D:Porphyria

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Disease Term
Synonyms Acute Intermittent Porphyria, D Aminolevulinic Acid, Delta Aminolevulinic Acid, Disorder Of Haem Metabolism, Disorder Of Heme Metabolism, DISORDER OF PORPHYRIN HAEM METABOLISM, Disorder Of Porphyrin Heme Metabolism, Disorder Of Porphyrin Metabolism, Haem Biosynthesis, Haem Metabolism Disorder, Heme Biosynthesis
Documents 412
Hot Single Events 148
Hot Interactions 10

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Porphyria. They are ordered first by their relevance to Porphyria and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT147040 Hmbs Negative_regulation of Nppa 1 0.07 0.95 0.55 100.00
2 INT147041 Hmbs Negative_regulation of Negative_regulation of Nppa 1 0.05 0.51 0.3 100.00
3 INT147046 Hmbs Negative_regulation of Positive_regulation of Nppa 1 0.00 0.49 0.25 100.00
4 INT147060 Hmbs Negative_regulation of Hmbs Negative_regulation of Nppa 1 0.01 0.44 0.25 100.00
5 INT315538 Negative_regulation of GLRX5 Negative_regulation of Gene_expression of SLC40A1 1 0.25 1.14 0 100.00
6 INT147049 CB Positive_regulation of Nppa 1 0.02 1.01 0.6 99.68
7 INT315533 Negative_regulation of GLRX5 Negative_regulation of Gene_expression of ALAS2 1 0.38 1.06 0 99.36
8 INT232890 Binding of Rab27a and Gopc 1 0.01 0.3 0 90.40
9 INT232894 Binding of ABR and Rab27a 1 0.08 0.3 0 90.40
10 INT158466 FECH Negative_regulation of Fech 1 0.23 0.57 0.2 88.80
11 INT178982 Binding of Clock and Npas2 1 0.14 0.08 0 77.60
12 INT178983 Binding of Npas2 and Arntl2 1 0.02 0.08 0 75.68
13 INT75791 Positive_regulation of Htr3a Regulation of Acot1 1 0.23 0.12 0.14 67.68
14 INT315535 Binding of ABCB7 and FECH 1 0.28 0.7 0 45.68
15 INT282684 FECH Positive_regulation of Negative_regulation of Ssbp3 1 0.00 1.54 0.08 25.00
16 INT208084 Tlr4 Positive_regulation of Eps8l1 1 0.00 0.5 0.23 5.00
17 INT208083 Binding of Arid3b and Eps8l1 1 0.01 0.4 0.16 5.00
18 INT232897 Binding of Rab27a and SAMSN1 1 0.00 0.73 0.08 5.00
19 INT232902 Binding of YWHAQ and Krt18 1 0.34 0.96 0.07 5.00
20 INT232901 Regulation of Binding of YWHAQ and Krt18 1 0.41 0.96 0.07 5.00
21 INT178984 Gmeb1 Positive_regulation of CXADR 1 0.00 0 0.05 5.00
22 INT178985 Positive_regulation of Gmeb1 Positive_regulation of CXADR 1 0.00 0 0.05 5.00
23 INT232900 Binding of ABR and Krt8 1 0.03 0.49 0.03 5.00
24 INT315543 NARFL Regulation of Gene_expression of HIF1A 1 0.01 0.63 0 5.00
25 INT232899 Krt18 Negative_regulation of Binding of ABR 1 0.05 0.68 0 5.00
26 INT315541 ACO1 Negative_regulation of Gene_expression of ALAS2 1 0.17 0.18 0 5.00
27 INT315534 Binding of ACO1 and ERN1 1 0.01 0.18 0 5.00
28 INT232893 Binding of ABR and Nup62 1 0.03 0.13 0 5.00
29 INT232895 Krt18 Positive_regulation of Gene_expression of ABR 1 0.46 0.09 0 5.00
