D:Precocious Puberty

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Disease Term
Synonyms Accelerated Sexual Maturation, Accelerated Sexual Maturity, Early Puberty, Maturation Sex Accelerated, Precocious Puberty Disorder, PRECOCIOUS SEXUAL DEVELOPMENT, PRECOCIOUS SEXUAL DEVELOPMENT DISORDER, Precocious True Puberty, Premature Puberty, Pubertas Praecox, PUBERTY PRECOCIOUS
Documents 160
Hot Single Events 121
Hot Interactions 5

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Precocious Puberty. They are ordered first by their relevance to Precocious Puberty and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT239080 Binding of PPY and KAT2B 1 0.02 2.38 0 100.00
2 INT41006 GNRH1 Negative_regulation of Localization of CGA 1 0.03 0.87 0.3 99.38
3 INT196592 Binding of CFD and GHRH 1 0.02 1.88 0.07 97.12
4 INT49372 Gh Positive_regulation of Gene_expression of IGFBP3 1 0.00 0.51 0.08 93.12
5 INT49363 Gh Positive_regulation of Igf1 1 0.00 0.49 0.08 90.60
6 INT16104 GNRH1 Positive_regulation of Lhb 2 0.03 0.53 0.14 79.92
7 INT93174 Ttf1 Positive_regulation of GNRH1 1 0.04 0.07 0 71.64
8 INT93172 Ttf1 Negative_regulation of Transcription of Penk 1 0.01 0.07 0 71.64
9 INT93173 Ttf1 Positive_regulation of Erbb2 1 0.05 0.07 0 71.64
10 INT339249 KISS1 Positive_regulation of GNRH1 1 0.64 0.21 0.03 66.88
11 INT339253 KISS1 Regulation of Localization of GNRH1 1 0.25 0.24 0.04 45.44
12 INT220148 Binding of IGF1 and IGFBP3 12 0.36 5.56 0.66 31.84
13 INT29837 Gnrh1 Positive_regulation of LH 6 0.67 0 3.53 25.00
14 INT43688 Gnrh1 Positive_regulation of CGA 1 0.06 0 0 25.00
15 INT239081 Binding of GH1 and MAS1 1 0.03 1.41 0.15 19.56
16 INT339254 GNRHR Regulation of GNRH1 1 0.24 0.23 0.12 9.04
17 INT339251 KISS1R Regulation of GNRH1 1 0.28 0.23 0.12 9.04
18 INT25248 GNRH1 Regulation of CGA 4 0.30 1.22 0.62 5.00
19 INT285746 IL6 Regulation of Localization of PRL 1 0.08 1.51 0.39 5.00
20 INT285749 IL6 Positive_regulation of Localization of PRL 1 0.08 1.51 0.39 5.00
21 INT285750 IL1B Positive_regulation of Localization of PRL 1 0.05 1.51 0.39 5.00
22 INT285744 IL1B Regulation of Localization of PRL 1 0.05 1.51 0.39 5.00
23 INT185530 Binding of AGT and EDNRA 1 0.00 0.31 0.38 5.00
24 INT285748 PRL Positive_regulation of Positive_regulation of C6orf25 1 0.01 1.01 0.31 5.00
25 INT185531 Binding of GRPR and NMBR 1 0.03 0 0.28 5.00
26 INT239087 Binding of SST and Negative_regulation of Localization of GH1 1 0.19 0.36 0.24 5.00
27 INT285745 IL31RA Positive_regulation of Gene_expression of MPL 1 0.19 1.04 0.22 5.00
28 INT339252 Positive_regulation of GNRH1 Positive_regulation of Localization of SCG5 1 0.51 0 0.17 5.00
29 INT289670 NPVF Negative_regulation of Positive_regulation of GNRH1 1 0.34 0.06 0.11 5.00
30 INT288219 Cigs1 Regulation of Nrgn 1 0.00 0.87 0.1 5.00
31 INT65896 GNRH1 Regulation of PLOD1 1 0.17 0.36 0.09 5.00
32 INT289671 NPVF Regulation of GNRH1 1 0.40 0.08 0.08 5.00
33 INT323043 Binding of CYP21A1P and HLA-DOA 1 0.04 1.48 0.06 5.00
34 INT323042 Binding of CYP21A2 and HLA-DOA 1 0.04 1.49 0.06 5.00
35 INT185529 Binding of P2RY14 and GPR87 1 0.03 0.07 0.04 5.00
36 INT289672 Binding of GNRH1 and INSR 1 0.02 0 0 5.00
37 INT289668 IH Regulation of GNRH1 1 0.01 0 0 5.00
38 INT289669 Negative_regulation of GNRH1 Regulation of Localization of CGA 1 0.06 0 0 5.00
