D:Pompes Disease

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Disease Term
Synonyms "alpha 1,4 Glucosidase Deficiency", "DEFICIENCY DISEASE LYSOSOMAL ALPHA 1,4 GLUCOSIDASE", "deficiency Of Exo 1,4 Alpha Glucosidase", "DEFICIENCY OF GLUCAN 1,4 ALPHA GLUCOSIDASE", "lysosomal Alpha 1,4 Glucosidase Deficiency Disease", "LYSOSOMAL ALPHA 1,4 GLUCOSIDASE DEFICIENCY", Acid Maltase Deficiency Disease, Adult Glycogen Storage Disease Type Ii, Amd Acid Maltase Deficiency, Deficiency Disease Acid Maltase, Deficiency Of Acid Maltase
Documents 36
Hot Single Events 21
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Pompes Disease. They are ordered first by their relevance to Pompes Disease and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT228522 Tmem170b Positive_regulation of Localization of INS 1 0.01 0.66 0.03 97.04
2 INT347806 Binding of MOCS1 and SMAP2 1 0.00 0.48 0.12 64.96
3 INT194861 Binding of IL1B and IL1R1 2 0.01 1.55 1.2 5.00
4 INT300956 Il4 Negative_regulation of IL8 1 0.02 0.37 0.48 5.00
5 INT300960 Il4 Negative_regulation of IL1B 1 0.03 0.37 0.48 5.00
6 INT300957 Binding of IL13 and Il4 1 0.01 0.58 0.48 5.00
7 INT300959 Il4 Negative_regulation of TNF 1 0.03 0.37 0.48 5.00
8 INT300955 Il4 Negative_regulation of Il6 1 0.03 0.37 0.48 5.00
9 INT300958 IL1B Positive_regulation of Il6 1 0.04 0.25 0.25 5.00
10 INT312546 Ros1 Positive_regulation of Positive_regulation of Mapk14 1 0.00 0.87 0.25 5.00
11 INT312550 DAK Positive_regulation of Rxra 1 0.00 1.48 0.18 5.00
12 INT312519 DAK Positive_regulation of PPARA 1 0.00 1.46 0.18 5.00
13 INT347807 GLA Positive_regulation of Positive_regulation of A4GALT 1 0.05 1.57 0.13 5.00
14 INT312547 Akt1 Positive_regulation of Phosphorylation of Ide 1 0.01 0.6 0.08 5.00
15 INT310674 Positive_regulation of Binding of ARSB and ELF3 1 0.07 2.46 0.05 5.00
16 INT331227 Binding of Becn1 and Pink1 1 0.03 1.13 0.05 5.00
17 INT310675 Binding of ARSB and ELF3 1 0.06 2.4 0.05 5.00
18 INT331234 Binding of Becn1 and Pik3c3 Positive_regulation of Pik3c3 1 0.00 0.47 0 5.00
19 INT331226 Binding of Becn1 and Pik3c3 1 0.02 0.47 0 5.00
20 INT331238 Binding of ULK1 and Pik3r1 1 0.09 0.48 0 5.00
21 INT331237 Negative_regulation of IMPA1 Negative_regulation of Itpr3 1 0.00 0.52 0 5.00
22 INT312956 Regulation of Binding of MOCS1 and MTTP 1 0.00 0.21 0 5.00
23 INT331232 Binding of Atg12 and Atg16l1 1 0.03 0.08 0 5.00
24 INT282995 Binding of Bcl2 and Becn1 21 0.03 9.8 0 5.00
25 INT331222 Tsc1 Negative_regulation of Mtor 1 0.00 0.68 0 5.00
26 INT331235 RASA1 Positive_regulation of Mtor 1 0.00 0.32 0 5.00
27 INT331225 Binding of Atg5 and Atg16l1 1 0.05 0.08 0 5.00
28 INT331231 Binding of Bcl2 and Mapk8 1 0.01 0.77 0 5.00
29 INT331230 Binding of Mapk8 and Becn1 1 0.02 0.77 0 5.00
30 INT331228 Atg5 Positive_regulation of Atg12 1 0.06 0.08 0 5.00
31 INT331224 Binding of Akt1 and Tsc2 1 0.03 0.33 0 5.00
32 INT312955 Binding of MOCS1 and MTTP 1 0.00 0.21 0 5.00
33 INT331223 Negative_regulation of Tsc1 Positive_regulation of Positive_regulation of Mtor 1 0.01 0.33 0 5.00
34 INT331229 Rasa1 Positive_regulation of Mtor 1 0.00 0.32 0 5.00
35 INT331233 Binding of Mtor and Rasa1 1 0.00 0.32 0 5.00
36 INT331236 Binding of RASA1 and Mtor 1 0.00 0.32 0 5.00
