D:Polyostotic Fibrous Dysplasia

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Disease Term
Synonyms Albright S Syndrome, Albright Syndrome, Albrights Syndrome, DYSPLASIA POLYOSTOTIC FIBROUS, Dysplasias Polyostotic Fibrous, FIBROUS DYSPLASIAS POLYOSTOTIC, MCCUNE ALBRIGHT SYNDROME, Polyostotic Fibrous Dysplasias, Syndrome Albright S, Syndrome Mccune Albright
Documents 62
Hot Single Events 36
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Polyostotic Fibrous Dysplasia. They are ordered first by their relevance to Polyostotic Fibrous Dysplasia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT196592 Binding of CFD and GHRH 1 0.02 1.88 0.07 100.00
2 INT239081 Binding of GH1 and MAS1 1 0.03 1.41 0.15 100.00
3 INT239080 Binding of PPY and KAT2B 1 0.02 2.38 0 94.64
4 INT303600 IGF1 Regulation of Gene_expression of GH1 1 0.39 0.83 0.14 41.92
5 INT266839 Fgf23 Negative_regulation of Slc34a1 1 0.21 0.88 0 27.08
6 INT339794 Sstr2 Positive_regulation of Gene_expression of Sstr5 1 0.08 0.25 0.64 5.00
7 INT239087 Binding of SST and Negative_regulation of Localization of GH1 1 0.19 0.36 0.24 5.00
8 INT266837 Dmp1 Negative_regulation of Gene_expression of Fgf23 1 0.48 2.41 0 5.00
9 INT266835 Pth Regulation of Slc34a3 1 0.19 0.07 0 5.00
10 INT266836 Pth Regulation of Slc34a1 1 0.09 0.07 0 5.00
11 INT266834 Pth Negative_regulation of Positive_regulation of Grxcr1 1 0.04 0.51 0 5.00
12 INT266833 Phex Regulation of Gene_expression of Fgf23 1 0.23 0.46 0 5.00
13 INT266838 Fgf23 Regulation of Slc34a1 1 0.13 0.3 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Polyostotic Fibrous Dysplasia. They are ordered first by their pain relevance and then by number of times they were reported in Polyostotic Fibrous Dysplasia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT131488 Binding of MAS1 9 0.36 8.49 1.01 100.00
2 INT181973 Positive_regulation of MAS1 8 0.49 7.64 1.07 100.00
3 INT149762 Regulation of MAS1 8 0.31 5.34 1.61 100.00
4 INT170854 Gene_expression of CFD 26 0.68 39.77 4.74 100.00
5 INT196595 Regulation of Localization of CFD 1 0.39 2.03 0.04 100.00
6 INT196594 Localization of CFD 4 0.65 4.36 0.39 100.00
7 INT125980 Binding of CFD 8 0.42 10.96 1.39 100.00
8 INT148341 Gene_expression of MAS1 9 0.65 4.19 0.68 100.00
9 INT196593 Phosphorylation of CFD 1 0.55 0.84 0.04 100.00
10 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 99.90
11 INT9683 Binding of GH1 57 0.47 21.14 5.99 99.76
12 INT15347 Positive_regulation of Localization of Pomc 81 0.70 28.1 31.01 99.52
13 INT1438 Localization of Pomc 360 0.81 101.26 116.47 99.16
14 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 98.48
15 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 98.36
16 INT1108 Gene_expression of PPY 58 0.75 36.57 10.76 97.92
17 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 97.80
18 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26 97.12
19 INT2544 Localization of PTH 39 0.81 30.55 2.22 96.88
20 INT62919 Regulation of Gnas 22 0.43 5.61 9.55 95.00
21 INT243713 Positive_regulation of Gene_expression of Gbp1 2 0.12 2.58 0 94.80
22 INT88237 Gene_expression of Gbp1 9 0.65 5.46 0.61 93.96
23 INT158 Localization of Prl 2431 0.81 378.96 952.2 93.20
24 INT180250 Positive_regulation of GLUL 23 0.29 7.57 3.23 92.44
25 INT118373 Gene_expression of Fgf23 16 0.77 29.62 1.04 91.24
26 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 90.80
27 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52 89.92
28 INT9677 Negative_regulation of Gene_expression of GH1 46 0.48 23.32 3.68 89.72
29 INT148562 Positive_regulation of GNAS 13 0.16 5.31 1.32 83.08
30 INT104907 Negative_regulation of Localization of Alpl 1 0.03 0.92 0.1 82.72
