D:Pouchitis

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pChart

Disease Term
Synonyms Ileitis Pouch, Pouch Ileitis
Documents 64
Hot Single Events 2
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Pouchitis. They are ordered first by their relevance to Pouchitis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT277995 TNF Positive_regulation of Gene_expression of Tnfrsf1a 1 0.03 1.48 0.22 5.00
2 INT277996 TNF Positive_regulation of Tnfrsf1a 1 0.03 1.48 0.22 5.00
3 INT288006 Binding of CD28 and LRRC23 1 0.02 0.54 0.19 5.00
4 INT211921 Gene_expression of Nek1 Positive_regulation of Cat 1 0.01 0.26 0.1 5.00
5 INT353070 ADAM17 Positive_regulation of TNF 1 0.19 1.66 0.08 5.00
6 INT280569 Binding of GEM and HIVEP1 1 0.00 1.59 0.03 5.00
7 INT288007 Binding of CD28 and CD40 1 0.05 0.51 0.03 5.00
8 INT280601 Binding of HIVEP1 and Dbi 1 0.00 1.57 0.03 5.00
9 INT261035 Hspg2 Positive_regulation of Gmcl1 1 0.01 0.4 0 5.00
10 INT286113 Binding of Fap and Rpe65 1 0.04 1.97 0 5.00
11 INT280568 MRAS Positive_regulation of RAF1 1 0.01 0.7 0 5.00
12 INT261036 Adm Regulation of Gmcl1 1 0.04 0.4 0 5.00
13 INT286114 Binding of MSH6 and Mutyh 1 0.17 0 0 5.00
14 INT280566 Binding of ARAF and BCL2 1 0.02 0.69 0 5.00
15 INT286111 Binding of Rpa3 and Mutyh 1 0.30 0 0 5.00
16 INT286112 Binding of Apc and Afap1 1 0.05 0.71 0 5.00
17 INT286110 Binding of Rpe65 and Gopc 1 0.01 1.97 0 5.00
18 INT286115 Binding of APEX1 and Mutyh 1 0.10 0 0 5.00
19 INT288008 Binding of CD40 and LRRC23 1 0.02 0.45 0 5.00
20 INT261034 Adm Positive_regulation of Gmcl1 1 0.03 0.4 0 5.00
21 INT286109 Binding of Pcna and Mutyh 1 0.30 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Pouchitis. They are ordered first by their pain relevance and then by number of times they were reported in Pouchitis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT263019 Gene_expression of DEFA6 4 0.25 4.14 1.17 89.80
2 INT263025 Positive_regulation of Gene_expression of DEFA6 2 0.16 1 0.28 85.60
3 INT204766 Gene_expression of Nod2 4 0.75 4.14 1.3 79.92
4 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 68.40
5 INT261008 Regulation of Gmcl1 1 0.29 1.64 0 67.92
6 INT120509 Gene_expression of Cat 65 0.77 50.9 9.75 63.80
7 INT117336 Gene_expression of Nek1 2 0.02 8.56 2.31 62.36
8 INT346908 Negative_regulation of DEFA5 1 0.03 0.41 0.11 62.16
9 INT125006 Gene_expression of DEFA5 2 0.05 3.38 0.38 61.00
10 INT346896 Binding of Nod2 1 0.21 0.72 0.26 53.92
11 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 48.72
12 INT65187 Positive_regulation of PNN 2 0.02 1.12 0.77 48.16
13 INT136271 Gene_expression of PNN 9 0.63 5.44 1 44.08
14 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 42.96
15 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 42.44
16 INT3926 Regulation of Bdkrb1 22 0.61 16.72 16.1 41.44
17 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 40.64
18 INT62826 Negative_regulation of Gene_expression of ICAM1 75 0.58 46.39 17.72 40.64
19 INT27466 Negative_regulation of Kng1 7 0.10 7.79 3.56 37.40
20 INT184185 Transcription of Kng1 1 0.05 1.66 0.62 37.40
21 INT19779 Binding of Dbi 41 0.36 8.8 5.87 31.04
22 INT48037 Regulation of Adm 8 0.44 3.96 1.24 17.84
23 INT346897 Positive_regulation of Atg16l1 1 0.16 0.57 0.19 16.64
24 INT102228 Localization of Adm 9 0.69 1.58 1.34 14.96
25 INT145520 Positive_regulation of Dss1 16 0.39 14.04 3.38 13.52
26 INT55344 Gene_expression of Ros1 396 0.54 217.64 59.98 12.96
27 INT55343 Localization of Ros1 39 0.60 34.51 12.5 12.96
28 INT20345 Gene_expression of Dbi 136 0.78 56.41 46.2 6.80
29 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
