D:Post Operative Pain

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Disease Term
Synonyms PAIN POSTOPERATIVE, Postherpetic Neuralgia, Postherpetic Pain, Postoperative Neuralgia, POSTOPERATIVE PAIN, Postoperative Pains
Documents 10568
Hot Single Events 200
Hot Interactions 13

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Post Operative Pain. They are ordered first by their relevance to Post Operative Pain and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT107268 Binding of ITGAL and NCR3 1 0.01 2.76 2.07 99.20
2 INT107269 Binding of HLA-A and NCR3 1 0.35 1.42 1.1 99.20
3 INT107264 Binding of TNF and NCR3 1 0.30 1.42 1.1 99.20
4 INT107263 Binding of HLA-DRB1 and NCR3 1 0.40 1.42 1.1 99.20
5 INT107265 Binding of HLA-DRB1 and ITGAL 1 0.01 1.41 1.1 98.80
6 INT107266 Binding of HLA-DRB1 and TNF 1 0.29 1.41 1.1 98.44
7 INT107267 Binding of HLA-A and TNF 1 0.34 1.41 1.1 98.44
8 INT155220 ABCG2 Positive_regulation of Abcc2 1 0.23 0.54 0.76 93.60
9 INT146520 Tmem132a Regulation of Gene_expression of Fos 1 0.69 0.5 2.18 92.84
10 INT114754 Il6 Positive_regulation of Gene_expression of Crp 2 0.08 1.67 0.47 92.80
11 INT114755 Il6 Positive_regulation of Crp 1 0.08 0.41 0.35 92.80
12 INT78820 Binding of Asap1 and tn 1 0.04 0.36 0.19 92.56
13 INT274871 Positive_regulation of Cbr2 Positive_regulation of Positive_regulation of Dusp6 1 0.02 0.72 0.67 92.44
14 INT313375 Cnr2 Positive_regulation of Phosphorylation of Mapk14 1 0.18 0.39 0.5 74.48
15 INT313373 Cnr2 Positive_regulation of Gene_expression of Gfap 1 0.32 0.39 0.5 74.48
16 INT313376 Cnr1 Positive_regulation of Phosphorylation of Mapk14 1 0.20 0.38 0.5 73.44
17 INT313371 Cnr1 Positive_regulation of Gene_expression of Gfap 1 0.35 0.39 0.5 73.44
18 INT190128 Positive_regulation of PTGER1 Negative_regulation of Gene_expression of CPOX 1 0.04 1.21 1.38 72.16
19 INT291578 Negative_regulation of Pde12 Positive_regulation of Pde5a 1 0.03 1.11 1.67 61.96
20 INT146518 Tmem132a Positive_regulation of Gene_expression of Fos 1 0.68 0.06 1.04 46.96
21 INT14910 Binding of GPR182 and SIT1 1 0.02 1.87 1.73 40.48
22 INT96228 COX5A Regulation of Ak1 1 0.01 0.6 0.6 25.00
23 INT313377 Trib3 Regulation of Gene_expression of Gfap 1 0.01 0.37 0.44 12.32
24 INT313378 Trib3 Regulation of Phosphorylation of Mapk14 1 0.01 0.37 0.44 12.32
25 INT312939 Binding of Hes3 and Setd1a 1 0.01 0.66 0 7.44
26 INT26824 Crh Positive_regulation of Localization of Penk 7 0.54 0.42 6.49 5.00
27 INT127128 Binding of CNR1 and CNR2 8 0.39 3.98 3.97 5.00
28 INT85743 Pdyn Positive_regulation of Oprk1 3 0.32 2.12 3.52 5.00
29 INT318474 Positive_regulation of OPRM1 Positive_regulation of Localization of CA2 1 0.17 0.55 2.7 5.00
30 INT114134 Penk Positive_regulation of Oprm1 2 0.24 1.48 2.68 5.00
31 INT318473 Positive_regulation of OPRM1 Positive_regulation of CA2 1 0.17 0.46 2.13 5.00
32 INT264953 Binding of POMC and TLR4 1 0.03 0.89 1.96 5.00
33 INT264947 Binding of POMC and TLR2 1 0.03 0.89 1.95 5.00
34 INT97208 Binding of Gabrg1 and Gabbr1 2 0.07 0.31 1.94 5.00
35 INT351281 AP1M2 Regulation of NCOR2 1 0.00 0.85 1.9 5.00
36 INT199486 Oprm1 Regulation of Gene_expression of Oprd1 1 0.02 0.49 1.84 5.00
37 INT199287 TNF Positive_regulation of Transcription of Oprm1 2 0.02 1.86 1.8 5.00
38 INT199503 ENG Positive_regulation of Oprk1 1 0.01 0.87 1.69 5.00
39 INT199504 ENG Positive_regulation of Oprm1 1 0.01 0.87 1.68 5.00
40 INT199497 Pdyn Negative_regulation of Il1 1 0.00 0.14 1.67 5.00
41 INT199490 Penk Positive_regulation of Oprk1 1 0.03 0.87 1.64 5.00
