D:Posterior Leukoencephalopathy Syndrome

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pChart

Disease Term
Synonyms Leukoencephalopathy Syndrome Posterior, Reversible Posterior Leukoencephalopathy Syndrome, SYNDROME POSTERIOR LEUKOENCEPHALOPATHY
Documents 87
Hot Single Events 2
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Posterior Leukoencephalopathy Syndrome. They are ordered first by their relevance to Posterior Leukoencephalopathy Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT306745 Binding of Il12a and IL23A 1 0.10 3.25 1.56 5.00
2 INT255690 Binding of VEGFA and Flt1 8 0.34 3.44 0.61 5.00
3 INT306732 Il17a Positive_regulation of Gene_expression of Il2 1 0.09 1.07 0.46 5.00
4 INT306731 Il22 Positive_regulation of Gene_expression of Il2 1 0.12 1.07 0.46 5.00
5 INT287380 Binding of VEGFA and Kdr 12 0.18 11.97 0.34 5.00
6 INT320794 Binding of VEGFA and Flt4 4 0.08 3.04 0.27 5.00
7 INT306714 IL23A Positive_regulation of TNF 1 0.29 0.5 0.21 5.00
8 INT306746 Il12a Positive_regulation of TNF 1 0.24 0.5 0.21 5.00
9 INT306744 IL23A Positive_regulation of Il12a 1 0.13 0.59 0.2 5.00
10 INT306747 IL23A Positive_regulation of Il17a 1 0.05 0.51 0.16 5.00
11 INT320789 NRP2 Positive_regulation of Binding of Flt1 and Kdr 1 0.00 0.68 0.08 5.00
12 INT320785 Binding of Flt1 and Kdr 1 0.15 0.67 0.08 5.00
13 INT320788 VEGFA Positive_regulation of Binding of Flt1 and Kdr 1 0.15 0.68 0.08 5.00
14 INT320795 Flt1 Negative_regulation of VEGFA 1 0.29 0.29 0.06 5.00
15 INT320786 Binding of Eng and Kdr 1 0.04 1.17 0.04 5.00
16 INT318787 Binding of AKT1 and VEGFA 1 0.37 0.34 0 5.00
17 INT353125 Negative_regulation of Binding of VEGFA and Kdr 1 0.04 5.92 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Posterior Leukoencephalopathy Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Posterior Leukoencephalopathy Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT120562 Negative_regulation of Egfr 108 0.59 79.38 3.11 91.12
2 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 80.56
3 INT254298 Protein_catabolism of AES 6 0.55 9.79 1.43 78.56
4 INT2393 Positive_regulation of Mb 174 0.69 93.59 26.79 75.00
5 INT200855 Positive_regulation of Kdr 14 0.45 11.14 0.77 73.92
6 INT264641 Binding of AES 25 0.42 18.56 6.98 73.12
7 INT201130 Localization of AES 31 0.63 25.45 5.12 72.24
8 INT306740 Localization of IL23A 3 0.58 2.66 0.69 56.64
9 INT87239 Localization of Il12a 51 0.75 31.95 12.05 51.60
10 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 46.80
11 INT24080 Negative_regulation of Mtor 64 0.37 41.56 5.19 41.44
12 INT147583 Gene_expression of AIS 82 0.58 48.7 7.11 40.24
13 INT105210 Positive_regulation of Adrm1 7 0.06 4.09 0.5 24.56
14 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 14.24
15 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 11.52
16 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 11.44
17 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 9.12
18 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 8.56
19 INT126477 Gene_expression of Sdf2l1 43 0.66 22.02 3.97 7.00
20 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.80
