D:Premature Aging

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pChart

Disease Term
Synonyms None
Documents 42
Hot Single Events 45
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Premature Aging. They are ordered first by their relevance to Premature Aging and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT310727 Binding of DKC1 and TERT 1 0.23 0.91 0.05 39.92
2 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36 5.00
3 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87 5.00
4 INT55162 Binding of NFKB1 and RELA 10 0.30 2.82 1.18 5.00
5 INT323278 Dhfr Negative_regulation of Negative_regulation of Igkv1-131 1 0.02 0.93 1.02 5.00
6 INT206074 Binding of IL6 and IL6ST 7 0.32 3.79 1.01 5.00
7 INT64956 IRF6 Positive_regulation of Gene_expression of IL6 4 0.19 1.4 0.63 5.00
8 INT323280 Dhfr Negative_regulation of Igkv1-131 1 0.02 0.47 0.51 5.00
9 INT115186 IL6 Positive_regulation of Phosphorylation of STAT3 2 0.19 0.35 0.48 5.00
10 INT211308 Binding of Cd4 and Cd8a 3 0.19 0.3 0.31 5.00
11 INT206089 Negative_regulation of FOSB Negative_regulation of Gene_expression of PTGS2 1 0.00 0.97 0.19 5.00
12 INT206081 IL6ST Negative_regulation of IL6 1 0.11 0.81 0.17 5.00
13 INT206059 IL6 Positive_regulation of INS 1 0.02 1.16 0.16 5.00
14 INT206070 ANG Positive_regulation of Transcription of IL6 1 0.05 1.5 0.15 5.00
15 INT206065 EDN1 Positive_regulation of IL6 1 0.03 0.47 0.12 5.00
16 INT214032 Binding of GCAT and BPIFA4P 1 0.00 0.51 0.1 5.00
17 INT206056 PTK2B Negative_regulation of Positive_regulation of IRF6 1 0.00 0.66 0.1 5.00
18 INT214014 Binding of Dysf and Nav1 1 0.00 0.5 0.1 5.00
19 INT214012 Binding of Ank1 and Nav1 1 0.01 0.51 0.1 5.00
20 INT214011 Negative_regulation of Binding of Ank1 and Nav1 1 0.01 0.51 0.1 5.00
21 INT214016 Dysf Negative_regulation of Binding of Dysf and Nav1 1 0.00 0.5 0.1 5.00
22 INT206042 Negative_regulation of FDPS Negative_regulation of Binding of FDPS and GGPS1 1 0.00 0 0.09 5.00
23 INT206054 RAC1 Positive_regulation of STAT3 1 0.07 0.11 0.09 5.00
24 INT206075 Negative_regulation of FDPS Negative_regulation of Binding of GGPS1 1 0.01 0 0.09 5.00
25 INT206078 Binding of FDPS and GGPS1 1 0.00 0 0.09 5.00
26 INT305257 Obsty1 Regulation of Gene_expression of Mapk1 1 0.03 2.05 0.08 5.00
27 INT305274 Obsty1 Regulation of Gene_expression of Prkag1 1 0.01 0.94 0.08 5.00
28 INT206072 ANG Positive_regulation of IL6 1 0.05 0.5 0.08 5.00
29 INT232897 Binding of Rab27a and SAMSN1 1 0.00 0.73 0.08 5.00
30 INT206080 ANG Regulation of Gene_expression of IL6 1 0.03 0.4 0.07 5.00
31 INT232902 Binding of YWHAQ and Krt18 1 0.34 0.96 0.07 5.00
32 INT206063 ANG Positive_regulation of Gene_expression of KRT20 1 0.00 1.01 0.07 5.00
33 INT232901 Regulation of Binding of YWHAQ and Krt18 1 0.41 0.96 0.07 5.00
34 INT329429 Binding of Col7a1 and Hmgcr 1 0.01 0.28 0.06 5.00
35 INT206087 RAC1 Positive_regulation of Gene_expression of STAT3 1 0.08 0.05 0.05 5.00
36 INT337386 Lipg Regulation of GK2 1 0.00 0.15 0.05 5.00
37 INT214033 OGG1 Negative_regulation of BPIFA4P 1 0.08 0.71 0.05 5.00
38 INT206083 LDLR Positive_regulation of Binding of STAT3 1 0.02 0.53 0.04 5.00
39 INT206073 Negative_regulation of RAC1 Positive_regulation of IL6 1 0.14 0.06 0.04 5.00