30 INT232898 Binding of KRT1 and Krt8 1 0.27 1.22 0 5.00
31 INT232896 Krt8 Negative_regulation of Binding of ABR 1 0.04 0.68 0 5.00
32 INT232892 Krt18 Positive_regulation of Gene_expression of Krt8 1 0.30 0.09 0 5.00
33 INT232889 Binding of Krt18 and Krt8 1 0.22 1.09 0 5.00
34 INT315532 Binding of NFS1 and ISCU 1 0.19 0.37 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Porphyria. They are ordered first by their pain relevance and then by number of times they were reported in Porphyria. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT15509 Negative_regulation of HMBS 14 0.58 13.13 2.78 100.00
2 INT74178 Gene_expression of HMBS 24 0.76 9.62 1.36 100.00
3 INT50291 Positive_regulation of HMBS 10 0.67 8.89 0.73 100.00
4 INT102747 Gene_expression of Hmbs 17 0.78 10.53 1.34 100.00
5 INT22591 Negative_regulation of Hmbs 6 0.51 5.04 1.74 100.00
6 INT178338 Gene_expression of Tbx15 50 0.65 38.65 12.19 100.00
7 INT3784 Regulation of Hmbs 4 0.38 2.79 2.11 100.00
8 INT3188 Regulation of Localization of Acot1 84 0.59 8.94 38.56 100.00
9 INT120656 Localization of HMBS 3 0.16 2.6 0.23 100.00
10 INT22593 Negative_regulation of Positive_regulation of Hmbs 1 0.41 1.58 0.64 100.00
11 INT22592 Positive_regulation of Hmbs 2 0.48 2.27 0.87 100.00
12 INT3323 Gene_expression of ALAS2 10 0.58 7.51 0.21 100.00
13 INT120657 Positive_regulation of Localization of HMBS 1 0.00 0.83 0.09 100.00
14 INT112989 Gene_expression of AIP 3 0.56 25.4 4.23 100.00
15 INT148671 Gene_expression of Aip 26 0.63 24.32 3.91 100.00
16 INT73982 Gene_expression of Hmox1 141 0.78 119.43 32.17 100.00
17 INT112990 Negative_regulation of AIP 1 0.10 0.59 0.09 100.00
18 INT158692 Negative_regulation of Gene_expression of HMBS 1 0.25 0.67 0.09 100.00
19 INT3322 Positive_regulation of Gene_expression of ALAS2 4 0.43 3.25 0 100.00
20 INT47948 Localization of Alad 1 0.14 1.47 0.07 100.00
21 INT57135 Gene_expression of Hmbs 1 0.32 0.55 0.82 100.00
22 INT120062 Binding of AIP 4 0.42 28.86 3.91 100.00
23 INT315560 Gene_expression of SLC19A2 1 0.55 1.32 0 100.00
24 INT62580 Gene_expression of Cyp2e1 31 0.78 15.4 11.08 100.00
25 INT158463 Regulation of Hmbs 7 0.31 4.87 0.4 100.00
26 INT4436 Gene_expression of ABCB7 7 0.65 9.26 0.93 100.00
27 INT94423 Binding of ALAS2 4 0.32 2.1 0.61 100.00
28 INT315551 Negative_regulation of Gene_expression of ALAS2 1 0.37 1.11 0 100.00
29 INT315586 Gene_expression of SLC25A38 1 0.52 0.51 0 100.00
30 INT35990 Negative_regulation of Sds 8 0.49 4.47 4.96 99.96
31 INT196373 Negative_regulation of Vmn2r81 1 0.02 1.96 0 99.96
32 INT789 Positive_regulation of YY1 69 0.67 14.07 47.06 99.92
33 INT17969 Negative_regulation of Regulation of Cck 9 0.43 1.03 7.04 99.92
34 INT3948 Regulation of Cck 291 0.62 58.07 255.88 99.92
