D:Post-partum Depression

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Disease Term
Synonyms Baby Blues, DEPRESSION POST NATAL, DEPRESSION POST PARTUM, Depression Postnatal, Depression Postpartum, Maternity Blues, Post Natal Depression, Post Partum Depression, POSTNATAL BLUES, POSTNATAL DEPRESSION, Postnatal Depression Excluding Psychosis
Documents 121
Hot Single Events 26
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Post-partum Depression. They are ordered first by their relevance to Post-partum Depression and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT304339 Negative_regulation of CD79A Positive_regulation of NRP2 1 0.06 0.86 0.33 84.96
2 INT304338 CD79A Positive_regulation of NRP2 1 0.08 0.84 0.32 84.96
3 INT341777 SLC6A4 Regulation of EPHB1 1 0.02 0.96 0.3 65.36
4 INT105771 CRH Negative_regulation of Localization of GNRH1 1 0.35 0.56 0.39 25.00
5 INT105772 SST Negative_regulation of Localization of GH1 1 0.10 0.54 0.38 25.00
6 INT105770 SST Negative_regulation of Localization of TRH 1 0.17 0.54 0.38 25.00
7 INT304340 FKBP5 Regulation of NR3C1 1 0.05 0.71 0.37 5.00
8 INT102341 Binding of Slc6a3 and Flvcr2 2 0.06 0 0.34 5.00
9 INT323152 Binding of DBT and ESR1 2 0.02 1.29 0.27 5.00
10 INT341779 DBT Positive_regulation of PRKCA 1 0.02 0 0.22 5.00
11 INT341778 DBT Positive_regulation of MAP2K6 1 0.00 0 0.21 5.00
12 INT201440 Negative_regulation of Ngf Positive_regulation of Slc6a3 1 0.10 0 0.2 5.00
13 INT201443 Ngf Positive_regulation of Slc6a3 1 0.11 0 0.19 5.00
14 INT341775 DBT Regulation of Binding of ESR1 1 0.02 0.1 0.11 5.00
15 INT341776 ESR1 Positive_regulation of Gene_expression of SLC6A3 1 0.06 0.08 0.09 5.00
16 INT201446 GOPC Positive_regulation of Slc6a3 1 0.03 0.07 0.08 5.00
17 INT201439 Dlat Regulation of Localization of Slc6a3 1 0.04 0 0.06 5.00
18 INT201445 ESR1 Regulation of Slc6a3 1 0.02 0.05 0.04 5.00
19 INT201442 Dlat Regulation of Slc6a3 1 0.04 0.18 0.04 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Post-partum Depression. They are ordered first by their pain relevance and then by number of times they were reported in Post-partum Depression. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT5623 Positive_regulation of Nppa 174 0.70 69.96 52.33 100.00
2 INT6210 Binding of Nppa 39 0.47 14.35 7.21 100.00
3 INT2116 Negative_regulation of VSX1 29 0.36 10.67 1.89 100.00
4 INT91610 Binding of ZFP91 4 0.31 2.86 1.11 99.96
5 INT207165 Gene_expression of DAK 18 0.08 9.41 2.69 99.66
6 INT187712 Negative_regulation of DBT 11 0.19 2.99 0.65 99.20
7 INT175365 Localization of Prdm6 2 0.54 0.1 0.05 98.72
8 INT179696 Negative_regulation of DAK 5 0.02 16.79 9.42 98.44
9 INT5454 Localization of CRH 124 0.79 79.18 41.53 98.20
10 INT179693 Positive_regulation of DAK 14 0.04 6.02 1.4 98.08
11 INT6441 Positive_regulation of CRH 98 0.69 57.22 24.12 98.04
12 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 97.52
13 INT90082 Positive_regulation of Degs1 2 0.04 6.09 1.9 94.60
14 INT36678 Binding of TIMP1 33 0.36 14.99 7.87 94.44