39 INT210285 Ccrs1 Regulation of RAI1 1 0.00 0.37 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Precocious Puberty. They are ordered first by their pain relevance and then by number of times they were reported in Precocious Puberty. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT3180 Positive_regulation of PPY 39 0.63 25.57 10.15 100.00
2 INT31226 Localization of PPY 20 0.78 9.93 6.8 100.00
3 INT239083 Binding of PPY 9 0.32 7.59 2.9 100.00
4 INT8916 Regulation of Igf1 45 0.60 13.06 5.81 100.00
5 INT1108 Gene_expression of PPY 58 0.75 36.57 10.76 100.00
6 INT22022 Regulation of PPY 8 0.26 5.52 5.02 100.00
7 INT49361 Regulation of Positive_regulation of Igf1 2 0.45 2.15 1.49 100.00
8 INT4612 Positive_regulation of Localization of CGA 64 0.64 8.51 22.39 100.00
9 INT6299 Regulation of Localization of Lhb 104 0.61 8.98 48.79 100.00
10 INT74018 Binding of XRCC1 19 0.31 24.78 1.24 99.98
11 INT18660 Binding of Gnrhr 45 0.41 10.6 16.85 99.98
12 INT5131 Gene_expression of GNRH1 109 0.78 28.79 23.94 99.92
13 INT5127 Localization of Lhb 488 0.80 50.48 162.66 99.84
14 INT1361 Negative_regulation of Gnrhr 118 0.58 57.77 35.54 99.80
15 INT93171 Positive_regulation of Gene_expression of Ttf1 1 0.57 0.32 0 99.74
16 INT1530 Regulation of Gh 382 0.61 115.96 112.47 99.72
17 INT2136 Gene_expression of Cga 21 0.77 9.83 2.62 99.66
18 INT17539 Positive_regulation of Igf1 68 0.69 28.47 13.02 99.52
19 INT4771 Gene_expression of CGB 23 0.67 14.22 3.42 99.52
20 INT49130 Positive_regulation of IGFBP3 49 0.63 27.55 4.78 99.52
21 INT4289 Positive_regulation of Localization of Gnrh1 202 0.70 12.3 84.01 99.48
22 INT93168 Gene_expression of Ttf1 24 0.63 17.18 1.14 99.38
23 INT439 Localization of Gnrh1 976 0.81 100.96 363.25 99.32
24 INT2159 Regulation of Localization of Gnrh1 200 0.62 13.28 99.07 99.32
25 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 99.24
26 INT7113 Negative_regulation of Localization of CGA 71 0.51 17.7 23.42 99.22
27 INT5135 Negative_regulation of GNRH1 106 0.58 36.63 27.71 99.20
28 INT2197 Gene_expression of Gnrh1 184 0.78 40.04 50.57 99.16
29 INT3104 Negative_regulation of CGA 76 0.54 29.81 12.23 99.08
30 INT243713 Positive_regulation of Gene_expression of Gbp1 2 0.12 2.58 0 98.88
31 INT8336 Transcription of Gnrh1 22 0.71 4.37 4.69 98.80
32 INT3933 Positive_regulation of PLOD1 128 0.70 30.76 42.03 98.80
33 INT1793 Localization of CGA 379 0.81 67.38 114.69 98.76
34 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 98.76
35 INT7975 Regulation of PLOD1 97 0.62 20.9 30.51 98.72
36 INT3500 Positive_regulation of Gene_expression of Gnrh1 25 0.69 4.59 6.69 98.66
37 INT1792 Positive_regulation of CGA 123 0.70 64.73 20.79 98.56
38 INT5128 Positive_regulation of Lhb 232 0.69 44.23 71.26 98.32
39 INT88237 Gene_expression of Gbp1 9 0.65 5.46 0.61 98.04
40 INT5710 Negative_regulation of Localization of Lhb 146 0.57 20.51 58.33 97.96
41 INT913 Regulation of Localization of PLOD1 71 0.62 8.64 32.72 97.86
42 INT8915 Gene_expression of Igf1 199 0.78 78.58 32.51 97.72
43 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26 97.72
44 INT920 Localization of PLOD1 223 0.81 42.25 78.7 97.64
45 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 97.56
46 INT22834 Negative_regulation of CYP21A2 28 0.58 23.07 7.13 97.28
47 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 97.16