42 INT199501 Pdyn Positive_regulation of Oprm1 1 0.01 0.86 1.63 5.00
43 INT109739 Binding of ITPA and Pcyt1b 1 0.16 0.72 1.6 5.00
44 INT264950 Binding of FPR1 and BOC 1 0.11 0.67 1.55 5.00
45 INT291583 GUCY2C Regulation of Pde5a 1 0.00 1.12 1.45 5.00
46 INT199494 Crh Positive_regulation of Localization of Pdyn 1 0.02 0.43 1.4 5.00
47 INT293200 Positive_regulation of Grin1 Positive_regulation of Phosphorylation of Grin2b 1 0.24 0.4 1.39 5.00
48 INT15846 Crh Positive_regulation of Localization of ENG 3 0.07 0.42 1.38 5.00
49 INT262377 Binding of Comt and Fmod 1 0.06 1.47 1.29 5.00
50 INT190130 Binding of CPOX and MRXS5 1 0.00 1.4 1.23 5.00
51 INT199493 Ngf Regulation of Oprd1 1 0.05 1.05 1.15 5.00
52 INT89938 Tlr4 Positive_regulation of Gene_expression of TNF 6 0.25 1.3 1.12 5.00
53 INT229913 Positive_regulation of Ntsr1 Positive_regulation of Gene_expression of Egr1 1 0.12 1.33 1.11 5.00
54 INT283934 Phax Negative_regulation of Positive_regulation of Mapk14 1 0.03 2.06 1.09 5.00
55 INT229914 Egr1 Positive_regulation of Phosphorylation of Mapk3 1 0.46 1.03 1.02 5.00
56 INT283932 Positive_regulation of Mapk14 Regulation of Gene_expression of Trpv1 1 0.14 1.28 0.99 5.00
57 INT274895 Positive_regulation of Cbr2 Negative_regulation of Gene_expression of TNF 1 0.06 1.21 0.99 5.00
58 INT264944 Binding of POMC and BOC 1 0.07 0.44 0.89 5.00
59 INT339318 Ngf Positive_regulation of Pik3cg 1 0.02 0.69 0.87 5.00
60 INT199499 Il6 Positive_regulation of Transcription of Oprm1 1 0.01 0.8 0.86 5.00
61 INT199492 Il6 Positive_regulation of Transcription of Oprm1 1 0.01 0.81 0.86 5.00
62 INT199487 Il6 Positive_regulation of Oprm1 1 0.01 0.8 0.86 5.00
63 INT199491 Il6 Positive_regulation of Positive_regulation of Il6 1 0.00 0.81 0.86 5.00
64 INT199500 Il6 Positive_regulation of Oprm1 1 0.01 0.8 0.85 5.00
65 INT265566 Binding of PDE4D and PTPN5 1 0.03 0.81 0.85 5.00
66 INT291581 Pde5a Regulation of Localization of Abat 1 0.03 0 0.83 5.00
67 INT199495 Il4 Positive_regulation of Positive_regulation of Oprm1 1 0.00 0.98 0.78 5.00
68 INT199476 Il4 Positive_regulation of Transcription of Stat6 1 0.01 0.97 0.77 5.00
69 INT259556 PLEK Negative_regulation of Gene_expression of VEGFA 1 0.46 2.15 0.73 5.00
70 INT259557 PLEK Negative_regulation of Positive_regulation of VEGFA 1 0.46 2.15 0.73 5.00
71 INT199488 Il4 Positive_regulation of Transcription of Oprm1 1 0.01 0.84 0.73 5.00
72 INT199489 Stat6 Positive_regulation of Oprm1 1 0.02 0.85 0.68 5.00
73 INT264943 Negative_regulation of Binding of FPR1 and BOC 1 0.13 0.22 0.64 5.00
74 INT264946 Binding of FPR1 and GOPC 1 0.08 0.21 0.64 5.00
75 INT264952 Binding of GOPC and BOC 1 0.05 0.22 0.64 5.00
76 INT291579 Pde12 Regulation of Binding of Pde5a 1 0.02 0.41 0.6 5.00
77 INT139901 Ins1 Positive_regulation of Akt1 9 0.31 4.58 0.6 5.00
78 INT318472 CA2 Regulation of OPRM1 1 0.17 0 0.51 5.00
79 INT264948 BOC Negative_regulation of FPR1 1 0.13 0.18 0.48 5.00
80 INT264949 BOC Negative_regulation of Localization of FPR1 1 0.13 0.18 0.48 5.00
81 INT264975 BOC Negative_regulation of Localization of Oprd1 1 0.01 0.17 0.48 5.00
82 INT291580 Pde5a Regulation of Abat 1 0.04 0.39 0.48 5.00
83 INT264945 GOPC Positive_regulation of Positive_regulation of FPR1 1 0.10 0.2 0.44 5.00
84 INT274864 Negative_regulation of Mapk1 Negative_regulation of Gene_expression of TNF 1 0.05 1.15 0.41 5.00
85 INT274867 Negative_regulation of Mapk1 Negative_regulation of TNF 1 0.03 1.15 0.41 5.00
86 INT351237 HRAS Regulation of CBL 1 0.00 0.48 0.4 5.00
87 INT276216 Binding of Akt1 and Ins1 2 0.03 2.61 0.4 5.00