15 INT32129 Gene_expression of Esrra 8 0.36 5.64 0.97 94.04
16 INT345258 Negative_regulation of Negative_regulation of DAK 1 0.01 0.67 0.26 93.60
17 INT16260 Gene_expression of Bdnf 671 0.78 283.44 339.1 92.52
18 INT312549 Binding of DAK 2 0.01 1.72 0.59 92.04
19 INT63507 Gene_expression of SERPINE2 8 0.70 8.35 5.56 92.04
20 INT34624 Negative_regulation of REM1 22 0.38 9.25 4.22 91.00
21 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 90.08
22 INT2761 Regulation of Gabrg1 119 0.61 18.8 60.52 88.52
23 INT182720 Binding of SHE 18 0.26 9.15 2.24 88.40
24 INT156794 Gene_expression of CISH 41 0.58 23.09 5.03 85.56
25 INT206664 Positive_regulation of Gene_expression of CISH 3 0.20 0.59 0.74 85.56
26 INT240064 Regulation of DAK 4 0.06 0.29 0.56 82.00
27 INT161879 Negative_regulation of Gene_expression of Lamc2 1 0.04 0.57 0.31 77.56
28 INT47683 Negative_regulation of Bdnf 92 0.59 47.53 43.55 77.28
29 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 77.12
30 INT151847 Gene_expression of Lamc2 5 0.14 4.53 0.97 76.80
31 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 76.40
32 INT114163 Regulation of HTR5A 2 0.27 0.2 1.61 75.48
33 INT79780 Gene_expression of Cyp4a3 14 0.56 5.19 1.12 75.04
34 INT28458 Localization of Slc6a3 31 0.76 2.33 12.49 75.04
35 INT109255 Gene_expression of IFNW1 4 0.02 2.72 1.3 74.56
36 INT78719 Binding of Ucp1 8 0.41 8.93 4.5 74.52
37 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 73.36
38 INT244368 Binding of CENPI 1 0.04 0.65 0.25 72.20
39 INT206665 Gene_expression of SGMS1 1 0.14 0.23 0.19 71.28
40 INT244367 Gene_expression of CENPI 1 0.07 0.2 0.11 69.12
41 INT54356 Regulation of Slc6a3 48 0.58 5.86 15.24 64.96
42 INT133060 Regulation of Bai1 1 0.03 0.74 0.86 64.76
43 INT161877 Regulation of Esrra 2 0.33 0.62 0.34 64.72
44 INT31705 Gene_expression of Fads1 12 0.22 1.43 6.69 62.68
45 INT345253 Negative_regulation of Gene_expression of Fads1 1 0.16 1.07 0.3 62.68
46 INT44544 Gene_expression of ENOPH1 18 0.76 10.28 2.35 61.60
47 INT38556 Gene_expression of DBT 47 0.50 12.52 5.6 61.44
48 INT44550 Positive_regulation of Gene_expression of AVP 38 0.70 22.27 8.62 61.36
49 INT174193 Gene_expression of LILRA3 20 0.28 12.65 5.1 61.12
50 INT70738 Negative_regulation of Gabrg2 7 0.57 4 2.96 60.96
51 INT161878 Negative_regulation of Gene_expression of Gabrg2 2 0.57 0.75 0.4 60.96
52 INT3679 Gene_expression of AVP 171 0.78 72.9 35.23 60.76
53 INT99496 Gene_expression of HSD17B7 5 0.78 1.24 1.02 60.08
54 INT99497 Positive_regulation of Gene_expression of HSD17B7 1 0.47 0.35 0.13 60.08
55 INT70739 Gene_expression of Gabrg2 11 0.75 4.15 4.18 60.00
56 INT683 Positive_regulation of AVP 173 0.70 74.55 46.41 55.20
57 INT99495 Gene_expression of SRD5A1 14 0.77 5 9.21 53.92
58 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21 52.48
59 INT89825 Gene_expression of CYP11A1 3 0.75 2.33 2.01 51.52
60 INT443 Localization of POMC 1020 0.81 284.52 443.17 50.68
61 INT249 Localization of GHRH 215 0.80 78.02 51.87 50.68
62 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52 50.68
