D:Porphyria

Disease Term Synonyms Acute Intermittent Porphyria, D Aminolevulinic Acid, Delta Aminolevulinic Acid, Disorder Of Haem Metabolism, Disorder Of Heme Metabolism, DISORDER OF PORPHYRIN HAEM METABOLISM, Disorder Of Porphyrin Heme Metabolism, Disorder Of Porphyrin Metabolism, Haem Biosynthesis, Haem Metabolism Disorder, Heme Biosynthesis Documents 412 Hot Single Events 148 Hot Interactions 10

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Porphyria. They are ordered first by their relevance to Porphyria and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Interaction String	Documents	TM Confidence	Disease Relevance	Overall Pain Relevance	Term Relevance
1	INT147040	Hmbs Negative_regulation of Nppa	1	0.07	0.95	0.55	100.00
2	INT147041	Hmbs Negative_regulation of Negative_regulation of Nppa	1	0.05	0.51	0.3	100.00
3	INT147046	Hmbs Negative_regulation of Positive_regulation of Nppa	1	0.00	0.49	0.25	100.00
4	INT147060	Hmbs Negative_regulation of Hmbs Negative_regulation of Nppa	1	0.01	0.44	0.25	100.00
5	INT315538	Negative_regulation of GLRX5 Negative_regulation of Gene_expression of SLC40A1	1	0.25	1.14	0	100.00
6	INT147049	CB Positive_regulation of Nppa	1	0.02	1.01	0.6	99.68
7	INT315533	Negative_regulation of GLRX5 Negative_regulation of Gene_expression of ALAS2	1	0.38	1.06	0	99.36
8	INT232890	Binding of Rab27a and Gopc	1	0.01	0.3	0	90.40
9	INT232894	Binding of ABR and Rab27a	1	0.08	0.3	0	90.40
10	INT158466	FECH Negative_regulation of Fech	1	0.23	0.57	0.2	88.80
11	INT178982	Binding of Clock and Npas2	1	0.14	0.08	0	77.60
12	INT178983	Binding of Npas2 and Arntl2	1	0.02	0.08	0	75.68
13	INT75791	Positive_regulation of Htr3a Regulation of Acot1	1	0.23	0.12	0.14	67.68
14	INT315535	Binding of ABCB7 and FECH	1	0.28	0.7	0	45.68
15	INT282684	FECH Positive_regulation of Negative_regulation of Ssbp3	1	0.00	1.54	0.08	25.00
16	INT208084	Tlr4 Positive_regulation of Eps8l1	1	0.00	0.5	0.23	5.00
17	INT208083	Binding of Arid3b and Eps8l1	1	0.01	0.4	0.16	5.00
18	INT232897	Binding of Rab27a and SAMSN1	1	0.00	0.73	0.08	5.00
19	INT232902	Binding of YWHAQ and Krt18	1	0.34	0.96	0.07	5.00
20	INT232901	Regulation of Binding of YWHAQ and Krt18	1	0.41	0.96	0.07	5.00
21	INT178984	Gmeb1 Positive_regulation of CXADR	1	0.00	0	0.05	5.00
22	INT178985	Positive_regulation of Gmeb1 Positive_regulation of CXADR	1	0.00	0	0.05	5.00
23	INT232900	Binding of ABR and Krt8	1	0.03	0.49	0.03	5.00
24	INT315543	NARFL Regulation of Gene_expression of HIF1A	1	0.01	0.63	0	5.00
25	INT232899	Krt18 Negative_regulation of Binding of ABR	1	0.05	0.68	0	5.00
26	INT315541	ACO1 Negative_regulation of Gene_expression of ALAS2	1	0.17	0.18	0	5.00
27	INT315534	Binding of ACO1 and ERN1	1	0.01	0.18	0	5.00
28	INT232893	Binding of ABR and Nup62	1	0.03	0.13	0	5.00