88 INT313380 Binding of Cnr1 and Trpv1 1 0.36 0.09 0.39 5.00
89 INT274865 Positive_regulation of Mapk1 Negative_regulation of Gene_expression of TNF 1 0.04 1.08 0.35 5.00
90 INT274866 Mapk1 Positive_regulation of Gene_expression of TNF 1 0.06 0.35 0.33 5.00
91 INT274872 Positive_regulation of Cbr2 Positive_regulation of Dusp6 1 0.02 0.63 0.32 5.00
92 INT313374 Cnr1 Regulation of Gene_expression of Cnr2 1 0.36 0 0.3 5.00
93 INT215683 P2ry2 Positive_regulation of Gene_expression of Il6 1 0.02 0.76 0.29 5.00
94 INT298348 ANGPT2 Positive_regulation of Phosphorylation of Stat3 1 0.18 0.14 0.28 5.00
95 INT323926 MRM1 Positive_regulation of MRI1 1 0.04 0.44 0.26 5.00
96 INT323346 Positive_regulation of Tyrp1 Positive_regulation of Positive_regulation of Gpr35 1 0.11 0.76 0.21 5.00
97 INT254687 Positive_regulation of Map2k1 Positive_regulation of Gene_expression of Mmp13 1 0.06 0.2 0.2 5.00
98 INT274832 Dusp6 Positive_regulation of Localization of Tlr4 1 0.00 0 0.19 5.00
99 INT254683 Positive_regulation of Map2k1 Positive_regulation of Gene_expression of Plaur 1 0.01 0.07 0.18 5.00
100 INT254691 Gopc Positive_regulation of Positive_regulation of Map2k2 1 0.07 0.07 0.18 5.00
101 INT254698 Gopc Positive_regulation of Positive_regulation of Map2k1 1 0.06 0.07 0.18 5.00
102 INT304964 Binding of AMT and PTK2B 1 0.23 0.78 0.18 5.00
103 INT254685 Map2k2 Positive_regulation of Mmp3 1 0.04 0.08 0.18 5.00
104 INT300305 Mapk14 Positive_regulation of Gene_expression of Ctgf 1 0.19 1.25 0.17 5.00
105 INT309779 PTH Negative_regulation of Gene_expression of COL5A2 1 0.00 0.52 0.14 5.00
106 INT323345 Ido1 Positive_regulation of Gene_expression of Tlr4 1 0.14 0.69 0.13 5.00
107 INT266681 TRD@ Regulation of CRP 1 0.06 0.5 0.13 5.00
108 INT266683 IL1B Positive_regulation of Gene_expression of PROC 1 0.00 1.62 0.11 5.00
109 INT216075 ATD Regulation of Cfp 1 0.07 0.11 0.11 5.00
110 INT300313 TGFB1 Positive_regulation of Mapk14 1 0.01 1.5 0.11 5.00
111 INT300306 Agt Positive_regulation of Mapk14 1 0.14 1.51 0.11 5.00
112 INT309780 Binding of PTH and PTH1R 3 0.12 0.3 0.09 5.00
113 INT257870 Agt Positive_regulation of Akt1 2 0.18 1.5 0.09 5.00
114 INT300304 Positive_regulation of Mapk14 Positive_regulation of Agt 1 0.14 1.5 0.08 5.00
115 INT215767 Binding of P2ry1 and Ca2 1 0.02 0.2 0.08 5.00
116 INT201378 Bdnf Regulation of Gene_expression of Ltp 1 0.00 0.21 0.07 5.00
117 INT298349 HES3 Positive_regulation of Shh 1 0.12 0.14 0.07 5.00
118 INT215693 Trib3 Regulation of Gene_expression of Ccnd1 1 0.00 0.09 0.07 5.00
119 INT298350 HES3 Positive_regulation of HES3 Positive_regulation of Shh 1 0.09 0.14 0.07 5.00
120 INT300308 Positive_regulation of Mapk14 Positive_regulation of Trib3 1 0.03 1.42 0.07 5.00
121 INT300309 Akt1 Regulation of Rorb 1 0.05 3.28 0.06 5.00
122 INT312940 Chol1 Positive_regulation of Setd1a 1 0.00 0 0.06 5.00
123 INT300310 Akt1 Regulation of Foxo3 1 0.21 1.5 0.06 5.00
124 INT274863 Mapk1 Positive_regulation of Tlr4 1 0.01 0.1 0.05 5.00
125 INT274833 Negative_regulation of Dusp6 Positive_regulation of Mapk1 1 0.01 0 0.04 5.00
126 INT274830 Tlr4 Positive_regulation of Gene_expression of Dusp6 1 0.00 0.06 0.03 5.00
127 INT312943 ANTXR1 Regulation of Gene_expression of Hes3 1 0.00 0.67 0.03 5.00
128 INT215691 Binding of P2ry2 and P2rx3 1 0.08 0.46 0.03 5.00
129 INT215765 Binding of P2ry1 and P2ry2 1 0.07 0.46 0.03 5.00
130 INT215684 Binding of P2ry2 and P2rx4 1 0.06 0.46 0.03 5.00
131 INT312942 ANTXR1 Regulation of Localization of Hes3 1 0.00 0.67 0.03 5.00