35 INT36449 Negative_regulation of G6PD 74 0.59 54.15 8.85 99.92
36 INT315592 Positive_regulation of Gene_expression of SLC40A1 1 0.41 3.52 0 99.88
37 INT1352 Localization of Acot1 728 0.80 73.01 296.01 99.84
38 INT1353 Negative_regulation of Localization of Acot1 153 0.53 15.05 75.17 99.84
39 INT8528 Negative_regulation of Gene_expression of Fos 100 0.59 41.15 55.6 99.84
40 INT32852 Negative_regulation of FECH 18 0.57 10.59 3.08 99.78
41 INT40216 Positive_regulation of Alas1 11 0.65 6.08 1.8 99.74
42 INT127038 Gene_expression of Alas1 6 0.72 3.94 1.48 99.70
43 INT102745 Positive_regulation of Hmbs 17 0.61 12.41 0.78 99.68
44 INT1108 Gene_expression of PPY 58 0.75 36.57 10.76 99.66
45 INT112991 Positive_regulation of Gene_expression of PPY 7 0.29 6.26 0.99 99.66
46 INT40215 Negative_regulation of Fech 9 0.57 8.39 1.85 99.62
47 INT170444 Binding of Gopc 172 0.39 45.05 20.71 99.60
48 INT178971 Regulation of Clock 1 0.14 0.1 0 99.60
49 INT8205 Negative_regulation of Nppa 77 0.59 26.43 25.72 99.52
50 INT32515 Negative_regulation of B4GALNT1 82 0.43 28.1 17.46 99.44
51 INT315565 Negative_regulation of Gene_expression of SLC40A1 1 0.25 1.73 0 99.44
52 INT3180 Positive_regulation of PPY 39 0.63 25.57 10.15 99.40
53 INT118264 Binding of Hmbs 6 0.37 4.87 0.33 99.40
54 INT5378 Regulation of Gene_expression of Fos 47 0.60 14.47 26.41 99.38
55 INT11275 Regulation of Fos 37 0.60 5.79 18.18 99.38
56 INT214 Localization of AVP 370 0.81 208.51 91.09 99.34
57 INT243268 Gene_expression of SLC40A1 6 0.60 4.18 0.13 99.28
58 INT5379 Gene_expression of Fos 656 0.78 255.5 292.54 99.16
59 INT89 Positive_regulation of Gast 187 0.70 80.49 42.07 99.14
60 INT8047 Positive_regulation of Nts 20 0.67 7.96 10.35 99.14
61 INT8724 Positive_regulation of Mln 21 0.66 14.12 6.17 99.14
62 INT37865 Positive_regulation of Alad 5 0.27 3.13 0.6 99.12
63 INT102744 Positive_regulation of Gene_expression of Hmbs 4 0.70 2.97 0.35 99.08
64 INT3321 Positive_regulation of ALAS2 10 0.51 3.08 0.32 98.92
65 INT55034 Positive_regulation of Adm 27 0.61 14.1 6.13 98.88
66 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 98.84
67 INT39419 Positive_regulation of Negative_regulation of Tdo2 3 0.43 0.19 1.09 98.72
68 INT102746 Negative_regulation of Hmbs 11 0.59 8.35 0.77 98.68
69 INT45263 Gene_expression of Alas1 3 0.29 1.39 0.24 98.68
70 INT24800 Negative_regulation of AMPD1 44 0.59 21.19 6.76 98.66
71 INT16537 Regulation of Positive_regulation of Nppa 2 0.45 1.44 0.76 98.62
72 INT3766 Positive_regulation of Localization of Acot1 192 0.69 21.8 85.35 98.48
73 INT5623 Positive_regulation of Nppa 174 0.70 69.96 52.33 98.40
74 INT6656 Gene_expression of YY1 135 0.75 24.73 72.16 98.40
75 INT16587 Regulation of Negative_regulation of Nppa 3 0.53 0.84 0.82 98.38