29	INT232895	Krt18 Positive_regulation of Gene_expression of ABR	1	0.46	0.09	0	5.00
30	INT232898	Binding of KRT1 and Krt8	1	0.27	1.22	0	5.00
31	INT232896	Krt8 Negative_regulation of Binding of ABR	1	0.04	0.68	0	5.00
32	INT232892	Krt18 Positive_regulation of Gene_expression of Krt8	1	0.30	0.09	0	5.00
33	INT232889	Binding of Krt18 and Krt8	1	0.22	1.09	0	5.00
34	INT315532	Binding of NFS1 and ISCU	1	0.19	0.37	0	5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Porphyria. They are ordered first by their pain relevance and then by number of times they were reported in Porphyria. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Event String	Documents	TM Confidence	Disease Relevance	Overall Pain Relevance	Term Relevance
1	INT15509	Negative_regulation of HMBS	14	0.58	13.13	2.78	100.00
2	INT74178	Gene_expression of HMBS	24	0.76	9.62	1.36	100.00
3	INT50291	Positive_regulation of HMBS	10	0.67	8.89	0.73	100.00
4	INT102747	Gene_expression of Hmbs	17	0.78	10.53	1.34	100.00
5	INT22591	Negative_regulation of Hmbs	6	0.51	5.04	1.74	100.00
6	INT178338	Gene_expression of Tbx15	50	0.65	38.65	12.19	100.00
7	INT3784	Regulation of Hmbs	4	0.38	2.79	2.11	100.00
8	INT3188	Regulation of Localization of Acot1	84	0.59	8.94	38.56	100.00
9	INT120656	Localization of HMBS	3	0.16	2.6	0.23	100.00
10	INT22593	Negative_regulation of Positive_regulation of Hmbs	1	0.41	1.58	0.64	100.00
11	INT22592	Positive_regulation of Hmbs	2	0.48	2.27	0.87	100.00
12	INT3323	Gene_expression of ALAS2	10	0.58	7.51	0.21	100.00
13	INT120657	Positive_regulation of Localization of HMBS	1	0.00	0.83	0.09	100.00
14	INT112989	Gene_expression of AIP	3	0.56	25.4	4.23	100.00
15	INT148671	Gene_expression of Aip	26	0.63	24.32	3.91	100.00
16	INT73982	Gene_expression of Hmox1	141	0.78	119.43	32.17	100.00
17	INT112990	Negative_regulation of AIP	1	0.10	0.59	0.09	100.00
18	INT158692	Negative_regulation of Gene_expression of HMBS	1	0.25	0.67	0.09	100.00
19	INT3322	Positive_regulation of Gene_expression of ALAS2	4	0.43	3.25	0	100.00
20	INT47948	Localization of Alad	1	0.14	1.47	0.07	100.00
21	INT57135	Gene_expression of Hmbs	1	0.32	0.55	0.82	100.00
22	INT120062	Binding of AIP	4	0.42	28.86	3.91	100.00
23	INT315560	Gene_expression of SLC19A2	1	0.55	1.32	0	100.00
24	INT62580	Gene_expression of Cyp2e1	31	0.78	15.4	11.08	100.00
25	INT158463	Regulation of Hmbs	7	0.31	4.87	0.4	100.00
26	INT4436	Gene_expression of ABCB7	7	0.65	9.26	0.93	100.00
27	INT94423	Binding of ALAS2	4	0.32	2.1	0.61	100.00
28	INT315551	Negative_regulation of Gene_expression of ALAS2	1	0.37	1.11	0	100.00
29	INT315586	Gene_expression of SLC25A38	1	0.52	0.51	0	100.00
30	INT35990	Negative_regulation of Sds	8	0.49	4.47	4.96	99.96
31	INT196373	Negative_regulation of Vmn2r81	1	0.02	1.96	0	99.96
32	INT789	Positive_regulation of YY1	69	0.67	14.07	47.06	99.92
