 10.96 99.76
16 INT6481 Binding of TNF 624 0.48 510.2 214.82 99.66
17 INT78901 Localization of CCL5 67 0.78 40.79 20.59 99.42
18 INT78899 Gene_expression of CCL5 155 0.77 84.02 55.09 99.42
19 INT78895 Regulation of CCL5 30 0.46 20.45 10.18 99.42
20 INT24741 Positive_regulation of Rf 16 0.17 18.23 4.75 99.36
21 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 99.22
22 INT6477 Gene_expression of IL1RN 213 0.77 114.69 58.62 99.20
23 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 99.12
24 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 99.12
25 INT2867 Gene_expression of CALCA 247 0.78 78.78 138.47 99.12
26 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 99.12
27 INT161599 Binding of Saa 11 0.41 8.61 2.34 98.86
28 INT91758 Binding of CCR5 28 0.45 20.16 7.07 98.32
29 INT56651 Binding of HLA-DRB1 58 0.48 52.25 13.68 98.08
30 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 97.92
31 INT79545 Positive_regulation of Gene_expression of ESR1 82 0.64 39.42 12.18 97.92
32 INT6852 Localization of TNF 883 0.81 705.95 270.84 97.92
33 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 97.88
34 INT52625 Regulation of IL1RN 30 0.61 19.12 11.31 97.84
35 INT88322 Gene_expression of CCR5 111 0.78 77.36 39.84 97.80
36 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 97.64
37 INT23402 Binding of HLA-DOA 74 0.48 52.01 10.89 97.60
38 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 97.58
39 INT171951 Localization of CADM1 1 0.11 1.45 0.05 97.48
40 INT37296 Binding of Esr1 117 0.43 62.51 27.33 97.00
41 INT77675 Gene_expression of Saa 40 0.58 43.37 18.69 96.96
42 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 96.80
43 INT58288 Positive_regulation of Gene_expression of Crp 83 0.61 82.23 23.7 96.60
44 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52 96.32
45 INT143230 Gene_expression of CRYGD 61 0.65 52.11 15.93 96.28
46 INT171946 Positive_regulation of Binding of CCR5 1 0.47 3.86 0.66 95.96
47 INT1767 Positive_regulation of PROC 83 0.67 54.14 17 95.84
48 INT8541 Gene_expression of Csrp1 42 0.76 23.72 6.9 95.48
49 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 95.44
50 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 95.36
51 INT117080 Localization of Csrp1 6 0.42 7.23 3.09 94.64
52 INT48244 Gene_expression of Il4 172 0.76 132.38 73.42 93.96
53 INT120664 Positive_regulation of TACC2 3 0.01 7.43 1.08 93.96
54 INT67248 Gene_expression of TACC2 12 0.50 13.51 3.65 93.96
55 INT8798 Positive_regulation of Csrp1 61 0.69 63.86 14.14 93.04
56 INT143228 Positive_regulation of Amh-rs3 1 0.02 6.36 1.32 92.88
57 INT143227 Gene_expression of Amh-rs3 1 0.03 4.2 0.86 92.88
58 INT143231 Positive_regulation of CRYGD 20 0.49 14.87 3.67 92.88
59 INT143229 Positive_regulation of Positive_regulation of CRYGD 2 0.49 2.49 0.47 92.88
60 INT143226 Positive_regulation of Positive_regulation of Amh-rs3 1 0.02 2.12 0.44 92.88
61 INT2038 Localization of Esr1 104 0.79 40.12 13.27 92.72
62 INT93717 Gene_expression of Mmp3 85 0.78 33.95 24.89 92.28
63 INT77677 Positive_regulation of Saa 30 0.49 33.19 11.18 92.26
64 INT9118 Gene_expression of Ceacam1 37 0.75 17.19 6.12 91.92
65 INT91721 Binding of IL18 21 0.48 21.17 6.56 90.40
66 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 89.92
67 INT49993 Positive_regulation of Gene_expression of Il6 149 0.70 88.07 53.78 89.92
68 INT131202 Negative_regulation of SAA@ 1 0.57 0.62 0.14 89.32
69 INT80549 Binding of ICAM1 53 0.47 42.76 9.72 88.64
70 INT63340 Positive_regulation of Gene_expression of ICAM1 109 0.70 90.82 20.61 88.52
71 INT285 Positive_regulation of Salpa1 73 0.68 61.47 9.19 86.16
72 INT22454 Regulation of Crp 213 0.62 160.67 49.24 85.68
73 INT6474 Positive_regulation of Gene_expression of IL1RN 34 0.69 21.87 10.99 85.12
74 INT27680 Negative_regulation of Ggt6 6 0.57 3.4 1.1 84.24
75 INT35175 Localization of IL18 18 0.80 12.96 3.83 83.96
76 INT284 Positive_regulation of Ggt6 18 0.67 13.56 4.62 83.68