48 INT326 Gene_expression of Gnrhr 105 0.76 35.87 34.93 96.78
49 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 96.58
50 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 96.58
51 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 96.58
52 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 96.40
53 INT5130 Regulation of GNRH1 139 0.62 31.95 42.08 96.04
54 INT93166 Positive_regulation of Ttf1 4 0.41 3.62 0.08 95.92
55 INT9559 Positive_regulation of Transcription of Gnrh1 1 0.69 0.82 0.66 95.72
56 INT180250 Positive_regulation of GLUL 23 0.29 7.57 3.23 95.56
57 INT917 Positive_regulation of Localization of PLOD1 51 0.69 8.53 22.87 95.52
58 INT15606 Localization of FSHB 24 0.78 9.16 2.49 95.52
59 INT4937 Negative_regulation of Oprd1 224 0.59 44.51 171.11 95.52
60 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 95.28
61 INT11918 Localization of CGB 35 0.51 8.21 15.01 95.04
62 INT986 Negative_regulation of Localization of GHRH 16 0.58 8.57 3.16 94.68
63 INT16235 Positive_regulation of CGB 27 0.70 15.71 4.06 94.12
64 INT249 Localization of GHRH 215 0.80 78.02 51.87 94.04
65 INT2123 Positive_regulation of Gnrh1 209 0.70 24.2 68.97 93.88
66 INT48725 Gene_expression of IGFBP3 128 0.78 78.83 8.19 93.12
67 INT9494 Positive_regulation of Gene_expression of Igf1 34 0.67 17.77 6.26 93.12
68 INT49371 Positive_regulation of Gene_expression of IGFBP3 27 0.70 23.13 1.9 93.12
69 INT15692 Regulation of HTC2 4 0.27 4.75 1.61 93.12
70 INT14971 Regulation of Afp 12 0.44 11.35 1.48 93.12
71 INT211969 Positive_regulation of Best1 34 0.11 14.92 1.44 93.04
72 INT133474 Localization of SDHA 1 0.14 2.19 0.07 93.00
73 INT7394 Positive_regulation of Localization of GNRH1 67 0.69 7.22 25.29 92.80
74 INT7395 Localization of GNRH1 399 0.81 62.88 117.68 92.16
75 INT8089 Binding of Gnrh1 47 0.48 10.04 13.99 91.84
76 INT2220 Regulation of Gene_expression of Gnrh1 12 0.61 2.16 3.53 91.60
77 INT49370 Localization of IGFBP3 21 0.81 9.85 0.71 91.44
78 INT5865 Positive_regulation of Localization of Gh 282 0.69 84.86 93.5 91.40
79 INT49362 Positive_regulation of Localization of Igf1 4 0.65 2.26 0.53 91.40
80 INT17620 Positive_regulation of Gnrh1 23 0.70 9.77 3.79 91.36
81 INT5868 Positive_regulation of GNRH1 122 0.69 20.96 32.8 90.84
82 INT93170 Regulation of Gene_expression of Ttf1 1 0.50 0.09 0 90.64
83 INT1893 Localization of Gh 1041 0.79 340.23 256.58 90.60
84 INT49360 Localization of Igf1 22 0.76 6.96 4.26 90.48
85 INT416 Regulation of LH 253 0.62 31.48 125.55 90.40
86 INT1002 Regulation of Localization of Ggh 10 0.58 0.63 5.98 90.40
87 INT4530 Regulation of Ggh 9 0.54 2.5 3.96 90.40
88 INT19 Regulation of Gnrhr 131 0.62 36.4 55.66 90.24
89 INT1045 Localization of LH 1211 0.81 87.04 456.25 89.64
90 INT1000 Localization of Ggh 31 0.75 2.74 16.41 89.64
91 INT767 Localization of Gnrhr 565 0.80 106.68 214.57 89.28
92 INT3559 Negative_regulation of Localization of Gnrhr 73 0.58 18.89 26.41 89.28
93 INT158 Localization of Prl 2431 0.81 378.96 952.2 87.52
94 INT2165 Localization of Cga 41 0.80 4.02 19.53 87.52
95 INT2261 Gene_expression of Lhb 121 0.77 42.78 26.04 87.28
96 INT16920 Positive_regulation of NR0B1 6 0.43 3.51 0.76 87.04
97 INT107960 Positive_regulation of Ncoa1 3 0.37 1.59 0.08 87.04
98 INT239084 Localization of KAT2B 4 0.73 3.08 0.36 86.84