31 INT252 Localization of GH1 529 0.80 227.4 122.05 82.24
32 INT121347 Binding of GNAS 8 0.13 3.99 1.47 81.96
33 INT266830 Regulation of Slc34a3 1 0.42 1.85 0 81.68
34 INT266831 Positive_regulation of Slc34a3 1 0.47 1.79 0 80.40
35 INT3180 Positive_regulation of PPY 39 0.63 25.57 10.15 80.24
36 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 80.08
37 INT104906 Negative_regulation of Alpl 5 0.31 1.72 0.21 78.68
38 INT104905 Localization of Alpl 2 0.08 1.08 0.13 78.68
39 INT425 Localization of PRL 455 0.81 189.64 144.8 76.80
40 INT695 Binding of POMC 304 0.48 56.66 126.85 75.96
41 INT1530 Regulation of Gh 382 0.61 115.96 112.47 75.00
42 INT75315 Regulation of Ghr 4 0.22 1.5 1.34 75.00
43 INT1893 Localization of Gh 1041 0.79 340.23 256.58 75.00
44 INT3161 Regulation of Localization of Gh 163 0.61 35.43 59.45 75.00
45 INT19963 Gene_expression of COL1A1 118 0.59 42.11 15.15 75.00
46 INT19086 Negative_regulation of COL1A1 32 0.38 16.77 5.98 75.00
47 INT19965 Positive_regulation of COL1A1 23 0.45 14.49 4.38 75.00
48 INT79261 Positive_regulation of Gene_expression of COL1A1 24 0.36 7.49 2.45 75.00
49 INT113717 Negative_regulation of Gene_expression of COL1A1 21 0.41 6.14 2.01 75.00
50 INT34741 Positive_regulation of Gene_expression of GH1 58 0.67 35.06 7.8 71.80
51 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 71.52
52 INT5128 Positive_regulation of Lhb 232 0.69 44.23 71.26 69.44
53 INT26538 Positive_regulation of FSHR 103 0.69 30.95 15.33 69.44
54 INT239084 Localization of KAT2B 4 0.73 3.08 0.36 68.88
55 INT239085 Binding of KAT2B 1 0.18 2.04 0.09 68.88
56 INT239082 Binding of BCAM 1 0.03 2.03 0.09 68.68
57 INT239086 Localization of BCAM 2 0.54 2.32 0.09 68.68
58 INT15610 Localization of GOPC 223 0.65 68.26 28.7 68.08
59 INT105021 Binding of GOPC 187 0.40 60.39 20.38 68.08
60 INT70362 Transcription of GH1 9 0.56 2.01 0.69 60.88
61 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 59.36
62 INT443 Localization of POMC 1020 0.81 284.52 443.17 58.32
63 INT22413 Positive_regulation of Cyp39a1 2 0.08 2.49 0.09 57.20
64 INT318008 Positive_regulation of Amh 1 0.25 1.47 0 55.76
65 INT239093 Gene_expression of PTTG1 84 0.65 83.94 1.87 55.28
66 INT31226 Localization of PPY 20 0.78 9.93 6.8 51.12
67 INT1577 Negative_regulation of Gene_expression of PRL 24 0.59 7.7 3.15 50.64
68 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32 50.08
69 INT48725 Gene_expression of IGFBP3 128 0.78 78.83 8.19 50.00
70 INT48728 Negative_regulation of IGFBP3 28 0.59 14.84 1.21 50.00
71 INT117849 Negative_regulation of Gene_expression of IGFBP3 8 0.39 8.75 0.75 50.00
72 INT22500 Negative_regulation of Pth 6 0.43 3.41 2.83 49.52
73 INT239095 Negative_regulation of PTTG1 2 0.32 8.24 0.09 46.48
74 INT249 Localization of GHRH 215 0.80 78.02 51.87 46.08
75 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 41.60
76 INT318002 Gene_expression of Dmrta1 1 0.70 1.18 0 39.84
77 INT4485 Negative_regulation of Positive_regulation of PRL 11 0.43 4.24 3.89 38.96
78 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 38.52
79 INT318005 Negative_regulation of Dmrta1 1 0.39 1.13 0 36.64
80 INT239083 Binding of PPY 9 0.32 7.59 2.9 34.88
81 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9 34.80
82 INT318001 Gene_expression of Nobox 1 0.48 1.03 0 30.08
83 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 29.96
84 INT202241 Positive_regulation of Negative_regulation of IGF1 5 0.48 1.56 0.82 29.96
85 INT266819 Regulation of Localization of Grxcr1 2 0.06 1.28 0 23.36
86 INT266818 Localization of Grxcr1 7 0.12 3.9 0 23.00
87 INT266828 Negative_regulation of Fgf23 3 0.42 5.63 0.04 22.56
88 INT70263 Negative_regulation of Cyp39a1 2 0.05 0.96 0 22.20