33	INT17969	Negative_regulation of Regulation of Cck	9	0.43	1.03	7.04	99.92
34	INT3948	Regulation of Cck	291	0.62	58.07	255.88	99.92
35	INT36449	Negative_regulation of G6PD	74	0.59	54.15	8.85	99.92
36	INT315592	Positive_regulation of Gene_expression of SLC40A1	1	0.41	3.52	0	99.88
37	INT1352	Localization of Acot1	728	0.80	73.01	296.01	99.84
38	INT1353	Negative_regulation of Localization of Acot1	153	0.53	15.05	75.17	99.84
39	INT8528	Negative_regulation of Gene_expression of Fos	100	0.59	41.15	55.6	99.84
40	INT32852	Negative_regulation of FECH	18	0.57	10.59	3.08	99.78
41	INT40216	Positive_regulation of Alas1	11	0.65	6.08	1.8	99.74
42	INT127038	Gene_expression of Alas1	6	0.72	3.94	1.48	99.70
43	INT102745	Positive_regulation of Hmbs	17	0.61	12.41	0.78	99.68
44	INT1108	Gene_expression of PPY	58	0.75	36.57	10.76	99.66
45	INT112991	Positive_regulation of Gene_expression of PPY	7	0.29	6.26	0.99	99.66
46	INT40215	Negative_regulation of Fech	9	0.57	8.39	1.85	99.62
47	INT170444	Binding of Gopc	172	0.39	45.05	20.71	99.60
48	INT178971	Regulation of Clock	1	0.14	0.1	0	99.60
49	INT8205	Negative_regulation of Nppa	77	0.59	26.43	25.72	99.52
50	INT32515	Negative_regulation of B4GALNT1	82	0.43	28.1	17.46	99.44
51	INT315565	Negative_regulation of Gene_expression of SLC40A1	1	0.25	1.73	0	99.44
52	INT3180	Positive_regulation of PPY	39	0.63	25.57	10.15	99.40
53	INT118264	Binding of Hmbs	6	0.37	4.87	0.33	99.40
54	INT5378	Regulation of Gene_expression of Fos	47	0.60	14.47	26.41	99.38
55	INT11275	Regulation of Fos	37	0.60	5.79	18.18	99.38
56	INT214	Localization of AVP	370	0.81	208.51	91.09	99.34
57	INT243268	Gene_expression of SLC40A1	6	0.60	4.18	0.13	99.28
58	INT5379	Gene_expression of Fos	656	0.78	255.5	292.54	99.16
59	INT89	Positive_regulation of Gast	187	0.70	80.49	42.07	99.14
60	INT8047	Positive_regulation of Nts	20	0.67	7.96	10.35	99.14
61	INT8724	Positive_regulation of Mln	21	0.66	14.12	6.17	99.14
62	INT37865	Positive_regulation of Alad	5	0.27	3.13	0.6	99.12
63	INT102744	Positive_regulation of Gene_expression of Hmbs	4	0.70	2.97	0.35	99.08
64	INT3321	Positive_regulation of ALAS2	10	0.51	3.08	0.32	98.92
65	INT55034	Positive_regulation of Adm	27	0.61	14.1	6.13	98.88
66	INT9852	Positive_regulation of Gpt	563	0.70	364.64	146.82	98.84
67	INT39419	Positive_regulation of Negative_regulation of Tdo2	3	0.43	0.19	1.09	98.72
68	INT102746	Negative_regulation of Hmbs	11	0.59	8.35	0.77	98.68
69	INT45263	Gene_expression of Alas1	3	0.29	1.39	0.24	98.68
70	INT24800	Negative_regulation of AMPD1	44	0.59	21.19	6.76	98.66
71	INT16537	Regulation of Positive_regulation of Nppa	2	0.45	1.44	0.76	98.62
72	INT3766	Positive_regulation of Localization of Acot1	192	0.69	21.8	85.35	98.48
73	INT5623	Positive_regulation of Nppa	174	0.70	69.96	52.33	98.40