77 INT62827 Positive_regulation of ICAM1 184 0.70 180.95 36.28 82.32
78 INT89292 Positive_regulation of CCR5 27 0.70 15.12 8.59 81.76
79 INT52740 Binding of ACLS 5 0.31 3 0.54 76.40
80 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 74.40
81 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 74.16
82 INT143225 Regulation of Amh-rs3 1 0.01 2.11 0.48 73.72
83 INT232234 Positive_regulation of Positive_regulation of Saa 2 0.41 5.59 1.28 73.36
84 INT133567 Regulation of IL18 11 0.50 9.54 2.31 73.12
85 INT120665 Binding of TACC2 4 0.07 4.33 0.46 69.12
86 INT73927 Gene_expression of FBL 10 0.48 3.55 1.72 68.24
87 INT16405 Regulation of CD8A 38 0.45 19.04 5.31 67.60
88 INT17747 Regulation of Cd4 14 0.41 10.02 2.12 67.60
89 INT111726 Regulation of Scd4 1 0.03 0.07 0 67.60
90 INT13397 Localization of DMD 21 0.78 7.96 1.08 65.28
91 INT113420 Positive_regulation of Gene_expression of IL18 22 0.69 19.96 5.53 65.20
92 INT69036 Gene_expression of IL18 99 0.77 77.92 25.95 64.88
93 INT346112 Negative_regulation of Negative_regulation of IgG 1 0.01 0.05 0.63 50.40
94 INT725 Negative_regulation of IgG 62 0.41 37.21 8.16 50.00
95 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33 48.16
96 INT25162 Positive_regulation of ACPP 7 0.41 4.51 0.62 46.72
97 INT19399 Gene_expression of Rf 43 0.36 33.39 13.53 45.84
98 INT67985 Regulation of Saa 9 0.44 9.36 3 43.08
99 INT77676 Regulation of Gene_expression of Saa 4 0.29 3.2 1.61 43.08
100 INT77674 Positive_regulation of Gene_expression of Saa 11 0.36 11.92 6.09 42.80
101 INT6511 Positive_regulation of AFP 76 0.70 70.15 7.28 42.48
102 INT87963 Regulation of Tg 3 0.45 2.7 0.32 42.40
103 INT16997 Binding of PRTN3 34 0.48 33.44 6.45 39.92
104 INT258962 Protein_catabolism of Saa 1 0.43 1.47 0.44 39.16
105 INT58038 Binding of Drb1 5 0.22 3.42 3 38.08
106 INT19330 Binding of HLA-A 99 0.48 76.26 22.85 29.52
107 INT10721 Gene_expression of BDNF-AS 119 0.76 72.8 16.29 29.04
108 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 28.32
109 INT181001 Regulation of PRTN3 5 0.18 6.07 3.39 27.84
110 INT69992 Negative_regulation of Hmox2 93 0.50 49.01 44.07 25.00
111 INT106807 Binding of Lama5 2 0.08 1.71 0.24 25.00
112 INT16669 Gene_expression of CNDP2 8 0.26 1.7 1.12 19.76
113 INT12324 Positive_regulation of PRTN3 26 0.70 18.82 4.55 19.04
114 INT201997 Gene_expression of PEPB 1 0.27 0.63 0.23 18.48
115 INT134651 Binding of TLR4 89 0.48 66.96 23.19 12.12
116 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 9.44
117 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 5.00
118 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 5.00
119 INT156 Negative_regulation of Prl 542 0.59 131.97 192.24 5.00
120 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 5.00
121 INT214 Localization of AVP 370 0.81 208.51 91.09 5.00
122 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
123 INT19511 Localization of Il6 212 0.81 118.17 67.67 5.00
124 INT10706 Regulation of Il6 150 0.62 93.23 62.34 5.00
125 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 5.00
126 INT34729 Positive_regulation of IFN1@ 233 0.67 128.04 30.38 5.00
127 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57 5.00
128 INT51474 Binding of Il6 55 0.48 44.99 20.52 5.00
129 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26 5.00
130 INT112017 Regulation of Hand2 77 0.36 62.23 18.04 5.00
131 INT871 Negative_regulation of Gene_expression of Prl 53 0.58 18.89 17.79 5.00
132 INT4067 Negative_regulation of Esr1 97 0.50 43.45 17.52 5.00
133 INT17237 Regulation of Esr1 74 0.43 49.09 17.25 5.00
134 INT96155 Gene_expression of Cd86 134 0.77 50.56 17.13 5.00
135 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92 5.00
136 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 5.00
137 INT170754 Localization of IFN1@ 121 0.78 66.78 15.6 5.00
138 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 5.00