40 INT206067 Gene_expression of RAC1 Positive_regulation of Positive_regulation of IL6 1 0.16 0.07 0.04 5.00
41 INT214015 Negative_regulation of Binding of Dnahc8 and Ank2 1 0.04 1.09 0.04 5.00
42 INT214013 Binding of Dnahc8 and Ank2 1 0.03 1.08 0.04 5.00
43 INT323286 CYP4A11 Positive_regulation of Kcnma1 1 0.01 0.45 0.04 5.00
44 INT206068 RAC1 Positive_regulation of IL6 1 0.16 0.06 0.04 5.00
45 INT206066 LDLR Positive_regulation of Phosphorylation of STAT3 1 0.02 0.52 0.04 5.00
46 INT170457 RASGRP1 Regulation of TP53 1 0.02 0.58 0.04 5.00
47 INT290810 Gsk3b Regulation of Arntl 1 0.15 0 0.04 5.00
48 INT206071 IRF6 Positive_regulation of Positive_regulation of IL1B 1 0.00 0.58 0.03 5.00
49 INT206076 IL6 Positive_regulation of Positive_regulation of STAT3 1 0.19 0.3 0.03 5.00
50 INT206061 RAC1 Positive_regulation of Positive_regulation of STAT3 1 0.07 0.43 0.03 5.00
51 INT290808 Gsk3b Positive_regulation of Arntl 1 0.25 0.17 0.03 5.00
52 INT232900 Binding of ABR and Krt8 1 0.03 0.49 0.03 5.00
53 INT189375 Rpa1 Regulation of ERCC6 1 0.04 0.05 0 5.00
54 INT305279 Lep Regulation of Gene_expression of Akt1 1 0.18 0.83 0 5.00
55 INT206085 FDPS Positive_regulation of AGFG1 1 0.00 0.4 0 5.00
56 INT305266 Obsty1 Negative_regulation of Phosphorylation of Mapk14 1 0.03 1.05 0 5.00
57 INT206058 EGFR Negative_regulation of Gene_expression of IL6 1 0.07 0.62 0 5.00
58 INT206079 ANG Regulation of KRT20 1 0.00 0.54 0 5.00
59 INT290811 Binding of Mgst1 and Gsk3b 1 0.05 0 0 5.00
60 INT200211 Gh Positive_regulation of Localization of Igf1 1 0.38 2.05 0 5.00
61 INT290807 Positive_regulation of Akt1 Positive_regulation of Phosphorylation of Gsk3b 1 0.14 0 0 5.00
62 INT290813 Arntl Positive_regulation of Gene_expression of Clock 1 0.21 0 0 5.00
63 INT305273 Binding of Lep and Leprot 1 0.06 0.92 0 5.00
64 INT206069 ANG Positive_regulation of Gene_expression of IL6 1 0.05 0.51 0 5.00
65 INT189373 Rpa1 Negative_regulation of ERCC6 1 0.03 0 0 5.00
66 INT305281 Obsty1 Regulation of Localization of Gopc 1 0.02 1.49 0 5.00
67 INT232890 Binding of Rab27a and Gopc 1 0.01 0.3 0 5.00
68 INT305256 Binding of Car2 and Lipo2 1 0.01 0.89 0 5.00
69 INT305265 Obsty1 Negative_regulation of Phosphorylation of Nos3 1 0.05 0.78 0 5.00
70 INT206088 IL6 Positive_regulation of JAK1 1 0.18 0.05 0 5.00
71 INT305278 Lep Negative_regulation of Obsty1 1 0.07 0.94 0 5.00
72 INT232899 Krt18 Negative_regulation of Binding of ABR 1 0.05 0.68 0 5.00
73 INT305276 Obsty1 Regulation of Phosphorylation of Mapk1 1 0.02 1.11 0 5.00
74 INT206178 Foxm1 Positive_regulation of Protein_catabolism of Olr1 1 0.00 0.47 0 5.00
75 INT335042 Binding of CNBP and ANAPC16 1 0.01 0.4 0 5.00
76 INT290809 Binding of Arntl and Gsk3b 1 0.20 0 0 5.00
77 INT206086 LDLR Positive_regulation of Localization of IL6 1 0.03 0.42 0 5.00
78 INT206060 FDPS Positive_regulation of AKT1 1 0.00 0.4 0 5.00
79 INT206055 F2 Positive_regulation of Gene_expression of IL6 1 0.01 1.24 0 5.00
80 INT305255 Obsty1 Positive_regulation of Phosphorylation of Akt1 1 0.05 2.09 0 5.00
81 INT206082 IL6 Positive_regulation of Gene_expression of CCL2 1 0.07 0.3 0 5.00
82 INT232893 Binding of ABR and Nup62 1 0.03 0.13 0 5.00