21 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.40
22 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
23 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
24 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
25 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
26 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
27 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
28 INT118381 Gene_expression of Il17a 405 0.76 306.97 112.06 5.00
29 INT11807 Gene_expression of Il2 266 0.78 112 64.97 5.00
30 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 5.00
31 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 5.00
32 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 5.00
33 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
34 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 5.00
35 INT16428 Positive_regulation of Gtf3a 135 0.20 106.44 26.67 5.00
36 INT69036 Gene_expression of IL18 99 0.77 77.92 25.95 5.00
37 INT150022 Positive_regulation of Il17a 69 0.64 70.04 21.87 5.00
38 INT11804 Positive_regulation of Gene_expression of Il2 70 0.70 33 21.63 5.00
39 INT112029 Positive_regulation of Pik3r1 90 0.67 38.76 20.95 5.00
40 INT160564 Gene_expression of Il22 64 0.55 59.29 20.9 5.00
41 INT60690 Positive_regulation of Gene_expression of Il12a 69 0.63 41.41 20.85 5.00
42 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14 5.00
43 INT14701 Negative_regulation of IFNA1 118 0.54 84.19 20.08 5.00
44 INT88949 Positive_regulation of Il12a 79 0.60 47.68 19.98 5.00
45 INT27670 Negative_regulation of Ace 122 0.57 79.21 18.08 5.00
46 INT9656 Regulation of Gene_expression of Il6 57 0.62 33.3 17.71 5.00
47 INT168263 Gene_expression of IL23A 57 0.58 47.1 17.67 5.00
48 INT34057 Negative_regulation of Gene_expression of IFNA1 65 0.58 43.46 17.25 5.00
49 INT68681 Transcription of VEGFA 132 0.71 80.47 17.03 5.00
50 INT93948 Negative_regulation of Gene_expression of Il12a 48 0.55 27.77 16.87 5.00
51 INT103757 Negative_regulation of Il12a 37 0.55 21.62 16.38 5.00
52 INT52107 Transcription of IL8 63 0.72 41.66 16.06 5.00
53 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59 5.00
54 INT96775 Gene_expression of Pdgfa 42 0.54 29.78 15.46 5.00
55 INT161515 Positive_regulation of Gene_expression of Il17a 50 0.64 41.52 13.82 5.00
56 INT34904 Negative_regulation of Gtf3a 48 0.15 38.88 13.73 5.00
57 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
58 INT20378 Localization of Hand1 53 0.71 41.96 13.31 5.00
59 INT27268 Localization of Gtf3a 71 0.21 56.93 12.51 5.00
60 INT94464 Negative_regulation of Hand1 44 0.41 31.5 12.39 5.00
61 INT111476 Gene_expression of TP63 88 0.76 61.08 11.64 5.00
62 INT95565 Positive_regulation of IL12A 47 0.56 33.96 10.16 5.00
63 INT134625 Gene_expression of Kdr 116 0.71 53.13 10.09 5.00
64 INT107307 Transcription of IFNA1 30 0.52 18.16 9.61 5.00
65 INT24328 Gene_expression of Egf 97 0.75 59.65 9.42 5.00
66 INT226463 Positive_regulation of IL23A 23 0.45 21.58 9.18 5.00
67 INT113705 Gene_expression of Egfr 228 0.78 149.05 7.59 5.00
68 INT224648 Gene_expression of Il21 15 0.39 18.71 7.47 5.00