76 INT158690 Negative_regulation of 3.8-1.4 2 0.07 2.77 0.13 98.24
77 INT43820 Positive_regulation of Twist1 75 0.59 42.15 8.47 98.24
78 INT158691 Negative_regulation of BTF3P4 1 0.03 0.59 0.08 98.02
79 INT39418 Negative_regulation of Tdo2 12 0.57 0.8 6.93 98.00
80 INT46038 Positive_regulation of ALAS1 3 0.60 0.9 1 97.98
81 INT57136 Regulation of Alas1 3 0.51 0.6 0.71 97.96
82 INT44122 Positive_regulation of AMPD1 4 0.44 1.88 0.92 97.90
83 INT4402 Positive_regulation of Binding of CYP2B6 3 0.49 0.33 1.35 97.88
84 INT4403 Binding of CYP2B6 113 0.48 21.17 33.83 97.88
85 INT1354 Negative_regulation of Acot1 87 0.43 15.01 36.44 97.84
86 INT8050 Positive_regulation of Gene_expression of Nts 10 0.66 2.31 4.69 97.70
87 INT8048 Gene_expression of Nts 45 0.74 8.9 21.84 97.38
88 INT315567 Positive_regulation of Negative_regulation of CIAO1 1 0.22 1.29 0 97.34
89 INT196375 Negative_regulation of Ppox 2 0.08 2.73 0 97.28
90 INT315559 Negative_regulation of CIAO1 1 0.19 2.53 0 97.18
91 INT53567 Positive_regulation of FECH 14 0.45 11.03 1.82 97.12
92 INT1189 Gene_expression of AMPD1 7 0.59 4.1 0.9 97.08
93 INT70616 Positive_regulation of LOC689539 1 0.17 0.6 0.43 96.88
94 INT208055 Gene_expression of Eps8l1 1 0.04 1.09 0.48 96.84
95 INT208053 Positive_regulation of Gene_expression of Eps8l1 1 0.03 0.37 0.09 96.84
96 INT2039 Regulation of CYP2B6 30 0.60 7.75 6.43 96.68
97 INT315630 Gene_expression of FXN 8 0.64 20.05 0.05 96.68
98 INT315552 Negative_regulation of GLRX5 1 0.38 2.17 0 96.68
99 INT208058 Gene_expression of Arid3b 1 0.14 2.57 1.62 96.56
100 INT208067 Positive_regulation of Gene_expression of Arid3b 1 0.09 1.18 0.89 96.56
101 INT74177 Positive_regulation of Gene_expression of HMBS 6 0.49 2.77 0.3 96.36
102 INT178972 Transcription of Alas1 1 0.46 0.1 0 96.28
103 INT93702 Localization of Hmbs 1 0.81 4.84 1.26 96.08
104 INT315603 Positive_regulation of Gene_expression of SLC19A2 1 0.41 0.48 0 95.32
105 INT315635 Positive_regulation of FXN 2 0.41 5.76 0 94.80
106 INT11077 Positive_regulation of Htr3a 63 0.67 15.61 22.7 94.32
107 INT64609 Negative_regulation of PLXNA3 5 0.57 3.64 1.94 94.16
108 INT158461 Positive_regulation of Localization of Alas1 1 0.04 1.48 0.52 94.04
109 INT158460 Localization of Alas1 1 0.06 0.74 0.26 93.72
110 INT315562 Gene_expression of GLRX5 1 0.69 4.92 0 93.36
111 INT120652 Positive_regulation of Alad 2 0.42 1.2 0.12 93.32
112 INT58409 Negative_regulation of Alad 5 0.43 1.15 0.32 93.32
113 INT196374 Negative_regulation of Positive_regulation of Alas1 1 0.16 0.67 0.12 92.60
114 INT1928 Negative_regulation of Lpl 18 0.51 11.22 2.49 92.60
115 INT16110 Positive_regulation of ZC3H12D 30 0.46 6.27 18.72 92.24
116 INT196372 Positive_regulation of Alas1 1 0.19 1.91 0.22 91.84