83 INT305254 Obsty1 Regulation of Gene_expression of Nos3 1 0.03 0.97 0 5.00
84 INT232895 Krt18 Positive_regulation of Gene_expression of ABR 1 0.46 0.09 0 5.00
85 INT305272 Gene_expression of Lep Positive_regulation of Positive_regulation of Stat3 1 0.40 0.46 0 5.00
86 INT305264 Positive_regulation of Binding of Lep and Leprot 1 0.08 0.93 0 5.00
87 INT189330 PPA1 Positive_regulation of ERCC6 1 0.10 0 0 5.00
88 INT206180 Foxm1 Positive_regulation of Transcription of Olr1 1 0.00 0.48 0 5.00
89 INT305280 Lep Positive_regulation of Gene_expression of Leprot 1 0.07 1.03 0 5.00
90 INT305258 Lep Regulation of Gene_expression of Stat3 1 0.24 0.92 0 5.00
91 INT305252 Obsty1 Positive_regulation of Mapk8 1 0.05 1.52 0 5.00
92 INT305277 Positive_regulation of Binding of Lep and Obsty1 1 0.08 0.93 0 5.00
93 INT305271 Binding of Lep and Obsty1 1 0.06 4.86 0 5.00
94 INT170459 Binding of CD1A and GOPC 1 0.07 0.1 0 5.00
95 INT337352 Binding of ARNT and HIF1A 1 0.14 0.61 0 5.00
96 INT189333 CSNK2A1 Positive_regulation of Phosphorylation of ERCC6 1 0.10 0 0 5.00
97 INT305267 Lep Regulation of Obsty1 1 0.04 0.97 0 5.00
98 INT206077 RAC1 Positive_regulation of Phosphorylation of STAT3 1 0.07 0.35 0 5.00
99 INT170458 Binding of MKI67 and THY1 1 0.01 0 0 5.00
100 INT305268 Obsty1 Positive_regulation of Lipo2 1 0.00 0.93 0 5.00
101 INT232898 Binding of KRT1 and Krt8 1 0.27 1.22 0 5.00
102 INT305261 Gene_expression of Lep Positive_regulation of Gene_expression of Stat3 1 0.40 0.46 0 5.00
103 INT305263 Obsty1 Regulation of Phosphorylation of Prkag1 1 0.01 0.78 0 5.00
104 INT323279 Binding of Nos3 and Arg2 1 0.01 0.67 0 5.00
105 INT305259 Binding of Car2 and Obsty1 1 0.02 1.2 0 5.00
106 INT232896 Krt8 Negative_regulation of Binding of ABR 1 0.04 0.68 0 5.00
107 INT232892 Krt18 Positive_regulation of Gene_expression of Krt8 1 0.30 0.09 0 5.00
108 INT189374 Binding of RAD51 and Rad54l 1 0.01 0 0 5.00
109 INT305253 Obsty1 Negative_regulation of Phosphorylation of Akt1 1 0.04 2.36 0 5.00
110 INT206181 FDPS Positive_regulation of ras 1 0.00 0.4 0 5.00
111 INT232889 Binding of Krt18 and Krt8 1 0.22 1.09 0 5.00
112 INT305260 Obsty1 Regulation of Prkag1 1 0.01 0.78 0 5.00
113 INT305269 Lep Positive_regulation of Phosphorylation of Stat3 1 0.40 1.03 0 5.00
114 INT189331 PPA1 Negative_regulation of Phosphorylation of ERCC6 1 0.06 0 0 5.00
115 INT290806 Gene_expression of Akt1 Positive_regulation of Phosphorylation of Gsk3b 1 0.14 0 0 5.00
116 INT305262 Obsty1 Positive_regulation of Phosphorylation of Nos3 1 0.05 0.96 0 5.00
117 INT232894 Binding of ABR and Rab27a 1 0.08 0.3 0 5.00
118 INT206084 EGF Negative_regulation of Gene_expression of IL6 1 0.05 0.61 0 5.00
119 INT305270 Lep Negative_regulation of Localization of Car2 1 0.16 1.28 0 5.00
120 INT170456 Binding of CD14 and GOPC 1 0.10 0.26 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Premature Aging. They are ordered first by their pain relevance and then by number of times they were reported in Premature Aging. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT39587 Gene_expression of CP 42 0.65 31.48 11.87 100.00
2 INT162842 Positive_regulation of Gene_expression of CP 1 0.17 2.48 0.96 100.00
3 INT162843 Negative_regulation of Gene_expression of CP 2 0.11 2.79 0.45 100.00
