D:Precancerous Conditions

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Disease Term
Synonyms CONDITION PRECANCEROUS, CONDITION PRENEOPLASTIC, CONDITIONS PRECANCEROUS, CONDITIONS PRENEOPLASTIC, PRECANCEROUS CONDITION, Preneoplastic Condition, Preneoplastic Conditions
Documents 28
Hot Single Events 6
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Precancerous Conditions. They are ordered first by their relevance to Precancerous Conditions and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT257745 SAGE1 Positive_regulation of AXL 1 0.07 1.96 0.69 5.00
2 INT144035 IL6 Positive_regulation of STAT3 4 0.31 2.58 0.56 5.00
3 INT257738 PIK3CA Regulation of Localization of ACTN4 1 0.16 1.03 0.39 5.00
4 INT257741 HRAS Negative_regulation of PTEN 1 0.15 1.06 0.35 5.00
5 INT257737 Positive_regulation of HRAS Negative_regulation of PTEN 1 0.17 1.07 0.35 5.00
6 INT257746 SHC1 Positive_regulation of Positive_regulation of PIK3CA 1 0.26 1.04 0.34 5.00
7 INT257743 Binding of PIK3CA and SHC1 1 0.21 1.03 0.31 5.00
8 INT257735 GAS6 Positive_regulation of Gene_expression of SAGE1 1 0.04 0.98 0.31 5.00
9 INT257739 SAGE1 Positive_regulation of DDR1 1 0.00 0.91 0.31 5.00
10 INT257744 Binding of PIK3R2 and SHC1 1 0.08 0.96 0.28 5.00
11 INT257740 SAGE1 Positive_regulation of Gene_expression of AXL 1 0.07 0.72 0.27 5.00
12 INT252357 Binding of THBS1 and Cd36 2 0.01 2.4 0.21 5.00
13 INT353808 HLA-DMA Regulation of HLA-B 1 0.00 1.72 0.19 5.00
14 INT173430 Binding of FLT4 and VEGFA 10 0.25 9.38 0.19 5.00
15 INT298641 PPARA Regulation of STAT3 1 0.23 0.98 0.16 5.00
16 INT298639 GDE1 Negative_regulation of AKT1 1 0.00 1.14 0.14 5.00
17 INT298634 Binding of IL6 and STAT3 1 0.04 1.41 0.08 5.00
18 INT291837 Binding of Pecam1 and Vegfa 1 0.09 1.1 0.07 5.00
19 INT298638 IL6 Positive_regulation of IL6R 1 0.00 0.9 0.05 5.00
20 INT298635 PPARA Negative_regulation of Localization of ZDHHC2 1 0.01 0.21 0.05 5.00
21 INT298683 ecs Positive_regulation of Gene_expression of VEGFA 1 0.02 1.41 0.04 5.00
22 INT298637 ZDHHC2 Negative_regulation of Gene_expression of VEGFA 1 0.01 0.27 0.04 5.00
23 INT298633 STAT3 Regulation of MCL1 1 0.04 0.85 0.03 5.00
24 INT298640 IL6R Positive_regulation of STAT3 1 0.01 0.73 0.03 5.00
25 INT298684 ecs Positive_regulation of Gene_expression of KDR 1 0.01 1.2 0 5.00
26 INT144032 STAT3 Regulation of BCL2 2 0.07 0.86 0 5.00
27 INT298632 STAT3 Positive_regulation of MIR21 1 0.03 0.84 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Precancerous Conditions. They are ordered first by their pain relevance and then by number of times they were reported in Precancerous Conditions. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT103350 Gene_expression of DNMT1 15 0.67 9.77 3.83 92.56
2 INT201859 Positive_regulation of Gene_expression of DNMT1 4 0.60 6.43 0.75 92.56
3 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 85.68
4 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42 85.12
5 INT86369 Positive_regulation of Gene_expression of PCNA 40 0.67 26.66 3.57 85.12
6 INT86370 Regulation of CDH1 10 0.54 13.89 0.7 81.60
7 INT86368 Gene_expression of TEP1 31 0.50 16.36 1.63 79.24
8 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 67.60