117 INT4259 Positive_regulation of Npr1 262 0.70 49.37 123.11 91.64
118 INT38299 Negative_regulation of FCGR2C 6 0.21 3.92 0.52 91.08
119 INT53747 Positive_regulation of Cyp2e1 34 0.70 29.03 13.39 90.96
120 INT62689 Negative_regulation of PPOX 7 0.58 4.66 0.28 90.04
121 INT297436 Positive_regulation of Gene_expression of Alas1 1 0.26 0.23 0 89.76
122 INT208062 Regulation of Gene_expression of Arid3b 1 0.10 0.8 0.28 89.24
123 INT315621 Gene_expression of CIAO1 1 0.34 4.11 0 89.20
124 INT315587 Positive_regulation of Gene_expression of CIAO1 1 0.22 1.6 0 89.20
125 INT242866 Regulation of HFE 2 0.39 1.84 0 88.84
126 INT49441 Negative_regulation of Cpox 494 0.59 303.22 177.46 88.40
127 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 88.40
128 INT127040 Negative_regulation of Alas1 2 0.35 0.72 0.54 87.92
129 INT12951 Negative_regulation of Cat 126 0.57 64.39 20.61 87.76
130 INT171423 Regulation of DNLZ 2 0.10 1.8 0.19 85.08
131 INT171422 Regulation of EPHB6 1 0.44 0.53 0.07 85.08
132 INT208068 Positive_regulation of Positive_regulation of Arid3b 1 0.13 0.08 0.11 83.76
133 INT315563 Positive_regulation of Gene_expression of FXN 4 0.41 5.05 0 83.44
134 INT25916 Positive_regulation of GZMM 2 0.47 0.64 0.47 83.44
135 INT208063 Positive_regulation of Arid3b 1 0.13 0.8 1.16 83.20
136 INT315550 Transcription of GLRX5 1 0.53 0.66 0 83.20
137 INT100573 Gene_expression of Lpl 13 0.53 2.09 0.16 83.12
138 INT315593 Regulation of Transcription of SLC40A1 1 0.26 1.7 0 82.40
139 INT315575 Transcription of SLC40A1 1 0.40 0.85 0 82.40
140 INT321657 Positive_regulation of Positive_regulation of Fech 1 0.02 0.8 0 82.32
141 INT199651 Binding of Fxn 3 0.30 1.45 0.03 82.00
142 INT321658 Positive_regulation of Fech 1 0.02 0.8 0 81.88
143 INT12915 Gene_expression of MGP 18 0.75 7.53 4.15 81.80
144 INT315628 Negative_regulation of Gene_expression of FXN 2 0.36 2.37 0 81.76
145 INT19637 Localization of TF 14 0.73 5.74 0.86 81.64
146 INT282679 Localization of FECH 1 0.12 9.57 0.23 81.36
147 INT5380 Positive_regulation of Gene_expression of Fos 243 0.70 105.65 131.05 80.72
148 INT196376 Positive_regulation of Gene_expression of Alas1 1 0.19 1.01 0.25 80.40
149 INT302084 Negative_regulation of WNT2 2 0.09 0.83 1.26 79.84
150 INT302086 Gene_expression of WNT2 3 0.14 0.97 0.38 79.84
151 INT315606 Regulation of Gene_expression of WNT2 1 0.08 0.84 0 79.84
152 INT91158 Regulation of Ros1 26 0.25 17 4.23 79.12
153 INT46036 Regulation of ALAS1 2 0.39 0.23 0.72 78.40
154 INT171428 Gene_expression of AKAP13 2 0.02 0.86 0 77.96
155 INT84130 Gene_expression of Foxo1 1 0.26 0.97 1.22 77.92
156 INT196377 Gene_expression of Nrf1 4 0.68 5.97 2.63 77.92
157 INT49246 Negative_regulation of Urod 1 0.22 1.04 0.11 77.68