37 INT331221 Binding of Akt1 and Tsc1 1 0.03 0.33 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Pompes Disease. They are ordered first by their pain relevance and then by number of times they were reported in Pompes Disease. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 100.00
2 INT14572 Binding of INS 205 0.48 175.43 13.38 100.00
3 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61 99.88
4 INT112328 Negative_regulation of PHKG1 2 0.46 0.83 0.1 99.72
5 INT812 Localization of INS 1026 0.81 515.6 145.31 99.68
6 INT46305 Negative_regulation of GAA 2 0.57 1.17 0.07 99.14
7 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 98.96
8 INT3550 Negative_regulation of GLA 52 0.59 33.93 5.26 98.64
9 INT1114 Localization of Ins1 748 0.80 192.95 165.48 98.48
10 INT1988 Positive_regulation of Localization of Ins1 254 0.69 59.25 68.37 98.48
11 INT2579 Protein_catabolism of Ins1 43 0.99 9.91 5.14 98.08
12 INT39106 Regulation of Protein_catabolism of Ins1 2 0.37 1.02 0.54 98.08
13 INT1472 Positive_regulation of Ins1 349 0.69 146.2 86.36 97.40
14 INT39105 Positive_regulation of Protein_catabolism of Ins1 5 0.61 2.01 0.75 97.40
15 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 96.44
16 INT1200 Negative_regulation of Ins1 274 0.58 155.17 56.14 90.84
17 INT97452 Positive_regulation of MOCS1 20 0.39 11.4 2.59 89.84
18 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79 86.40
19 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 84.48
20 INT97453 Negative_regulation of MOCS1 25 0.04 13.4 2.4 83.64
21 INT2936 Gene_expression of AGL 36 0.49 9.55 3.63 82.64
22 INT3659 Negative_regulation of Gcg 26 0.51 10.08 7.39 79.80
23 INT24412 Localization of WDTC1 18 0.68 12.45 4.5 79.52
24 INT24416 Localization of ATP8A2 4 0.73 2.21 1.2 79.52
25 INT24413 Negative_regulation of Localization of ATP8A2 1 0.42 0.08 0.16 79.52
26 INT116728 Negative_regulation of ARSH 9 0.13 9.67 0.27 79.40
27 INT6110 Negative_regulation of Gene_expression of Ins1 83 0.56 60.59 16.07 79.08
28 INT3657 Gene_expression of Ins1 514 0.78 321.69 75.76 78.68
29 INT24415 Negative_regulation of WDTC1 8 0.57 2.66 1.47 78.40
30 INT24414 Negative_regulation of ATP8A2 5 0.43 1.63 1.46 78.08
31 INT3656 Positive_regulation of Gene_expression of Ins1 74 0.54 44.94 17.36 77.84
32 INT28060 Positive_regulation of Hdlcl1 48 0.66 37.31 3.79 77.56
33 INT69947 Negative_regulation of MTAP 5 0.40 2.63 0.48 75.00
34 INT335760 Negative_regulation of Nxf1 1 0.15 1.93 0 72.24
35 INT157301 Negative_regulation of Map1lc3a 5 0.28 3.2 0.41 71.92
36 INT254887 Negative_regulation of Lamp1 2 0.20 3.17 0 71.92
37 INT254876 Negative_regulation of Localization of Lamp1 2 0.20 2.07 0 71.92
38 INT254878 Localization of Map1lc3a 5 0.57 3.32 0.2 71.28
39 INT254882 Localization of Lamp1 3 0.43 2.05 0 71.28
40 INT29333 Positive_regulation of Enpep 8 0.70 3.22 3.25 68.04
41 INT2562 Positive_regulation of Gusb 9 0.69 2.92 1.59 68.04
42 INT16060 Positive_regulation of Ctsd 7 0.70 2.99 0.86 68.04
43 INT29334 Positive_regulation of Positive_regulation of Enpep 2 0.47 1.12 0.44 68.04
44 INT178243 Positive_regulation of Hexa 1 0.19 1.1 0.05 68.04
45 INT38366 Regulation of Cat 45 0.62 23.45 5.34 65.64
46 INT347808 Binding of SMAP2 1 0.00 0.47 0.12 63.60
47 INT153679 Regulation of AGL 4 0.04 1.49 0.07 62.48
48 INT7459 Positive_regulation of Lpl 15 0.70 6.96 1.81 53.56