89 INT921 Regulation of GH1 172 0.60 52.88 51.04 18.64
90 INT11729 Regulation of IGF1 71 0.61 44.58 9.71 18.64
91 INT4378 Regulation of Gene_expression of GH1 26 0.47 10.2 4.61 18.64
92 INT131187 Regulation of Gene_expression of IGF1 18 0.62 11.18 3.05 18.64
93 INT266823 Regulation of Grxcr1 3 0.06 1.4 0.03 16.76
94 INT118371 Positive_regulation of Fgf23 15 0.69 25.34 0.85 14.24
95 INT135880 Positive_regulation of Gene_expression of Fgf23 4 0.46 7.52 0.29 14.24
96 INT2005 Positive_regulation of Gene_expression of PRL 55 0.70 21.4 13.44 6.60
97 INT118372 Regulation of Fgf23 4 0.55 3.31 0.15 5.04
98 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
99 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 5.00
100 INT2640 Gene_expression of Pomc 424 0.78 120.72 155.37 5.00
101 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
102 INT7395 Localization of GNRH1 399 0.81 62.88 117.68 5.00
103 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
104 INT203 Positive_regulation of Pomc 257 0.70 90.56 92.84 5.00
105 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 5.00
106 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 5.00
107 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 5.00
108 INT462 Regulation of Pomc 157 0.62 41.67 67.27 5.00
109 INT253 Regulation of PRL 184 0.62 47.27 65.79 5.00
110 INT1437 Negative_regulation of Pomc 132 0.59 35.22 60.97 5.00
111 INT5118 Regulation of SST 97 0.62 34.35 51.74 5.00
112 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
113 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 5.00
114 INT1894 Negative_regulation of Localization of Gh 168 0.58 64.12 43.56 5.00
115 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
116 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
117 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 5.00
118 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92 5.00
119 INT691 Binding of SST 67 0.48 24.66 32.67 5.00
120 INT6277 Positive_regulation of Gene_expression of Pomc 76 0.70 21.45 31.09 5.00
121 INT2261 Gene_expression of Lhb 121 0.77 42.78 26.04 5.00
122 INT7394 Positive_regulation of Localization of GNRH1 67 0.69 7.22 25.29 5.00
123 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 5.00
124 INT16303 Negative_regulation of Localization of GH1 89 0.59 37.31 22.15 5.00
125 INT11628 Regulation of Localization of Pomc 44 0.61 10.46 18.66 5.00
126 INT10841 Positive_regulation of Gene_expression of Gh 101 0.59 45.39 16.96 5.00
127 INT6278 Negative_regulation of Gene_expression of Pomc 35 0.59 11.07 14.8 5.00
128 INT27266 Regulation of Gene_expression of Pomc 41 0.62 6.74 14.59 5.00
129 INT4145 Gene_expression of FSHR 124 0.77 44.98 13.04 5.00
130 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 5.00
131 INT35467 Gene_expression of DIO2 37 0.65 9.56 12.61 5.00
132 INT107033 Gene_expression of Slc37a4 66 0.62 27.34 12.35 5.00
133 INT76428 Gene_expression of Sstr2 24 0.76 6.09 12.32 5.00
134 INT1436 Negative_regulation of Localization of Pomc 41 0.58 10.85 11.26 5.00
135 INT987 Localization of TRH 37 0.78 10.53 11.1 5.00
136 INT10009 Positive_regulation of TRH 31 0.67 8.94 11.03 5.00
137 INT91774 Gene_expression of Nr3c1 27 0.78 16.14 10.7 5.00
138 INT952 Negative_regulation of GHRH 57 0.56 25.3 10.34 5.00
139 INT31780 Binding of DIO2 17 0.36 10.07 10 5.00
140 INT8740 Localization of Gcg 65 0.78 19 9.81 5.00
141 INT26751 Regulation of Nr3c1 13 0.61 6.58 8.65 5.00
142 INT34777 Localization of IGF1 82 0.80 42.68 8.62 5.00
143 INT156827 Localization of MRI1 25 0.65 16.06 8.33 5.00
144 INT1499 Negative_regulation of Gene_expression of Gh 58 0.42 25.17 7.86 5.00
145 INT110599 Gene_expression of Bglap 49 0.74 41.23 6.97 5.00