74	INT6656	Gene_expression of YY1	135	0.75	24.73	72.16	98.40
75	INT16587	Regulation of Negative_regulation of Nppa	3	0.53	0.84	0.82	98.38
76	INT158690	Negative_regulation of 3.8-1.4	2	0.07	2.77	0.13	98.24
77	INT43820	Positive_regulation of Twist1	75	0.59	42.15	8.47	98.24
78	INT158691	Negative_regulation of BTF3P4	1	0.03	0.59	0.08	98.02
79	INT39418	Negative_regulation of Tdo2	12	0.57	0.8	6.93	98.00
80	INT46038	Positive_regulation of ALAS1	3	0.60	0.9	1	97.98
81	INT57136	Regulation of Alas1	3	0.51	0.6	0.71	97.96
82	INT44122	Positive_regulation of AMPD1	4	0.44	1.88	0.92	97.90
83	INT4402	Positive_regulation of Binding of CYP2B6	3	0.49	0.33	1.35	97.88
84	INT4403	Binding of CYP2B6	113	0.48	21.17	33.83	97.88
85	INT1354	Negative_regulation of Acot1	87	0.43	15.01	36.44	97.84
86	INT8050	Positive_regulation of Gene_expression of Nts	10	0.66	2.31	4.69	97.70
87	INT8048	Gene_expression of Nts	45	0.74	8.9	21.84	97.38
88	INT315567	Positive_regulation of Negative_regulation of CIAO1	1	0.22	1.29	0	97.34
89	INT196375	Negative_regulation of Ppox	2	0.08	2.73	0	97.28
90	INT315559	Negative_regulation of CIAO1	1	0.19	2.53	0	97.18
91	INT53567	Positive_regulation of FECH	14	0.45	11.03	1.82	97.12
92	INT1189	Gene_expression of AMPD1	7	0.59	4.1	0.9	97.08
93	INT70616	Positive_regulation of LOC689539	1	0.17	0.6	0.43	96.88
94	INT208055	Gene_expression of Eps8l1	1	0.04	1.09	0.48	96.84
95	INT208053	Positive_regulation of Gene_expression of Eps8l1	1	0.03	0.37	0.09	96.84
96	INT2039	Regulation of CYP2B6	30	0.60	7.75	6.43	96.68
97	INT315630	Gene_expression of FXN	8	0.64	20.05	0.05	96.68
98	INT315552	Negative_regulation of GLRX5	1	0.38	2.17	0	96.68
99	INT208058	Gene_expression of Arid3b	1	0.14	2.57	1.62	96.56
100	INT208067	Positive_regulation of Gene_expression of Arid3b	1	0.09	1.18	0.89	96.56
101	INT74177	Positive_regulation of Gene_expression of HMBS	6	0.49	2.77	0.3	96.36
102	INT178972	Transcription of Alas1	1	0.46	0.1	0	96.28
103	INT93702	Localization of Hmbs	1	0.81	4.84	1.26	96.08
104	INT315603	Positive_regulation of Gene_expression of SLC19A2	1	0.41	0.48	0	95.32
105	INT315635	Positive_regulation of FXN	2	0.41	5.76	0	94.80
106	INT11077	Positive_regulation of Htr3a	63	0.67	15.61	22.7	94.32
107	INT64609	Negative_regulation of PLXNA3	5	0.57	3.64	1.94	94.16
108	INT158461	Positive_regulation of Localization of Alas1	1	0.04	1.48	0.52	94.04
109	INT158460	Localization of Alas1	1	0.06	0.74	0.26	93.72
110	INT315562	Gene_expression of GLRX5	1	0.69	4.92	0	93.36
111	INT120652	Positive_regulation of Alad	2	0.42	1.2	0.12	93.32
112	INT58409	Negative_regulation of Alad	5	0.43	1.15	0.32	93.32
113	INT196374	Negative_regulation of Positive_regulation of Alas1	1	0.16	0.67	0.12	92.60
114	INT1928	Negative_regulation of Lpl	18	0.51	11.22	2.49	92.60
115	INT16110	Positive_regulation of ZC3H12D	30	0.46	6.27	18.72	92.24