4 INT107926 Negative_regulation of CP 9 0.41 4.37 0.21 100.00
5 INT251827 Regulation of POLG 3 0.59 2.94 0.04 97.72
6 INT99348 Negative_regulation of PARP1 38 0.58 30.96 3.36 97.52
7 INT97519 Binding of WRN 2 0.27 1.92 0.14 97.00
8 INT341107 Negative_regulation of Localization of ELN 1 0.41 0.66 0.1 96.32
9 INT274185 Localization of ELN 4 0.73 1.25 0.1 96.32
10 INT126586 Binding of PARP1 15 0.43 4.96 0.53 96.20
11 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 94.16
12 INT1196 Positive_regulation of Positive_regulation of POMC 51 0.70 15.99 28.58 94.12
13 INT21254 Regulation of Positive_regulation of POMC 12 0.61 3.64 4.67 94.12
14 INT132754 Regulation of Wrn 1 0.39 0.8 0.1 93.20
15 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 93.16
16 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 93.16
17 INT55171 Gene_expression of RELA 80 0.75 17.17 4.47 93.16
18 INT110252 Positive_regulation of Gene_expression of RELA 29 0.49 6.36 1.31 93.16
19 INT66213 Localization of RELA 63 0.78 14.71 8.77 92.84
20 INT73557 Positive_regulation of RELA 57 0.46 8.7 3.43 92.84
21 INT108875 Positive_regulation of Localization of RELA 9 0.49 1.43 1.72 92.84
22 INT12082 Localization of IL6 365 0.81 241.78 105.78 92.52
23 INT50230 Positive_regulation of Localization of IL6 105 0.70 69.21 29.52 92.52
24 INT151702 Binding of ERCC6 6 0.37 1.47 0.09 92.28
25 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 92.16
26 INT62169 Positive_regulation of MC1R 72 0.69 14.56 27.52 91.60
27 INT117116 Positive_regulation of Positive_regulation of MC1R 7 0.49 1.57 1.91 91.60
28 INT117115 Regulation of Positive_regulation of MC1R 1 0.33 0.38 0.29 91.60
29 INT128328 Gene_expression of Arntl 44 0.74 3.77 2.63 91.04
30 INT305242 Binding of Obsty1 1 0.07 9.33 0.17 90.16
31 INT290795 Gene_expression of Slc2a2 3 0.44 1.22 0.16 88.80
32 INT39733 Localization of NFKB1 59 0.79 22.76 13.99 88.08
33 INT66209 Negative_regulation of Localization of NFKB1 23 0.58 8.2 5.31 88.08
34 INT66211 Positive_regulation of Localization of NFKB1 20 0.68 8.18 5.01 88.08
35 INT164154 Negative_regulation of PHLDA2 2 0.26 5.67 1.13 87.76
36 INT66242 Gene_expression of Ptgis 15 0.64 6.73 3.84 87.60
37 INT51054 Negative_regulation of Localization of IL6 45 0.59 24.48 18.97 86.64
38 INT138715 Gene_expression of POLG 12 0.66 6.97 0.23 85.04
39 INT695 Binding of POMC 304 0.48 56.66 126.85 84.24
40 INT105021 Binding of GOPC 187 0.40 60.39 20.38 84.24
41 INT126582 Negative_regulation of Polb 1 0.01 0.54 0.19 82.72
42 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 82.60
43 INT100861 Binding of CRP 179 0.48 175.2 26.45 80.84
44 INT281018 Regulation of Arntl 12 0.47 0.81 0.24 80.40
45 INT272772 Gene_expression of Fto 2 0.76 3.76 0.52 80.36
46 INT214005 Gene_expression of Ank2 1 0.78 29.4 1.88 79.76
47 INT6174 Regulation of Gene_expression of POMC 49 0.61 9.75 27.69 79.04
48 INT91609 Regulation of Gene_expression of MC1R 11 0.62 2.75 7.34 79.04
49 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 78.56
50 INT56130 Gene_expression of MC1R 259 0.78 62.7 97.55 78.56
51 INT126580 Gene_expression of sal 16 0.50 5.52 0.82 78.44
52 INT57763 Gene_expression of Lmna 25 0.78 7.11 4.6 78.00