9 INT91371 Negative_regulation of STAT3 34 0.59 25 4.08 66.32
10 INT28118 Binding of Atm 13 0.38 12.24 0.68 64.56
11 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 59.12
12 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 59.12
13 INT64844 Protein_catabolism of PMEL 1 0.75 0.22 0.05 50.44
14 INT173159 Localization of PPARA 96 0.74 64.55 10.26 39.96
15 INT65659 Positive_regulation of STAT3 132 0.70 69.56 15.95 27.68
16 INT48232 Gene_expression of MMP1 245 0.78 96.31 57.72 23.28
17 INT92823 Positive_regulation of Gene_expression of MMP1 65 0.68 25.69 14.31 23.28
18 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66 20.40
19 INT93684 Gene_expression of STAT3 66 0.78 34.42 5.94 20.40
20 INT119048 Negative_regulation of Gene_expression of HIF1A 10 0.57 9.23 1.5 20.40
21 INT158508 Negative_regulation of Gene_expression of STAT3 2 0.43 1.74 0.15 20.40
22 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 19.52
23 INT112364 Negative_regulation of HIF1A 22 0.57 16.95 2.13 18.80
24 INT144039 Negative_regulation of Negative_regulation of STAT3 2 0.55 0.85 0.07 18.32
25 INT91372 Negative_regulation of Positive_regulation of STAT3 8 0.40 2 0.5 17.76
26 INT244405 Gene_expression of HPV6AI1 3 0.03 6.1 0.03 17.12
27 INT93663 Positive_regulation of MMP1 72 0.67 33.38 19.86 14.44
28 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
29 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
30 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
31 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
32 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
33 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
34 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
35 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
36 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 5.00
37 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
38 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
39 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 5.00
40 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
41 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 5.00
42 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 5.00
43 INT4241 Regulation of CALCA 87 0.62 28.19 55.29 5.00
44 INT78899 Gene_expression of CCL5 155 0.77 84.02 55.09 5.00
45 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15 5.00
46 INT52611 Negative_regulation of Ptgs2 142 0.59 66.31 52.71 5.00
47 INT26500 Gene_expression of MMP2 201 0.78 110.57 46.9 5.00
48 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
49 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
50 INT114751 Gene_expression of Mapk1 137 0.76 60.14 39.98 5.00
51 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
52 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
53 INT103094 Binding of PPARA 308 0.47 177.26 34.75 5.00
54 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 5.00
55 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81 5.00
56 INT50230 Positive_regulation of Localization of IL6 105 0.70 69.21 29.52 5.00
57 INT86437 Binding of IL6 154 0.48 121.22 29.3 5.00
58 INT11361 Gene_expression of SERPINE1 183 0.78 136.45 27.97 5.00