69 INT134624 Gene_expression of Flt1 77 0.66 48.86 7.27 5.00
70 INT70814 Negative_regulation of Il2 40 0.56 13.36 7.22 5.00
71 INT30443 Positive_regulation of AIS 30 0.54 22.59 7.2 5.00
72 INT76120 Gene_expression of Ptprc 102 0.59 30.42 7.02 5.00
73 INT228469 Negative_regulation of Il17a 19 0.54 18.76 6.43 5.00
74 INT135170 Positive_regulation of Hif1a 86 0.67 99.4 6.07 5.00
75 INT86111 Positive_regulation of Positive_regulation of VEGFA 38 0.69 33.81 5.78 5.00
76 INT112124 Positive_regulation of Egfr 71 0.70 47.82 5.61 5.00
77 INT106189 Regulation of Il12a 18 0.44 12.4 5.3 5.00
78 INT246031 Gene_expression of IL22 10 0.40 9.48 5.11 5.00
79 INT175312 Positive_regulation of Gene_expression of IL23A 17 0.45 14.8 5.05 5.00
80 INT98251 Binding of IL12A 20 0.37 16.03 4.51 5.00
81 INT26404 Positive_regulation of ATM 15 0.49 10.94 4.39 5.00
82 INT103153 Positive_regulation of Transcription of VEGFA 34 0.69 22.16 4.22 5.00
83 INT296054 Positive_regulation of Il22 13 0.33 17.97 4.06 5.00
84 INT235510 Binding of Il17a 14 0.34 10.67 3.99 5.00
85 INT285489 Positive_regulation of Gene_expression of Il22 9 0.32 10.97 3.63 5.00
86 INT174160 Binding of Il12a 19 0.24 12.61 3.4 5.00
87 INT12844 Binding of TP63 15 0.47 10.57 3.38 5.00
88 INT250884 Binding of IL23A 5 0.19 7.17 3.17 5.00
89 INT114181 Negative_regulation of Positive_regulation of Il12a 7 0.34 3.65 2.82 5.00
90 INT139562 Transcription of IL18 10 0.68 6.14 2.73 5.00
91 INT14447 Localization of F2 20 0.79 12.77 2.67 5.00
92 INT306726 Localization of Il22 4 0.57 5.52 2.57 5.00
93 INT15540 Positive_regulation of PDGFA 24 0.47 19.01 2.5 5.00
94 INT36338 Gene_expression of NRP2 29 0.67 6.47 2.4 5.00
95 INT176088 Gene_expression of Tek 39 0.65 14.25 2.19 5.00
96 INT250888 Negative_regulation of IL23A 4 0.30 6.13 2.15 5.00
97 INT140175 Regulation of Kit 23 0.62 8.59 1.79 5.00
98 INT196158 Binding of NRP2 16 0.06 7.03 1.73 5.00
99 INT255663 Binding of Flt1 11 0.32 6.92 1.64 5.00
100 INT113985 Positive_regulation of TP63 9 0.50 8.79 1.62 5.00
101 INT206471 Positive_regulation of Ptk2 34 0.51 25.75 1.61 5.00
102 INT193823 Positive_regulation of Gene_expression of TP63 7 0.18 7.74 1.57 5.00
103 INT110028 Transcription of Il12a 6 0.49 1.48 1.51 5.00
104 INT2824 Positive_regulation of HTN1 10 0.40 10.41 1.4 5.00
105 INT109536 Negative_regulation of Vegfa 15 0.46 10.35 1.39 5.00
106 INT199550 Negative_regulation of Flt1 18 0.37 12.57 1.37 5.00
107 INT285482 Negative_regulation of Il22 3 0.30 3.02 1.37 5.00
108 INT306739 Positive_regulation of Gene_expression of IL22 2 0.28 2.2 1.36 5.00
109 INT199567 Binding of Kdr 18 0.47 13.81 1.34 5.00
110 INT152255 Gene_expression of ATM 14 0.71 12.53 1.26 5.00
111 INT182474 Gene_expression of Cdh5 17 0.57 14.58 1.23 5.00
112 INT285470 Regulation of Il22 4 0.11 4.18 1.21 5.00
113 INT278117 Negative_regulation of TP63 5 0.32 3.38 1.13 5.00
114 INT237904 Negative_regulation of Localization of Hand1 5 0.24 3.52 1.09 5.00
115 INT158542 Gene_expression of HTN1 10 0.75 10.69 1.07 5.00
116 INT306735 Positive_regulation of Positive_regulation of IL23A 4 0.26 3.25 1.04 5.00
117 INT112717 Negative_regulation of Binding of VEGFA 21 0.56 11.07 0.99 5.00