132 INT274829 Tlr4 Regulation of Gene_expression of Dusp6 1 0.00 0.06 0.03 5.00
133 INT215766 Dio1 Regulation of Cdk6 1 0.01 0.05 0 5.00
134 INT215707 Cdkn2a Negative_regulation of Cdkn1b 1 0.01 0 0 5.00
135 INT254689 Gene_expression of Map2k2 Positive_regulation of Map2k1 1 0.30 0.4 0 5.00
136 INT215686 Cdkn2b Negative_regulation of Cdkn1c 1 0.01 0 0 5.00
137 INT215698 Lamtor1 Negative_regulation of Kras 1 0.00 0 0 5.00
138 INT294065 ANGPT2 Positive_regulation of VEGFA 1 0.02 0.1 0 5.00
139 INT354566 F2 Positive_regulation of PRNP 1 0.00 0.05 0 5.00
140 INT254707 Positive_regulation of Map2k1 Regulation of Gene_expression of BAK1 1 0.05 0.67 0 5.00
141 INT254692 Positive_regulation of Map2k1 Regulation of Gene_expression of Mdk 1 0.05 0.42 0 5.00
142 INT215706 Binding of Cdk6 and Lamtor1 1 0.04 0 0 5.00
143 INT254695 Positive_regulation of Map2k2 Regulation of Mcl1 1 0.03 0.84 0 5.00
144 INT215764 Dio1 Regulation of Ces1c 1 0.00 0.05 0 5.00
145 INT294066 ANGPT1 Positive_regulation of VEGFA 1 0.01 0.1 0 5.00
146 INT215700 Binding of Cdkn2b and Cdk6 1 0.02 0 0 5.00
147 INT215685 Slc3a1 Regulation of Ces1c 1 0.00 0.05 0 5.00
148 INT215768 Dio1 Regulation of Cdk4 1 0.01 0.05 0 5.00
149 INT215690 Binding of Cdk6 and Cdkn1c 1 0.03 0 0 5.00
150 INT266682 TRD@ Negative_regulation of TNF 1 0.12 1.55 0 5.00
151 INT215697 Lamtor1 Negative_regulation of Cdkn1b 1 0.02 0 0 5.00
152 INT215778 Lamtor1 Negative_regulation of Binding of Cdkn2b and Cdk6 1 0.01 0 0 5.00
153 INT215774 Cdkn2b Negative_regulation of Binding of Cdkn1b and Cdk6 1 0.00 0 0 5.00
154 INT254693 Gene_expression of Map2k1 Regulation of Map2k2 1 0.29 0.78 0 5.00
155 INT312944 ANTXR1 Positive_regulation of Localization of Hes3 1 0.01 0.36 0 5.00
156 INT215777 Cdkn2b Negative_regulation of Binding of Cdkn2b and Cdk6 1 0.00 0 0 5.00
157 INT215682 Binding of Cdkn1b and Cdk6 1 0.03 0 0 5.00
158 INT215699 Cdkn2a Negative_regulation of Cdkn1c 1 0.01 0 0 5.00
159 INT215773 Cdkn2b Negative_regulation of Binding of Cdk6 and Cdkn1c 1 0.00 0 0 5.00
160 INT254686 Gene_expression of Map2k1 Regulation of Gene_expression of Mdk 1 0.08 0.42 0 5.00
161 INT215701 Slc3a1 Regulation of Cdk6 1 0.01 0.05 0 5.00
162 INT215696 Cdkn2a Negative_regulation of Kras 1 0.00 0 0 5.00
163 INT215780 Cdkn2b Negative_regulation of Binding of Cdk6 and Lamtor1 1 0.01 0 0 5.00
164 INT215702 Stmn1 Negative_regulation of Kras 1 0.00 0 0 5.00
165 INT254703 Map2k1 Positive_regulation of Phosphorylation of MAPK1 1 0.10 0.91 0 5.00
166 INT254696 Map2k2 Regulation of Map2k1 1 0.18 0.78 0 5.00
167 INT300303 Binding of Gk and Foxo3 1 0.09 1.53 0 5.00
168 INT215776 Lamtor1 Negative_regulation of Binding of Kras and Cdk6 1 0.00 0 0 5.00
169 INT300307 Binding of Tp53 and Sirt1 1 0.24 0.98 0 5.00
170 INT254708 Map2k2 Positive_regulation of Phosphorylation of MAPK1 1 0.11 0.86 0 5.00
171 INT254699 Positive_regulation of Map2k2 Regulation of Bcl2l1 1 0.04 0.89 0 5.00
172 INT215709 Slc3a1 Regulation of Cdk4 1 0.01 0.05 0 5.00
173 INT254706 Positive_regulation of Map2k1 Positive_regulation of Phosphorylation of MAPK3 1 0.07 0.91 0 5.00
174 INT312945 ANTXR1 Regulation of Setd1a 1 0.00 0.36 0 5.00
175 INT254688 Gene_expression of Map2k2 Regulation of Gene_expression of Mdk 1 0.09 0.42 0 5.00
176 INT254704 Positive_regulation of Map2k1 Positive_regulation of Phosphorylation of MAPK1 1 0.10 1.43 0 5.00
177 INT215695 Lamtor1 Negative_regulation of Cdkn1c 1 0.02 0 0 5.00
178 INT254702 Map2k1 Positive_regulation of Phosphorylation of MAPK3 1 0.07 0.91 0 5.00
179 INT215782 Lamtor1 Negative_regulation of Binding of Cdkn1b and Cdk6 1 0.01 0 0 5.00