63 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 50.00
64 INT16259 Positive_regulation of Bdnf 336 0.70 183.48 209.82 50.00
65 INT16253 Positive_regulation of Gene_expression of Bdnf 196 0.70 92.67 113.01 50.00
66 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 50.00
67 INT52692 Gene_expression of Ptgs2 160 0.78 85.06 55.73 50.00
68 INT49993 Positive_regulation of Gene_expression of Il6 149 0.70 88.07 53.78 50.00
69 INT47680 Regulation of Gene_expression of Bdnf 92 0.62 41.61 53.24 50.00
70 INT5704 Binding of Slc3a1 78 0.43 8.52 51.78 50.00
71 INT2783 Gene_expression of Slc3a1 86 0.65 8.84 45.4 50.00
72 INT67620 Negative_regulation of Gene_expression of Bdnf 53 0.59 22.45 28.5 50.00
73 INT52693 Positive_regulation of Gene_expression of Ptgs2 57 0.70 25.51 21.18 50.00
74 INT13989 Negative_regulation of Slc3a1 27 0.24 5.34 16.76 50.00
75 INT18412 Binding of PLEK 49 0.47 17.82 10.72 50.00
76 INT21579 Negative_regulation of Gene_expression of TIMP1 25 0.57 12.41 6.94 50.00
77 INT21582 Regulation of Gene_expression of TIMP1 20 0.61 12.39 4.77 50.00
78 INT66366 Positive_regulation of Gsk3b 15 0.68 6.56 4.27 50.00
79 INT53677 Positive_regulation of Binding of Slc3a1 4 0.35 1.28 1.56 50.00
80 INT32545 Localization of Gsk3b 9 0.07 2.88 1.11 50.00
81 INT345255 Positive_regulation of Negative_regulation of Slc3a1 2 0.07 1.31 0.89 50.00
82 INT345254 Positive_regulation of Localization of Gsk3b 2 0.01 0.91 0.24 50.00
83 INT229696 Gene_expression of Rxrg 3 0.07 0.26 0.2 50.00
84 INT345259 Protein_catabolism of DAK 1 0.02 0 0.04 50.00
85 INT10796 Gene_expression of CYP2B6 131 0.77 30.14 35.27 48.24
86 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 48.16
87 INT8392 Regulation of Gene_expression of Qrfp 37 0.54 6.9 19.02 43.52
88 INT8346 Gene_expression of Qrfp 136 0.70 19.49 70.21 43.08
89 INT20462 Binding of ESR1 210 0.44 102.7 26.34 42.16
90 INT173092 Regulation of BAI1 3 0.24 3.16 0.44 39.56
91 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 38.64
92 INT158078 Gene_expression of Gper 7 0.67 1.13 1.26 35.60
93 INT201434 Negative_regulation of Gene_expression of Gper 1 0.11 0 0.08 35.60
94 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 35.04
95 INT51265 Phosphorylation of TNF 32 0.81 25.33 10.75 35.04
96 INT183791 Positive_regulation of Phosphorylation of TNF 6 0.49 4.72 1.56 35.04
97 INT212498 Gene_expression of USP39 2 0.51 1.84 0.32 28.56
98 INT6782 Gene_expression of SCN5A 156 0.78 33.13 17.88 26.32
99 INT425 Localization of PRL 455 0.81 189.64 144.8 25.96
100 INT252 Localization of GH1 529 0.80 227.4 122.05 25.00
101 INT7395 Localization of GNRH1 399 0.81 62.88 117.68 25.00
102 INT16303 Negative_regulation of Localization of GH1 89 0.59 37.31 22.15 25.00
103 INT5452 Regulation of CRH 56 0.62 15.32 12.42 25.00
104 INT987 Localization of TRH 37 0.78 10.53 11.1 25.00
105 INT68285 Gene_expression of SERPINB3 24 0.75 25.4 0.45 25.00
106 INT98778 Gene_expression of DHRS9 2 0.51 0.06 0.16 25.00
107 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 23.16