59 INT101517 Negative_regulation of PPARA 168 0.57 112.24 21.41 5.00
60 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 5.00
61 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61 5.00
62 INT14737 Gene_expression of FN1 117 0.78 78.74 18.99 5.00
63 INT51054 Negative_regulation of Localization of IL6 45 0.59 24.48 18.97 5.00
64 INT61519 Gene_expression of Mpo 112 0.78 89.29 18.22 5.00
65 INT61626 Transcription of IL6 73 0.72 42.04 17.86 5.00
66 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 5.00
67 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 5.00
68 INT1888 Protein_catabolism of F13A1 97 0.99 63.48 14.82 5.00
69 INT11636 Positive_regulation of SERPINE1 85 0.69 68.73 14.8 5.00
70 INT103096 Regulation of PPARA 113 0.60 62.47 14.57 5.00
71 INT100139 Positive_regulation of Gene_expression of PPARA 160 0.63 97.78 14.53 5.00
72 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 5.00
73 INT109034 Gene_expression of Eif2ak3 37 0.77 17.11 14.19 5.00
74 INT72127 Protein_catabolism of MMRN1 68 0.52 56 14.13 5.00
75 INT12156 Positive_regulation of MET 43 0.67 17.75 12.64 5.00
76 INT13499 Gene_expression of Agtr2 68 0.76 35.64 10.59 5.00
77 INT100379 Positive_regulation of HIF1A 69 0.69 57.31 10.4 5.00
78 INT78895 Regulation of CCL5 30 0.46 20.45 10.18 5.00
79 INT61171 Gene_expression of S100A8 92 0.76 57.74 9.98 5.00
80 INT126031 Negative_regulation of Gene_expression of MMP9 40 0.57 22.71 9.79 5.00
81 INT122584 Negative_regulation of Gene_expression of PPARA 56 0.58 37.61 9.76 5.00
82 INT35164 Negative_regulation of IGHE 96 0.58 76.3 9.74 5.00
83 INT70134 Negative_regulation of TXK 124 0.23 81.96 9.59 5.00
84 INT11047 Positive_regulation of Positive_regulation of IL6 45 0.66 28.7 9.37 5.00
85 INT27551 Gene_expression of SERPINH1 45 0.62 42.87 9.04 5.00
86 INT70017 Positive_regulation of BCL2 87 0.67 66.62 8.68 5.00
87 INT144430 Gene_expression of Erbb2 137 0.77 103.87 8.66 5.00
88 INT91370 Phosphorylation of STAT3 123 0.82 49.25 8.42 5.00
89 INT1150 Gene_expression of ecs 42 0.59 29.38 7.73 5.00
90 INT8669 Positive_regulation of Afp 66 0.70 58.21 7.67 5.00
91 INT103154 Gene_expression of FLT1 138 0.76 58.5 7.41 5.00
92 INT6596 Positive_regulation of HLA-DRB1 33 0.61 27.01 7.26 5.00
93 INT58365 Gene_expression of LTF 51 0.78 44.14 7.25 5.00
94 INT67822 Binding of SERPINH1 17 0.36 19.05 7.24 5.00
95 INT69439 Regulation of ROS1 46 0.45 31.22 6.94 5.00
96 INT14903 Negative_regulation of SOD1 81 0.57 42.02 6.91 5.00
97 INT3757 Positive_regulation of Gene_expression of ALB 45 0.69 23.73 6.85 5.00
98 INT69441 Regulation of Gene_expression of ROS1 38 0.50 26.78 6.78 5.00
99 INT16068 Gene_expression of SERPINB1 27 0.60 20.51 6.56 5.00
100 INT57720 Localization of IGHG3 33 0.74 20.24 6.25 5.00
101 INT181194 Regulation of Gene_expression of PPARA 31 0.44 21.27 5.96 5.00
102 INT64724 Positive_regulation of Transcription of IL6 26 0.69 13.63 5.96 5.00
103 INT86111 Positive_regulation of Positive_regulation of VEGFA 38 0.69 33.81 5.78 5.00
104 INT86025 Positive_regulation of Positive_regulation of PPARA 34 0.52 22.89 5.74 5.00
105 INT11360 Localization of SERPINE1 41 0.80 33.98 5.61 5.00