180 INT215688 Cdkn2b Negative_regulation of Kras 1 0.00 0 0 5.00
181 INT215704 Stmn1 Negative_regulation of Cdkn1c 1 0.00 0 0 5.00
182 INT254684 Map2k2 Positive_regulation of Map2k1 1 0.45 0.4 0 5.00
183 INT215692 Stmn1 Negative_regulation of Cdkn1b 1 0.00 0 0 5.00
184 INT215694 Cdkn2b Negative_regulation of Cdkn1b 1 0.01 0 0 5.00
185 INT215781 Cdkn2b Negative_regulation of Binding of Kras and Cdk6 1 0.00 0 0 5.00
186 INT215703 Binding of Kras and Cdk6 1 0.01 0 0 5.00
187 INT254705 Map2k2 Positive_regulation of Phosphorylation of MAPK3 1 0.08 0.86 0 5.00
188 INT254694 Positive_regulation of Map2k2 Regulation of Bcl2 1 0.02 0.89 0 5.00
189 INT215779 Lamtor1 Negative_regulation of Binding of Cdk6 and Lamtor1 1 0.01 0 0 5.00
190 INT274831 Dusp6 Positive_regulation of Tlr4 1 0.00 0 0 5.00
191 INT215775 Lamtor1 Negative_regulation of Binding of Cdk6 and Cdkn1c 1 0.01 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Post Operative Pain. They are ordered first by their pain relevance and then by number of times they were reported in Post Operative Pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 100.00
2 INT22454 Regulation of Crp 213 0.62 160.67 49.24 100.00
3 INT81280 Binding of Atp9a 20 0.47 11.14 3.24 100.00
4 INT155150 Gene_expression of Spic 5 0.26 1.21 0.86 100.00
5 INT158 Localization of Prl 2431 0.81 378.96 952.2 100.00
6 INT161 Regulation of Localization of Prl 615 0.62 65.37 298.66 100.00
7 INT37896 Positive_regulation of Gene_expression of PTGS1 37 0.67 17.28 9.27 100.00
8 INT22785 Negative_regulation of PRNP 12 0.57 5.09 1.57 100.00
9 INT37390 Regulation of Crp 39 0.46 28.74 11.45 99.96
10 INT19511 Localization of Il6 212 0.81 118.17 67.67 99.96
11 INT10166 Localization of Tnf 237 0.81 153.95 88.64 99.96
12 INT10169 Positive_regulation of Localization of Tnf 44 0.70 27.71 16.75 99.96
13 INT68744 Localization of Cxcl1 18 0.80 8.65 8.6 99.96
14 INT278362 Negative_regulation of Hps5 2 0.21 15.71 4.44 99.92
15 INT125411 Negative_regulation of Phosphorylation of Mapk14 31 0.57 18.55 19.98 99.92
16 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5 99.84
17 INT118906 Regulation of Mapk14 21 0.44 17.95 11.63 99.84
18 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 99.84
19 INT128695 Regulation of Gene_expression of Mapk14 14 0.44 11.49 7.14 99.84
20 INT126047 Regulation of Phosphorylation of Mapk14 7 0.60 5.05 5.03 99.84
21 INT7572 Regulation of Crhr1 8 0.45 5.6 8.93 99.84
22 INT58288 Positive_regulation of Gene_expression of Crp 83 0.61 82.23 23.7 99.84
23 INT50671 Regulation of Gene_expression of CPOX 45 0.54 30.99 13.83 99.84
24 INT50491 Regulation of Gene_expression of PTGS1 17 0.47 6 5.4 99.84
25 INT5137 Binding of PCa 45 0.47 16.91 18.47 99.82
26 INT23402 Binding of HLA-DOA 74 0.48 52.01 10.89 99.80
27 INT2640 Gene_expression of Pomc 424 0.78 120.72 155.37 99.80
28 INT462 Regulation of Pomc 157 0.62 41.67 67.27 99.80
29 INT27266 Regulation of Gene_expression of Pomc 41 0.62 6.74 14.59 99.80
30 INT3679 Gene_expression of AVP 171 0.78 72.9 35.23 99.78
31 INT19330 Binding of HLA-A 99 0.48 76.26 22.85 99.76
32 INT97701 Phosphorylation of Mapk14 191 0.82 115.33 100.46 99.74
33 INT11072 Binding of HELT 4 0.31 3.81 0.89 99.72
34 INT1456 Regulation of Oprl1 61 0.62 19.5 52.87 99.72
35 INT2782 Regulation of Gene_expression of Pomc 75 0.62 15.04 38.97 99.68
36 INT119988 Positive_regulation of LASP1 2 0.32 1.06 0.64 99.66
37 INT10706 Regulation of Il6 150 0.62 93.23 62.34 99.64
38 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29 99.64