146 INT28861 Binding of Gh 61 0.46 25.61 6.38 5.00
147 INT5126 Positive_regulation of Positive_regulation of Lhb 16 0.48 2.12 5.23 5.00
148 INT22022 Regulation of PPY 8 0.26 5.52 5.02 5.00
149 INT57274 Positive_regulation of Gene_expression of COL7A1 50 0.69 24.19 4.72 5.00
150 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45 5.00
151 INT8744 Regulation of Localization of Gcg 14 0.60 2.06 4.3 5.00
152 INT17620 Positive_regulation of Gnrh1 23 0.70 9.77 3.79 5.00
153 INT131165 Positive_regulation of Gene_expression of Nr3c1 8 0.70 7.18 3.44 5.00
154 INT155983 Gene_expression of Cyp11a1 7 0.58 2.6 3.38 5.00
155 INT48726 Gene_expression of IGFBP1 27 0.67 9.45 3.36 5.00
156 INT4488 Gene_expression of TSHB 10 0.41 4.69 3.09 5.00
157 INT123802 Localization of Sstr2 8 0.80 3.54 3.01 5.00
158 INT16130 Binding of IGF1 67 0.48 27.43 2.95 5.00
159 INT136964 Gene_expression of Dmp1 10 0.75 3.69 2.83 5.00
160 INT9089 Positive_regulation of Ceacam1 17 0.69 7.09 2.49 5.00
161 INT173236 Binding of Sstr2 8 0.25 1.64 2.41 5.00
162 INT15607 Localization of GNRHR 14 0.62 7.56 2.3 5.00
163 INT149451 Gene_expression of Sstr5 3 0.39 1.5 2.24 5.00
164 INT57018 Gene_expression of GANAB 9 0.08 3.76 1.79 5.00
165 INT78938 Binding of IGFBP3 40 0.45 27.95 1.73 5.00
166 INT48616 Positive_regulation of IGFBP1 14 0.43 5.62 1.56 5.00
167 INT102064 Binding of Sstr5 3 0.20 0.86 1.55 5.00
168 INT135959 Negative_regulation of Gene_expression of Igf1 37 0.56 21.16 1.41 5.00
169 INT184303 Positive_regulation of Bglap 16 0.66 8.66 1.25 5.00
170 INT192300 Positive_regulation of Gene_expression of IGFBP1 6 0.60 2.85 0.81 5.00
171 INT16003 Gene_expression of Phex 3 0.65 4.68 0.77 5.00
172 INT316547 Binding of Sst1 2 0.10 0.84 0.74 5.00
173 INT278006 Binding of Sstr3 2 0.33 1.07 0.71 5.00
174 INT158836 Positive_regulation of Localization of TRH 7 0.49 2.61 0.67 5.00
175 INT339791 Negative_regulation of Gene_expression of Sstr2 1 0.14 0.25 0.63 5.00
176 INT178752 Binding of IGFBP1 8 0.15 4.58 0.61 5.00
177 INT335719 Positive_regulation of Gene_expression of DIO2 3 0.23 0.59 0.61 5.00
178 INT55047 Gene_expression of GNRHR 8 0.78 5.2 0.53 5.00
179 INT211968 Localization of Best1 11 0.40 9.33 0.38 5.00
180 INT173238 Negative_regulation of Sstr2 2 0.16 0.68 0.34 5.00
181 INT125804 Localization of Pth 9 0.69 3.93 0.29 5.00
182 INT12531 Localization of GANAB 3 0.09 2.79 0.26 5.00
183 INT325236 Positive_regulation of Localization of Sstr2 2 0.25 0.81 0.22 5.00
184 INT130802 Localization of FGF23 2 0.17 1.78 0.2 5.00
185 INT266832 Positive_regulation of Grxcr1 9 0.12 7.91 0.19 5.00
186 INT172368 Negative_regulation of Binding of IGF1 3 0.42 1.57 0.18 5.00
187 INT266822 Negative_regulation of Grxcr1 10 0.10 8.12 0.17 5.00
188 INT167957 Gene_expression of Grxcr1 8 0.10 3.43 0.14 5.00
189 INT151342 Positive_regulation of Positive_regulation of FSHR 5 0.20 1.79 0.11 5.00
190 INT117827 Positive_regulation of PHEX 3 0.41 1.59 0.08 5.00
191 INT266826 Binding of Fgf23 1 0.32 1.26 0.07 5.00
192 INT239094 Negative_regulation of Binding of GH1 2 0.34 1.61 0.06 5.00
193 INT266821 Positive_regulation of Negative_regulation of Grxcr1 1 0.06 1.51 0.06 5.00
194 INT266820 Positive_regulation of Positive_regulation of Grxcr1 1 0.06 1.58 0.06 5.00
195 INT239092 Positive_regulation of Binding of IGFBP1 1 0.04 0.6 0.04 5.00
196 INT231433 Positive_regulation of Binding of IGFBP3 2 0.34 0.6 0.04 5.00
197 INT318007 Regulation of Lhcgr 1 0.40 0.63 0 5.00
198 INT266824 Regulation of Positive_regulation of Fgf23 1 0.27 1.22 0 5.00
199 INT266829 Regulation of Cyp39a1 1 0.02 0.44 0 5.00
200 INT318006 Regulation of Dmrta1 1 0.41 0.63 0 5.00
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