108 INT918 Positive_regulation of Localization of PRL 90 0.70 23.97 40.3 23.16
109 INT2005 Positive_regulation of Gene_expression of PRL 55 0.70 21.4 13.44 23.16
110 INT1577 Negative_regulation of Gene_expression of PRL 24 0.59 7.7 3.15 22.52
111 INT916 Regulation of Localization of PRL 92 0.62 22.98 38.13 21.96
112 INT175369 Gene_expression of GLS2 1 0.24 0.05 0 20.40
113 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 14.40
114 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 14.40
115 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 14.24
116 INT79545 Positive_regulation of Gene_expression of ESR1 82 0.64 39.42 12.18 14.24
117 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 13.52
118 INT308082 Gene_expression of Drm 1 0.59 0.3 0.12 12.00
119 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
120 INT5680 Gene_expression of Ngf 530 0.78 264.29 310.56 5.00
121 INT3579 Localization of Oxt 555 0.81 43.35 292.44 5.00
122 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 5.00
123 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
124 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 5.00
125 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 5.00
126 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
127 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
128 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
129 INT12763 Phosphorylation of Prkcg 167 0.82 38.91 89.63 5.00
130 INT7885 Positive_regulation of Localization of Oxt 160 0.70 14.36 87.7 5.00
131 INT15898 Positive_regulation of Prkaca 199 0.70 50.89 87.54 5.00
132 INT17546 Negative_regulation of Ngf 135 0.59 60.28 77.19 5.00
133 INT5941 Gene_expression of Oxt 164 0.76 22.63 65.47 5.00
134 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6 5.00
135 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
136 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
137 INT9296 Negative_regulation of PLEK 100 0.57 36.65 27.52 5.00
138 INT80791 Gene_expression of Slc6a3 113 0.78 11.89 25.76 5.00
139 INT15089 Regulation of SLC6A4 48 0.62 17.87 25.6 5.00
140 INT956 Negative_regulation of PRL 94 0.59 42.72 23.01 5.00
141 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52 5.00
142 INT3589 Positive_regulation of SCN5A 101 0.57 46.01 21.73 5.00
143 INT61825 Negative_regulation of Slc6a3 47 0.59 6.52 21.27 5.00
144 INT81210 Positive_regulation of PRKG1 71 0.70 26.83 19.89 5.00
145 INT7581 Binding of ADHD1 132 0.46 135.1 19.73 5.00
146 INT871 Negative_regulation of Gene_expression of Prl 53 0.58 18.89 17.79 5.00
147 INT1578 Negative_regulation of Localization of PRL 52 0.59 20.62 17.18 5.00
148 INT145097 Negative_regulation of Pain1 16 0.22 19.11 16.82 5.00
149 INT65214 Binding of Slc6a3 54 0.48 4.77 16.79 5.00
150 INT92354 Localization of ESR1 77 0.75 33.04 15.51 5.00
151 INT61172 Gene_expression of PRKCA 34 0.77 8.89 15.47 5.00
152 INT71634 Gene_expression of SLC6A3 45 0.78 13.48 15.23 5.00
153 INT7469 Positive_regulation of Gene_expression of Oxt 18 0.59 4.7 14.36 5.00