49 INT1928 Negative_regulation of Lpl 18 0.51 11.22 2.49 52.20
50 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 52.16
51 INT157302 Positive_regulation of Map1lc3a 27 0.66 11.31 0.79 52.16
52 INT157306 Positive_regulation of Positive_regulation of Map1lc3a 3 0.35 1.21 0.44 52.16
53 INT2275 Negative_regulation of Localization of Ins1 183 0.59 51.02 44.94 51.92
54 INT5219 Negative_regulation of DBP 43 0.57 23.35 4.26 50.00
55 INT5164 Negative_regulation of Ldlr 83 0.58 55.01 7.87 45.00
56 INT9660 Regulation of TNF 363 0.62 312.94 139.99 36.08
57 INT35465 Negative_regulation of Pfkm 8 0.57 3.84 2.6 35.64
58 INT36451 Gene_expression of G6PD 26 0.75 7.2 1.09 33.76
59 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 32.60
60 INT307146 Gene_expression of G6pdx 2 0.24 1.7 0.24 32.36
61 INT55597 Negative_regulation of Gpx1 59 0.55 28.3 8.83 29.08
62 INT168432 Negative_regulation of Positive_regulation of Gpx1 4 0.40 2.89 0.75 29.08
63 INT61513 Positive_regulation of Gpx1 71 0.64 37.91 17.07 28.68
64 INT335757 Positive_regulation of Positive_regulation of Gpx1 1 0.07 0.66 0 28.68
65 INT47055 Gene_expression of RBP1 8 0.75 7.85 0.86 22.24
66 INT13240 Gene_expression of TF 94 0.76 57.81 10.99 19.92
67 INT175106 Gene_expression of LCN1 6 0.75 4.59 0.83 18.88
68 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 17.92
69 INT71946 Negative_regulation of Ass1 7 0.41 1.9 2.68 10.48
70 INT55529 Negative_regulation of Gba 13 0.59 7.91 2.1 10.08
71 INT312527 Negative_regulation of G6pdx 1 0.11 0.45 0.2 7.20
72 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
73 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
74 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
75 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
76 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
77 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 5.00
78 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
79 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
80 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
81 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
82 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
83 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
84 INT92669 Gene_expression of Bdnf 309 0.78 178.26 116.68 5.00
85 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
86 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 5.00
87 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
88 INT9012 Localization of Vip 283 0.81 31.71 106.16 5.00
89 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
90 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
91 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
92 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 5.00
93 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
94 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79 5.00
95 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 5.00
96 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
97 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 5.00
98 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 5.00
99 INT6849 Localization of IL1B 229 0.81 112.56 69.63 5.00
100 INT7134 Localization of KNG1 127 0.79 65.73 67.97 5.00
101 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 5.00