39 INT10049 Negative_regulation of SERPINA1 56 0.59 44.52 9.93 99.64
40 INT6656 Gene_expression of YY1 135 0.75 24.73 72.16 99.64
41 INT1703 Regulation of PCa 52 0.52 23.65 20.6 99.60
42 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 99.60
43 INT8021 Gene_expression of Enpp1 43 0.78 31.46 10.8 99.60
44 INT103998 Positive_regulation of Phosphorylation of Grin2b 33 0.69 19.08 36.08 99.60
45 INT73351 Negative_regulation of Pnoc 13 0.42 5.71 14.17 99.60
46 INT133508 Positive_regulation of TKTL1 8 0.60 6.37 4.8 99.60
47 INT127353 Regulation of Phosphorylation of Grin2b 5 0.45 1.6 5.29 99.60
48 INT101965 Positive_regulation of Kcnj9 8 0.31 1.64 6.87 99.56
49 INT70625 Gene_expression of epi 3 0.59 1.54 1.12 99.56
50 INT59983 Regulation of BDKRB1 12 0.45 10.69 5.11 99.56
51 INT99070 Gene_expression of Mapk14 147 0.78 103.99 79.59 99.54
52 INT1438 Localization of Pomc 360 0.81 101.26 116.47 99.52
53 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78 99.52
54 INT107272 Binding of GPA33 1 0.24 1.37 0.76 99.52
55 INT68369 Transcription of TNC 13 0.72 8.69 4.42 99.52
56 INT156198 Negative_regulation of Vas1 3 0.30 0.97 1.65 99.50
57 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 99.48
58 INT207851 Regulation of Enpp1 5 0.45 4.42 2.96 99.48
59 INT88081 Negative_regulation of Gene_expression of Oprm1 45 0.59 16.56 37.5 99.44
60 INT162 Regulation of Prl 794 0.62 165.01 322.24 99.44
61 INT78798 Regulation of LUM 2 0.60 2.56 2.87 99.36
62 INT60122 Negative_regulation of MADD 3 0.11 2.23 0.93 99.32
63 INT16236 Negative_regulation of CFH 31 0.57 19.59 3.36 99.32
64 INT78233 Positive_regulation of P2rx3 36 0.56 21.49 17.25 99.30
65 INT49553 Regulation of Gene_expression of Gfap 42 0.62 17.04 23.65 99.28
66 INT35584 Binding of ACLY 22 0.35 31.78 7.17 99.28
67 INT104000 Phosphorylation of Grin2b 73 0.82 48.34 93.48 99.26
68 INT5228 Positive_regulation of Fos 934 0.70 209.8 503.87 99.24
69 INT5587 Regulation of Fos 191 0.62 40.81 99.7 99.24
70 INT695 Binding of POMC 304 0.48 56.66 126.85 99.24
71 INT17592 Positive_regulation of Regulation of Fos 21 0.67 3.54 10.07 99.24
72 INT18513 Binding of GRIN1 32 0.47 9.44 15.08 99.24
73 INT1436 Negative_regulation of Localization of Pomc 41 0.58 10.85 11.26 99.20
74 INT52688 Transcription of Ptgs2 16 0.69 8.31 7.52 99.16
75 INT8413 Gene_expression of Ptgs1 248 0.78 110.17 108.58 99.16
76 INT52692 Gene_expression of Ptgs2 160 0.78 85.06 55.73 99.16
77 INT62500 Transcription of Ptgs1 10 0.56 4.54 4.52 99.16
78 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 99.16
79 INT18621 Binding of ABAT 28 0.36 9.88 18.04 99.12
80 INT6042 Binding of Oprm1 248 0.48 31.77 154.34 99.12
81 INT12161 Positive_regulation of P2rx2 70 0.69 34.22 34.4 99.12
82 INT11624 Gene_expression of OPRM1 445 0.78 72.36 294.36 99.08
83 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 99.08
84 INT26112 Positive_regulation of Hrh2 10 0.69 4.28 5.54 99.08
85 INT314365 Binding of epi 1 0.03 4.91 2.7 99.04
86 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 99.00
87 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 99.00
88 INT133747 Positive_regulation of COX5A 5 0.49 1.9 2.57 99.00
89 INT2651 Positive_regulation of Pomc 403 0.70 95.72 206.24 99.00
90 INT207156 Binding of TKTL1 3 0.22 0.93 0.99 98.92
91 INT11493 Positive_regulation of KLK1 21 0.67 9.22 5 98.88
92 INT87322 Binding of ITGAL 23 0.47 15.73 4.68 98.84
93 INT67713 Gene_expression of St3gal1 2 0.31 1.22 1.7 98.84
94 INT114010 Gene_expression of Itga7 3 0.75 1.69 1.32 98.84