158 INT199652 Negative_regulation of Fxn 3 0.54 12.37 0.11 77.52
159 INT80223 Positive_regulation of Hmox1 128 0.68 77.71 17.64 76.88
160 INT682 Negative_regulation of AVP 97 0.59 50.67 23.91 76.80
161 INT115264 Binding of FECH 9 0.41 7.93 1.1 76.64
162 INT3782 Regulation of Fech 1 0.00 1.05 0.09 76.48
163 INT48037 Regulation of Adm 8 0.44 3.96 1.24 75.52
164 INT3783 Regulation of Alad 1 0.00 1.04 0.09 75.32
165 INT90 Localization of Gast 400 0.81 137.67 113 75.00
166 INT3785 Regulation of Urod 1 0.01 1.02 0.09 75.00
167 INT17934 Localization of MLN 16 0.80 2.83 2.24 75.00
168 INT16656 Negative_regulation of Gene_expression of YY1 8 0.57 2.62 2.12 75.00
169 INT3320 Regulation of ALAS2 3 0.33 0.93 1.05 75.00
170 INT315598 Localization of FXN 1 0.43 1.04 0.07 74.96
171 INT55052 Binding of Cat 10 0.36 5.46 0.92 72.40
172 INT55051 Negative_regulation of Binding of Cat 2 0.35 0.61 0.16 72.40
173 INT158469 Regulation of FECH 3 0.36 1.76 1.13 71.44
174 INT17143 Regulation of Cyp2c22 18 0.60 3.02 6.7 71.36
175 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45 70.96
176 INT38834 Positive_regulation of Positive_regulation of PPY 2 0.42 4.18 0.61 70.68
177 INT62690 Gene_expression of PPOX 7 0.77 3.3 0.13 69.96
178 INT50290 Binding of Cpox 29 0.27 17.19 8.01 69.92
179 INT48513 Positive_regulation of MMEL1 2 0.38 0.6 0.15 69.48
180 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 69.44
181 INT55343 Localization of Ros1 39 0.60 34.51 12.5 69.00
182 INT80486 Gene_expression of FECH 13 0.54 10.42 4.8 68.72
183 INT196371 Gene_expression of Ireb2 1 0.41 1.95 0 67.92
184 INT75790 Regulation of Positive_regulation of Htr3a 2 0.44 0.22 0.19 67.68
185 INT9660 Regulation of TNF 363 0.62 312.94 139.99 66.68
186 INT1166 Negative_regulation of Dbh 56 0.59 12.54 28.26 65.52
187 INT41892 Gene_expression of HBM 48 0.64 28.32 5.64 65.36
188 INT315576 Positive_regulation of Binding of CIAO1 1 0.22 0.67 0 65.16
189 INT315589 Binding of CIAO1 1 0.16 0.67 0 64.64
190 INT173223 Negative_regulation of BRCA2 7 0.54 6.79 0.25 63.96
191 INT119062 Negative_regulation of BRCA1 12 0.49 13.7 1.36 63.60
192 INT102813 Regulation of Gene_expression of TP53 25 0.59 25.95 0.75 63.16
193 INT149623 Negative_regulation of fc 17 0.12 10.56 4.05 63.16
194 INT315617 Positive_regulation of Gene_expression of SLC25A37 1 0.10 0.39 0 62.72
195 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26 62.56
196 INT315618 Gene_expression of SLC25A37 1 0.14 0.38 0 61.60
197 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 60.80
198 INT170296 Regulation of Gene_expression of Gopc 33 0.38 12.49 6 60.80
199 INT171426 Positive_regulation of DNLZ 3 0.09 1.31 0.03 60.28
200 INT60585 Regulation of TP53 59 0.59 54.55 5.21 59.76
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