53 INT231266 Gene_expression of Prh1 13 0.08 3.95 1.02 77.52
54 INT213995 Positive_regulation of Ank2 1 0.50 2.86 0 75.80
55 INT30170 Gene_expression of Car2 330 0.66 77.26 46.76 72.88
56 INT60713 Binding of Col7a1 47 0.43 22.52 6.29 71.08
57 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 69.96
58 INT158837 Binding of POLG 4 0.37 4.69 0.44 68.08
59 INT1416 Transcription of POMC 40 0.72 10.71 15.38 67.72
60 INT305247 Gene_expression of Obsty1 1 0.11 11.21 0.11 67.28
61 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 67.16
62 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 66.76
63 INT60527 Transcription of IL10 16 0.56 13.57 6.42 66.76
64 INT290781 Phosphorylation of Stk3 1 0.61 0.07 0.04 65.96
65 INT232882 Transcription of ABR 1 0.09 0.61 0 64.32
66 INT214004 Regulation of Gene_expression of Ank2 1 0.45 2.79 0.38 62.28
67 INT84572 Gene_expression of Zmat3 67 0.07 37.61 5.86 60.08
68 INT329428 Positive_regulation of Gene_expression of Apod 1 0.57 1.95 0.15 59.72
69 INT233551 Gene_expression of Apod 8 0.74 12.25 1.4 59.32
70 INT188242 Negative_regulation of Positive_regulation of CRP 4 0.23 3.94 0.22 58.96
71 INT204013 Phosphorylation of Arntl 2 0.63 1.02 0.41 58.12
72 INT62681 Negative_regulation of LEP 93 0.59 66.97 15.77 57.96
73 INT188241 Negative_regulation of ADIPOQ 16 0.43 22.16 1.47 57.96
74 INT69867 Gene_expression of Mip 36 0.75 24.54 10.38 57.52
75 INT210590 Positive_regulation of Gene_expression of Mip 10 0.67 8.09 1.68 57.52
76 INT290784 Regulation of Localization of Arntl 1 0.47 0.06 0.03 57.48
77 INT290791 Localization of Arntl 1 0.61 0.06 0.03 57.08
78 INT101483 Gene_expression of Lep 159 0.78 104.77 25.12 55.80
79 INT135374 Binding of Gsk3b 46 0.48 24.36 4.75 54.76
80 INT189355 Phosphorylation of ERCC6 1 0.79 1.11 0.16 54.52
81 INT65261 Regulation of Col7a1 18 0.55 8.7 1.33 54.52
82 INT290800 Protein_catabolism of Arntl 1 0.76 0.84 0.21 52.72
83 INT290782 Regulation of Phosphorylation of Arntl 1 0.34 0.11 0.07 52.72
84 INT17246 Negative_regulation of POLG 16 0.56 9.69 0.79 51.72
85 INT168409 Positive_regulation of Ccl5 47 0.64 45.84 10.83 48.88
86 INT181345 Positive_regulation of Ccl12 6 0.61 9.68 2.07 48.88
87 INT181019 Positive_regulation of Ccl7 5 0.42 5.52 1.27 48.88
88 INT181352 Positive_regulation of Ccl8 3 0.53 5.44 1.23 48.88
89 INT157805 Negative_regulation of Gene_expression of Col7a1 22 0.34 12.85 3.51 48.68
90 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 48.36
91 INT305230 Regulation of Binding of Obsty1 1 0.07 1.84 0.04 47.36
92 INT65304 Positive_regulation of Gene_expression of MC1R 34 0.70 11.32 12.09 46.12
93 INT290802 Positive_regulation of Protein_catabolism of Arntl 1 0.38 0 0.03 42.92
94 INT166131 Positive_regulation of Positive_regulation of Col7a1 8 0.46 6.4 1.65 42.32
95 INT126585 Positive_regulation of Positive_regulation of PARP1 3 0.55 2.84 0.56 41.96
96 INT126584 Regulation of Positive_regulation of PARP1 1 0.24 0.78 0.49 41.96
97 INT65260 Positive_regulation of Col7a1 95 0.69 61.73 18.42 41.76
98 INT204006 Negative_regulation of Localization of Gsk3b 6 0.40 1.66 0.6 41.64
99 INT126583 Positive_regulation of PARP1 50 0.68 41.44 7.78 41.40
100 INT126581 Positive_regulation of Gli3 6 0.35 1.59 2.48 41.20