139 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 5.00
140 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19 5.00
141 INT8065 Binding of AGT 54 0.48 20.54 10.85 5.00
142 INT87863 Positive_regulation of IL18 40 0.69 34.08 9.53 5.00
143 INT20664 Binding of ACE 60 0.48 35.27 9.16 5.00
144 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 5.00
145 INT27551 Gene_expression of SERPINH1 45 0.62 42.87 9.04 5.00
146 INT764 Gene_expression of OLAH 25 0.67 25.58 8.07 5.00
147 INT22024 Negative_regulation of HBG1 45 0.58 26 6.8 5.00
148 INT13396 Gene_expression of DMD 125 0.75 57.81 5.45 5.00
149 INT10916 Positive_regulation of BDNF-AS 39 0.49 25.88 5.28 5.00
150 INT9837 Negative_regulation of Rf 12 0.11 8.41 4.55 5.00
151 INT5148 Regulation of CD40LG 25 0.44 21.58 4.05 5.00
152 INT33735 Binding of ANGPTL5 39 0.32 14.23 3.66 5.00
153 INT16165 Regulation of DMD 114 0.60 35.13 3.64 5.00
154 INT134694 Binding of CYP27A1 10 0.47 5.61 3.56 5.00
155 INT76399 Binding of Serpina6 4 0.34 3.81 3.46 5.00
156 INT171998 Binding of DMD 58 0.47 38.13 3.35 5.00
157 INT81229 Binding of COL1A1 24 0.35 12.07 3.3 5.00
158 INT4479 Negative_regulation of Positive_regulation of REN 17 0.56 6.1 3.27 5.00
159 INT37193 Negative_regulation of BDNF-AS 21 0.37 15.06 3.12 5.00
160 INT142908 Localization of FGFR1 18 0.38 11.46 2.57 5.00
161 INT68091 Localization of COL1A1 19 0.66 9.13 2.56 5.00
162 INT61684 Localization of COL1A2 20 0.73 9.31 2.26 5.00
163 INT9188 Localization of HBG1 12 0.75 8.14 2.24 5.00
164 INT2611 Negative_regulation of AQP1 17 0.39 10.04 2.15 5.00
165 INT41775 Gene_expression of NEUROG1 10 0.71 5.46 2.14 5.00
166 INT201993 Binding of NEUROG1 4 0.09 4.62 1.85 5.00
167 INT163960 Localization of Saa 4 0.49 4.28 1.75 5.00
168 INT172041 Gene_expression of FLG 6 0.65 3.55 1.58 5.00
169 INT211054 Positive_regulation of AQP1 3 0.33 4.53 1.41 5.00
170 INT8067 Negative_regulation of Binding of AGT 12 0.25 10.33 1.39 5.00
171 INT6514 Positive_regulation of Gene_expression of PTH 28 0.67 30.28 1.37 5.00
172 INT89198 Transcription of Saa 2 0.45 2.59 1.31 5.00
173 INT85427 Regulation of BDNF-AS 9 0.05 5.66 1.28 5.00
174 INT91872 Gene_expression of RPA1 9 0.77 5.28 1.12 5.00
175 INT85831 Positive_regulation of CA9 5 0.60 8.29 1.02 5.00
176 INT98409 Binding of Rf 4 0.08 3.97 0.94 5.00
177 INT192686 Positive_regulation of Positive_regulation of DMD 8 0.41 4.66 0.93 5.00
178 INT41590 Positive_regulation of PAX5 10 0.42 3.1 0.91 5.00
179 INT62155 Positive_regulation of Gene_expression of DMD 17 0.67 6.17 0.82 5.00
180 INT204852 Gene_expression of Cd83 7 0.48 3.15 0.76 5.00
181 INT30978 Binding of CA9 3 0.20 3.05 0.75 5.00
182 INT204776 Negative_regulation of Saa 2 0.28 1.83 0.73 5.00
183 INT259902 Regulation of Gene_expression of ACE 3 0.45 1.87 0.7 5.00
184 INT72446 Negative_regulation of Binding of ACE 4 0.42 2.48 0.62 5.00
185 INT254248 Regulation of Rf 2 0.16 0.46 0.53 5.00
186 INT237093 Binding of crf 5 0.38 16.18 0.38 5.00
187 INT73925 Regulation of FBL 3 0.22 2.19 0.31 5.00
188 INT211055 Binding of PAX5 2 0.33 0.85 0.18 5.00
189 INT211051 Gene_expression of FITM1 2 0.28 0.55 0.15 5.00
190 INT201994 Regulation of TACC2 2 0.03 0.21 0.1 5.00
191 INT192687 Negative_regulation of PAX5 9 0.40 1.42 0.08 5.00
192 INT211048 Negative_regulation of Binding of PAX5 1 0.29 0.1 0.05 5.00
193 INT211050 Positive_regulation of Binding of PAX5 1 0.34 0.1 0.05 5.00
194 INT133103 Negative_regulation of Localization of COL1A2 2 0.04 1.49 0.03 5.00
195 INT132717 Localization of PAX5 3 0.50 1.27 0.03 5.00
196 INT211053 Positive_regulation of Gene_expression of FITM1 2 0.18 0.13 0 5.00
197 INT316745 Phosphorylation of IL18 1 0.70 0.79 0 5.00
198 INT300037 Localization of EEF1A2 2 0.73 2.02 0 5.00
199 INT171994 Regulation of Positive_regulation of DMD 4 0.15 0.82 0 5.00
200 INT211052 Regulation of Regulation of DMD 2 0.12 0.59 0 5.00
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