106 INT77281 Negative_regulation of HIVEP1 132 0.49 102.78 5.36 5.00
107 INT3165 Gene_expression of LYZ 25 0.65 16.72 5.16 5.00
108 INT105393 Positive_regulation of Localization of VEGFA 66 0.70 45.45 4.9 5.00
109 INT81485 Negative_regulation of IL1RN 19 0.57 8.3 4.69 5.00
110 INT103155 Gene_expression of KDR 78 0.66 50.53 4.38 5.00
111 INT63113 Positive_regulation of HRAS 30 0.67 22.85 4.28 5.00
112 INT745 Gene_expression of Afp 65 0.78 52.89 4.24 5.00
113 INT156097 Negative_regulation of Localization of VEGFA 70 0.58 34.96 4.17 5.00
114 INT88545 Localization of MMRN1 21 0.78 16.67 4.01 5.00
115 INT41878 Positive_regulation of EP300 13 0.61 5.24 3.95 5.00
116 INT1149 Binding of ecs 19 0.37 13.67 3.9 5.00
117 INT15375 Gene_expression of AXL 21 0.65 18.5 3.74 5.00
118 INT123908 Positive_regulation of HLA-DQB1 12 0.21 10.5 3.71 5.00
119 INT121818 Binding of STAT3 25 0.47 11.16 3.67 5.00
120 INT90406 Gene_expression of IL6R 27 0.38 15.74 3.64 5.00
121 INT24231 Localization of SERPINB1 13 0.61 3.1 3.61 5.00
122 INT17685 Negative_regulation of Cog1 23 0.42 15.65 3.56 5.00
123 INT169495 Negative_regulation of Mirlet7a-1 10 0.58 4 3.53 5.00
124 INT10106 Positive_regulation of Msr1 16 0.50 5.86 3.52 5.00
125 INT79477 Binding of HLA-DMA 19 0.26 13.78 3.47 5.00
126 INT75133 Positive_regulation of JUND 15 0.51 6.69 3.26 5.00
127 INT62112 Binding of S100A8 37 0.36 17.18 3.16 5.00
128 INT9884 Localization of CD79A 41 0.78 21.75 3.06 5.00
129 INT105783 Protein_catabolism of IL6 7 0.48 4.72 2.95 5.00
130 INT1653 Positive_regulation of DSP 8 0.49 3.3 2.93 5.00
131 INT172177 Protein_catabolism of INCENP 18 0.37 6.34 2.91 5.00
132 INT105390 Positive_regulation of Gene_expression of HIF1A 27 0.49 26.3 2.88 5.00
133 INT164582 Negative_regulation of MCL1 56 0.56 67.11 2.82 5.00
134 INT89397 Positive_regulation of PIK3CA 33 0.67 16.98 2.78 5.00
135 INT176531 Gene_expression of SHC1 3 0.67 9.5 2.62 5.00
136 INT111298 Gene_expression of ACTN4 12 0.70 9.42 2.6 5.00
137 INT147582 Negative_regulation of AIS 13 0.37 13.26 2.46 5.00
138 INT227267 Gene_expression of hf 7 0.43 19.8 2.38 5.00
139 INT192337 Positive_regulation of DDR1 11 0.41 10.34 2.38 5.00
140 INT205081 Positive_regulation of Gene_expression of AXL 10 0.58 11.27 2.37 5.00
141 INT40565 Gene_expression of SLPI 15 0.75 7.25 2.21 5.00
142 INT58469 Negative_regulation of Positive_regulation of IL6 16 0.42 8.1 2.14 5.00
143 INT37394 Localization of ecs 9 0.34 6.41 2.11 5.00
144 INT171514 Binding of EP300 13 0.32 4.32 2.01 5.00
145 INT171070 Positive_regulation of Hey2 8 0.05 10.12 1.96 5.00
146 INT199084 Gene_expression of Cd36 31 0.53 16.94 1.94 5.00
147 INT101243 Regulation of STAT3 12 0.62 9.98 1.92 5.00
148 INT173180 Positive_regulation of Binding of PPARA 14 0.49 3.66 1.88 5.00
149 INT257755 Positive_regulation of SHC1 1 0.60 4.97 1.87 5.00
150 INT130195 Positive_regulation of ACTN4 4 0.42 3.48 1.7 5.00
151 INT257754 Positive_regulation of Gene_expression of ACTN4 1 0.45 4.58 1.7 5.00
152 INT26451 Gene_expression of KLK1 14 0.75 5.79 1.66 5.00
153 INT43637 Positive_regulation of AXL 11 0.58 11.71 1.59 5.00
154 INT650 Gene_expression of Afp 13 0.78 7.44 1.47 5.00
155 INT173198 Regulation of Binding of PPARA 17 0.43 9.58 1.47 5.00