101 INT204018 Localization of Gsk3b 27 0.71 13.67 1.87 41.16
102 INT94784 Binding of ROS1 113 0.40 71.57 10.26 40.72
103 INT214040 Negative_regulation of Binding of UTRN 1 0.07 0.73 0 40.56
104 INT214044 Binding of UTRN 2 0.19 1.2 0 40.56
105 INT310728 Binding of DKC1 1 0.25 2.36 0.38 39.92
106 INT214047 Negative_regulation of Gene_expression of UTRN 1 0.07 0.73 0 39.84
107 INT214046 Gene_expression of UTRN 2 0.26 0.73 0 39.84
108 INT290777 Phosphorylation of Clock 1 0.42 0.41 0.14 37.84
109 INT214038 Localization of GABPA 1 0.03 1.42 0 32.72
110 INT305644 Negative_regulation of Gene_expression of Lmna 1 0.43 0.27 0.07 30.84
111 INT65258 Regulation of Gene_expression of Col7a1 17 0.55 8.26 2.57 29.32
112 INT115921 Positive_regulation of AHR 22 0.49 12.03 3.53 28.36
113 INT96872 Positive_regulation of ARNT 2 0.32 1.82 0.23 27.08
114 INT101481 Positive_regulation of Lep 81 0.69 62.59 9.95 26.52
115 INT136488 Regulation of LMNA 13 0.60 3.53 0.2 26.28
116 INT305228 Positive_regulation of Obsty1 1 0.07 4.12 0 25.80
117 INT214000 Binding of Ank2 1 0.48 1.12 0.12 25.04
118 INT4988 Gene_expression of KRT1 64 0.77 43.4 4.12 23.36
119 INT36389 Binding of AHR 18 0.45 7.22 1.46 22.92
120 INT204011 Phosphorylation of Per2 23 0.72 1.25 0.67 22.76
121 INT219493 Binding of ARNT 3 0.23 1.4 0 20.60
122 INT214009 Positive_regulation of Gene_expression of Ank2 1 0.70 2.86 0 19.92
123 INT188240 Transcription of KL 1 0.54 1.88 0 18.24
124 INT290797 Negative_regulation of Phosphorylation of Arntl 1 0.45 0 0.03 17.60
125 INT213997 Negative_regulation of Gene_expression of Ank2 1 0.43 5.06 0.22 17.36
126 INT278977 Gene_expression of LEPR 5 0.75 1.99 0.69 16.48
127 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 15.84
128 INT278709 Gene_expression of CBL 4 0.14 3.91 0.85 15.84
129 INT124372 Gene_expression of Gsk3b 164 0.75 95.64 14.35 15.20
130 INT119719 Positive_regulation of CBL 3 0.49 1.67 0.09 14.64
131 INT290801 Regulation of Protein_catabolism of Clock 1 0.12 0.1 0.04 12.92
132 INT290785 Protein_catabolism of Clock 1 0.29 0.1 0.04 12.40
133 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71 12.36
134 INT199308 Gene_expression of Krt8 37 0.75 23.17 1.06 12.20
135 INT202193 Gene_expression of Krt19 4 0.45 5.02 1.17 10.84
136 INT78281 Gene_expression of Krt7 28 0.70 26.77 0.97 10.84
137 INT232826 Gene_expression of Krt18 26 0.68 14.24 0.48 10.84
138 INT268620 Regulation of Localization of Gsk3b 3 0.35 2.12 0.28 10.60
139 INT100379 Positive_regulation of HIF1A 69 0.69 57.31 10.4 10.16
140 INT266161 Regulation of Negative_regulation of POLG 1 0.38 0.56 0 8.48
141 INT124370 Positive_regulation of Gene_expression of Gsk3b 47 0.67 24.56 5.4 7.48
142 INT135373 Regulation of Gsk3b 35 0.62 18.11 3.53 5.68
143 INT75137 Regulation of Akt1 74 0.48 37.89 9.7 5.28
144 INT121496 Gene_expression of TERT 107 0.78 45.6 7.42 5.04
145 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
146 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
147 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 5.00
148 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
149 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
150 INT1893 Localization of Gh 1041 0.79 340.23 256.58 5.00