30 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
31 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
32 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
33 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
34 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
35 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
36 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
37 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
38 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
39 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
40 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 5.00
41 INT118381 Gene_expression of Il17a 405 0.76 306.97 112.06 5.00
42 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
43 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
44 INT940 Negative_regulation of Ptgs1 219 0.59 104.34 95.97 5.00
45 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 5.00
46 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
47 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
48 INT6849 Localization of IL1B 229 0.81 112.56 69.63 5.00
49 INT11937 Localization of Il6 228 0.81 139.83 64.39 5.00
50 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
51 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 5.00
52 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
53 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05 5.00
54 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01 5.00
55 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
56 INT72651 Gene_expression of TH1L 114 0.75 80.15 35.15 5.00
57 INT20380 Gene_expression of Il5 172 0.78 104.75 34.78 5.00
58 INT10763 Localization of IL2 157 0.80 81.11 33.21 5.00
59 INT5989 Positive_regulation of Dbi 79 0.49 24.38 32.56 5.00
60 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 5.00
61 INT90792 Localization of Il10 144 0.80 87.88 30.03 5.00
62 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27 5.00
63 INT133876 Positive_regulation of Gene_expression of Ros1 141 0.32 75.55 27.45 5.00
64 INT145426 Positive_regulation of Ros1 185 0.56 106.76 27.21 5.00
65 INT2609 Localization of ELANE 111 0.81 50.22 26.63 5.00
66 INT70048 Positive_regulation of Gene_expression of IL10 90 0.55 71.34 25.66 5.00
67 INT68758 Positive_regulation of Ros1 125 0.46 82.72 25.27 5.00
68 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19 5.00
69 INT93738 Gene_expression of Tnfrsf1a 63 0.74 57.66 23.09 5.00
70 INT16721 Negative_regulation of Cat 56 0.59 44.44 22.84 5.00
71 INT69322 Negative_regulation of MAPK14 70 0.54 42.92 22.71 5.00
72 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03 5.00
73 INT11157 Binding of EGF 88 0.48 53.73 21.25 5.00
74 INT28216 Gene_expression of HRAS 173 0.75 93.97 20.78 5.00
75 INT63340 Positive_regulation of Gene_expression of ICAM1 109 0.70 90.82 20.61 5.00
76 INT20379 Localization of Il4 85 0.73 51.22 20.55 5.00
77 INT86751 Negative_regulation of Il10 62 0.59 40.1 20.51 5.00
78 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 5.00
79 INT112017 Regulation of Hand2 77 0.36 62.23 18.04 5.00
80 INT116978 Gene_expression of CCR6 53 0.78 56 17.73 5.00
81 INT104045 Regulation of Hand1 65 0.35 51.32 16.26 5.00
82 INT10000 Regulation of Gene_expression of IL2 56 0.45 15.33 16.2 5.00
83 INT152730 Positive_regulation of S100a8 48 0.68 47.67 15.4 5.00
84 INT11762 Regulation of Dbi 40 0.62 7.83 14.48 5.00
85 INT4931 Localization of IFNG 53 0.78 33.25 13.65 5.00
86 INT11699 Binding of HLA-E 85 0.47 52.51 13.41 5.00
87 INT20378 Localization of Hand1 53 0.71 41.96 13.31 5.00