156 INT166021 Positive_regulation of MCL1 36 0.67 62.97 1.44 5.00
157 INT112963 Regulation of Positive_regulation of PPARA 8 0.44 5.29 1.43 5.00
158 INT258548 Positive_regulation of Meta 10 0.67 5.05 1.42 5.00
159 INT115502 Gene_expression of SAGE1 12 0.65 6.07 1.39 5.00
160 INT109536 Negative_regulation of Vegfa 15 0.46 10.35 1.39 5.00
161 INT140296 Negative_regulation of XIAP 9 0.45 13.61 1.37 5.00
162 INT143716 Phosphorylation of Chuk 16 0.41 5.25 1.35 5.00
163 INT39468 Positive_regulation of hf 10 0.33 13.5 1.32 5.00
164 INT215380 Positive_regulation of Gene_expression of Cd36 12 0.47 8.51 1.3 5.00
165 INT109924 Localization of EPHB2 6 0.73 2.07 1.28 5.00
166 INT182474 Gene_expression of Cdh5 17 0.57 14.58 1.23 5.00
167 INT118196 Gene_expression of ROM1 18 0.66 4.81 1.19 5.00
168 INT123877 Negative_regulation of ABL1 40 0.57 27.94 1.17 5.00
169 INT206136 Positive_regulation of Gene_expression of STAT3 14 0.46 4.3 1.1 5.00
170 INT92588 Positive_regulation of IGF2 8 0.58 4.2 1.07 5.00
171 INT257750 Positive_regulation of Gene_expression of SHC1 1 0.60 3.1 1.04 5.00
172 INT102249 Binding of HIF1A 39 0.36 30.47 1.04 5.00
173 INT208125 Gene_expression of DDR1 10 0.06 8.15 1.03 5.00
174 INT257763 Positive_regulation of Gene_expression of GAS6 1 0.32 3.4 1.02 5.00
175 INT235793 Positive_regulation of Gene_expression of DDR1 3 0.04 4.29 1.01 5.00
176 INT73939 Negative_regulation of Cd36 7 0.57 6.3 0.95 5.00
177 INT167546 Positive_regulation of Gene_expression of ecs 6 0.07 5.78 0.92 5.00
178 INT64958 Negative_regulation of Transcription of IL6 6 0.50 3.58 0.92 5.00
179 INT114176 Positive_regulation of SOS1 3 0.20 1.5 0.86 5.00
180 INT48717 Positive_regulation of Localization of SERPINE1 6 0.66 2.64 0.83 5.00
181 INT257762 Positive_regulation of GAS6 1 0.32 2.7 0.81 5.00
182 INT100378 Protein_catabolism of HIF1A 7 0.96 5.05 0.8 5.00
183 INT178485 Binding of Cd36 11 0.22 6.65 0.8 5.00
184 INT173082 Positive_regulation of Binding of VEGFA 20 0.48 11.16 0.79 5.00
185 INT76751 Negative_regulation of Protein_catabolism of F13A1 7 0.13 5.16 0.79 5.00
186 INT257759 Gene_expression of GAS6 1 0.36 2.61 0.78 5.00
187 INT85023 Negative_regulation of Gene_expression of Agtr2 4 0.57 2.97 0.71 5.00
188 INT209935 Regulation of Regulation of PPARA 4 0.44 1.56 0.69 5.00
189 INT100382 Positive_regulation of Protein_catabolism of HIF1A 2 0.45 1.75 0.64 5.00
190 INT44478 Negative_regulation of PTEN 32 0.57 27.45 0.63 5.00
191 INT142005 Gene_expression of COL18A1 6 0.75 4.53 0.62 5.00
192 INT649 Positive_regulation of Afp 10 0.55 6.5 0.62 5.00
193 INT217168 Gene_expression of MIR21 30 0.55 30.86 0.62 5.00
194 INT44419 Transcription of CD79A 5 0.67 3.83 0.6 5.00
195 INT224608 Positive_regulation of Gene_expression of SERPINH1 4 0.55 3.34 0.58 5.00
196 INT88870 Negative_regulation of PDXP 4 0.43 4.64 0.57 5.00
197 INT15046 Positive_regulation of Gene_expression of Afp 6 0.46 5.95 0.52 5.00
198 INT56094 Protein_catabolism of SERPINE1 2 0.61 1.66 0.47 5.00
199 INT68285 Gene_expression of SERPINB3 24 0.75 25.4 0.45 5.00
200 INT263204 Transcription of SERPINB1 4 0.11 3.09 0.45 5.00
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