116	INT196372	Positive_regulation of Alas1	1	0.19	1.91	0.22	91.84
117	INT4259	Positive_regulation of Npr1	262	0.70	49.37	123.11	91.64
118	INT38299	Negative_regulation of FCGR2C	6	0.21	3.92	0.52	91.08
119	INT53747	Positive_regulation of Cyp2e1	34	0.70	29.03	13.39	90.96
120	INT62689	Negative_regulation of PPOX	7	0.58	4.66	0.28	90.04
121	INT297436	Positive_regulation of Gene_expression of Alas1	1	0.26	0.23	0	89.76
122	INT208062	Regulation of Gene_expression of Arid3b	1	0.10	0.8	0.28	89.24
123	INT315621	Gene_expression of CIAO1	1	0.34	4.11	0	89.20
124	INT315587	Positive_regulation of Gene_expression of CIAO1	1	0.22	1.6	0	89.20
125	INT242866	Regulation of HFE	2	0.39	1.84	0	88.84
126	INT49441	Negative_regulation of Cpox	494	0.59	303.22	177.46	88.40
127	INT50058	Negative_regulation of Cpox	907	0.58	426.28	428.29	88.40
128	INT127040	Negative_regulation of Alas1	2	0.35	0.72	0.54	87.92
129	INT12951	Negative_regulation of Cat	126	0.57	64.39	20.61	87.76
130	INT171423	Regulation of DNLZ	2	0.10	1.8	0.19	85.08
131	INT171422	Regulation of EPHB6	1	0.44	0.53	0.07	85.08
132	INT208068	Positive_regulation of Positive_regulation of Arid3b	1	0.13	0.08	0.11	83.76
133	INT315563	Positive_regulation of Gene_expression of FXN	4	0.41	5.05	0	83.44
134	INT25916	Positive_regulation of GZMM	2	0.47	0.64	0.47	83.44
135	INT208063	Positive_regulation of Arid3b	1	0.13	0.8	1.16	83.20
136	INT315550	Transcription of GLRX5	1	0.53	0.66	0	83.20
137	INT100573	Gene_expression of Lpl	13	0.53	2.09	0.16	83.12
138	INT315593	Regulation of Transcription of SLC40A1	1	0.26	1.7	0	82.40
139	INT315575	Transcription of SLC40A1	1	0.40	0.85	0	82.40
140	INT321657	Positive_regulation of Positive_regulation of Fech	1	0.02	0.8	0	82.32
141	INT199651	Binding of Fxn	3	0.30	1.45	0.03	82.00
142	INT321658	Positive_regulation of Fech	1	0.02	0.8	0	81.88
143	INT12915	Gene_expression of MGP	18	0.75	7.53	4.15	81.80
144	INT315628	Negative_regulation of Gene_expression of FXN	2	0.36	2.37	0	81.76
145	INT19637	Localization of TF	14	0.73	5.74	0.86	81.64
146	INT282679	Localization of FECH	1	0.12	9.57	0.23	81.36
147	INT5380	Positive_regulation of Gene_expression of Fos	243	0.70	105.65	131.05	80.72
148	INT196376	Positive_regulation of Gene_expression of Alas1	1	0.19	1.01	0.25	80.40
149	INT302084	Negative_regulation of WNT2	2	0.09	0.83	1.26	79.84
150	INT302086	Gene_expression of WNT2	3	0.14	0.97	0.38	79.84
151	INT315606	Regulation of Gene_expression of WNT2	1	0.08	0.84	0	79.84
152	INT91158	Regulation of Ros1	26	0.25	17	4.23	79.12
153	INT46036	Regulation of ALAS1	2	0.39	0.23	0.72	78.40
154	INT171428	Gene_expression of AKAP13	2	0.02	0.86	0	77.96
155	INT84130	Gene_expression of Foxo1	1	0.26	0.97	1.22	77.92
156	INT196377	Gene_expression of Nrf1	4	0.68	5.97	2.63	77.92
157	INT49246	Negative_regulation of Urod	1	0.22	1.04	0.11	77.68