88 INT87235 Negative_regulation of Il4 54 0.48 31.51 13.15 5.00
89 INT36287 Binding of CD4 96 0.47 58.93 11.88 5.00
90 INT72221 Localization of PRKCA 17 0.81 1.23 11.47 5.00
91 INT204112 Gene_expression of GEM 43 0.75 38.74 11.23 5.00
92 INT23177 Negative_regulation of Gene_expression of HLA-DRA 50 0.44 16.99 10.55 5.00
93 INT16404 Regulation of CD4 54 0.61 33.05 10.29 5.00
94 INT95565 Positive_regulation of IL12A 47 0.56 33.96 10.16 5.00
95 INT79720 Positive_regulation of Cat 57 0.70 31.81 10.11 5.00
96 INT132586 Negative_regulation of Hand2 40 0.30 26.58 9.28 5.00
97 INT87193 Gene_expression of Tnfrsf1b 30 0.58 29.4 9.22 5.00
98 INT5512 Negative_regulation of Dbi 32 0.36 7.33 9.1 5.00
99 INT111133 Negative_regulation of Mapk3 31 0.57 10.89 8.9 5.00
100 INT49802 Localization of MUC1 75 0.81 44.74 8.87 5.00
101 INT91337 Gene_expression of CCL4 29 0.75 16.23 8.64 5.00
102 INT65959 Positive_regulation of Gene_expression of BCL2 75 0.70 77.3 8.27 5.00
103 INT61628 Negative_regulation of Gene_expression of IL4 31 0.55 20.96 8.18 5.00
104 INT32454 Gene_expression of Ptafr 3 0.65 15.19 7.87 5.00
105 INT103909 Gene_expression of NOD2 37 0.77 21.9 7.36 5.00
106 INT96994 Phosphorylation of EGFR 99 0.82 52.75 7.33 5.00
107 INT181525 Localization of Il13 24 0.66 21.51 6.55 5.00
108 INT69985 Positive_regulation of Negative_regulation of TNF 21 0.50 13.26 6.31 5.00
109 INT11154 Binding of EGFR 149 0.48 96.23 6.29 5.00
110 INT55034 Positive_regulation of Adm 27 0.61 14.1 6.13 5.00
111 INT39416 Gene_expression of Cd79a 81 0.64 45.17 6.08 5.00
112 INT14849 Binding of IgG-2a 12 0.39 5.96 6.06 5.00
113 INT3819 Positive_regulation of Apc 36 0.69 27.03 6.02 5.00
114 INT4697 Positive_regulation of Gene_expression of HLA-B 32 0.61 17.32 5.97 5.00
115 INT91159 Negative_regulation of Ros1 35 0.44 26.12 5.97 5.00
116 INT124605 Gene_expression of Ifih1 16 0.57 7.36 5.33 5.00
117 INT102547 Gene_expression of Cd68 25 0.75 14.47 5.22 5.00
118 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22 5.00
119 INT105284 Gene_expression of Ocln 39 0.78 14.98 5.08 5.00
120 INT73262 Negative_regulation of BCL2 67 0.57 61.01 5.07 5.00
121 INT24889 Negative_regulation of CABIN1 36 0.48 16.76 4.73 5.00
122 INT98251 Binding of IL12A 20 0.37 16.03 4.51 5.00
123 INT125005 Negative_regulation of SLPI 9 0.42 5.79 4.43 5.00
124 INT187836 Binding of Tnfrsf1a 19 0.46 18.08 4.33 5.00
125 INT20372 Localization of Il5 26 0.41 18.33 4.27 5.00
126 INT70756 Gene_expression of Adm 28 0.77 13.33 4.22 5.00
127 INT3817 Negative_regulation of Apc 29 0.58 22.12 3.91 5.00
128 INT99509 Gene_expression of CFLAR 25 0.75 22.59 3.78 5.00
129 INT124655 Negative_regulation of PECAM1 13 0.23 10.32 3.78 5.00
130 INT93468 Gene_expression of Cldn1 15 0.27 10.12 3.51 5.00
131 INT32453 Positive_regulation of Gene_expression of Ptafr 2 0.58 7.01 3.47 5.00
132 INT148288 Gene_expression of CCL15 9 0.25 6.53 3.41 5.00
133 INT16234 Positive_regulation of CFH 25 0.50 26.05 3.33 5.00
134 INT36286 Binding of Cd3e 33 0.36 10.11 3.21 5.00
135 INT23577 Localization of IgG-2a 8 0.73 5.32 3.1 5.00
136 INT93913 Positive_regulation of CD40 21 0.58 23.47 3.1 5.00
137 INT9884 Localization of CD79A 41 0.78 21.75 3.06 5.00
138 INT103910 Binding of NOD2 19 0.47 12.24 2.93 5.00
139 INT134795 Positive_regulation of Scrib 30 0.22 36.91 2.81 5.00
140 INT145328 Negative_regulation of Scrib 25 0.16 26.79 2.66 5.00
141 INT134375 Gene_expression of Cflar 14 0.58 8.4 2.66 5.00
142 INT191017 Localization of Cd79a 28 0.56 13.94 2.55 5.00
143 INT4419 Gene_expression of GOT1 20 0.65 22.53 2.53 5.00
144 INT6117 Gene_expression of Gmcl1 4 0.49 2.39 2.33 5.00