99 INT239085 Binding of KAT2B 1 0.18 2.04 0.09 86.84
100 INT7234 Binding of GNRH1 43 0.47 21.59 12.36 86.68
101 INT239082 Binding of BCAM 1 0.03 2.03 0.09 86.64
102 INT239086 Localization of BCAM 2 0.54 2.32 0.09 86.64
103 INT15610 Localization of GOPC 223 0.65 68.26 28.7 86.04
104 INT105021 Binding of GOPC 187 0.40 60.39 20.38 86.04
105 INT956 Negative_regulation of PRL 94 0.59 42.72 23.01 85.44
106 INT1577 Negative_regulation of Gene_expression of PRL 24 0.59 7.7 3.15 85.44
107 INT2106 Regulation of Localization of LH 279 0.62 22.37 122.77 85.36
108 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 84.92
109 INT1047 Negative_regulation of LH 314 0.59 53.71 135.89 84.76
110 INT32612 Negative_regulation of FSHB 3 0.41 2.17 0.58 84.76
111 INT29619 Negative_regulation of Gene_expression of FSHB 5 0.05 0.59 0.57 84.76
112 INT1046 Gene_expression of LH 180 0.77 29.75 66.87 84.08
113 INT15604 Gene_expression of FSHB 30 0.56 9.7 2.45 84.08
114 INT1639 Negative_regulation of OPRM1 107 0.59 13.86 90.37 84.08
115 INT28861 Binding of Gh 61 0.46 25.61 6.38 84.00
116 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52 83.76
117 INT3161 Regulation of Localization of Gh 163 0.61 35.43 59.45 83.48
118 INT131488 Binding of MAS1 9 0.36 8.49 1.01 82.92
119 INT1499 Negative_regulation of Gene_expression of Gh 58 0.42 25.17 7.86 81.20
120 INT318002 Gene_expression of Dmrta1 1 0.70 1.18 0 80.96
121 INT93167 Transcription of Ttf1 2 0.56 0.22 0 80.16
122 INT31073 Regulation of Negative_regulation of GNRH1 2 0.27 1.55 0.62 79.56
123 INT695 Binding of POMC 304 0.48 56.66 126.85 79.08
124 INT2138 Negative_regulation of Cga 5 0.43 3.37 2.1 78.52
125 INT158150 Regulation of KISS1 2 0.44 0.65 0.38 78.32
126 INT318005 Negative_regulation of Dmrta1 1 0.39 1.13 0 77.76
127 INT9118 Gene_expression of Ceacam1 37 0.75 17.19 6.12 77.32
128 INT318008 Positive_regulation of Amh 1 0.25 1.47 0 77.28
129 INT68394 Gene_expression of KISS1 15 0.73 5.33 2.03 76.36
130 INT170854 Gene_expression of CFD 26 0.68 39.77 4.74 75.84
131 INT1638 Negative_regulation of PLOD1 92 0.59 21.69 26.61 75.20
132 INT62919 Regulation of Gnas 22 0.43 5.61 9.55 75.12
133 INT3803 Negative_regulation of Igf1 45 0.58 15.95 7.98 75.00
134 INT745 Gene_expression of Afp 65 0.78 52.89 4.24 75.00
135 INT9500 Negative_regulation of Ceacam1 26 0.58 6.89 3.91 75.00
136 INT157 Positive_regulation of Localization of Prl 790 0.70 104.54 374.78 75.00
137 INT6511 Positive_regulation of AFP 76 0.70 70.15 7.28 75.00
138 INT339255 Positive_regulation of KISS1 1 0.44 0.22 0.03 74.96
139 INT912 Localization of FSHR 91 0.79 23.61 15.58 74.88
140 INT923 Positive_regulation of Localization of FSHR 14 0.43 2.48 4.96 74.88
141 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 73.12
142 INT4485 Negative_regulation of Positive_regulation of PRL 11 0.43 4.24 3.89 73.12
143 INT3589 Positive_regulation of SCN5A 101 0.57 46.01 21.73 72.96
144 INT107962 Gene_expression of Pttg1 34 0.53 34.05 3.11 72.84
145 INT107961 Positive_regulation of Gene_expression of Pttg1 2 0.38 11.69 1.09 72.84
146 INT89858 Positive_regulation of STAT6 10 0.66 7.81 1.47 72.80
147 INT217730 Positive_regulation of Localization of MTOR 4 0.33 0.86 0 72.76
148 INT1794 Regulation of Localization of CGA 136 0.57 13.39 59.07 72.36
149 INT36534 Negative_regulation of Positive_regulation of PLOD1 5 0.56 1.39 2.14 72.00