102 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 5.00
103 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 5.00
104 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
105 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 5.00
106 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 5.00
107 INT30170 Gene_expression of Car2 330 0.66 77.26 46.76 5.00
108 INT18522 Positive_regulation of Gene_expression of IFNA1 248 0.67 160.85 44.87 5.00
109 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 5.00
110 INT17561 Localization of Car2 303 0.79 60.95 44.52 5.00
111 INT25610 Positive_regulation of Gene_expression of Il1 136 0.67 104.43 43.86 5.00
112 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 5.00
113 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82 5.00
114 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
115 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
116 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 5.00
117 INT2429 Negative_regulation of Mpo 128 0.59 93.76 39.57 5.00
118 INT6484 Binding of IL1B 122 0.47 75.84 35.07 5.00
119 INT79060 Gene_expression of NOS2 116 0.78 69.25 34.84 5.00
120 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 5.00
121 INT5489 Localization of CA2 172 0.80 39.46 33.56 5.00
122 INT10763 Localization of IL2 157 0.80 81.11 33.21 5.00
123 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 5.00
124 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2 5.00
125 INT9655 Regulation of Il6 98 0.62 70.92 31.95 5.00
126 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81 5.00
127 INT124860 Gene_expression of Bace1 330 0.78 157.11 31.65 5.00
128 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 5.00
129 INT6660 Positive_regulation of Jun 148 0.69 67.58 29.73 5.00
130 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 5.00
131 INT133876 Positive_regulation of Gene_expression of Ros1 141 0.32 75.55 27.45 5.00
132 INT37296 Binding of Esr1 117 0.43 62.51 27.33 5.00
133 INT145426 Positive_regulation of Ros1 185 0.56 106.76 27.21 5.00
134 INT69157 Gene_expression of IL5 127 0.77 102.58 26.81 5.00
135 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 5.00
136 INT70048 Positive_regulation of Gene_expression of IL10 90 0.55 71.34 25.66 5.00
137 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53 5.00
138 INT18400 Localization of Glp1r 97 0.80 11.96 24.32 5.00
139 INT79061 Positive_regulation of NOS2 92 0.65 58.89 23.96 5.00
140 INT44954 Gene_expression of APP 191 0.78 105.86 23.9 5.00
141 INT74423 Localization of IL10 91 0.80 61.6 22.95 5.00
142 INT23564 Negative_regulation of Car2 103 0.50 27.28 21.86 5.00
143 INT112029 Positive_regulation of Pik3r1 90 0.67 38.76 20.95 5.00
144 INT20379 Localization of Il4 85 0.73 51.22 20.55 5.00
145 INT1756 Negative_regulation of DNAH8 105 0.59 42.73 20.24 5.00
146 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 5.00
147 INT113399 Positive_regulation of Pla2g4a 36 0.67 33.83 18.78 5.00
148 INT20631 Positive_regulation of CHKB 166 0.69 109.86 17.92 5.00
149 INT4067 Negative_regulation of Esr1 97 0.50 43.45 17.52 5.00
150 INT32515 Negative_regulation of B4GALNT1 82 0.43 28.1 17.46 5.00
151 INT17237 Regulation of Esr1 74 0.43 49.09 17.25 5.00
152 INT34057 Negative_regulation of Gene_expression of IFNA1 65 0.58 43.46 17.25 5.00