95 INT154126 Regulation of Gene_expression of St3gal1 1 0.19 0.17 0.56 98.84
96 INT154125 Regulation of Gene_expression of Itga7 1 0.44 0.17 0.56 98.84
97 INT86544 Positive_regulation of Camk2a 20 0.47 4.59 11.37 98.82
98 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 98.80
99 INT96116 Transcription of COL1A1 10 0.44 4.57 1.81 98.80
100 INT1975 Regulation of Regulation of Prl 32 0.59 5.78 18.53 98.76
101 INT111369 Transcription of Mt1a 4 0.68 1.01 3.35 98.72
102 INT111368 Transcription of Mt2A 1 0.69 0.94 2.66 98.72
103 INT111367 Regulation of Transcription of Mt2A 1 0.44 0.65 1.5 98.72
104 INT111366 Regulation of Transcription of Mt1a 1 0.43 0.65 1.5 98.72
105 INT49172 Regulation of Nos1 43 0.52 27.53 23.66 98.68
106 INT886 Gene_expression of Pomc 676 0.78 129.87 295.98 98.64
107 INT6214 Negative_regulation of Adarb1 123 0.50 26.39 89.57 98.56
108 INT322474 Regulation of PGAP1 1 0.38 4.82 5.06 98.56
109 INT5680 Gene_expression of Ngf 530 0.78 264.29 310.56 98.56
110 INT11854 Gene_expression of Il1rl1 57 0.77 30.19 38.25 98.56
111 INT9382 Regulation of TRPV1 149 0.62 53.99 77.46 98.44
112 INT9383 Localization of TRPV1 98 0.81 33.23 46.24 98.44
113 INT131454 Binding of Shc4 2 0.31 0.82 0.14 98.44
114 INT154123 Regulation of Itga7 1 0.44 0.17 0.56 98.40
115 INT9377 Positive_regulation of Positive_regulation of TRPV1 43 0.70 15.81 24.47 98.36
116 INT24961 Positive_regulation of Defb22 8 0.03 3.56 6.04 98.32
117 INT1221 Regulation of SGCG 65 0.60 24.21 22.94 98.32
118 INT89854 Regulation of Nos2 49 0.61 42.58 24.1 98.32
119 INT274886 Positive_regulation of Cbr2 1 0.25 10.54 6.65 98.24
120 INT87687 Positive_regulation of Trpv1 409 0.70 210.24 257.59 98.16
121 INT3244 Negative_regulation of eCB 37 0.03 16.69 12.61 98.12
122 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45 98.08
123 INT144 Positive_regulation of H1 10 0.64 2.77 4.13 98.08
124 INT91238 Regulation of Negative_regulation of Oprm1 6 0.45 1.4 7.85 98.04
125 INT443 Localization of POMC 1020 0.81 284.52 443.17 98.00
126 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 98.00
127 INT222660 Phosphorylation of Tyr 2 0.06 5.31 12.33 97.96
128 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05 97.92
129 INT45412 Regulation of St3gal1 2 0.19 0.33 0.65 97.92
130 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6 97.88
131 INT57592 Negative_regulation of TAs 17 0.33 9.49 4.51 97.80
132 INT4369 Gene_expression of Ldha 157 0.76 88.12 22.45 97.80
133 INT12602 Negative_regulation of Oprm1 190 0.59 36.11 177.85 97.76
134 INT56404 Gene_expression of EDA 16 0.75 7.09 4.24 97.76
135 INT198840 Transcription of EDA 1 0.58 0.97 1.26 97.76
136 INT47459 Gene_expression of Rac1 101 0.68 45.27 24.33 97.76
137 INT98062 Regulation of Gene_expression of Rac1 4 0.39 1.41 1.21 97.76
138 INT154115 Positive_regulation of Localization of PENK 5 0.49 3.15 6.93 97.76
139 INT50970 Positive_regulation of Ntrk1 51 0.57 29.38 22.83 97.64
140 INT1169 Negative_regulation of Bche 322 0.59 149.22 61.27 97.60
141 INT3950 Gene_expression of Ptger2 293 0.77 122.28 62.42 97.60
142 INT11894 Negative_regulation of Gene_expression of Ptger2 47 0.55 16.95 11.59 97.60
143 INT4862 Localization of PENK 62 0.81 11.57 40.28 97.58
144 INT78479 Negative_regulation of Localization of PENK 2 0.43 1.9 1.81 97.58
145 INT14501 Gene_expression of CST3 28 0.75 25.77 5.16 97.56
146 INT15613 Negative_regulation of Ptgs2 160 0.59 71.08 65.08 97.48
147 INT222732 Positive_regulation of Negative_regulation of TAS 1 0.36 0.95 0.19 97.48
148 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 97.44