150 INT5372 Localization of LHB 55 0.68 9.47 19 71.84
151 INT11371 Positive_regulation of Localization of LHB 8 0.47 1.4 2.93 71.84
152 INT217732 Localization of MTOR 11 0.56 3.19 0.03 71.80
153 INT93169 Binding of Ttf1 3 0.30 2.04 0.03 71.64
154 INT318001 Gene_expression of Nobox 1 0.48 1.03 0 71.20
155 INT55047 Gene_expression of GNRHR 8 0.78 5.2 0.53 70.24
156 INT34741 Positive_regulation of Gene_expression of GH1 58 0.67 35.06 7.8 69.96
157 INT149762 Regulation of MAS1 8 0.31 5.34 1.61 69.36
158 INT196594 Localization of CFD 4 0.65 4.36 0.39 68.52
159 INT196595 Regulation of Localization of CFD 1 0.39 2.03 0.04 68.52
160 INT8530 Transcription of Penk 48 0.70 11.67 16.34 68.48
161 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 67.04
162 INT2262 Negative_regulation of Lhb 142 0.59 25.47 44.81 65.32
163 INT184882 Regulation of AMBP 5 0.34 3.3 0.94 64.88
164 INT75315 Regulation of Ghr 4 0.22 1.5 1.34 64.04
165 INT27644 Gene_expression of BRD2 23 0.65 6.97 2.23 63.92
166 INT41719 Gene_expression of MTOR 27 0.77 19.43 1.44 63.80
167 INT50950 Localization of Afp 9 0.50 5.04 0.18 62.36
168 INT36192 Localization of HTC2 11 0.70 2.95 3.3 62.08
169 INT5711 Positive_regulation of Localization of Lhb 90 0.70 10.92 36.76 61.00
170 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 60.64
171 INT26538 Positive_regulation of FSHR 103 0.69 30.95 15.33 59.92
172 INT125980 Binding of CFD 8 0.42 10.96 1.39 59.12
173 INT7396 Regulation of Localization of GNRH1 81 0.62 6.57 31.31 58.32
174 INT15887 Gene_expression of Nbr1 39 0.77 23.91 7.34 58.28
175 INT339257 Gene_expression of KISS1R 1 0.73 0.62 0.38 57.88
176 INT252 Localization of GH1 529 0.80 227.4 122.05 53.40
177 INT38828 Negative_regulation of STS 14 0.44 7.27 0.68 51.04
178 INT23367 Positive_regulation of Positive_regulation of Gnrh1 9 0.50 0.97 2.97 50.00
179 INT27671 Regulation of Transcription of Gnrh1 4 0.45 0.25 1.52 50.00
180 INT55850 Negative_regulation of Positive_regulation of CGA 2 0.55 0.08 0.46 50.00
181 INT350951 Gene_expression of Rcc2 1 0.03 1.73 0.14 49.92
182 INT350952 Negative_regulation of Gene_expression of Rcc2 1 0.02 1.75 0.14 49.92
183 INT239093 Gene_expression of PTTG1 84 0.65 83.94 1.87 49.12
184 INT7397 Negative_regulation of Localization of GNRH1 86 0.59 15.45 29.78 47.84
185 INT239095 Negative_regulation of PTTG1 2 0.32 8.24 0.09 40.32
186 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 38.68
187 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 36.72
188 INT6417 Negative_regulation of ABAT 49 0.51 19.6 36.81 33.76
189 INT207443 Binding of ERAL1 5 0.19 3.69 1.47 32.40
190 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9 28.64
191 INT285754 Gene_expression of MPL 1 0.22 2.05 0.21 26.96
192 INT211970 Negative_regulation of Best1 49 0.14 37.33 2.32 26.88
193 INT318003 Regulation of Nobox 1 0.41 0.64 0 26.72
194 INT318006 Regulation of Dmrta1 1 0.41 0.63 0 25.92
195 INT15419 Gene_expression of IL31RA 6 0.65 5.02 1.19 25.80
196 INT318004 Regulation of Nr5a1 1 0.43 0.63 0 25.36
197 INT7035 Regulation of CGA 87 0.45 29.04 28.45 25.00
198 INT299403 Regulation of Star 5 0.39 0.78 0 24.80
199 INT318000 Regulation of Fshr 1 0.41 0.63 0 24.32
200 INT318007 Regulation of Lhcgr 1 0.40 0.63 0 23.84
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