118 INT158541 Positive_regulation of Gene_expression of HTN1 3 0.40 5.88 0.97 5.00
119 INT306723 Binding of Il22 3 0.11 2.44 0.97 5.00
120 INT156351 Positive_regulation of Flt1 22 0.51 20.05 0.91 5.00
121 INT171361 Regulation of Egfr 16 0.62 8.36 0.81 5.00
122 INT173100 Binding of KDR 39 0.39 22.48 0.81 5.00
123 INT181129 Positive_regulation of Araf 8 0.21 4.3 0.79 5.00
124 INT131286 Binding of Egfr 26 0.44 13.58 0.78 5.00
125 INT44293 Regulation of TP63 6 0.24 2.88 0.76 5.00
126 INT158303 Transcription of IL23A 2 0.52 0.81 0.72 5.00
127 INT178489 Negative_regulation of Kdr 31 0.42 25.65 0.66 5.00
128 INT233837 Negative_regulation of Hif1a 9 0.26 12.72 0.65 5.00
129 INT306730 Regulation of Gene_expression of Il22 1 0.06 1.04 0.62 5.00
130 INT48212 Binding of ATM 5 0.47 3.89 0.57 5.00
131 INT306729 Negative_regulation of Ccl20 1 0.05 1.01 0.57 5.00
132 INT306725 Negative_regulation of Defb4 1 0.01 1.02 0.57 5.00
133 INT174873 Regulation of Transcription of VEGFA 8 0.43 3.71 0.55 5.00
134 INT255313 Positive_regulation of Positive_regulation of AIS 2 0.04 3.83 0.55 5.00
135 INT143125 Binding of FLT1 48 0.40 13.6 0.51 5.00
136 INT306741 Positive_regulation of Positive_regulation of TP63 2 0.05 1.16 0.49 5.00
137 INT47030 Negative_regulation of ARMC9 22 0.38 13.08 0.47 5.00
138 INT299802 Negative_regulation of Transcription of IFNA1 2 0.09 0.54 0.41 5.00
139 INT315892 Negative_regulation of Binding of ATM 1 0.07 1.41 0.4 5.00
140 INT196002 Positive_regulation of Flt4 4 0.22 3.51 0.37 5.00
141 INT186272 Positive_regulation of Positive_regulation of Il12a 7 0.26 4.45 0.36 5.00
142 INT320784 Protein_catabolism of Hif1a 3 0.61 2.41 0.34 5.00
143 INT306727 Positive_regulation of Positive_regulation of Il22 1 0.12 1.26 0.3 5.00
144 INT200550 Regulation of Flt1 7 0.45 5.22 0.27 5.00
145 INT306742 Negative_regulation of Positive_regulation of IL23A 1 0.22 0.52 0.24 5.00
146 INT339443 Negative_regulation of Nphs1 1 0.16 1.24 0.23 5.00
147 INT205603 Regulation of Pdgfa 5 0.16 4.84 0.15 5.00
148 INT175416 Regulation of Negative_regulation of EGFR 4 0.60 3.94 0.14 5.00
149 INT90940 Binding of Eng 5 0.35 1.92 0.13 5.00
150 INT306736 Negative_regulation of Transcription of IL18 2 0.38 0.31 0.11 5.00
151 INT306724 Negative_regulation of Transcription of Il12a 1 0.18 0.3 0.1 5.00
152 INT306733 Negative_regulation of Transcription of IL23A 1 0.22 0.31 0.1 5.00
153 INT163458 Negative_regulation of Regulation of Kit 2 0.12 1.61 0.06 5.00
154 INT279191 Regulation of Negative_regulation of Egfr 2 0.45 1.44 0.05 5.00
155 INT199551 Regulation of Rcc1 2 0.01 2.63 0.05 5.00
156 INT320783 Binding of Flt4 2 0.26 0.98 0.05 5.00
157 INT339444 Protein_catabolism of Vhl 1 0.60 1.06 0.04 5.00
158 INT339447 Regulation of Vhl 1 0.18 1.07 0.04 5.00
159 INT278062 Negative_regulation of Vhl 2 0.33 2.72 0.04 5.00
160 INT353123 Negative_regulation of Negative_regulation of Kdr 1 0.05 0.78 0 5.00
161 INT318795 Positive_regulation of ISPD 1 0.01 0.44 0 5.00
162 INT339446 Negative_regulation of Positive_regulation of Flt1 1 0.15 0.6 0 5.00
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