151 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 5.00
152 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
153 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 5.00
154 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 5.00
155 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
156 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
157 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 5.00
158 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
159 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 5.00
160 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 5.00
161 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
162 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
163 INT10272 Gene_expression of Il1b 194 0.78 121.02 103.03 5.00
164 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
165 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79 5.00
166 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
167 INT54571 Positive_regulation of NFKB1 263 0.70 138.99 87.32 5.00
168 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46 5.00
169 INT84546 Positive_regulation of Ppara 481 0.70 334.21 83.45 5.00
170 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
171 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 5.00
172 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 5.00
173 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
174 INT6489 Positive_regulation of Gene_expression of Tnf 140 0.70 92.31 67.85 5.00
175 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85 5.00
176 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 5.00
177 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
178 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01 5.00
179 INT314 Positive_regulation of Ren 212 0.70 66.68 55.56 5.00
180 INT69876 Negative_regulation of Nfkb1 147 0.58 89.81 55.5 5.00
181 INT96914 Phosphorylation of Mapk14 168 0.82 108.46 53.32 5.00
182 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15 5.00
183 INT122041 Binding of Ppara 308 0.48 189.17 51.48 5.00
184 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
185 INT55671 Gene_expression of Ik 151 0.27 80.1 48.49 5.00
186 INT789 Positive_regulation of YY1 69 0.67 14.07 47.06 5.00
187 INT110023 Negative_regulation of Mapk14 127 0.59 84.27 45.42 5.00
188 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01 5.00
189 INT6979 Positive_regulation of CA2 206 0.67 50.79 44.97 5.00
190 INT17561 Localization of Car2 303 0.79 60.95 44.52 5.00
191 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
192 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02 5.00
193 INT52531 Gene_expression of Nfkb1 153 0.75 82.84 42.9 5.00
194 INT13354 Transcription of TNF 108 0.72 85.81 42.32 5.00
195 INT65245 Gene_expression of Nos3 121 0.78 98.14 41.56 5.00
196 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
197 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 5.00
198 INT114751 Gene_expression of Mapk1 137 0.76 60.14 39.98 5.00
199 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
200 INT173693 Localization of Gopc 249 0.65 70.49 38.81 5.00
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