153 INT109316 Negative_regulation of Mapk8 72 0.59 50.59 17.24 5.00
154 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83 5.00
155 INT124371 Negative_regulation of Gsk3b 170 0.55 87.92 15.51 5.00
156 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 5.00
157 INT109511 Gene_expression of Bax 133 0.78 113.22 14.36 5.00
158 INT124372 Gene_expression of Gsk3b 164 0.75 95.64 14.35 5.00
159 INT173505 Localization of Hand2 63 0.57 45.32 13.66 5.00
160 INT109304 Positive_regulation of Phosphorylation of Akt1 113 0.69 40.92 13.49 5.00
161 INT2038 Localization of Esr1 104 0.79 40.12 13.27 5.00
162 INT17811 Positive_regulation of Localization of Vip 35 0.67 0.85 12.67 5.00
163 INT398 Localization of AGT 45 0.78 16.97 11.54 5.00
164 INT96915 Phosphorylation of Mapk8 73 0.81 40.69 11.44 5.00
165 INT95369 Positive_regulation of Gene_expression of NOS2 36 0.55 25.09 11.37 5.00
166 INT25170 Positive_regulation of Localization of Car2 78 0.67 15.25 11.24 5.00
167 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75 5.00
168 INT11936 Positive_regulation of Positive_regulation of Il6 34 0.50 26.85 10.59 5.00
169 INT58904 Localization of TH1L 40 0.68 27.11 10.52 5.00
170 INT86361 Positive_regulation of Positive_regulation of NOS1 39 0.53 18.93 10.42 5.00
171 INT17421 Negative_regulation of Alox5 41 0.57 15.23 10.05 5.00
172 INT62166 Positive_regulation of Gene_expression of Gpt 64 0.50 39.13 9.69 5.00
173 INT179696 Negative_regulation of DAK 5 0.02 16.79 9.42 5.00
174 INT41569 Regulation of APP 32 0.62 17.15 9.4 5.00
175 INT135372 Positive_regulation of Gsk3b 72 0.70 50.03 9.28 5.00
176 INT1129 Binding of Car2 69 0.35 14.01 9.2 5.00
177 INT22056 Positive_regulation of CYBB 88 0.68 32.13 7.95 5.00
178 INT126200 Negative_regulation of Bace1 73 0.58 50.19 7.44 5.00
179 INT84932 Negative_regulation of APP 29 0.57 28.45 7.2 5.00
180 INT69289 Negative_regulation of Cftr 44 0.57 13.28 6.97 5.00
181 INT11591 Gene_expression of IgG2a 53 0.65 23.14 6.73 5.00
182 INT112459 Localization of Gba 12 0.80 1.45 6.4 5.00
183 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24 5.00
184 INT57562 Gene_expression of GLA 52 0.77 24.62 6.14 5.00
185 INT75832 Positive_regulation of Positive_regulation of IL8 30 0.70 20.77 6.05 5.00
186 INT25394 Negative_regulation of Gene_expression of Csf2 22 0.52 13.18 5.84 5.00
187 INT49632 Negative_regulation of NBL1 11 0.57 1.11 5.67 5.00
188 INT80657 Gene_expression of SLC17A5 50 0.75 39.98 5.44 5.00
189 INT102547 Gene_expression of Cd68 25 0.75 14.47 5.22 5.00
190 INT24080 Negative_regulation of Mtor 64 0.37 41.56 5.19 5.00
191 INT116744 Binding of Pik3r1 22 0.36 12.77 5.01 5.00
192 INT91225 Positive_regulation of Pla2g2a 22 0.57 14.77 5.01 5.00
193 INT131152 Gene_expression of Cr1l 17 0.75 10.83 4.88 5.00
194 INT26167 Positive_regulation of Hrasls 18 0.23 8.67 4.87 5.00
195 INT37661 Negative_regulation of SERPINC1 48 0.59 38.6 4.77 5.00
196 INT23045 Positive_regulation of Hbb 31 0.64 19.35 4.54 5.00
197 INT72703 Gene_expression of Ide 79 0.70 45.04 4.47 5.00
198 INT181596 Binding of IL1R1 9 0.36 7.99 4.32 5.00
199 INT94427 Positive_regulation of Positive_regulation of NOS2 14 0.47 11.15 4.3 5.00
200 INT111066 Regulation of Bace1 40 0.61 31.47 4.28 5.00
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