158	INT199652	Negative_regulation of Fxn	3	0.54	12.37	0.11	77.52
159	INT80223	Positive_regulation of Hmox1	128	0.68	77.71	17.64	76.88
160	INT682	Negative_regulation of AVP	97	0.59	50.67	23.91	76.80
161	INT115264	Binding of FECH	9	0.41	7.93	1.1	76.64
162	INT3782	Regulation of Fech	1	0.00	1.05	0.09	76.48
163	INT48037	Regulation of Adm	8	0.44	3.96	1.24	75.52
164	INT3783	Regulation of Alad	1	0.00	1.04	0.09	75.32
165	INT90	Localization of Gast	400	0.81	137.67	113	75.00
166	INT3785	Regulation of Urod	1	0.01	1.02	0.09	75.00
167	INT17934	Localization of MLN	16	0.80	2.83	2.24	75.00
168	INT16656	Negative_regulation of Gene_expression of YY1	8	0.57	2.62	2.12	75.00
169	INT3320	Regulation of ALAS2	3	0.33	0.93	1.05	75.00
170	INT315598	Localization of FXN	1	0.43	1.04	0.07	74.96
171	INT55052	Binding of Cat	10	0.36	5.46	0.92	72.40
172	INT55051	Negative_regulation of Binding of Cat	2	0.35	0.61	0.16	72.40
173	INT158469	Regulation of FECH	3	0.36	1.76	1.13	71.44
174	INT17143	Regulation of Cyp2c22	18	0.60	3.02	6.7	71.36
175	INT57749	Negative_regulation of Gene_expression of TP53	39	0.56	36.79	4.45	70.96
176	INT38834	Positive_regulation of Positive_regulation of PPY	2	0.42	4.18	0.61	70.68
177	INT62690	Gene_expression of PPOX	7	0.77	3.3	0.13	69.96
178	INT50290	Binding of Cpox	29	0.27	17.19	8.01	69.92
179	INT48513	Positive_regulation of MMEL1	2	0.38	0.6	0.15	69.48
180	INT28361	Gene_expression of TP53	443	0.78	384.86	28.8	69.44
181	INT55343	Localization of Ros1	39	0.60	34.51	12.5	69.00
182	INT80486	Gene_expression of FECH	13	0.54	10.42	4.8	68.72
183	INT196371	Gene_expression of Ireb2	1	0.41	1.95	0	67.92
184	INT75790	Regulation of Positive_regulation of Htr3a	2	0.44	0.22	0.19	67.68
185	INT9660	Regulation of TNF	363	0.62	312.94	139.99	66.68
186	INT1166	Negative_regulation of Dbh	56	0.59	12.54	28.26	65.52
187	INT41892	Gene_expression of HBM	48	0.64	28.32	5.64	65.36
188	INT315576	Positive_regulation of Binding of CIAO1	1	0.22	0.67	0	65.16
189	INT315589	Binding of CIAO1	1	0.16	0.67	0	64.64
190	INT173223	Negative_regulation of BRCA2	7	0.54	6.79	0.25	63.96
191	INT119062	Negative_regulation of BRCA1	12	0.49	13.7	1.36	63.60
192	INT102813	Regulation of Gene_expression of TP53	25	0.59	25.95	0.75	63.16
193	INT149623	Negative_regulation of fc	17	0.12	10.56	4.05	63.16
194	INT315617	Positive_regulation of Gene_expression of SLC25A37	1	0.10	0.39	0	62.72
195	INT14724	Negative_regulation of CYP19A1	233	0.59	96.56	18.26	62.56
196	INT315618	Gene_expression of SLC25A37	1	0.14	0.38	0	61.60
197	INT120811	Gene_expression of Gopc	1174	0.59	428.49	150.55	60.80
198	INT170296	Regulation of Gene_expression of Gopc	33	0.38	12.49	6	60.80
199	INT171426	Positive_regulation of DNLZ	3	0.09	1.31	0.03	60.28
200	INT60585	Regulation of TP53	59	0.59	54.55	5.21	59.76