145 INT205683 Localization of Ptafr 4 0.12 4.63 2.31 5.00
146 INT172078 Localization of Cd3e 22 0.37 9.88 2.27 5.00
147 INT14384 Gene_expression of Prf1 9 0.60 3.03 2.22 5.00
148 INT134374 Positive_regulation of Gene_expression of Cflar 4 0.14 2.12 2.18 5.00
149 INT250888 Negative_regulation of IL23A 4 0.30 6.13 2.15 5.00
150 INT21611 Negative_regulation of RASGRP1 20 0.35 11.76 2.15 5.00
151 INT228061 Positive_regulation of Localization of Hand1 8 0.26 6.39 2.06 5.00
152 INT112368 Positive_regulation of Cacna1c 8 0.46 2.94 1.97 5.00
153 INT106636 Binding of PRKCA 7 0.28 3.06 1.93 5.00
154 INT117346 Positive_regulation of ADAM17 5 0.50 6.69 1.86 5.00
155 INT123873 Positive_regulation of Negative_regulation of Cat 7 0.50 2.86 1.86 5.00
156 INT23932 Negative_regulation of ST8SIA2 4 0.22 1.26 1.73 5.00
157 INT3818 Regulation of Apc 13 0.39 12.52 1.68 5.00
158 INT46162 Regulation of C6orf25 12 0.39 5.42 1.61 5.00
159 INT190367 Gene_expression of Defa1 10 0.75 8.92 1.5 5.00
160 INT256598 Gene_expression of DEFB103A 8 0.65 5.06 1.49 5.00
161 INT18156 Gene_expression of Fap 18 0.73 27.02 1.46 5.00
162 INT155845 Transcription of SOAT1 6 0.67 2.89 1.4 5.00
163 INT262876 Localization of ST8SIA2 2 0.16 1.41 1.39 5.00
164 INT46736 Negative_regulation of Odc1 10 0.51 7.6 1.39 5.00
165 INT108325 Gene_expression of Scrib 26 0.39 48.33 1.39 5.00
166 INT96993 Positive_regulation of Phosphorylation of EGFR 15 0.59 5.44 1.37 5.00
167 INT220177 Binding of Apc 21 0.37 15.34 1.37 5.00
168 INT172452 Gene_expression of Myc 121 0.78 69.56 1.36 5.00
169 INT211919 Regulation of Dss1 4 0.32 1.74 1.34 5.00
170 INT110434 Positive_regulation of Gene_expression of Apc 20 0.50 11.37 1.3 5.00
171 INT153706 Gene_expression of CLDN7 5 0.49 3.02 1.26 5.00
172 INT244123 Localization of Defa1 5 0.78 3.42 1.23 5.00
173 INT100621 Localization of HLA-DRA 7 0.40 2.86 1.2 5.00
174 INT68565 Gene_expression of Fap 14 0.57 24.39 1.14 5.00
175 INT166171 Negative_regulation of Gene_expression of HRAS 5 0.07 3.98 1.11 5.00
176 INT71031 Gene_expression of ADRB1 5 0.55 2.96 1.01 5.00
177 INT262878 Gene_expression of ST8SIA2 7 0.39 4.7 1.01 5.00
178 INT107400 Localization of Das 4 0.28 2.95 1 5.00
179 INT107107 Gene_expression of DEFA1 4 0.01 3.37 1 5.00
180 INT277920 Binding of MADCAM1 4 0.14 3.11 0.96 5.00
181 INT23660 Negative_regulation of Fap 5 0.35 8.93 0.95 5.00
182 INT213501 Negative_regulation of Gene_expression of Defa1 4 0.42 4.74 0.93 5.00
183 INT263027 Positive_regulation of DEFB103A 5 0.45 2.89 0.92 5.00
184 INT116197 Positive_regulation of Gene_expression of CFLAR 6 0.67 7.11 0.9 5.00
185 INT262858 Positive_regulation of Defa1 2 0.67 1.54 0.89 5.00
186 INT31775 Positive_regulation of Gclc 3 0.38 0.52 0.84 5.00
187 INT131384 Binding of Mutyh 5 0.26 2.41 0.78 5.00
188 INT87734 Regulation of ARAF 4 0.23 2.44 0.76 5.00
189 INT50501 Negative_regulation of TBXAS1 3 0.30 1.26 0.74 5.00
190 INT261004 Negative_regulation of Cldn1 3 0.19 3.27 0.71 5.00
191 INT70652 Negative_regulation of Binding of EGF 7 0.43 4.23 0.7 5.00
192 INT205206 Gene_expression of Cldn2 17 0.27 3.4 0.66 5.00
193 INT210390 Binding of PDGFA 12 0.36 6.78 0.63 5.00
194 INT191533 Gene_expression of TRAF3IP2 2 0.36 1.83 0.62 5.00
195 INT160941 Negative_regulation of LASP1 2 0.29 1.57 0.59 5.00
196 INT282380 Binding of Atg16l1 4 0.38 2.06 0.58 5.00
197 INT60570 Regulation of Gclm 2 0.26 1.3 0.54 5.00
198 INT74101 Negative_regulation of Adm 3 0.06 1.2 0.53 5.00
199 INT277994 Binding of Trap1 7 0.26 6.21 0.53 5.00
200 INT16671 Gene_expression of MBTPS1 7 0.30 4.8 0.52 5.00
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