149 INT278318 Gene_expression of Hps5 10 0.37 4.24 1.27 97.44
150 INT17489 Regulation of F13A1 28 0.45 15.79 4.93 97.44
151 INT19689 Regulation of Tes 5 0.24 1.01 2.76 97.36
152 INT48393 Positive_regulation of Localization of CSF2 14 0.60 8.92 6.1 97.36
153 INT61664 Regulation of GRIN1 38 0.60 16.45 25.35 97.36
154 INT322475 Negative_regulation of PGAP1 9 0.36 4.78 4.69 97.16
155 INT45014 Regulation of IL1RL1 12 0.14 1.87 2.67 97.16
156 INT109633 Negative_regulation of TP53INP2 5 0.15 2.29 6.46 97.16
157 INT75938 Regulation of TP53INP2 9 0.09 2.45 7.21 97.16
158 INT6864 Positive_regulation of Gene_expression of Gfap 110 0.70 59.01 47.07 97.10
159 INT97702 Positive_regulation of Phosphorylation of Mapk14 69 0.69 49.21 36.81 97.10
160 INT64201 Negative_regulation of Trpv1 203 0.59 79.18 119.75 97.08
161 INT683 Positive_regulation of AVP 173 0.70 74.55 46.41 97.04
162 INT46159 Positive_regulation of Positive_regulation of AVP 4 0.50 1.24 2.45 97.04
163 INT46160 Regulation of Positive_regulation of AVP 4 0.53 0.99 2.14 97.04
164 INT51921 Gene_expression of Cpox 501 0.73 229.81 157.81 97.04
165 INT22517 Gene_expression of Mop3 5 0.03 0.18 3.43 97.04
166 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 96.92
167 INT57699 Positive_regulation of CD1A 11 0.50 8.49 2.93 96.88
168 INT36443 Regulation of Trf 4 0.61 1.65 1.18 96.80
169 INT109851 Negative_regulation of P2RX3 7 0.57 3.55 3.61 96.80
170 INT5842 Gene_expression of Gfap 372 0.78 153.71 127.71 96.72
171 INT154730 Regulation of Slc6a5 3 0.43 1.91 1.56 96.72
172 INT19396 Regulation of Rac1 66 0.53 37.41 30.01 96.72
173 INT164696 Localization of Depmq1 3 0.01 1.46 3.76 96.72
174 INT121419 Localization of Cnr2 11 0.80 4.98 7.14 96.68
175 INT79955 Localization of Cnr1 26 0.81 8.44 19.06 96.68
176 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 96.52
177 INT55944 Positive_regulation of Cpox 214 0.57 105.14 81.4 96.52
178 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 96.52
179 INT83529 Positive_regulation of Positive_regulation of Cpox 8 0.29 7.22 6.7 96.52
180 INT14690 Localization of CSF2 124 0.80 85.17 27.26 96.36
181 INT10272 Gene_expression of Il1b 194 0.78 121.02 103.03 96.36
182 INT118267 Negative_regulation of ARSD 14 0.36 8.27 1.44 96.36
183 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 96.28
184 INT46722 Regulation of Gene_expression of Csf2 8 0.45 4.84 1.45 96.28
185 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 96.20
186 INT89404 Regulation of Negative_regulation of TNF 30 0.45 24.47 12.71 96.20
187 INT55256 Negative_regulation of Localization of Il6 38 0.58 16.12 13.67 96.16
188 INT6406 Binding of Oprm1 280 0.48 40.54 226.26 96.16
189 INT158059 Negative_regulation of ASD1 2 0.08 1.11 0.4 96.16
190 INT24958 Gene_expression of Nkx1-1 106 0.74 51.29 76.88 96.08
191 INT22516 Gene_expression of H2-M3 17 0.25 2.98 13.59 96.08
192 INT145586 Negative_regulation of Olr886 1 0.09 0.65 0.75 96.04
193 INT50230 Positive_regulation of Localization of IL6 105 0.70 69.21 29.52 96.04
194 INT51054 Negative_regulation of Localization of IL6 45 0.59 24.48 18.97 96.04
195 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 96.04
196 INT85938 Localization of GRIK1 2 0.58 1.19 2.68 96.00
197 INT11378 Negative_regulation of Positive_regulation of IL1B 23 0.59 10.28 7.26 95.98
198 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 95.84
199 INT73010 Gene_expression of Tmem132a 8 0.77 4.38 8.86 95.84
200 INT56651 Binding of HLA-DRB1 58 0.48 52.25 13.68 95.76
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