154 INT77619 Gene_expression of Prkaca 43 0.75 8.55 14.13 5.00
155 INT52714 Regulation of PRKCA 28 0.61 7.73 13.66 5.00
156 INT635 Negative_regulation of MAOB 51 0.59 24.5 12.66 5.00
157 INT49975 Binding of SLC6A3 34 0.47 9.86 12.41 5.00
158 INT11288 Negative_regulation of CRH 44 0.00 16.69 12.37 5.00
159 INT72221 Localization of PRKCA 17 0.81 1.23 11.47 5.00
160 INT14132 Negative_regulation of HTR1A 25 0.57 4.93 10.91 5.00
161 INT86729 Positive_regulation of CDCP1 37 0.07 18.74 10.76 5.00
162 INT80110 Regulation of Positive_regulation of TNF 34 0.44 25.79 9.78 5.00
163 INT144689 Regulation of RCT 49 0.53 25.91 9.6 5.00
164 INT12398 Regulation of Flvcr2 11 0.39 1.8 9.47 5.00
165 INT97649 Gene_expression of Dlat 48 0.66 13.77 8.94 5.00
166 INT89677 Gene_expression of PRKG1 38 0.78 13.98 8.56 5.00
167 INT28457 Positive_regulation of Slc6a3 26 0.50 3.64 7.76 5.00
168 INT66318 Gene_expression of NR3C1 26 0.76 20 7.55 5.00
169 INT50387 Negative_regulation of AR 67 0.45 26.31 6.61 5.00
170 INT7205 Positive_regulation of HBG1 65 0.69 40.35 6.37 5.00
171 INT77252 Gene_expression of Nr3c1 17 0.67 9.71 5.38 5.00
172 INT23598 Binding of SCN5A 32 0.40 16 5.35 5.00
173 INT81796 Binding of AGRP 62 0.36 37.19 5.3 5.00
174 INT64723 Regulation of Positive_regulation of IL6 13 0.61 12.59 5.19 5.00
175 INT58097 Transcription of Oxt 18 0.69 1.62 4.6 5.00
176 INT181244 Gene_expression of ZBTB32 20 0.59 0.56 4.33 5.00
177 INT187346 Regulation of Dlat 12 0.29 1.82 4.28 5.00
178 INT201438 Phosphorylation of Slc6a3 3 0.68 0.79 4.19 5.00
179 INT72747 Localization of IgG 55 0.53 30.88 4.19 5.00
180 INT42317 Negative_regulation of Dlat 21 0.43 3.13 4.11 5.00
181 INT52980 Positive_regulation of Dlat 20 0.37 5.14 4.06 5.00
182 INT119053 Positive_regulation of SLC6A3 15 0.65 2.51 4 5.00
183 INT39945 Binding of Dlat 27 0.32 14.95 3.88 5.00
184 INT172677 Gene_expression of SHE 65 0.59 25.86 3.85 5.00
185 INT89678 Positive_regulation of Gene_expression of PRKG1 15 0.70 5.99 3.84 5.00
186 INT93110 Regulation of CDCP1 16 0.03 7.98 3.83 5.00
187 INT178631 Phosphorylation of ESR1 21 0.75 9.16 3.36 5.00
188 INT122577 Regulation of SLC6A3 9 0.53 1.47 3.09 5.00
189 INT181246 Positive_regulation of ZBTB32 13 0.61 1.37 2.85 5.00
190 INT158083 Gene_expression of FGD1 24 0.67 6.82 2.83 5.00
191 INT174727 Positive_regulation of Positive_regulation of ESR1 14 0.44 6.3 2.7 5.00
192 INT169987 Transcription of GOPC 45 0.60 21.88 2.61 5.00
193 INT287307 Binding of ENO1 9 0.48 11.24 2.51 5.00
194 INT188756 Positive_regulation of AGRP 43 0.60 23.67 2.51 5.00
195 INT229111 Localization of SLC6A3 5 0.68 1.12 2.48 5.00
196 INT111584 Positive_regulation of Negative_regulation of Slc6a3 4 0.47 0.68 2.31 5.00
197 INT54615 Gene_expression of GPER 25 0.75 8.23 2.27 5.00
198 INT150384 Binding of RCT 10 0.25 3.1 2.05 5.00
199 INT169874 Positive_regulation of Gene_expression of Prkaca 11 0.38 1.64 2.01 5.00
200 INT77990 Protein_catabolism of Slc6a3 6 0.72 0.99 1.84 5.00
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